ES2046671T3 - Un procedimiento para la preparacion de tetrahidroimidazo(1,4)benzodiazepin-2-tionas. - Google Patents

Un procedimiento para la preparacion de tetrahidroimidazo(1,4)benzodiazepin-2-tionas.

Info

Publication number
ES2046671T3
ES2046671T3 ES199090200348T ES90200348T ES2046671T3 ES 2046671 T3 ES2046671 T3 ES 2046671T3 ES 199090200348 T ES199090200348 T ES 199090200348T ES 90200348 T ES90200348 T ES 90200348T ES 2046671 T3 ES2046671 T3 ES 2046671T3
Authority
ES
Spain
Prior art keywords
alkyl
tetrahidroimidazo
tionas
benzodiazepin
procedure
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES199090200348T
Other languages
English (en)
Inventor
Michael Joseph Kukla
Henry Joseph Breslin
Alfons Herman Margaretha Raeymaekers
Josephus Ludovicus Hubertus Van Gelder
Paul Adriaan Janssen
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Janssen Pharmaceutica NV
Original Assignee
Janssen Pharmaceutica NV
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB898904108A external-priority patent/GB8904108D0/en
Priority claimed from GB898920354A external-priority patent/GB8920354D0/en
Application filed by Janssen Pharmaceutica NV filed Critical Janssen Pharmaceutica NV
Application granted granted Critical
Publication of ES2046671T3 publication Critical patent/ES2046671T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/06—Peri-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Communicable Diseases (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Virology (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

NUEVO TETRAHIDROIMIDAZOL [1,4]BENZODIACEPIN-2-TIONAS DE FORMULA (I): DONDE R1 ES UN ALQUIL DE C1-6, ALQUENIL C3-6, SULFONIL C3-6, CICLOALQUIL C3-6 O ALQUIL C1-6 ALQUIL SUSTITUIDO CON ARIL O CON CICLOALQUIL C3-6; R (AL CUADRADO) , R3 SON HIDROGENO O ALQUIL C1-6; R4, R5 SON HIDROGENO, ALQUIL C1-6, HALO, CIANO, NITRO, TRIFLUOROMETIL, HIDROXI, ALQUILOXI C1-6, AMINO O MONO O DI(ALQUILAMINO C1-6); EL ARIL ES OPCIONALMENTE FENIL SUSTITUIDO. LAS COMPOSICIONES FARMACEUTICAS CONTIENEN ESTOS COMPUESTOS COMO INGREDIENTE ACTIVO; TAMBIEN SE REVELAN LOS PROCESOS PARA PREPARAR DICHOS COMPUESTOS Y COMPOSICIONES.
ES199090200348T 1989-02-23 1990-02-16 Un procedimiento para la preparacion de tetrahidroimidazo(1,4)benzodiazepin-2-tionas. Expired - Lifetime ES2046671T3 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB898904108A GB8904108D0 (en) 1989-02-23 1989-02-23 Antiviral tetrahydroimidazo(1,4)benzodiazepin-2-thiones
GB898920354A GB8920354D0 (en) 1989-09-08 1989-09-08 Antiviral tetrahydroimidazo(1,4)benzodiazepin-2-thiones
US40662689A 1989-09-13 1989-09-13

Publications (1)

Publication Number Publication Date
ES2046671T3 true ES2046671T3 (es) 1994-02-01

Family

ID=27264337

Family Applications (1)

Application Number Title Priority Date Filing Date
ES199090200348T Expired - Lifetime ES2046671T3 (es) 1989-02-23 1990-02-16 Un procedimiento para la preparacion de tetrahidroimidazo(1,4)benzodiazepin-2-tionas.

Country Status (28)

Country Link
EP (1) EP0384522B1 (es)
JP (1) JP2588624B2 (es)
AP (1) AP139A (es)
AT (1) ATE84534T1 (es)
AU (1) AU617926B2 (es)
CA (1) CA2010639C (es)
CY (1) CY1868A (es)
DE (1) DE69000743T2 (es)
DK (1) DK0384522T3 (es)
EG (1) EG19674A (es)
ES (1) ES2046671T3 (es)
FI (1) FI92830C (es)
GR (1) GR3006855T3 (es)
HK (1) HK114995A (es)
HU (2) HU204831B (es)
IE (1) IE63155B1 (es)
IL (1) IL93136A (es)
JO (1) JO1610B1 (es)
LV (1) LV5782B4 (es)
MA (1) MA21748A1 (es)
MY (1) MY106231A (es)
NO (1) NO173503C (es)
NZ (1) NZ232548A (es)
OA (1) OA09196A (es)
PH (1) PH27113A (es)
PT (1) PT93227B (es)
TN (1) TNSN90021A1 (es)
YU (1) YU47219B (es)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8806449D0 (en) * 1988-03-18 1988-04-20 Janssen Pharmaceutica Nv Antiviral hexahydroimiazo(1 4)benzodiazepin-2-ones
NZ235137A (en) * 1989-09-13 1992-02-25 Janssen Pharmaceutica Nv Tetrahydroimidazo(1,4)benzodiazepine derivatives, preparation and pharmaceutical compositions thereof
NZ238664A (en) * 1990-07-06 1992-12-23 Janssen Pharmaceutica Nv Substituted tetrahydroimidazo(1,4)benzodiazepin-2-(thi)ones and pharmaceutical anti-viral compositions
DE4036552C1 (es) * 1990-11-16 1992-02-06 Boehringer Mannheim Gmbh, 6800 Mannheim, De
DE4103803A1 (de) * 1991-02-08 1992-08-13 Boehringer Mannheim Gmbh Neue 4,5,6,7-tetrahydro-imidazo-(4,5,ljk)(1,4)- benzodiazepin-2-(1h)-thione, verfahren zu ihrer herstellung sowie arzneimittel und zwischenprodukte zur herstellung dieser verbindungen
GB9109557D0 (en) * 1991-05-02 1991-06-26 Wellcome Found Chemical compounds
WO1992020344A1 (en) * 1991-05-16 1992-11-26 Glaxo Group Limited Antiviral combinations containing nucleoside analogs
US5593993A (en) * 1991-08-02 1997-01-14 Medivir Ab Method for inhibition of HIV related viruses
IL102548A (en) * 1991-08-02 1998-08-16 Medivir Ab Use of painting derivatives in the preparation of drugs for VIH inhibition and treatment of SDIA and new compounds
WO1993006106A1 (en) * 1991-09-24 1993-04-01 Janssen Pharmaceutica N.V. PROCESS FOR PREPARING ENANTIOMERICALLY PURE IMIDAZO[4,5,1-jk][1,4]-BENZODIAZEPIN-2(1H^_)-THIONES
US6177435B1 (en) 1992-05-13 2001-01-23 Glaxo Wellcome Inc. Therapeutic combinations
ES2138624T3 (es) * 1992-05-13 2000-01-16 Wellcome Found Combinaciones terapeuticas.
GR920100326A (el) * 1992-07-21 1994-03-31 Medivir Ag Ενώσεις και μέ?οδοι αναστολής του HIV και των σχετικών ιών.
US5519021A (en) * 1992-08-07 1996-05-21 Merck & Co., Inc. Benzoxazinones as inhibitors of HIV reverse transcriptase
DE19946289A1 (de) * 1999-09-28 2001-03-29 Basf Ag Benzodiazepin-Derivate, deren Herstellung und Anwendung

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4075206A (en) * 1977-02-25 1978-02-21 Eli Lilly And Company Substituted pyrroloquinoxalinones and diones
FR2534257A1 (fr) * 1982-10-12 1984-04-13 Roussel Uclaf Nouveaux derives de la 6-amino 7-hydroxy 4,5,6,7-tetrahydro-imidazo/4,5,1-j-k/ /1/ benzazepin-2(1h)-one, leurs sels, application a titre de medicaments, compositions les renfermant et un intermediaire
GB8333581D0 (en) * 1983-12-16 1984-01-25 Wyeth John & Brother Ltd Heterocyclic compounds
GB8806449D0 (en) * 1988-03-18 1988-04-20 Janssen Pharmaceutica Nv Antiviral hexahydroimiazo(1 4)benzodiazepin-2-ones

Also Published As

Publication number Publication date
DE69000743D1 (de) 1993-02-25
FI92830C (fi) 1995-01-10
JO1610B1 (en) 1990-07-01
HUT54158A (en) 1991-01-28
GR3006855T3 (es) 1993-06-30
YU33490A (sh) 1992-09-07
HU204831B (en) 1992-02-28
NO900848D0 (no) 1990-02-22
HU900896D0 (en) 1990-05-28
LV5782A4 (lv) 1996-12-20
EP0384522B1 (en) 1993-01-13
OA09196A (en) 1992-06-30
CY1868A (en) 1996-04-05
JP2588624B2 (ja) 1997-03-05
PT93227A (pt) 1990-08-31
DK0384522T3 (da) 1993-04-19
IL93136A0 (en) 1990-11-05
LV5782B4 (lv) 1997-06-20
CA2010639A1 (en) 1990-08-23
ATE84534T1 (de) 1993-01-15
NO900848L (no) 1990-08-24
HK114995A (en) 1995-07-21
EP0384522A1 (en) 1990-08-29
NO173503C (no) 1993-12-22
NO173503B (no) 1993-09-13
IE900650L (en) 1990-08-23
YU47219B (sh) 1995-01-31
NZ232548A (en) 1991-03-26
DE69000743T2 (de) 1993-05-13
FI900897A0 (fi) 1990-02-22
AP9000166A0 (en) 1990-04-30
MA21748A1 (fr) 1990-10-01
HU211250A9 (en) 1995-11-28
AU5003890A (en) 1990-08-30
MY106231A (en) 1995-04-29
IL93136A (en) 1995-01-24
TNSN90021A1 (fr) 1991-03-05
JPH02270876A (ja) 1990-11-05
FI92830B (fi) 1994-09-30
CA2010639C (en) 2001-04-17
PH27113A (en) 1993-03-16
AP139A (en) 1991-10-15
IE63155B1 (en) 1995-03-22
EG19674A (en) 1996-06-30
AU617926B2 (en) 1991-12-05
PT93227B (pt) 1996-01-31

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