KR830004210A - 2-아미노-3-벤조일-페닐아세트아미드 및 환상 동족체 - Google Patents
2-아미노-3-벤조일-페닐아세트아미드 및 환상 동족체 Download PDFInfo
- Publication number
- KR830004210A KR830004210A KR1019800003740A KR800003740A KR830004210A KR 830004210 A KR830004210 A KR 830004210A KR 1019800003740 A KR1019800003740 A KR 1019800003740A KR 800003740 A KR800003740 A KR 800003740A KR 830004210 A KR830004210 A KR 830004210A
- Authority
- KR
- South Korea
- Prior art keywords
- lower alkyl
- formula
- hydrogen
- compound
- halogen
- Prior art date
Links
- 125000004122 cyclic group Chemical group 0.000 title 1
- QEFAQIPZVLVERP-UHFFFAOYSA-N nepafenac Chemical compound NC(=O)CC1=CC=CC(C(=O)C=2C=CC=CC=2)=C1N QEFAQIPZVLVERP-UHFFFAOYSA-N 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 claims 6
- 150000001875 compounds Chemical class 0.000 claims 4
- 229910052739 hydrogen Inorganic materials 0.000 claims 4
- 239000001257 hydrogen Substances 0.000 claims 4
- 125000003545 alkoxy group Chemical group 0.000 claims 3
- 229910052736 halogen Inorganic materials 0.000 claims 3
- 150000002367 halogens Chemical group 0.000 claims 3
- 150000002431 hydrogen Chemical class 0.000 claims 3
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 3
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims 3
- 125000004414 alkyl thio group Chemical group 0.000 claims 1
- 125000000753 cycloalkyl group Chemical group 0.000 claims 1
- 125000002147 dimethylamino group Chemical group [H]C([H])([H])N(*)C([H])([H])[H] 0.000 claims 1
- 125000000623 heterocyclic group Chemical group 0.000 claims 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims 1
- 125000000250 methylamino group Chemical group [H]N(*)C([H])([H])[H] 0.000 claims 1
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims 1
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 claims 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
- C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
- C07D295/182—Radicals derived from carboxylic acids
- C07D295/185—Radicals derived from carboxylic acids from aliphatic carboxylic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pain & Pain Management (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Rheumatology (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
내용 없음
Description
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음
Claims (1)
- 다음 일반식(Ⅳ)의 화합물을 다음 일반식(Ⅲ)의 화합물과 반응시켜 다음 일반식(Ⅱ)의 화합물을 얻고 이를 라니니켈로 처리하여 다음 일반식(Ⅰ)의 화합물을 제조하는 방법.상기 구조식에서R은 수소, 또는 저급알킬이고,R1및 R2는 수소, 저급알킬, 시클로알킬, 페닐 또는 저급알킬, 저급알콕시, 할로겐, 니트로 또는 트리 플루오로메틸로 치환된 페닐이거나R1및 R2는 근접한 질소와 함께 복소환 잔기를 형성하고,R3는 저급알킬 또는 페닐이고,X는 수소, 저급알킬, 저급알콕시, 할로겐 또는 트리플루오로메틸이고,Y는 수소, 저급알킬, 저급알콕시, 할로겐, 트리플루오로메틸, 저급알킬티오, 저급알킬옥시티오 또는 저급알킬디옥시티오이고,Am은 1급 아미노(NH2), 메틸아미노 또는 디메틸아미노이고,n은 1 내지 3이다.※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US7886079A | 1979-09-26 | 1979-09-26 | |
| US078,860 | 1979-09-26 | ||
| US78860 | 1979-09-26 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| KR830004210A true KR830004210A (ko) | 1983-07-06 |
| KR840000763B1 KR840000763B1 (ko) | 1984-06-08 |
Family
ID=22146633
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1019800003740A KR840000763B1 (ko) | 1979-09-26 | 1980-09-25 | 2-아미노-3-벤조일-페닐아세트아미드의 제조방법 |
Country Status (36)
| Country | Link |
|---|---|
| JP (1) | JPS5657751A (ko) |
| KR (1) | KR840000763B1 (ko) |
| AT (1) | AT374170B (ko) |
| AU (1) | AU532359B2 (ko) |
| BE (1) | BE885393A (ko) |
| BR (1) | BR8006042A (ko) |
| CA (1) | CA1128512A (ko) |
| CH (1) | CH646138A5 (ko) |
| CS (1) | CS227012B2 (ko) |
| DE (1) | DE3035688A1 (ko) |
| DK (1) | DK154136C (ko) |
| EG (1) | EG15020A (ko) |
| ES (2) | ES8200329A1 (ko) |
| FI (1) | FI72967C (ko) |
| FR (1) | FR2465710A1 (ko) |
| GB (1) | GB2059963B (ko) |
| GR (1) | GR70049B (ko) |
| HK (1) | HK59383A (ko) |
| HU (1) | HU183215B (ko) |
| IE (1) | IE50268B1 (ko) |
| IL (1) | IL60999A (ko) |
| IN (3) | IN151313B (ko) |
| IT (1) | IT1133823B (ko) |
| KE (1) | KE3307A (ko) |
| LU (1) | LU82797A1 (ko) |
| MX (1) | MX7159E (ko) |
| NL (1) | NL8005346A (ko) |
| NO (1) | NO152128C (ko) |
| NZ (1) | NZ195061A (ko) |
| PH (1) | PH22628A (ko) |
| PL (1) | PL128998B1 (ko) |
| PT (1) | PT71839B (ko) |
| SE (1) | SE448626B (ko) |
| SG (1) | SG42983G (ko) |
| YU (3) | YU41734B (ko) |
| ZA (1) | ZA805476B (ko) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL61945A (en) * | 1980-02-19 | 1984-09-30 | Robins Co Inc A H | 2-amino-3-(hydroxy(phenyl)methyl)phenylacetic acids,esters and amides and pharmaceutical compositions containing them |
| US6646001B2 (en) | 1997-12-19 | 2003-11-11 | Alcon Manufacturing, Ltd. | Use of non-steroidal anti-inflammatory agents in combination with prostaglandin FP receptor agonists to treat glaucoma and ocular hypertension |
| US6066671A (en) * | 1997-12-19 | 2000-05-23 | Alcon Laboratories, Inc. | Treatment of GLC1A glaucoma with 3-benzoyl-phenylacetic acids, esters, or amides |
| GB9727523D0 (en) | 1997-12-31 | 1998-02-25 | Pharmacia & Upjohn Spa | Alpha-aminoamide derivatives useful as analgesic agents |
| AR030345A1 (es) * | 2000-08-14 | 2003-08-20 | Alcon Inc | Metodo de tratamiento de desordenes relacionados con angiogenesis |
| JP4350508B2 (ja) | 2001-09-03 | 2009-10-21 | ニユーロン・フアーマシユーテイカルズ・エツセ・ピー・アー | ガバペンチンまたはその類似体とα−アミノアミドとを含む薬剤組成物およびその鎮痛用途 |
| EP1438956A1 (en) | 2003-01-16 | 2004-07-21 | Newron Pharmaceuticals S.p.A. | Alpha-aminoamide derivatives useful as antimigraine agents |
| CZ2009367A3 (cs) * | 2009-06-08 | 2010-06-16 | Farmak, A.S. | Postup prípravy 2-amino-3-benzoylfenylacetamidu (nepafenacu) s minimem vedlejších produktu |
| CN112794809B (zh) * | 2019-11-14 | 2023-12-29 | 南京济群医药科技股份有限公司 | 一种高纯度奈帕芬胺中间体的制备方法 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1226344A (ko) * | 1967-07-31 | 1971-03-24 | ||
| CH577461A5 (ko) * | 1975-08-13 | 1976-07-15 | Robins Co Inc A H | |
| IL61945A (en) * | 1980-02-19 | 1984-09-30 | Robins Co Inc A H | 2-amino-3-(hydroxy(phenyl)methyl)phenylacetic acids,esters and amides and pharmaceutical compositions containing them |
-
1980
- 1980-09-04 ZA ZA00805476A patent/ZA805476B/xx unknown
- 1980-09-08 IL IL60999A patent/IL60999A/xx unknown
- 1980-09-08 AU AU62116/80A patent/AU532359B2/en not_active Ceased
- 1980-09-11 CS CS806196A patent/CS227012B2/cs unknown
- 1980-09-17 IE IE1946/80A patent/IE50268B1/en unknown
- 1980-09-20 EG EG80573A patent/EG15020A/xx active
- 1980-09-22 GR GR62936A patent/GR70049B/el unknown
- 1980-09-22 DE DE19803035688 patent/DE3035688A1/de active Granted
- 1980-09-22 BR BR8006042A patent/BR8006042A/pt unknown
- 1980-09-23 PH PH24613A patent/PH22628A/en unknown
- 1980-09-23 AT AT0474580A patent/AT374170B/de not_active IP Right Cessation
- 1980-09-24 SE SE8006668A patent/SE448626B/sv not_active IP Right Cessation
- 1980-09-24 FI FI803002A patent/FI72967C/fi not_active IP Right Cessation
- 1980-09-24 LU LU82797A patent/LU82797A1/fr unknown
- 1980-09-25 NL NL8005346A patent/NL8005346A/nl not_active Application Discontinuation
- 1980-09-25 FR FR8020596A patent/FR2465710A1/fr active Granted
- 1980-09-25 ES ES495329A patent/ES8200329A1/es not_active Expired
- 1980-09-25 YU YU2450/80A patent/YU41734B/xx unknown
- 1980-09-25 PT PT71839A patent/PT71839B/pt unknown
- 1980-09-25 GB GB8030955A patent/GB2059963B/en not_active Expired
- 1980-09-25 PL PL1980226919A patent/PL128998B1/pl unknown
- 1980-09-25 MX MX809050U patent/MX7159E/es unknown
- 1980-09-25 CH CH719180A patent/CH646138A5/fr not_active IP Right Cessation
- 1980-09-25 DK DK405780A patent/DK154136C/da not_active IP Right Cessation
- 1980-09-25 HU HU802347A patent/HU183215B/hu not_active IP Right Cessation
- 1980-09-25 NO NO802834A patent/NO152128C/no unknown
- 1980-09-25 BE BE0/202226A patent/BE885393A/fr not_active IP Right Cessation
- 1980-09-25 CA CA361,068A patent/CA1128512A/en not_active Expired
- 1980-09-25 KR KR1019800003740A patent/KR840000763B1/ko active
- 1980-09-26 JP JP13415280A patent/JPS5657751A/ja active Granted
- 1980-09-26 IT IT24948/80A patent/IT1133823B/it active
- 1980-09-26 IN IN1092/CAL/80A patent/IN151313B/en unknown
- 1980-09-26 NZ NZ195061A patent/NZ195061A/en unknown
-
1981
- 1981-06-12 ES ES503019A patent/ES503019A0/es active Granted
-
1982
- 1982-12-30 IN IN1509/CAL/82A patent/IN156255B/en unknown
- 1982-12-30 IN IN1508/CAL/82A patent/IN156254B/en unknown
-
1983
- 1983-03-28 YU YU730/83A patent/YU43305B/xx unknown
- 1983-03-28 YU YU731/83A patent/YU43306B/xx unknown
- 1983-07-19 SG SG42983A patent/SG42983G/en unknown
- 1983-07-21 KE KE3307A patent/KE3307A/xx unknown
- 1983-11-24 HK HK593/83A patent/HK59383A/xx unknown
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