DK509382A - Fremgangsmaade til fremstilling af antifibrinolytisk virksomme forbindelser - Google Patents

Fremgangsmaade til fremstilling af antifibrinolytisk virksomme forbindelser Download PDF

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Publication number
DK509382A
DK509382A DK509382A DK509382A DK509382A DK 509382 A DK509382 A DK 509382A DK 509382 A DK509382 A DK 509382A DK 509382 A DK509382 A DK 509382A DK 509382 A DK509382 A DK 509382A
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DK
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Prior art keywords
carbon atoms
image
groups containing
antifibrinolytic
procedure
Prior art date
Application number
DK509382A
Other languages
English (en)
Other versions
DK159148C (da
DK159148B (da
Inventor
Carl Magnus Erik Svahn
Ferenc Merenyi
Lennart Elof Karlsson
Gunnar Hanshoff
Original Assignee
Kabivitrum Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kabivitrum Ab filed Critical Kabivitrum Ab
Publication of DK509382A publication Critical patent/DK509382A/da
Publication of DK159148B publication Critical patent/DK159148B/da
Application granted granted Critical
Publication of DK159148C publication Critical patent/DK159148C/da

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/87—Benzo [c] furans; Hydrogenated benzo [c] furans
    • C07D307/89—Benzo [c] furans; Hydrogenated benzo [c] furans with two oxygen atoms directly attached in positions 1 and 3

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Diabetes (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Hematology (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Lubricants (AREA)
  • Fats And Perfumes (AREA)
  • Dental Preparations (AREA)
  • Materials For Medical Uses (AREA)
  • Compression Or Coding Systems Of Tv Signals (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Chemical And Physical Treatments For Wood And The Like (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
DK509382A 1981-11-17 1982-11-16 Analogifremgangsmaade til fremstilling af tranexamsyrederivater DK159148C (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
SE8106818 1981-11-17
SE8106818 1981-11-17

Publications (3)

Publication Number Publication Date
DK509382A true DK509382A (da) 1983-05-18
DK159148B DK159148B (da) 1990-09-10
DK159148C DK159148C (da) 1991-02-11

Family

ID=20345052

Family Applications (1)

Application Number Title Priority Date Filing Date
DK509382A DK159148C (da) 1981-11-17 1982-11-16 Analogifremgangsmaade til fremstilling af tranexamsyrederivater

Country Status (10)

Country Link
US (1) US4483867A (da)
EP (1) EP0079872B1 (da)
JP (1) JPS5892611A (da)
AT (1) ATE12224T1 (da)
CA (1) CA1202637A (da)
DE (1) DE3262698D1 (da)
DK (1) DK159148C (da)
FI (1) FI73969C (da)
HK (1) HK49688A (da)
NO (1) NO160778C (da)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL67445A (en) * 1982-12-09 1985-11-29 Teva Pharma Ethoxycarbonyloxy ethyl esters of non-steroidal anti-inflammatory carboxylic acids
IL67623A (en) * 1983-01-05 1984-09-30 Teva Pharma 1'-ethoxycarbonyloxyethyl ester of valproic acid,its preparation and pharmaceutical compositions containing it
EP0168043B1 (de) * 1984-07-11 1990-11-07 MERCK PATENT GmbH Flüssigkristall-Phase
FR2657257B1 (fr) * 1990-01-19 1994-09-02 Rhone Poulenc Sante Procede de preparation de medicaments sous forme de perles.
JPH0725724B2 (ja) * 1992-06-23 1995-03-22 財団法人生産開発科学研究所 トラネキサム酸亜鉛化合物
SE9300013L (sv) * 1992-12-30 1994-07-01 Kabi Pharmacia Ab Nytt förfarande och mellanprodukter för framställning av pro- läkemedel
US5720948A (en) * 1995-11-07 1998-02-24 Helene Curtis Inc. Non-ionic surfactant emulsion vehicles and their use for deposition of drug into and across skin
US6110970A (en) * 1997-03-11 2000-08-29 Beacon Laboratories, Inc. Nitrogen-containing oxyalkylene esters and uses thereof
DE19943635A1 (de) * 1999-09-13 2001-03-15 Bayer Ag Neuartige Aminodicarbonsäurederivate mit pharmazeutischen Eigenschaften
US8048917B2 (en) 2005-04-06 2011-11-01 Xenoport, Inc. Prodrugs of GABA analogs, compositions and uses thereof
US7186855B2 (en) 2001-06-11 2007-03-06 Xenoport, Inc. Prodrugs of GABA analogs, compositions and uses thereof
US20050025825A1 (en) * 2003-07-31 2005-02-03 Xanodyne Pharmacal, Inc. Tranexamic acid formulations with reduced adverse effects
US20090214644A1 (en) * 2003-07-31 2009-08-27 Xanodyne Pharmaceuticals, Inc. Tranexamic acid formulations with reduced adverse effects
WO2005019163A2 (en) 2003-08-20 2005-03-03 Xenoport, Inc. Acyloxyalkyl carbamate prodrugs, methods of synthesis and use
WO2005066122A2 (en) 2003-12-30 2005-07-21 Xenoport, Inc. Synthesis of acyloxyalkyl carbamate prodrugs and intermediates thereof
US20050244495A1 (en) 2004-03-04 2005-11-03 Xanodyne Pharmaceuticals, Inc. Tranexamic acid formulations
US20090215898A1 (en) * 2004-03-04 2009-08-27 Xanodyne Pharmaceuticals, Inc. Tranexamic acid formulations
US7947739B2 (en) 2004-03-04 2011-05-24 Ferring B.V. Tranexamic acid formulations
US8022106B2 (en) * 2004-03-04 2011-09-20 Ferring B.V. Tranexamic acid formulations
CN101253148B (zh) 2005-06-20 2013-01-02 克塞诺波特公司 凝血酸的酰氧基烷基氨基甲酸酯前药，合成和使用的方法
US20100280117A1 (en) * 2009-04-30 2010-11-04 Xanodyne Pharmaceuticals, Inc. Menorrhagia Instrument and Method for the Treatment of Menstrual Bleeding Disorders
WO2011028234A1 (en) 2009-09-04 2011-03-10 Xenoport, Inc. Uses of acyloxyalkyl carbamate prodrugs of tranexamic acid
WO2011091164A1 (en) 2010-01-22 2011-07-28 Xenoport, Inc. Oral dosage forms having a high loading of a tranexamic acid prodrug
AU2013292076B2 (en) * 2012-07-18 2017-02-23 Proyecto De Biomedicina Cima, S.L. New antifibrinolytic compounds
CN110621771A (zh) 2017-05-17 2019-12-27 国立研究开发法人农业·食品产业技术综合研究机构 Vitrigel膜干燥体的制造方法以及制造装置
CN108976146B (zh) * 2017-05-31 2020-11-27 首都医科大学 氨基正己酰氨甲环酰氨基正己酰芳香氨基酸，其合成，活性和应用

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB949512A (en) * 1961-05-15 1964-02-12 Mitsubishi Chem Ind Pharmaceutical compositions containing 4-(aminomethyl)-cyclohexane-1-carboxylic acid
US3939200A (en) * 1966-01-06 1976-02-17 Rohm And Haas Company Aliphatic acyl-containing amine hydrochlorides
CA929942A (en) * 1968-10-14 1973-07-10 Okano Atsuji Esters and their production
US3995055A (en) * 1975-02-28 1976-11-30 Daiichi Seiyaku Co., Ltd. Method for treating peptic ulcers
GB1580783A (en) * 1978-04-27 1980-12-03 Daiichi Seiyaku Co Process for producing 4' - (2 - carboxyethyl)phenyl trans - 4 - aminomethyl-cyclohexanecarboxylate or the acid-additsalts thereof and intermediates for producing the same

Also Published As

Publication number Publication date
CA1202637A (en) 1986-04-01
US4483867A (en) 1984-11-20
NO160778C (no) 1989-05-31
DK159148C (da) 1991-02-11
ATE12224T1 (de) 1985-04-15
JPH0326183B2 (da) 1991-04-10
HK49688A (en) 1988-07-15
DE3262698D1 (en) 1985-04-25
NO160778B (no) 1989-02-20
FI73969C (fi) 1987-12-10
FI73969B (fi) 1987-08-31
JPS5892611A (ja) 1983-06-02
FI823923A0 (fi) 1982-11-16
DK159148B (da) 1990-09-10
EP0079872B1 (en) 1985-03-20
FI823923L (fi) 1983-05-18
NO823836L (no) 1983-05-18
EP0079872A1 (en) 1983-05-25

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