DK159148C - Analogifremgangsmaade til fremstilling af tranexamsyrederivater - Google Patents

Analogifremgangsmaade til fremstilling af tranexamsyrederivater

Info

Publication number
DK159148C
DK159148C DK509382A DK509382A DK159148C DK 159148 C DK159148 C DK 159148C DK 509382 A DK509382 A DK 509382A DK 509382 A DK509382 A DK 509382A DK 159148 C DK159148 C DK 159148C
Authority
DK
Denmark
Prior art keywords
carbon atoms
image
preparation
acid derivatives
groups containing
Prior art date
Application number
DK509382A
Other languages
English (en)
Other versions
DK509382A (da
DK159148B (da
Inventor
Carl Magnus Erik Svahn
Ferenc Merenyi
Lennart Elof Karlsson
Gunnar Hanshoff
Original Assignee
Kabivitrum Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kabivitrum Ab filed Critical Kabivitrum Ab
Publication of DK509382A publication Critical patent/DK509382A/da
Publication of DK159148B publication Critical patent/DK159148B/da
Application granted granted Critical
Publication of DK159148C publication Critical patent/DK159148C/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/87—Benzo [c] furans; Hydrogenated benzo [c] furans
    • C07D307/89—Benzo [c] furans; Hydrogenated benzo [c] furans with two oxygen atoms directly attached in positions 1 and 3
DK509382A 1981-11-17 1982-11-16 Analogifremgangsmaade til fremstilling af tranexamsyrederivater DK159148C (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
SE8106818 1981-11-17
SE8106818 1981-11-17

Publications (3)

Publication Number Publication Date
DK509382A DK509382A (da) 1983-05-18
DK159148B DK159148B (da) 1990-09-10
DK159148C true DK159148C (da) 1991-02-11

Family

ID=20345052

Family Applications (1)

Application Number Title Priority Date Filing Date
DK509382A DK159148C (da) 1981-11-17 1982-11-16 Analogifremgangsmaade til fremstilling af tranexamsyrederivater

Country Status (10)

Country Link
US (1) US4483867A (da)
EP (1) EP0079872B1 (da)
JP (1) JPS5892611A (da)
AT (1) ATE12224T1 (da)
CA (1) CA1202637A (da)
DE (1) DE3262698D1 (da)
DK (1) DK159148C (da)
FI (1) FI73969C (da)
HK (1) HK49688A (da)
NO (1) NO160778C (da)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL67445A (en) * 1982-12-09 1985-11-29 Teva Pharma Ethoxycarbonyloxy ethyl esters of non-steroidal anti-inflammatory carboxylic acids
IL67623A (en) * 1983-01-05 1984-09-30 Teva Pharma 1'-ethoxycarbonyloxyethyl ester of valproic acid,its preparation and pharmaceutical compositions containing it
DE3580406D1 (de) * 1984-07-11 1990-12-13 Merck Patent Gmbh Fluessigkristall-phase.
FR2657257B1 (fr) * 1990-01-19 1994-09-02 Rhone Poulenc Sante Procede de preparation de medicaments sous forme de perles.
JPH0725724B2 (ja) * 1992-06-23 1995-03-22 財団法人生産開発科学研究所 トラネキサム酸亜鉛化合物
SE9300013L (sv) * 1992-12-30 1994-07-01 Kabi Pharmacia Ab Nytt förfarande och mellanprodukter för framställning av pro- läkemedel
US5720948A (en) * 1995-11-07 1998-02-24 Helene Curtis Inc. Non-ionic surfactant emulsion vehicles and their use for deposition of drug into and across skin
US6110970A (en) * 1997-03-11 2000-08-29 Beacon Laboratories, Inc. Nitrogen-containing oxyalkylene esters and uses thereof
DE19943635A1 (de) * 1999-09-13 2001-03-15 Bayer Ag Neuartige Aminodicarbonsäurederivate mit pharmazeutischen Eigenschaften
US7186855B2 (en) 2001-06-11 2007-03-06 Xenoport, Inc. Prodrugs of GABA analogs, compositions and uses thereof
US8048917B2 (en) 2005-04-06 2011-11-01 Xenoport, Inc. Prodrugs of GABA analogs, compositions and uses thereof
US20090214644A1 (en) * 2003-07-31 2009-08-27 Xanodyne Pharmaceuticals, Inc. Tranexamic acid formulations with reduced adverse effects
US20050025825A1 (en) * 2003-07-31 2005-02-03 Xanodyne Pharmacal, Inc. Tranexamic acid formulations with reduced adverse effects
PT1660440E (pt) 2003-08-20 2012-05-15 Xenoport Inc Pró-fármacos de aciloxialquilcarbamato, métodos de síntese e utilização
EP2371815A1 (en) 2003-12-30 2011-10-05 XenoPort, Inc. Sythesis of acyloxyalkyl carbamate prodrugs and intermediates thereof
US20090215898A1 (en) * 2004-03-04 2009-08-27 Xanodyne Pharmaceuticals, Inc. Tranexamic acid formulations
US20050244495A1 (en) 2004-03-04 2005-11-03 Xanodyne Pharmaceuticals, Inc. Tranexamic acid formulations
US8022106B2 (en) * 2004-03-04 2011-09-20 Ferring B.V. Tranexamic acid formulations
US7947739B2 (en) 2004-03-04 2011-05-24 Ferring B.V. Tranexamic acid formulations
JP4938771B2 (ja) 2005-06-20 2012-05-23 ゼノポート，インコーポレーテッド トラネキサム酸のカルバミン酸アシルオキシアルキルプロドラッグ、合成法、および使用
US20100280117A1 (en) * 2009-04-30 2010-11-04 Xanodyne Pharmaceuticals, Inc. Menorrhagia Instrument and Method for the Treatment of Menstrual Bleeding Disorders
US20110060040A1 (en) * 2009-09-04 2011-03-10 Xenoport, Inc. Uses of acyloxyalkyl carbamate prodrugs of tranexamic acid
US20110184060A1 (en) 2010-01-22 2011-07-28 Xenoport, Inc. Oral dosage forms having a high loading of a tranexamic acid prodrug
WO2014012964A1 (en) * 2012-07-18 2014-01-23 Proyecto De Biomedicina Cima, S.L. New antifibrinolytic compounds
EP3626812A4 (en) 2017-05-17 2021-02-17 National Agriculture and Food Research Organization MANUFACTURING METHOD AND PRODUCTION DEVICE FOR DRIED VITRIGEL FILM
CN108976146B (zh) * 2017-05-31 2020-11-27 首都医科大学 氨基正己酰氨甲环酰氨基正己酰芳香氨基酸，其合成，活性和应用

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB949512A (en) * 1961-05-15 1964-02-12 Mitsubishi Chem Ind Pharmaceutical compositions containing 4-(aminomethyl)-cyclohexane-1-carboxylic acid
US3939200A (en) * 1966-01-06 1976-02-17 Rohm And Haas Company Aliphatic acyl-containing amine hydrochlorides
US3699149A (en) * 1968-10-14 1972-10-17 Daiichi Seiyaku Co Phenyl esters of t-amcha
US3995055A (en) * 1975-02-28 1976-11-30 Daiichi Seiyaku Co., Ltd. Method for treating peptic ulcers
GB1580783A (en) * 1978-04-27 1980-12-03 Daiichi Seiyaku Co Process for producing 4' - (2 - carboxyethyl)phenyl trans - 4 - aminomethyl-cyclohexanecarboxylate or the acid-additsalts thereof and intermediates for producing the same

Also Published As

Publication number Publication date
FI73969C (fi) 1987-12-10
NO160778B (no) 1989-02-20
ATE12224T1 (de) 1985-04-15
FI73969B (fi) 1987-08-31
NO160778C (no) 1989-05-31
JPS5892611A (ja) 1983-06-02
DE3262698D1 (en) 1985-04-25
EP0079872B1 (en) 1985-03-20
US4483867A (en) 1984-11-20
HK49688A (en) 1988-07-15
CA1202637A (en) 1986-04-01
JPH0326183B2 (da) 1991-04-10
DK509382A (da) 1983-05-18
FI823923A0 (fi) 1982-11-16
FI823923L (fi) 1983-05-18
DK159148B (da) 1990-09-10
NO823836L (no) 1983-05-18
EP0079872A1 (en) 1983-05-25

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