JPS52128329A - Anilide derivative - Google Patents
Anilide derivativeInfo
- Publication number
- JPS52128329A JPS52128329A JP4186876A JP4186876A JPS52128329A JP S52128329 A JPS52128329 A JP S52128329A JP 4186876 A JP4186876 A JP 4186876A JP 4186876 A JP4186876 A JP 4186876A JP S52128329 A JPS52128329 A JP S52128329A
- Authority
- JP
- Japan
- Prior art keywords
- anilide derivative
- alkoxy
- halogen
- alkyl
- independently
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Abstract
PURPOSE: An anilide derivative of formula I (R1, R3 are H, alkyl independently with each other;R2 is H, alkyl, acyl;Y is halogen, OH, NH2, alkoxy, acyloxy, etc.;Z1W4 are H, halogen, haloalkyl, alkoxy, etc. independently with each other), such as N-(2'-hydroxy-2'-methyl-3'-chloropropanoyl)-3,4,4-trichloroaniline.
COPYRIGHT: (C)1977,JPO&Japio
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP4186876A JPS6044294B2 (en) | 1976-04-15 | 1976-04-15 | Anilide derivative |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP4186876A JPS6044294B2 (en) | 1976-04-15 | 1976-04-15 | Anilide derivative |
Publications (2)
Publication Number | Publication Date |
---|---|
JPS52128329A true JPS52128329A (en) | 1977-10-27 |
JPS6044294B2 JPS6044294B2 (en) | 1985-10-02 |
Family
ID=12620227
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP4186876A Expired JPS6044294B2 (en) | 1976-04-15 | 1976-04-15 | Anilide derivative |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS6044294B2 (en) |
Cited By (47)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS5495519A (en) * | 1977-12-15 | 1979-07-28 | Ici Ltd | Novel acylanilide*its manufacture and drug composition having anti male sex hormone action containing said anilide |
JPS5933250A (en) * | 1982-07-23 | 1984-02-23 | インペリアル・ケミカル・インダストリ−ズ・ピ−エルシ− | Acylanilide, manufacture and antiandrogenic medicinal or veterinary composition |
US4845119A (en) * | 1985-02-18 | 1989-07-04 | Imperial Chemical Industries Plc | Alkene, alkyne or cycloalkylene derivatives |
US4873329A (en) * | 1984-03-07 | 1989-10-10 | Imperial Chemical Industries Plc | Alkene, alkyne or cycloalkylene derivatives |
US4880839A (en) * | 1986-07-18 | 1989-11-14 | Imperial Chemical Industries Plc | Acyanilide derivatives |
US5236953A (en) * | 1982-04-14 | 1993-08-17 | Imperial Chemical Industries Plc | Alkene, alkyne or cycloalkylene derivatives |
US6019957A (en) * | 1997-06-04 | 2000-02-01 | The University Of Tennessee Research Corporation | Non-steroidal radiolabeled agonist/antagonist compounds and their use in prostate cancer imaging |
US6071957A (en) * | 1996-11-27 | 2000-06-06 | The University Of Tennessee Research Corporation | Irreversible non-steroidal antagonist compound and its use in the treatment of prostate cancer |
US6160011A (en) * | 1997-05-30 | 2000-12-12 | The University Of Tennessee Research Corporation | Non-steroidal agonist compounds and their use in male hormone therapy |
US6602869B1 (en) * | 1999-04-01 | 2003-08-05 | L'oreal S.A. | Compounds derived from benzoic acid esters, composition containing said compounds and use thereof |
US6838484B2 (en) | 2000-08-24 | 2005-01-04 | University Of Tennessee Research Foundation | Formulations comprising selective androgen receptor modulators |
US6995284B2 (en) | 2000-08-24 | 2006-02-07 | The University Of Tennessee Research Foundation | Synthesis of selective androgen receptor modulators |
US6998500B2 (en) | 2000-08-24 | 2006-02-14 | University Of Tennessee Research Foundation | Selective androgen receptor modulators and methods of use thereof |
US7022870B2 (en) | 2002-06-17 | 2006-04-04 | University Of Tennessee Research Foundation | N-bridged selective androgen receptor modulators and methods of use thereof |
US7026500B2 (en) | 2000-08-24 | 2006-04-11 | University Of Tennessee Research Foundation | Halogenated selective androgen receptor modulators and methods of use thereof |
US7253210B2 (en) | 2002-10-15 | 2007-08-07 | University Of Tennessee Research Foundation | Methylene-bridged selective androgen receptor modulators and methods of use thereof |
US7344700B2 (en) | 2002-02-28 | 2008-03-18 | University Of Tennessee Research Corporation | Radiolabeled selective androgen receptor modulators and their use in prostate cancer imaging and therapy |
US7547728B2 (en) | 2001-12-06 | 2009-06-16 | University Of Tennessee Research Foundation | Treating muscle wasting with selective androgen receptor modulators |
US7595402B2 (en) | 2003-12-16 | 2009-09-29 | Gtx, Inc. | Prodrugs of selective androgen receptor modulators and methods of use thereof |
US7622503B2 (en) | 2000-08-24 | 2009-11-24 | University Of Tennessee Research Foundation | Selective androgen receptor modulators and methods of use thereof |
US7645898B2 (en) | 2000-08-24 | 2010-01-12 | University Of Tennessee Research Foundation | Selective androgen receptor modulators and method of use thereof |
US7705182B2 (en) | 2002-02-28 | 2010-04-27 | University Of Tennessee Research Foundation | Multi-substituted selective androgen receptor modulators and methods of use thereof |
US7741371B2 (en) | 2002-06-17 | 2010-06-22 | University Of Tennessee Research Foundation | Selective androgen receptor modulators and methods of use thereof |
US7772433B2 (en) | 2002-02-28 | 2010-08-10 | University Of Tennessee Research Foundation | SARMS and method of use thereof |
US7776921B2 (en) | 2002-02-07 | 2010-08-17 | University Of Tennessee Research Foundation | Treating benign prostate hyperplasia with SARMS |
US7803970B2 (en) | 2002-02-28 | 2010-09-28 | University Of Tennessee Research Foundation | Multi-substitued selective androgen receptor modulators and methods of use thereof |
US7855229B2 (en) | 2000-08-24 | 2010-12-21 | University Of Tennessee Research Foundation | Treating wasting disorders with selective androgen receptor modulators |
US7919647B2 (en) | 2000-08-24 | 2011-04-05 | University Of Tennessee Research Foundation | Selective androgen receptor modulators and methods of use thereof |
US7968721B2 (en) | 2003-01-13 | 2011-06-28 | University Of Tennessee Research Foundation | Large-scale synthesis of selective androgen receptor modulators |
US8008348B2 (en) | 2001-12-06 | 2011-08-30 | University Of Tennessee Research Foundation | Treating muscle wasting with selective androgen receptor modulators |
US8080682B2 (en) | 2006-08-24 | 2011-12-20 | University Of Tennessee Research Foundation | Substituted acylanilides and methods of use thereof |
US8309603B2 (en) | 2004-06-07 | 2012-11-13 | University Of Tennessee Research Foundation | SARMs and method of use thereof |
US8445534B2 (en) | 2000-08-24 | 2013-05-21 | University Of Tennessee Research Foundation | Treating androgen decline in aging male (ADAM)-associated conditions with SARMs |
US8853266B2 (en) | 2001-12-06 | 2014-10-07 | University Of Tennessee Research Foundation | Selective androgen receptor modulators for treating diabetes |
US9604916B2 (en) | 2012-07-13 | 2017-03-28 | Gtx, Inc. | Method of treating androgen receptor (AR)-positive breast cancers with selective androgen receptor modulator (SARMs) |
US9622992B2 (en) | 2012-07-13 | 2017-04-18 | Gtx, Inc. | Method of treating androgen receptor (AR)-positive breast cancers with selective androgen receptor modulator (SARMs) |
US9730908B2 (en) | 2006-08-24 | 2017-08-15 | University Of Tennessee Research Foundation | SARMs and method of use thereof |
US9744149B2 (en) | 2012-07-13 | 2017-08-29 | Gtx, Inc. | Method of treating androgen receptor (AR)-positive breast cancers with selective androgen receptor modulator (SARMs) |
US9844528B2 (en) | 2006-08-24 | 2017-12-19 | University Of Tennessee Research Foundation | SARMs and method of use thereof |
US9884038B2 (en) | 2004-06-07 | 2018-02-06 | University Of Tennessee Research Foundation | Selective androgen receptor modulator and methods of use thereof |
US9889110B2 (en) | 2004-06-07 | 2018-02-13 | University Of Tennessee Research Foundation | Selective androgen receptor modulator for treating hormone-related conditions |
US9969683B2 (en) | 2012-07-13 | 2018-05-15 | Gtx, Inc. | Method of treating estrogen receptor (ER)-positive breast cancers with selective androgen receptor modulator (SARMS) |
US10010521B2 (en) | 2006-08-24 | 2018-07-03 | University Of Tennessee Research Foundation | SARMs and method of use thereof |
US10258596B2 (en) | 2012-07-13 | 2019-04-16 | Gtx, Inc. | Method of treating HER2-positive breast cancers with selective androgen receptor modulators (SARMS) |
US10314807B2 (en) | 2012-07-13 | 2019-06-11 | Gtx, Inc. | Method of treating HER2-positive breast cancers with selective androgen receptor modulators (SARMS) |
US10849873B2 (en) | 2012-07-13 | 2020-12-01 | Oncternal Therapeutics, Inc | Non-invasive method of evaluating breast cancers for selective androgen receptor modulator (SARM) therapy |
US11090283B2 (en) | 2007-09-11 | 2021-08-17 | University Of Tennessee Research Foundation | Solid forms of selective androgen receptor modulators |
-
1976
- 1976-04-15 JP JP4186876A patent/JPS6044294B2/en not_active Expired
Cited By (68)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0002892B1 (en) * | 1977-12-15 | 1985-02-06 | Imperial Chemical Industries Plc | Amide derivatives, process for their manufacture and pharmaceutical or veterinary compositions containing them |
JPS5495519A (en) * | 1977-12-15 | 1979-07-28 | Ici Ltd | Novel acylanilide*its manufacture and drug composition having anti male sex hormone action containing said anilide |
JPH0223537B2 (en) * | 1977-12-15 | 1990-05-24 | Ici Plc | |
US5236953A (en) * | 1982-04-14 | 1993-08-17 | Imperial Chemical Industries Plc | Alkene, alkyne or cycloalkylene derivatives |
JPH0432061B2 (en) * | 1982-07-23 | 1992-05-28 | ||
JPS5933250A (en) * | 1982-07-23 | 1984-02-23 | インペリアル・ケミカル・インダストリ−ズ・ピ−エルシ− | Acylanilide, manufacture and antiandrogenic medicinal or veterinary composition |
US4636505A (en) * | 1982-07-23 | 1987-01-13 | Imperial Chemical Industries Plc | Amide derivatives |
US4873329A (en) * | 1984-03-07 | 1989-10-10 | Imperial Chemical Industries Plc | Alkene, alkyne or cycloalkylene derivatives |
US5032592A (en) * | 1984-03-07 | 1991-07-16 | Imperial Chemical Industries Plc | Alkene, alkyne or cycloalkylene derivatives |
US4845119A (en) * | 1985-02-18 | 1989-07-04 | Imperial Chemical Industries Plc | Alkene, alkyne or cycloalkylene derivatives |
US5084478A (en) * | 1985-02-18 | 1992-01-28 | Imperial Chemical Industries Plc | Alkene, alkyne or cycloalkylene derivatives |
US4880839A (en) * | 1986-07-18 | 1989-11-14 | Imperial Chemical Industries Plc | Acyanilide derivatives |
US6071957A (en) * | 1996-11-27 | 2000-06-06 | The University Of Tennessee Research Corporation | Irreversible non-steroidal antagonist compound and its use in the treatment of prostate cancer |
US6482861B2 (en) | 1996-11-27 | 2002-11-19 | The University Of Tennessee Research Corporation | Irreversible non-steroidal antagonist compound and its use in the treatment of prostate cancer |
US7041844B2 (en) | 1996-11-27 | 2006-05-09 | The University Of Tennessee Research Corporation | Irreversible non-steroidal antagonist compound and its use in the treatment of prostate cancer |
US7129377B2 (en) | 1996-11-27 | 2006-10-31 | University Of Tennessee Research Foundation | Irreversible non-steroidal antagonist compound and its use in the treatment of prostate cancer |
US6160011A (en) * | 1997-05-30 | 2000-12-12 | The University Of Tennessee Research Corporation | Non-steroidal agonist compounds and their use in male hormone therapy |
US6019957A (en) * | 1997-06-04 | 2000-02-01 | The University Of Tennessee Research Corporation | Non-steroidal radiolabeled agonist/antagonist compounds and their use in prostate cancer imaging |
US6844003B2 (en) * | 1999-04-01 | 2005-01-18 | L'oreal | Compounds derived from benzoic acid esters, composition containing said compounds and use thereof |
US7125991B2 (en) | 1999-04-01 | 2006-10-24 | L'oreal S.A. | Compounds derived from benzoic acid esters, composition containing said compounds and use thereof |
US6602869B1 (en) * | 1999-04-01 | 2003-08-05 | L'oreal S.A. | Compounds derived from benzoic acid esters, composition containing said compounds and use thereof |
US8445534B2 (en) | 2000-08-24 | 2013-05-21 | University Of Tennessee Research Foundation | Treating androgen decline in aging male (ADAM)-associated conditions with SARMs |
US7645898B2 (en) | 2000-08-24 | 2010-01-12 | University Of Tennessee Research Foundation | Selective androgen receptor modulators and method of use thereof |
US7855229B2 (en) | 2000-08-24 | 2010-12-21 | University Of Tennessee Research Foundation | Treating wasting disorders with selective androgen receptor modulators |
US9493403B2 (en) | 2000-08-24 | 2016-11-15 | University Of Tennessee Research Foundation | Treating androgen decline in aging male (ADAM)-associated conditions with SARMs |
US6838484B2 (en) | 2000-08-24 | 2005-01-04 | University Of Tennessee Research Foundation | Formulations comprising selective androgen receptor modulators |
US6998500B2 (en) | 2000-08-24 | 2006-02-14 | University Of Tennessee Research Foundation | Selective androgen receptor modulators and methods of use thereof |
US6995284B2 (en) | 2000-08-24 | 2006-02-07 | The University Of Tennessee Research Foundation | Synthesis of selective androgen receptor modulators |
US7919647B2 (en) | 2000-08-24 | 2011-04-05 | University Of Tennessee Research Foundation | Selective androgen receptor modulators and methods of use thereof |
US7026500B2 (en) | 2000-08-24 | 2006-04-11 | University Of Tennessee Research Foundation | Halogenated selective androgen receptor modulators and methods of use thereof |
US7622503B2 (en) | 2000-08-24 | 2009-11-24 | University Of Tennessee Research Foundation | Selective androgen receptor modulators and methods of use thereof |
US8008348B2 (en) | 2001-12-06 | 2011-08-30 | University Of Tennessee Research Foundation | Treating muscle wasting with selective androgen receptor modulators |
US7547728B2 (en) | 2001-12-06 | 2009-06-16 | University Of Tennessee Research Foundation | Treating muscle wasting with selective androgen receptor modulators |
US8853266B2 (en) | 2001-12-06 | 2014-10-07 | University Of Tennessee Research Foundation | Selective androgen receptor modulators for treating diabetes |
US8088828B2 (en) | 2002-02-07 | 2012-01-03 | University Of Tennessee Research Foundation | Treating benign prostate hyperplasia with SARMS |
US7776921B2 (en) | 2002-02-07 | 2010-08-17 | University Of Tennessee Research Foundation | Treating benign prostate hyperplasia with SARMS |
US7772433B2 (en) | 2002-02-28 | 2010-08-10 | University Of Tennessee Research Foundation | SARMS and method of use thereof |
US7344700B2 (en) | 2002-02-28 | 2008-03-18 | University Of Tennessee Research Corporation | Radiolabeled selective androgen receptor modulators and their use in prostate cancer imaging and therapy |
US7705182B2 (en) | 2002-02-28 | 2010-04-27 | University Of Tennessee Research Foundation | Multi-substituted selective androgen receptor modulators and methods of use thereof |
US7803970B2 (en) | 2002-02-28 | 2010-09-28 | University Of Tennessee Research Foundation | Multi-substitued selective androgen receptor modulators and methods of use thereof |
US7741371B2 (en) | 2002-06-17 | 2010-06-22 | University Of Tennessee Research Foundation | Selective androgen receptor modulators and methods of use thereof |
US7022870B2 (en) | 2002-06-17 | 2006-04-04 | University Of Tennessee Research Foundation | N-bridged selective androgen receptor modulators and methods of use thereof |
US7253210B2 (en) | 2002-10-15 | 2007-08-07 | University Of Tennessee Research Foundation | Methylene-bridged selective androgen receptor modulators and methods of use thereof |
US7968721B2 (en) | 2003-01-13 | 2011-06-28 | University Of Tennessee Research Foundation | Large-scale synthesis of selective androgen receptor modulators |
US7595402B2 (en) | 2003-12-16 | 2009-09-29 | Gtx, Inc. | Prodrugs of selective androgen receptor modulators and methods of use thereof |
US8309603B2 (en) | 2004-06-07 | 2012-11-13 | University Of Tennessee Research Foundation | SARMs and method of use thereof |
US8669286B2 (en) | 2004-06-07 | 2014-03-11 | University Of Tennessee Research Foundation | SARMs and method of use thereof |
US10053418B2 (en) | 2004-06-07 | 2018-08-21 | University Of Tennessee Research Foundation | Selective androgen receptor modulator and methods of use thereof |
US9884038B2 (en) | 2004-06-07 | 2018-02-06 | University Of Tennessee Research Foundation | Selective androgen receptor modulator and methods of use thereof |
US9278914B2 (en) | 2004-06-07 | 2016-03-08 | University Of Tennessee Research Foundation | SARMs and method of use thereof |
US10662148B2 (en) | 2004-06-07 | 2020-05-26 | University Of Tennessee Research Foundation | Selective androgen receptor modulator and methods of use thereof |
US9889110B2 (en) | 2004-06-07 | 2018-02-13 | University Of Tennessee Research Foundation | Selective androgen receptor modulator for treating hormone-related conditions |
US8846756B2 (en) | 2006-08-24 | 2014-09-30 | University Of Tennessee Research Foundation | Substituted acylanilides and methods of use thereof |
US9730908B2 (en) | 2006-08-24 | 2017-08-15 | University Of Tennessee Research Foundation | SARMs and method of use thereof |
US9844528B2 (en) | 2006-08-24 | 2017-12-19 | University Of Tennessee Research Foundation | SARMs and method of use thereof |
US8426465B2 (en) | 2006-08-24 | 2013-04-23 | University Of Tennesse Research Foundation | Substituted acylanilides and methods of use thereof |
US8080682B2 (en) | 2006-08-24 | 2011-12-20 | University Of Tennessee Research Foundation | Substituted acylanilides and methods of use thereof |
US10300037B2 (en) | 2006-08-24 | 2019-05-28 | University Of Tennessee Research Foundation | SARMs and method of use thereof |
US10010521B2 (en) | 2006-08-24 | 2018-07-03 | University Of Tennessee Research Foundation | SARMs and method of use thereof |
US11090283B2 (en) | 2007-09-11 | 2021-08-17 | University Of Tennessee Research Foundation | Solid forms of selective androgen receptor modulators |
US9604916B2 (en) | 2012-07-13 | 2017-03-28 | Gtx, Inc. | Method of treating androgen receptor (AR)-positive breast cancers with selective androgen receptor modulator (SARMs) |
US10258596B2 (en) | 2012-07-13 | 2019-04-16 | Gtx, Inc. | Method of treating HER2-positive breast cancers with selective androgen receptor modulators (SARMS) |
US9969683B2 (en) | 2012-07-13 | 2018-05-15 | Gtx, Inc. | Method of treating estrogen receptor (ER)-positive breast cancers with selective androgen receptor modulator (SARMS) |
US10314807B2 (en) | 2012-07-13 | 2019-06-11 | Gtx, Inc. | Method of treating HER2-positive breast cancers with selective androgen receptor modulators (SARMS) |
US9744149B2 (en) | 2012-07-13 | 2017-08-29 | Gtx, Inc. | Method of treating androgen receptor (AR)-positive breast cancers with selective androgen receptor modulator (SARMs) |
US10849873B2 (en) | 2012-07-13 | 2020-12-01 | Oncternal Therapeutics, Inc | Non-invasive method of evaluating breast cancers for selective androgen receptor modulator (SARM) therapy |
US10987334B2 (en) | 2012-07-13 | 2021-04-27 | University Of Tennessee Research Foundation | Method of treating ER mutant expressing breast cancers with selective androgen receptor modulators (SARMs) |
US9622992B2 (en) | 2012-07-13 | 2017-04-18 | Gtx, Inc. | Method of treating androgen receptor (AR)-positive breast cancers with selective androgen receptor modulator (SARMs) |
Also Published As
Publication number | Publication date |
---|---|
JPS6044294B2 (en) | 1985-10-02 |
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