YU47219B - Antivirusna tetrahidroimidazo (1,4) benzodiazepin-2-tiona jedinjenja i postupak za njihovo dobijanje - Google Patents
Antivirusna tetrahidroimidazo (1,4) benzodiazepin-2-tiona jedinjenja i postupak za njihovo dobijanjeInfo
- Publication number
- YU47219B YU47219B YU33490A YU33490A YU47219B YU 47219 B YU47219 B YU 47219B YU 33490 A YU33490 A YU 33490A YU 33490 A YU33490 A YU 33490A YU 47219 B YU47219 B YU 47219B
- Authority
- YU
- Yugoslavia
- Prior art keywords
- alkyl
- tetrahydroimidaso
- benzodiazepine
- hydrogen
- virus
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/06—Peri-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Communicable Diseases (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Virology (AREA)
- Oncology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
ANTIVIRUSNA TETRAHIDROIMIDAZO (1,4) BENZODIAZEPIN-2-TIONA JEDINJENJA I POSTUPAK ZA NJIHOVO DOBIJANJE, jedinjenje koje ima formulu njenu farmaceutski prihvatljivu adicionu so ili stereohemijski izomerni oblik, naznačen time, što R1 jeste C1-6 alkil, C3-6 alkenil, C3-6 cikloalkil ili C1-6 alkil supstituisan sa arilom ili sa C3-6 cikloalkil; R2 vodonik ili C1-6 alkil; R3 vodonik ili C1-6 alkil; R4 i R5 su nezavisno svaki za sebe vodonik, C1-6 alkil, halogen, cijano, nitro, trifulormetil, hidroksi, C1-6 alkiloksi amino ili mono-ili di (C1-6 alkilamino); a aril je fenil koji je po slobodnom izboru supstituisan sa 1 do 3 supstituenta nezavisno odabranih od C1-6 alkil, halogena, hidroksi, C1-6 alkiloksi, amino, nitro i trifuluor-metila. Prijava sadrži još 1 nezavisan i 7 zavisnih zahteva.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
HR930480A HRP930480A2 (en) | 1989-02-23 | 1993-03-23 | Antiviral tetrahydroimidazo (1,4) benzodiazepine-2-thiones |
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB898904108A GB8904108D0 (en) | 1989-02-23 | 1989-02-23 | Antiviral tetrahydroimidazo(1,4)benzodiazepin-2-thiones |
GB898920354A GB8920354D0 (en) | 1989-09-08 | 1989-09-08 | Antiviral tetrahydroimidazo(1,4)benzodiazepin-2-thiones |
US40662689A | 1989-09-13 | 1989-09-13 |
Publications (2)
Publication Number | Publication Date |
---|---|
YU33490A YU33490A (sh) | 1992-09-07 |
YU47219B true YU47219B (sh) | 1995-01-31 |
Family
ID=27264337
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
YU33490A YU47219B (sh) | 1989-02-23 | 1990-02-20 | Antivirusna tetrahidroimidazo (1,4) benzodiazepin-2-tiona jedinjenja i postupak za njihovo dobijanje |
Country Status (28)
Country | Link |
---|---|
EP (1) | EP0384522B1 (sh) |
JP (1) | JP2588624B2 (sh) |
AP (1) | AP139A (sh) |
AT (1) | ATE84534T1 (sh) |
AU (1) | AU617926B2 (sh) |
CA (1) | CA2010639C (sh) |
CY (1) | CY1868A (sh) |
DE (1) | DE69000743T2 (sh) |
DK (1) | DK0384522T3 (sh) |
EG (1) | EG19674A (sh) |
ES (1) | ES2046671T3 (sh) |
FI (1) | FI92830C (sh) |
GR (1) | GR3006855T3 (sh) |
HK (1) | HK114995A (sh) |
HU (2) | HU204831B (sh) |
IE (1) | IE63155B1 (sh) |
IL (1) | IL93136A (sh) |
JO (1) | JO1610B1 (sh) |
LV (1) | LV5782B4 (sh) |
MA (1) | MA21748A1 (sh) |
MY (1) | MY106231A (sh) |
NO (1) | NO173503C (sh) |
NZ (1) | NZ232548A (sh) |
OA (1) | OA09196A (sh) |
PH (1) | PH27113A (sh) |
PT (1) | PT93227B (sh) |
TN (1) | TNSN90021A1 (sh) |
YU (1) | YU47219B (sh) |
Families Citing this family (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB8806449D0 (en) * | 1988-03-18 | 1988-04-20 | Janssen Pharmaceutica Nv | Antiviral hexahydroimiazo(1 4)benzodiazepin-2-ones |
NZ235137A (en) * | 1989-09-13 | 1992-02-25 | Janssen Pharmaceutica Nv | Tetrahydroimidazo(1,4)benzodiazepine derivatives, preparation and pharmaceutical compositions thereof |
NZ238664A (en) * | 1990-07-06 | 1992-12-23 | Janssen Pharmaceutica Nv | Substituted tetrahydroimidazo(1,4)benzodiazepin-2-(thi)ones and pharmaceutical anti-viral compositions |
DE4036552C1 (sh) * | 1990-11-16 | 1992-02-06 | Boehringer Mannheim Gmbh, 6800 Mannheim, De | |
DE4103803A1 (de) * | 1991-02-08 | 1992-08-13 | Boehringer Mannheim Gmbh | Neue 4,5,6,7-tetrahydro-imidazo-(4,5,ljk)(1,4)- benzodiazepin-2-(1h)-thione, verfahren zu ihrer herstellung sowie arzneimittel und zwischenprodukte zur herstellung dieser verbindungen |
GB9109557D0 (en) * | 1991-05-02 | 1991-06-26 | Wellcome Found | Chemical compounds |
WO1992020344A1 (en) * | 1991-05-16 | 1992-11-26 | Glaxo Group Limited | Antiviral combinations containing nucleoside analogs |
US5593993A (en) * | 1991-08-02 | 1997-01-14 | Medivir Ab | Method for inhibition of HIV related viruses |
IL102548A (en) * | 1991-08-02 | 1998-08-16 | Medivir Ab | Use of painting derivatives in the preparation of drugs for VIH inhibition and treatment of SDIA and new compounds |
ATE160147T1 (de) * | 1991-09-24 | 1997-11-15 | Janssen Pharmaceutica Nv | Verfahren zur herstellung von enantiomer reinem imidazo (4,5,1-jk) (1,4)-benzodiazepin-2(1h)- thionen |
US6177435B1 (en) | 1992-05-13 | 2001-01-23 | Glaxo Wellcome Inc. | Therapeutic combinations |
ES2138624T3 (es) * | 1992-05-13 | 2000-01-16 | Wellcome Found | Combinaciones terapeuticas. |
GR920100326A (el) * | 1992-07-21 | 1994-03-31 | Medivir Ag | Ενώσεις και μέ?οδοι αναστολής του HIV και των σχετικών ιών. |
US5665720A (en) * | 1992-08-07 | 1997-09-09 | Merck & Co., Inc. | Benzoxazinones as inhibitors of HIV reverse transcriptase |
DE19946289A1 (de) * | 1999-09-28 | 2001-03-29 | Basf Ag | Benzodiazepin-Derivate, deren Herstellung und Anwendung |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4075206A (en) * | 1977-02-25 | 1978-02-21 | Eli Lilly And Company | Substituted pyrroloquinoxalinones and diones |
FR2534257A1 (fr) * | 1982-10-12 | 1984-04-13 | Roussel Uclaf | Nouveaux derives de la 6-amino 7-hydroxy 4,5,6,7-tetrahydro-imidazo/4,5,1-j-k/ /1/ benzazepin-2(1h)-one, leurs sels, application a titre de medicaments, compositions les renfermant et un intermediaire |
GB8333581D0 (en) * | 1983-12-16 | 1984-01-25 | Wyeth John & Brother Ltd | Heterocyclic compounds |
GB8806449D0 (en) * | 1988-03-18 | 1988-04-20 | Janssen Pharmaceutica Nv | Antiviral hexahydroimiazo(1 4)benzodiazepin-2-ones |
-
1990
- 1990-01-23 IL IL9313690A patent/IL93136A/en not_active IP Right Cessation
- 1990-02-06 MY MYPI90000182A patent/MY106231A/en unknown
- 1990-02-14 NZ NZ232548A patent/NZ232548A/en unknown
- 1990-02-16 AT AT90200348T patent/ATE84534T1/de not_active IP Right Cessation
- 1990-02-16 ES ES199090200348T patent/ES2046671T3/es not_active Expired - Lifetime
- 1990-02-16 DE DE9090200348T patent/DE69000743T2/de not_active Expired - Fee Related
- 1990-02-16 DK DK90200348.2T patent/DK0384522T3/da active
- 1990-02-16 EP EP90200348A patent/EP0384522B1/en not_active Expired - Lifetime
- 1990-02-19 MA MA22010A patent/MA21748A1/fr unknown
- 1990-02-20 JO JO19901610A patent/JO1610B1/en active
- 1990-02-20 YU YU33490A patent/YU47219B/sh unknown
- 1990-02-21 AP APAP/P/1990/000166A patent/AP139A/en active
- 1990-02-21 EG EG11190A patent/EG19674A/xx active
- 1990-02-22 TN TNTNSN90021A patent/TNSN90021A1/fr unknown
- 1990-02-22 AU AU50038/90A patent/AU617926B2/en not_active Ceased
- 1990-02-22 NO NO900848A patent/NO173503C/no unknown
- 1990-02-22 JP JP2039883A patent/JP2588624B2/ja not_active Expired - Fee Related
- 1990-02-22 CA CA002010639A patent/CA2010639C/en not_active Expired - Fee Related
- 1990-02-22 PT PT93227A patent/PT93227B/pt not_active IP Right Cessation
- 1990-02-22 HU HU90896A patent/HU204831B/hu not_active IP Right Cessation
- 1990-02-22 IE IE65090A patent/IE63155B1/en not_active IP Right Cessation
- 1990-02-22 FI FI900897A patent/FI92830C/fi not_active IP Right Cessation
- 1990-02-23 PH PH40105A patent/PH27113A/en unknown
- 1990-02-23 OA OA59740A patent/OA09196A/xx unknown
-
1993
- 1993-01-21 GR GR930400107T patent/GR3006855T3/el unknown
-
1995
- 1995-06-28 HU HU95P/P00504P patent/HU211250A9/hu unknown
- 1995-07-13 HK HK114995A patent/HK114995A/xx not_active IP Right Cessation
-
1996
- 1996-04-05 CY CY186896A patent/CY1868A/xx unknown
- 1996-06-18 LV LV960193A patent/LV5782B4/xx unknown
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
YU47219B (sh) | Antivirusna tetrahidroimidazo (1,4) benzodiazepin-2-tiona jedinjenja i postupak za njihovo dobijanje | |
ES8506288A1 (es) | Procedimiento para la preparacion de derivados de n-(2-nitrofenil)-4-aminopirimidina | |
ES2089003T3 (es) | Isoxazoles con propiedades herbicidas. | |
AR021380A1 (es) | COMPUESTOS DIPEPTIDOS CON ELEVADA ACTIVIDAD FUNGUICIDA, SU EMPLEO EN AGRONOMIA, COMPOSICIONES FUNGUICIDAS QUE CONTIENEN A DICHOS COMPUESTOS, PROCEDIMIENTO PARA LA PREPARACIoN DE DICHAS COMPOSICIONES Y MÉTODO PARA COMBATIR INFECCIONES DE HONGOS EMPLEANDO EL COMPUESTO DIPÉPTIDO. | |
JPS52128329A (en) | Anilide derivative | |
PL247096A1 (en) | Agent for fighting against and/or preventing paralyzing effects of microorganisms and method of obtaining new derivatives of n-/2-nitrophenylo/-4-aminopyrimidines | |
ES8402575A1 (es) | "procedimiento para la preparacion de n-(2-piridiloxifenil)-n-benzoilureas substituidas". | |
DK159148C (da) | Analogifremgangsmaade til fremstilling af tranexamsyrederivater | |
SE7609986L (sv) | N-alkyldifenylaminderivat med rodenticid verkan, kompositioner innehallande desamma, samt deras anvendning for bekempande av rattor och moss | |
DE3581029D1 (de) | Substituierte carbodiimide. | |
ES8505975A1 (es) | Procedimiento para la produccion de s,s-dioxidos de 3-acilamino-benzoisotiazol | |
SE8001556L (sv) | Tetrahydrobensotiazolylimidazolidinoner | |
ES8504176A1 (es) | Un procedimiento para preparar derivados de esteres del acido propanoico | |
SE7609586L (sv) | N-alkyldifenylaminer | |
ATE33980T1 (de) | Benzaldoxim-carbamat-derivate. | |
YU74501A (sh) | Sinteza 3-amino-3-aril propionata | |
SE8302824L (sv) | Nya herbicidforeningar | |
YU48176B (sh) | Novi tetrahidroimidazo [1,4] benzodiazepin-2-(ti)oni i postupak njihovog dobijanja | |
GB1509840A (en) | Phenylsulphenylpiperazines | |
SE7513795L (sv) | Forfarande for framstellning av nya cyklopropylmetylamin-dervat | |
ES8303438A1 (es) | Un procedimiento para la preparacion de perfluoroamidas | |
ATE19629T1 (de) | N-substituierte derivate des tetrahydroisophthalimids. | |
ATE16588T1 (de) | 2,2-dihalogeno-3,3-dimethylcyclopropan-derivate | |
ES451217A1 (es) | Procedimiento para la obtencion de fenilureas de actividad herbicida. | |
JPS53111035A (en) | Phenylthiourea derivatives and insecticides containing the same as active ingredient |