JPS52128329A - Anilide derivative - Google Patents

Anilide derivative

Info

Publication number
JPS52128329A
JPS52128329A JP4186876A JP4186876A JPS52128329A JP S52128329 A JPS52128329 A JP S52128329A JP 4186876 A JP4186876 A JP 4186876A JP 4186876 A JP4186876 A JP 4186876A JP S52128329 A JPS52128329 A JP S52128329A
Authority
JP
Japan
Prior art keywords
anilide derivative
alkoxy
halogen
alkyl
independently
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP4186876A
Other languages
Japanese (ja)
Other versions
JPS6044294B2 (en
Inventor
Hiroshi Mori
Takeo Shibata
Rikio Ouchi
Nobuaki Yamagoshi
Shigeru Kurata
Eiichiro Shimazawa
Kazuo Iizuka
Mamoru Saegusa
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Aska Pharmaceutical Co Ltd
Original Assignee
Teikoku Hormone Manufacturing Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Teikoku Hormone Manufacturing Co Ltd filed Critical Teikoku Hormone Manufacturing Co Ltd
Priority to JP4186876A priority Critical patent/JPS6044294B2/en
Publication of JPS52128329A publication Critical patent/JPS52128329A/en
Publication of JPS6044294B2 publication Critical patent/JPS6044294B2/en
Expired legal-status Critical Current

Links

Abstract

PURPOSE: An anilide derivative of formula I (R1, R3 are H, alkyl independently with each other;R2 is H, alkyl, acyl;Y is halogen, OH, NH2, alkoxy, acyloxy, etc.;Z1W4 are H, halogen, haloalkyl, alkoxy, etc. independently with each other), such as N-(2'-hydroxy-2'-methyl-3'-chloropropanoyl)-3,4,4-trichloroaniline.
COPYRIGHT: (C)1977,JPO&Japio
JP4186876A 1976-04-15 1976-04-15 Anilide derivative Expired JPS6044294B2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP4186876A JPS6044294B2 (en) 1976-04-15 1976-04-15 Anilide derivative

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP4186876A JPS6044294B2 (en) 1976-04-15 1976-04-15 Anilide derivative

Publications (2)

Publication Number Publication Date
JPS52128329A true JPS52128329A (en) 1977-10-27
JPS6044294B2 JPS6044294B2 (en) 1985-10-02

Family

ID=12620227

Family Applications (1)

Application Number Title Priority Date Filing Date
JP4186876A Expired JPS6044294B2 (en) 1976-04-15 1976-04-15 Anilide derivative

Country Status (1)

Country Link
JP (1) JPS6044294B2 (en)

Cited By (47)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5495519A (en) * 1977-12-15 1979-07-28 Ici Ltd Novel acylanilide*its manufacture and drug composition having anti male sex hormone action containing said anilide
JPS5933250A (en) * 1982-07-23 1984-02-23 インペリアル・ケミカル・インダストリ−ズ・ピ−エルシ− Acylanilide, manufacture and antiandrogenic medicinal or veterinary composition
US4845119A (en) * 1985-02-18 1989-07-04 Imperial Chemical Industries Plc Alkene, alkyne or cycloalkylene derivatives
US4873329A (en) * 1984-03-07 1989-10-10 Imperial Chemical Industries Plc Alkene, alkyne or cycloalkylene derivatives
US4880839A (en) * 1986-07-18 1989-11-14 Imperial Chemical Industries Plc Acyanilide derivatives
US5236953A (en) * 1982-04-14 1993-08-17 Imperial Chemical Industries Plc Alkene, alkyne or cycloalkylene derivatives
US6019957A (en) * 1997-06-04 2000-02-01 The University Of Tennessee Research Corporation Non-steroidal radiolabeled agonist/antagonist compounds and their use in prostate cancer imaging
US6071957A (en) * 1996-11-27 2000-06-06 The University Of Tennessee Research Corporation Irreversible non-steroidal antagonist compound and its use in the treatment of prostate cancer
US6160011A (en) * 1997-05-30 2000-12-12 The University Of Tennessee Research Corporation Non-steroidal agonist compounds and their use in male hormone therapy
US6602869B1 (en) * 1999-04-01 2003-08-05 L'oreal S.A. Compounds derived from benzoic acid esters, composition containing said compounds and use thereof
US6838484B2 (en) 2000-08-24 2005-01-04 University Of Tennessee Research Foundation Formulations comprising selective androgen receptor modulators
US6995284B2 (en) 2000-08-24 2006-02-07 The University Of Tennessee Research Foundation Synthesis of selective androgen receptor modulators
US6998500B2 (en) 2000-08-24 2006-02-14 University Of Tennessee Research Foundation Selective androgen receptor modulators and methods of use thereof
US7022870B2 (en) 2002-06-17 2006-04-04 University Of Tennessee Research Foundation N-bridged selective androgen receptor modulators and methods of use thereof
US7026500B2 (en) 2000-08-24 2006-04-11 University Of Tennessee Research Foundation Halogenated selective androgen receptor modulators and methods of use thereof
US7253210B2 (en) 2002-10-15 2007-08-07 University Of Tennessee Research Foundation Methylene-bridged selective androgen receptor modulators and methods of use thereof
US7344700B2 (en) 2002-02-28 2008-03-18 University Of Tennessee Research Corporation Radiolabeled selective androgen receptor modulators and their use in prostate cancer imaging and therapy
US7547728B2 (en) 2001-12-06 2009-06-16 University Of Tennessee Research Foundation Treating muscle wasting with selective androgen receptor modulators
US7595402B2 (en) 2003-12-16 2009-09-29 Gtx, Inc. Prodrugs of selective androgen receptor modulators and methods of use thereof
US7622503B2 (en) 2000-08-24 2009-11-24 University Of Tennessee Research Foundation Selective androgen receptor modulators and methods of use thereof
US7645898B2 (en) 2000-08-24 2010-01-12 University Of Tennessee Research Foundation Selective androgen receptor modulators and method of use thereof
US7705182B2 (en) 2002-02-28 2010-04-27 University Of Tennessee Research Foundation Multi-substituted selective androgen receptor modulators and methods of use thereof
US7741371B2 (en) 2002-06-17 2010-06-22 University Of Tennessee Research Foundation Selective androgen receptor modulators and methods of use thereof
US7772433B2 (en) 2002-02-28 2010-08-10 University Of Tennessee Research Foundation SARMS and method of use thereof
US7776921B2 (en) 2002-02-07 2010-08-17 University Of Tennessee Research Foundation Treating benign prostate hyperplasia with SARMS
US7803970B2 (en) 2002-02-28 2010-09-28 University Of Tennessee Research Foundation Multi-substitued selective androgen receptor modulators and methods of use thereof
US7855229B2 (en) 2000-08-24 2010-12-21 University Of Tennessee Research Foundation Treating wasting disorders with selective androgen receptor modulators
US7919647B2 (en) 2000-08-24 2011-04-05 University Of Tennessee Research Foundation Selective androgen receptor modulators and methods of use thereof
US7968721B2 (en) 2003-01-13 2011-06-28 University Of Tennessee Research Foundation Large-scale synthesis of selective androgen receptor modulators
US8008348B2 (en) 2001-12-06 2011-08-30 University Of Tennessee Research Foundation Treating muscle wasting with selective androgen receptor modulators
US8080682B2 (en) 2006-08-24 2011-12-20 University Of Tennessee Research Foundation Substituted acylanilides and methods of use thereof
US8309603B2 (en) 2004-06-07 2012-11-13 University Of Tennessee Research Foundation SARMs and method of use thereof
US8445534B2 (en) 2000-08-24 2013-05-21 University Of Tennessee Research Foundation Treating androgen decline in aging male (ADAM)-associated conditions with SARMs
US8853266B2 (en) 2001-12-06 2014-10-07 University Of Tennessee Research Foundation Selective androgen receptor modulators for treating diabetes
US9604916B2 (en) 2012-07-13 2017-03-28 Gtx, Inc. Method of treating androgen receptor (AR)-positive breast cancers with selective androgen receptor modulator (SARMs)
US9622992B2 (en) 2012-07-13 2017-04-18 Gtx, Inc. Method of treating androgen receptor (AR)-positive breast cancers with selective androgen receptor modulator (SARMs)
US9730908B2 (en) 2006-08-24 2017-08-15 University Of Tennessee Research Foundation SARMs and method of use thereof
US9744149B2 (en) 2012-07-13 2017-08-29 Gtx, Inc. Method of treating androgen receptor (AR)-positive breast cancers with selective androgen receptor modulator (SARMs)
US9844528B2 (en) 2006-08-24 2017-12-19 University Of Tennessee Research Foundation SARMs and method of use thereof
US9884038B2 (en) 2004-06-07 2018-02-06 University Of Tennessee Research Foundation Selective androgen receptor modulator and methods of use thereof
US9889110B2 (en) 2004-06-07 2018-02-13 University Of Tennessee Research Foundation Selective androgen receptor modulator for treating hormone-related conditions
US9969683B2 (en) 2012-07-13 2018-05-15 Gtx, Inc. Method of treating estrogen receptor (ER)-positive breast cancers with selective androgen receptor modulator (SARMS)
US10010521B2 (en) 2006-08-24 2018-07-03 University Of Tennessee Research Foundation SARMs and method of use thereof
US10258596B2 (en) 2012-07-13 2019-04-16 Gtx, Inc. Method of treating HER2-positive breast cancers with selective androgen receptor modulators (SARMS)
US10314807B2 (en) 2012-07-13 2019-06-11 Gtx, Inc. Method of treating HER2-positive breast cancers with selective androgen receptor modulators (SARMS)
US10849873B2 (en) 2012-07-13 2020-12-01 Oncternal Therapeutics, Inc Non-invasive method of evaluating breast cancers for selective androgen receptor modulator (SARM) therapy
US11090283B2 (en) 2007-09-11 2021-08-17 University Of Tennessee Research Foundation Solid forms of selective androgen receptor modulators

Cited By (68)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0002892B1 (en) * 1977-12-15 1985-02-06 Imperial Chemical Industries Plc Amide derivatives, process for their manufacture and pharmaceutical or veterinary compositions containing them
JPS5495519A (en) * 1977-12-15 1979-07-28 Ici Ltd Novel acylanilide*its manufacture and drug composition having anti male sex hormone action containing said anilide
JPH0223537B2 (en) * 1977-12-15 1990-05-24 Ici Plc
US5236953A (en) * 1982-04-14 1993-08-17 Imperial Chemical Industries Plc Alkene, alkyne or cycloalkylene derivatives
JPH0432061B2 (en) * 1982-07-23 1992-05-28
JPS5933250A (en) * 1982-07-23 1984-02-23 インペリアル・ケミカル・インダストリ−ズ・ピ−エルシ− Acylanilide, manufacture and antiandrogenic medicinal or veterinary composition
US4636505A (en) * 1982-07-23 1987-01-13 Imperial Chemical Industries Plc Amide derivatives
US4873329A (en) * 1984-03-07 1989-10-10 Imperial Chemical Industries Plc Alkene, alkyne or cycloalkylene derivatives
US5032592A (en) * 1984-03-07 1991-07-16 Imperial Chemical Industries Plc Alkene, alkyne or cycloalkylene derivatives
US4845119A (en) * 1985-02-18 1989-07-04 Imperial Chemical Industries Plc Alkene, alkyne or cycloalkylene derivatives
US5084478A (en) * 1985-02-18 1992-01-28 Imperial Chemical Industries Plc Alkene, alkyne or cycloalkylene derivatives
US4880839A (en) * 1986-07-18 1989-11-14 Imperial Chemical Industries Plc Acyanilide derivatives
US6071957A (en) * 1996-11-27 2000-06-06 The University Of Tennessee Research Corporation Irreversible non-steroidal antagonist compound and its use in the treatment of prostate cancer
US6482861B2 (en) 1996-11-27 2002-11-19 The University Of Tennessee Research Corporation Irreversible non-steroidal antagonist compound and its use in the treatment of prostate cancer
US7041844B2 (en) 1996-11-27 2006-05-09 The University Of Tennessee Research Corporation Irreversible non-steroidal antagonist compound and its use in the treatment of prostate cancer
US7129377B2 (en) 1996-11-27 2006-10-31 University Of Tennessee Research Foundation Irreversible non-steroidal antagonist compound and its use in the treatment of prostate cancer
US6160011A (en) * 1997-05-30 2000-12-12 The University Of Tennessee Research Corporation Non-steroidal agonist compounds and their use in male hormone therapy
US6019957A (en) * 1997-06-04 2000-02-01 The University Of Tennessee Research Corporation Non-steroidal radiolabeled agonist/antagonist compounds and their use in prostate cancer imaging
US6844003B2 (en) * 1999-04-01 2005-01-18 L'oreal Compounds derived from benzoic acid esters, composition containing said compounds and use thereof
US7125991B2 (en) 1999-04-01 2006-10-24 L'oreal S.A. Compounds derived from benzoic acid esters, composition containing said compounds and use thereof
US6602869B1 (en) * 1999-04-01 2003-08-05 L'oreal S.A. Compounds derived from benzoic acid esters, composition containing said compounds and use thereof
US8445534B2 (en) 2000-08-24 2013-05-21 University Of Tennessee Research Foundation Treating androgen decline in aging male (ADAM)-associated conditions with SARMs
US7645898B2 (en) 2000-08-24 2010-01-12 University Of Tennessee Research Foundation Selective androgen receptor modulators and method of use thereof
US7855229B2 (en) 2000-08-24 2010-12-21 University Of Tennessee Research Foundation Treating wasting disorders with selective androgen receptor modulators
US9493403B2 (en) 2000-08-24 2016-11-15 University Of Tennessee Research Foundation Treating androgen decline in aging male (ADAM)-associated conditions with SARMs
US6838484B2 (en) 2000-08-24 2005-01-04 University Of Tennessee Research Foundation Formulations comprising selective androgen receptor modulators
US6998500B2 (en) 2000-08-24 2006-02-14 University Of Tennessee Research Foundation Selective androgen receptor modulators and methods of use thereof
US6995284B2 (en) 2000-08-24 2006-02-07 The University Of Tennessee Research Foundation Synthesis of selective androgen receptor modulators
US7919647B2 (en) 2000-08-24 2011-04-05 University Of Tennessee Research Foundation Selective androgen receptor modulators and methods of use thereof
US7026500B2 (en) 2000-08-24 2006-04-11 University Of Tennessee Research Foundation Halogenated selective androgen receptor modulators and methods of use thereof
US7622503B2 (en) 2000-08-24 2009-11-24 University Of Tennessee Research Foundation Selective androgen receptor modulators and methods of use thereof
US8008348B2 (en) 2001-12-06 2011-08-30 University Of Tennessee Research Foundation Treating muscle wasting with selective androgen receptor modulators
US7547728B2 (en) 2001-12-06 2009-06-16 University Of Tennessee Research Foundation Treating muscle wasting with selective androgen receptor modulators
US8853266B2 (en) 2001-12-06 2014-10-07 University Of Tennessee Research Foundation Selective androgen receptor modulators for treating diabetes
US8088828B2 (en) 2002-02-07 2012-01-03 University Of Tennessee Research Foundation Treating benign prostate hyperplasia with SARMS
US7776921B2 (en) 2002-02-07 2010-08-17 University Of Tennessee Research Foundation Treating benign prostate hyperplasia with SARMS
US7772433B2 (en) 2002-02-28 2010-08-10 University Of Tennessee Research Foundation SARMS and method of use thereof
US7344700B2 (en) 2002-02-28 2008-03-18 University Of Tennessee Research Corporation Radiolabeled selective androgen receptor modulators and their use in prostate cancer imaging and therapy
US7705182B2 (en) 2002-02-28 2010-04-27 University Of Tennessee Research Foundation Multi-substituted selective androgen receptor modulators and methods of use thereof
US7803970B2 (en) 2002-02-28 2010-09-28 University Of Tennessee Research Foundation Multi-substitued selective androgen receptor modulators and methods of use thereof
US7741371B2 (en) 2002-06-17 2010-06-22 University Of Tennessee Research Foundation Selective androgen receptor modulators and methods of use thereof
US7022870B2 (en) 2002-06-17 2006-04-04 University Of Tennessee Research Foundation N-bridged selective androgen receptor modulators and methods of use thereof
US7253210B2 (en) 2002-10-15 2007-08-07 University Of Tennessee Research Foundation Methylene-bridged selective androgen receptor modulators and methods of use thereof
US7968721B2 (en) 2003-01-13 2011-06-28 University Of Tennessee Research Foundation Large-scale synthesis of selective androgen receptor modulators
US7595402B2 (en) 2003-12-16 2009-09-29 Gtx, Inc. Prodrugs of selective androgen receptor modulators and methods of use thereof
US8309603B2 (en) 2004-06-07 2012-11-13 University Of Tennessee Research Foundation SARMs and method of use thereof
US8669286B2 (en) 2004-06-07 2014-03-11 University Of Tennessee Research Foundation SARMs and method of use thereof
US10053418B2 (en) 2004-06-07 2018-08-21 University Of Tennessee Research Foundation Selective androgen receptor modulator and methods of use thereof
US9884038B2 (en) 2004-06-07 2018-02-06 University Of Tennessee Research Foundation Selective androgen receptor modulator and methods of use thereof
US9278914B2 (en) 2004-06-07 2016-03-08 University Of Tennessee Research Foundation SARMs and method of use thereof
US10662148B2 (en) 2004-06-07 2020-05-26 University Of Tennessee Research Foundation Selective androgen receptor modulator and methods of use thereof
US9889110B2 (en) 2004-06-07 2018-02-13 University Of Tennessee Research Foundation Selective androgen receptor modulator for treating hormone-related conditions
US8846756B2 (en) 2006-08-24 2014-09-30 University Of Tennessee Research Foundation Substituted acylanilides and methods of use thereof
US9730908B2 (en) 2006-08-24 2017-08-15 University Of Tennessee Research Foundation SARMs and method of use thereof
US9844528B2 (en) 2006-08-24 2017-12-19 University Of Tennessee Research Foundation SARMs and method of use thereof
US8426465B2 (en) 2006-08-24 2013-04-23 University Of Tennesse Research Foundation Substituted acylanilides and methods of use thereof
US8080682B2 (en) 2006-08-24 2011-12-20 University Of Tennessee Research Foundation Substituted acylanilides and methods of use thereof
US10300037B2 (en) 2006-08-24 2019-05-28 University Of Tennessee Research Foundation SARMs and method of use thereof
US10010521B2 (en) 2006-08-24 2018-07-03 University Of Tennessee Research Foundation SARMs and method of use thereof
US11090283B2 (en) 2007-09-11 2021-08-17 University Of Tennessee Research Foundation Solid forms of selective androgen receptor modulators
US9604916B2 (en) 2012-07-13 2017-03-28 Gtx, Inc. Method of treating androgen receptor (AR)-positive breast cancers with selective androgen receptor modulator (SARMs)
US10258596B2 (en) 2012-07-13 2019-04-16 Gtx, Inc. Method of treating HER2-positive breast cancers with selective androgen receptor modulators (SARMS)
US9969683B2 (en) 2012-07-13 2018-05-15 Gtx, Inc. Method of treating estrogen receptor (ER)-positive breast cancers with selective androgen receptor modulator (SARMS)
US10314807B2 (en) 2012-07-13 2019-06-11 Gtx, Inc. Method of treating HER2-positive breast cancers with selective androgen receptor modulators (SARMS)
US9744149B2 (en) 2012-07-13 2017-08-29 Gtx, Inc. Method of treating androgen receptor (AR)-positive breast cancers with selective androgen receptor modulator (SARMs)
US10849873B2 (en) 2012-07-13 2020-12-01 Oncternal Therapeutics, Inc Non-invasive method of evaluating breast cancers for selective androgen receptor modulator (SARM) therapy
US10987334B2 (en) 2012-07-13 2021-04-27 University Of Tennessee Research Foundation Method of treating ER mutant expressing breast cancers with selective androgen receptor modulators (SARMs)
US9622992B2 (en) 2012-07-13 2017-04-18 Gtx, Inc. Method of treating androgen receptor (AR)-positive breast cancers with selective androgen receptor modulator (SARMs)

Also Published As

Publication number Publication date
JPS6044294B2 (en) 1985-10-02

Similar Documents

Publication Publication Date Title
JPS52128329A (en) Anilide derivative
JPS5297950A (en) Chalconeether derivatives
JPS5436235A (en) 4-n-alkyl-delta'-cyclohexene-1-carboxylic acids
JPS5424882A (en) Novel heterocyclic compounds and their preparation
JPS51125738A (en) Cyclohexene insecticides and tickicides
JPS51113846A (en) New herbicides
JPS53141336A (en) Preparation of monoazo dyes
JPS5353652A (en) Novel imidazole derivatives
JPS5239674A (en) Imidazole derivatives and agricultural bactericides therefrom
JPS5427578A (en) 1-carboxyalkylcarbamoyl-5-fluorouracil derivatives and their preparation
JPS5368777A (en) Preparation of phenyathridine
JPS5359680A (en) 1-(n-aralkylcarbamoyl)-5-fluorouracils and their preparation
JPS5293799A (en) Recerpine derivatives and antiarryhythics
JPS52134634A (en) 3,10-dialkoxy-4-halogeno-13-cyanotriphenodioxazines
JPS5359656A (en) Silacyclopropene derivatives and process for preparation of the same
JPS53101308A (en) Derivative of 5,6-dihydro-2h-pyran and its preparation
JPS51123823A (en) A barbituric acid insecticide and tickicide
JPS5432489A (en) 4-substd phenylphtharazine derivatives
JPS5439080A (en) Isoquinolinoacetic acids
JPS5283671A (en) 3-substituted-3-alkoxycarbonyl-2-piperidon
JPS5384935A (en) N-substitute benzanilides and bactericides containing the same
JPS5350179A (en) Novel 2-pyridone compounds and their preparation
JPS525778A (en) N-substituted-1-oxo-1,2,3,4-tetrahydro-isoqvinoline derivatives
JPS5257163A (en) Process for preparing gamma-lactones
JPS5430181A (en) 3,4-dihydrocarbostyril derivative