KR830007672A - 페니실란산술폰의 에스테르 제조 방법 - Google Patents
페니실란산술폰의 에스테르 제조 방법 Download PDFInfo
- Publication number
- KR830007672A KR830007672A KR1019810004830A KR810004830A KR830007672A KR 830007672 A KR830007672 A KR 830007672A KR 1019810004830 A KR1019810004830 A KR 1019810004830A KR 810004830 A KR810004830 A KR 810004830A KR 830007672 A KR830007672 A KR 830007672A
- Authority
- KR
- South Korea
- Prior art keywords
- group
- chlorine
- hydrogen atom
- halogenating agent
- carbon atoms
- Prior art date
Links
- 238000000034 method Methods 0.000 title claims 9
- 150000002148 esters Chemical class 0.000 title 1
- 239000003795 chemical substances by application Substances 0.000 claims 5
- 229910052801 chlorine Inorganic materials 0.000 claims 5
- 239000000460 chlorine Substances 0.000 claims 5
- 125000001309 chloro group Chemical group Cl* 0.000 claims 5
- 230000002140 halogenating effect Effects 0.000 claims 5
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims 5
- 125000004432 carbon atom Chemical group C* 0.000 claims 4
- 125000000217 alkyl group Chemical group 0.000 claims 3
- GDTBXPJZTBHREO-UHFFFAOYSA-N bromine Chemical group BrBr GDTBXPJZTBHREO-UHFFFAOYSA-N 0.000 claims 3
- ZCYVEMRRCGMTRW-UHFFFAOYSA-N 7553-56-2 Chemical group [I] ZCYVEMRRCGMTRW-UHFFFAOYSA-N 0.000 claims 2
- 229910052794 bromium Inorganic materials 0.000 claims 2
- 150000001875 compounds Chemical class 0.000 claims 2
- 229910052740 iodine Chemical group 0.000 claims 2
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 2
- CTSLXHKWHWQRSH-UHFFFAOYSA-N oxalyl chloride Chemical compound ClC(=O)C(Cl)=O CTSLXHKWHWQRSH-UHFFFAOYSA-N 0.000 claims 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 2
- WKBOTKDWSSQWDR-UHFFFAOYSA-N Bromine atom Chemical compound [Br] WKBOTKDWSSQWDR-UHFFFAOYSA-N 0.000 claims 1
- 125000000484 butyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 claims 1
- 239000012442 inert solvent Substances 0.000 claims 1
- 239000011630 iodine Substances 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
- C07D499/04—Preparation
- C07D499/08—Modification of a carboxyl radical directly attached in position 2, e.g. esterification
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Communicable Diseases (AREA)
- Pharmacology & Pharmacy (AREA)
- Oncology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
내용 없음
Description
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음
Claims (9)
- 하기 일반식(I)로 표시되는 화합물을 반응 불활성 용매중에서 할로겐화제와 반응시킴을 특징으로 하여 하기 일반식(II)로 표시되는 화합물을 제조하는 방법.(식중, X는 염소, 브롬 또는 요오드원자이고; R는 수소원자 또는 메틸기이며; R1는 탄소원자 1 내지 6의 알킬기, 탄소원자 3 내지 8의 시클로알킬벤질기, 또는 페닐기이며; n는 0 또는 1의 정수임).
- 제1항에 있어서 할로겐화제가 염소, 브롬, 요오드 또는 염화옥살릴임을 특징으로 하는 방법.
- 제2항에 있어서 R1이 탄소원자 1 내지 6의 알킬기이고, n이 0이며, 할로겐화제가 염소임을 특징으로 하는 방법.
- 제3항에 있어서 R의 수소원자이고, R1이 부틸기임을 특징으로 하는 방법.
- 제3항에 있어서 R이 수소원자이고 R1이 t부틸기임을 특징으로 하는 방법.
- 제3항에 있어서 R1이 페닐기이고 n이 0이며 할로겐화제가 염소임을 특징으로 하는 방법.
- 제6항에 있어서 R이 수소원자임을 특징으로 하는 방법.
- 제2항에 있어서 R1이 탄소원자 1 내지 6의 알킬기이고, n이 1이며, 할로겐화제가 염소임을 특징으로 하는 방법.
- 제8항에 있어서 R1이 메틸기이고, R이 수소원자임을 특징으로 하는 방법.※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US215,215 | 1980-12-11 | ||
| US215215 | 1980-12-11 | ||
| US06/215,215 US4361513A (en) | 1980-12-11 | 1980-12-11 | Esters of penicillanic acid sulfone |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| KR830007672A true KR830007672A (ko) | 1983-11-04 |
| KR850001340B1 KR850001340B1 (ko) | 1985-09-19 |
Family
ID=22802118
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1019810004830A KR850001340B1 (ko) | 1980-12-11 | 1981-12-10 | 페니실란산 술폰의 에스테르 제조 방법 |
Country Status (20)
| Country | Link |
|---|---|
| US (1) | US4361513A (ko) |
| EP (1) | EP0054397B1 (ko) |
| JP (1) | JPS57122089A (ko) |
| KR (1) | KR850001340B1 (ko) |
| AR (1) | AR229599A1 (ko) |
| AT (1) | ATE12233T1 (ko) |
| AU (1) | AU527159B2 (ko) |
| CA (1) | CA1177068A (ko) |
| DE (1) | DE3169462D1 (ko) |
| DK (1) | DK158228C (ko) |
| ES (1) | ES507867A0 (ko) |
| FI (1) | FI75824C (ko) |
| GR (1) | GR76963B (ko) |
| IE (1) | IE52111B1 (ko) |
| IL (1) | IL64497A0 (ko) |
| NO (1) | NO160517C (ko) |
| PH (1) | PH17469A (ko) |
| PT (1) | PT74111B (ko) |
| YU (1) | YU43053B (ko) |
| ZA (1) | ZA818579B (ko) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4746754A (en) * | 1986-05-16 | 1988-05-24 | The Dow Chemical Company | Preparation of carbonate diisocyanates and related compounds |
| US7968279B2 (en) * | 2008-08-13 | 2011-06-28 | Beckman Coulter, Inc. | Reference control for cell by cell analysis |
| CA2942216C (en) | 2013-03-13 | 2021-09-21 | Andrew Bacon | Improvements in the fuel efficiency of road vehicles |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS512477A (en) * | 1974-06-25 | 1976-01-10 | Zekoo Kk | Ijokeisha shindonokanchisochi |
| JPS512476A (ja) * | 1974-06-25 | 1976-01-10 | Inoue Japax Res | Hokokei |
| JPS6056160B2 (ja) * | 1977-06-07 | 1985-12-09 | フアイザ−・インコ−ポレ−テツド | β−ラクタマ−ゼ阻害剤としてのペニシラン酸１，１−ジオキシド |
| US4272439A (en) * | 1978-06-02 | 1981-06-09 | Schering Corporation | 6-(Substituted-hydroxymethylene penams) |
| US4241050A (en) * | 1978-09-01 | 1980-12-23 | Pfizer Inc. | Penam 1,1-dioxides as beta-lactamase inhibitors |
| AT365594B (de) * | 1978-11-24 | 1982-01-25 | Erba Farmitalia | Verfahren zur herstellung von neuen 7-oxo-4-thia1-aza-bicyclo-(3,2,0)heptanderivaten |
| US4256733A (en) * | 1979-09-26 | 1981-03-17 | Pfizer Inc. | Acetoxymethyl penam compounds as β-lactamase inhibitors |
-
1980
- 1980-12-11 US US06/215,215 patent/US4361513A/en not_active Expired - Lifetime
-
1981
- 1981-12-07 GR GR66707A patent/GR76963B/el unknown
- 1981-12-07 AR AR287708A patent/AR229599A1/es active
- 1981-12-07 PH PH26587A patent/PH17469A/en unknown
- 1981-12-08 DE DE8181305779T patent/DE3169462D1/de not_active Expired
- 1981-12-08 EP EP81305779A patent/EP0054397B1/en not_active Expired
- 1981-12-08 YU YU2881/81A patent/YU43053B/xx unknown
- 1981-12-08 AT AT81305779T patent/ATE12233T1/de not_active IP Right Cessation
- 1981-12-09 IL IL64497A patent/IL64497A0/xx not_active IP Right Cessation
- 1981-12-09 FI FI813956A patent/FI75824C/fi not_active IP Right Cessation
- 1981-12-10 IE IE2899/81A patent/IE52111B1/en not_active IP Right Cessation
- 1981-12-10 CA CA000391950A patent/CA1177068A/en not_active Expired
- 1981-12-10 NO NO814226A patent/NO160517C/no unknown
- 1981-12-10 DK DK547181A patent/DK158228C/da not_active IP Right Cessation
- 1981-12-10 AU AU78446/81A patent/AU527159B2/en not_active Ceased
- 1981-12-10 JP JP56199463A patent/JPS57122089A/ja active Granted
- 1981-12-10 PT PT74111A patent/PT74111B/pt not_active IP Right Cessation
- 1981-12-10 KR KR1019810004830A patent/KR850001340B1/ko active
- 1981-12-10 ES ES507867A patent/ES507867A0/es active Granted
- 1981-12-10 ZA ZA818579A patent/ZA818579B/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| FI75824C (fi) | 1988-08-08 |
| NO814226L (no) | 1982-06-14 |
| AU7844681A (en) | 1982-06-17 |
| ZA818579B (en) | 1982-11-24 |
| NO160517B (no) | 1989-01-16 |
| ES8302717A1 (es) | 1983-01-16 |
| IL64497A0 (en) | 1982-03-31 |
| YU43053B (en) | 1989-02-28 |
| IE812899L (en) | 1982-06-11 |
| FI813956L (fi) | 1982-06-12 |
| AU527159B2 (en) | 1983-02-17 |
| EP0054397B1 (en) | 1985-03-20 |
| JPS57122089A (en) | 1982-07-29 |
| IE52111B1 (en) | 1987-06-24 |
| CA1177068A (en) | 1984-10-30 |
| ES507867A0 (es) | 1983-01-16 |
| YU288181A (en) | 1983-12-31 |
| PT74111B (en) | 1983-12-19 |
| GR76963B (ko) | 1984-09-04 |
| FI75824B (fi) | 1988-04-29 |
| KR850001340B1 (ko) | 1985-09-19 |
| AR229599A1 (es) | 1983-09-30 |
| NO160517C (no) | 1989-04-26 |
| US4361513A (en) | 1982-11-30 |
| DK547181A (da) | 1982-06-12 |
| EP0054397A1 (en) | 1982-06-23 |
| PT74111A (en) | 1982-01-01 |
| DK158228C (da) | 1990-09-24 |
| DK158228B (da) | 1990-04-16 |
| ATE12233T1 (de) | 1985-04-15 |
| DE3169462D1 (en) | 1985-04-25 |
| PH17469A (en) | 1984-08-29 |
| JPS6251959B2 (ko) | 1987-11-02 |
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