ES8200329A1 - Un procedimiento para preparar 2-amino-3-benzoil-fenilaceta-midas y homologos ciclicos - Google Patents
Un procedimiento para preparar 2-amino-3-benzoil-fenilaceta-midas y homologos ciclicosInfo
- Publication number
- ES8200329A1 ES8200329A1 ES495329A ES495329A ES8200329A1 ES 8200329 A1 ES8200329 A1 ES 8200329A1 ES 495329 A ES495329 A ES 495329A ES 495329 A ES495329 A ES 495329A ES 8200329 A1 ES8200329 A1 ES 8200329A1
- Authority
- ES
- Spain
- Prior art keywords
- lower alkyl
- amino
- trifluoromethyl
- halogen
- phenylacetamides
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
- C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
- C07D295/182—Radicals derived from carboxylic acids
- C07D295/185—Radicals derived from carboxylic acids from aliphatic carboxylic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pain & Pain Management (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Rheumatology (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
PROCEDIMIENTO PARA PREPARAR 2-AMINO-3-BENZOIL-FENILACETAMINAS, Y SUS HOMOLOGOS CICLICOS, DE FORMULA (I), DONDE R ES HIDROGENO O ALCOHILO INFERIOR; R1, R2, X E Y PUEDEN SER DIFERENTES RADICALES; AM ES AMINO PRIMARIO, METILAMINO O DIMETILAMINO Y "N" ES 1, 2 O 3. CONSISTE EN SOMETER A REACCION DE REDUCCION UN COMPUESTO DE FORMULA (II), DONDE R3 ES FENILO O ALCOHILO INFERIOR. LA REDUCCION SE LLEVA A CABO CON NIQUEL RANEY EN TETRAHIDROFURANO. POSTERIORMENTE SE AISLAN LOS COMPUESTOS DE FORMULA (I) POR SEPARACION DEL DISOLVENTE Y CRISTALIZACION. DE APLICACION COMO ANTIINFLAMATORIOS, ANTIPIRETICOS, ANALGESICOS Y AGENTES DE INHIBICION DE LA AGREGACION DE PLAQUETAS SANGUINEAS.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US7886079A | 1979-09-26 | 1979-09-26 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| ES8200329A1 true ES8200329A1 (es) | 1981-10-16 |
| ES495329A0 ES495329A0 (es) | 1981-10-16 |
Family
ID=22146633
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES495329A Granted ES495329A0 (es) | 1979-09-26 | 1980-09-25 | Un procedimiento para preparar 2-amino-3-benzoil-fenilaceta-midas y homologos ciclicos |
| ES503019A Granted ES503019A0 (es) | 1979-09-26 | 1981-06-12 | Un procedimiento para preparar 2-amino-3-benzoil-fenilaceta-midas y homologos ciclicos |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES503019A Granted ES503019A0 (es) | 1979-09-26 | 1981-06-12 | Un procedimiento para preparar 2-amino-3-benzoil-fenilaceta-midas y homologos ciclicos |
Country Status (36)
| Country | Link |
|---|---|
| JP (1) | JPS5657751A (es) |
| KR (1) | KR840000763B1 (es) |
| AT (1) | AT374170B (es) |
| AU (1) | AU532359B2 (es) |
| BE (1) | BE885393A (es) |
| BR (1) | BR8006042A (es) |
| CA (1) | CA1128512A (es) |
| CH (1) | CH646138A5 (es) |
| CS (1) | CS227012B2 (es) |
| DE (1) | DE3035688A1 (es) |
| DK (1) | DK154136C (es) |
| EG (1) | EG15020A (es) |
| ES (2) | ES495329A0 (es) |
| FI (1) | FI72967C (es) |
| FR (1) | FR2465710A1 (es) |
| GB (1) | GB2059963B (es) |
| GR (1) | GR70049B (es) |
| HK (1) | HK59383A (es) |
| HU (1) | HU183215B (es) |
| IE (1) | IE50268B1 (es) |
| IL (1) | IL60999A (es) |
| IN (3) | IN151313B (es) |
| IT (1) | IT1133823B (es) |
| KE (1) | KE3307A (es) |
| LU (1) | LU82797A1 (es) |
| MX (1) | MX7159E (es) |
| NL (1) | NL8005346A (es) |
| NO (1) | NO152128C (es) |
| NZ (1) | NZ195061A (es) |
| PH (1) | PH22628A (es) |
| PL (1) | PL128998B1 (es) |
| PT (1) | PT71839B (es) |
| SE (1) | SE448626B (es) |
| SG (1) | SG42983G (es) |
| YU (3) | YU41734B (es) |
| ZA (1) | ZA805476B (es) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL61945A (en) * | 1980-02-19 | 1984-09-30 | Robins Co Inc A H | 2-amino-3-(hydroxy(phenyl)methyl)phenylacetic acids,esters and amides and pharmaceutical compositions containing them |
| US6646001B2 (en) | 1997-12-19 | 2003-11-11 | Alcon Manufacturing, Ltd. | Use of non-steroidal anti-inflammatory agents in combination with prostaglandin FP receptor agonists to treat glaucoma and ocular hypertension |
| US6066671A (en) * | 1997-12-19 | 2000-05-23 | Alcon Laboratories, Inc. | Treatment of GLC1A glaucoma with 3-benzoyl-phenylacetic acids, esters, or amides |
| GB9727523D0 (en) * | 1997-12-31 | 1998-02-25 | Pharmacia & Upjohn Spa | Alpha-aminoamide derivatives useful as analgesic agents |
| AR030345A1 (es) * | 2000-08-14 | 2003-08-20 | Alcon Inc | Metodo de tratamiento de desordenes relacionados con angiogenesis |
| AU2002333374B2 (en) | 2001-09-03 | 2007-03-22 | Newron Pharmaceuticals S.P.A. | Pharmaceutical composition comprising gabapentin or an analogue thereof and an (alpha)- aminoamide and its analgesic use |
| EP1438956A1 (en) | 2003-01-16 | 2004-07-21 | Newron Pharmaceuticals S.p.A. | Alpha-aminoamide derivatives useful as antimigraine agents |
| CZ2009367A3 (cs) * | 2009-06-08 | 2010-06-16 | Farmak, A.S. | Postup prípravy 2-amino-3-benzoylfenylacetamidu (nepafenacu) s minimem vedlejších produktu |
| CN112794809B (zh) * | 2019-11-14 | 2023-12-29 | 南京济群医药科技股份有限公司 | 一种高纯度奈帕芬胺中间体的制备方法 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1226344A (es) * | 1967-07-31 | 1971-03-24 | ||
| CH577461A5 (es) * | 1975-08-13 | 1976-07-15 | Robins Co Inc A H | |
| IL61945A (en) * | 1980-02-19 | 1984-09-30 | Robins Co Inc A H | 2-amino-3-(hydroxy(phenyl)methyl)phenylacetic acids,esters and amides and pharmaceutical compositions containing them |
-
1980
- 1980-09-04 ZA ZA00805476A patent/ZA805476B/xx unknown
- 1980-09-08 IL IL60999A patent/IL60999A/xx unknown
- 1980-09-08 AU AU62116/80A patent/AU532359B2/en not_active Ceased
- 1980-09-11 CS CS806196A patent/CS227012B2/cs unknown
- 1980-09-17 IE IE1946/80A patent/IE50268B1/en unknown
- 1980-09-20 EG EG80573A patent/EG15020A/xx active
- 1980-09-22 BR BR8006042A patent/BR8006042A/pt unknown
- 1980-09-22 GR GR62936A patent/GR70049B/el unknown
- 1980-09-22 DE DE19803035688 patent/DE3035688A1/de active Granted
- 1980-09-23 AT AT0474580A patent/AT374170B/de not_active IP Right Cessation
- 1980-09-23 PH PH24613A patent/PH22628A/en unknown
- 1980-09-24 FI FI803002A patent/FI72967C/fi not_active IP Right Cessation
- 1980-09-24 SE SE8006668A patent/SE448626B/sv not_active IP Right Cessation
- 1980-09-24 LU LU82797A patent/LU82797A1/fr unknown
- 1980-09-25 PL PL1980226919A patent/PL128998B1/pl unknown
- 1980-09-25 HU HU802347A patent/HU183215B/hu not_active IP Right Cessation
- 1980-09-25 NO NO802834A patent/NO152128C/no unknown
- 1980-09-25 KR KR1019800003740A patent/KR840000763B1/ko active
- 1980-09-25 PT PT71839A patent/PT71839B/pt unknown
- 1980-09-25 NL NL8005346A patent/NL8005346A/nl not_active Application Discontinuation
- 1980-09-25 YU YU2450/80A patent/YU41734B/xx unknown
- 1980-09-25 CA CA361,068A patent/CA1128512A/en not_active Expired
- 1980-09-25 DK DK405780A patent/DK154136C/da not_active IP Right Cessation
- 1980-09-25 ES ES495329A patent/ES495329A0/es active Granted
- 1980-09-25 FR FR8020596A patent/FR2465710A1/fr active Granted
- 1980-09-25 MX MX809050U patent/MX7159E/es unknown
- 1980-09-25 BE BE0/202226A patent/BE885393A/fr not_active IP Right Cessation
- 1980-09-25 CH CH719180A patent/CH646138A5/fr not_active IP Right Cessation
- 1980-09-25 GB GB8030955A patent/GB2059963B/en not_active Expired
- 1980-09-26 IT IT24948/80A patent/IT1133823B/it active
- 1980-09-26 NZ NZ195061A patent/NZ195061A/en unknown
- 1980-09-26 IN IN1092/CAL/80A patent/IN151313B/en unknown
- 1980-09-26 JP JP13415280A patent/JPS5657751A/ja active Granted
-
1981
- 1981-06-12 ES ES503019A patent/ES503019A0/es active Granted
-
1982
- 1982-12-30 IN IN1509/CAL/82A patent/IN156255B/en unknown
- 1982-12-30 IN IN1508/CAL/82A patent/IN156254B/en unknown
-
1983
- 1983-03-28 YU YU731/83A patent/YU43306B/xx unknown
- 1983-03-28 YU YU730/83A patent/YU43305B/xx unknown
- 1983-07-19 SG SG42983A patent/SG42983G/en unknown
- 1983-07-21 KE KE3307A patent/KE3307A/xx unknown
- 1983-11-24 HK HK593/83A patent/HK59383A/xx unknown
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MM4A | Patent lapsed |
Effective date: 19960506 |