ES542321A0 - Un procedimiento para la preparacion de derivados de la 2 pirimidinil-1-piperazina - Google Patents
Un procedimiento para la preparacion de derivados de la 2 pirimidinil-1-piperazinaInfo
- Publication number
- ES542321A0 ES542321A0 ES542321A ES542321A ES542321A0 ES 542321 A0 ES542321 A0 ES 542321A0 ES 542321 A ES542321 A ES 542321A ES 542321 A ES542321 A ES 542321A ES 542321 A0 ES542321 A0 ES 542321A0
- Authority
- ES
- Spain
- Prior art keywords
- piperazine derivatives
- pirimidinyl
- procedure
- preparation
- formula
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 229940066771 systemic antihistamines piperazine derivative Drugs 0.000 title abstract 3
- 238000000034 method Methods 0.000 title abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 239000000203 mixture Substances 0.000 abstract 2
- 239000011149 active material Substances 0.000 abstract 1
- 210000003169 central nervous system Anatomy 0.000 abstract 1
- 239000000543 intermediate Substances 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/32—One oxygen, sulfur or nitrogen atom
- C07D239/42—One nitrogen atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/26—Psychostimulants, e.g. nicotine, cocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
- C07D239/72—Quinazolines; Hydrogenated quinazolines
- C07D239/95—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in positions 2 and 4
- C07D239/96—Two oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Neurology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Hospice & Palliative Care (AREA)
- Anesthesiology (AREA)
- Rheumatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19833321969 DE3321969A1 (de) | 1983-06-18 | 1983-06-18 | 2-pyrimidinyl-1-piperazin-derivate, verfahren zu ihrer herstellung und diese enthaltende arzneimittel |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| ES8603465A1 ES8603465A1 (es) | 1985-12-16 |
| ES542321A0 true ES542321A0 (es) | 1985-12-16 |
Family
ID=6201759
Family Applications (6)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES533338A Expired ES8600275A1 (es) | 1983-06-18 | 1984-06-12 | Derivados de la 2-pirimidinil-1-piperazina |
| ES542323A Expired ES8603467A1 (es) | 1983-06-18 | 1985-04-16 | Un procedimiento para la preparacion de derivados de la 2 pirimidinil-1-piperazina |
| ES542322A Granted ES542322A0 (es) | 1983-06-18 | 1985-04-16 | Un procedimiento para la preparacion de derivados de la 2 pirimidinil-1-piperazina |
| ES542320A Granted ES542320A0 (es) | 1983-06-18 | 1985-04-16 | Un procedimiento para la preparacion de derivados de la 2 pirimidinil 1 piperazina |
| ES542319A Expired ES8607285A1 (es) | 1983-06-18 | 1985-04-16 | Un procedimiento para la preparacion de derivados de la 2 pirimidinil-1-piperazina |
| ES542321A Granted ES542321A0 (es) | 1983-06-18 | 1985-04-16 | Un procedimiento para la preparacion de derivados de la 2 pirimidinil-1-piperazina |
Family Applications Before (5)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES533338A Expired ES8600275A1 (es) | 1983-06-18 | 1984-06-12 | Derivados de la 2-pirimidinil-1-piperazina |
| ES542323A Expired ES8603467A1 (es) | 1983-06-18 | 1985-04-16 | Un procedimiento para la preparacion de derivados de la 2 pirimidinil-1-piperazina |
| ES542322A Granted ES542322A0 (es) | 1983-06-18 | 1985-04-16 | Un procedimiento para la preparacion de derivados de la 2 pirimidinil-1-piperazina |
| ES542320A Granted ES542320A0 (es) | 1983-06-18 | 1985-04-16 | Un procedimiento para la preparacion de derivados de la 2 pirimidinil 1 piperazina |
| ES542319A Expired ES8607285A1 (es) | 1983-06-18 | 1985-04-16 | Un procedimiento para la preparacion de derivados de la 2 pirimidinil-1-piperazina |
Country Status (18)
| Country | Link |
|---|---|
| US (4) | US4818756A (es) |
| EP (1) | EP0129128B1 (es) |
| JP (1) | JPH0660165B2 (es) |
| KR (1) | KR920000761B1 (es) |
| AT (1) | ATE58534T1 (es) |
| AU (1) | AU569086B2 (es) |
| CA (1) | CA1300624C (es) |
| DE (2) | DE3321969A1 (es) |
| DK (2) | DK165447C (es) |
| ES (6) | ES8600275A1 (es) |
| FI (1) | FI82936C (es) |
| GR (1) | GR82211B (es) |
| HU (1) | HU196391B (es) |
| IL (1) | IL72120A (es) |
| NZ (1) | NZ208529A (es) |
| PH (1) | PH22960A (es) |
| PT (1) | PT78751B (es) |
| ZA (1) | ZA844585B (es) |
Families Citing this family (45)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2536071B1 (fr) * | 1982-11-12 | 1986-07-11 | Sanofi Sa | Sels acides de 2-piperazinopyrimidine, procede pour leur preparation et compositions pharmaceutiques en contenant |
| US4524206A (en) * | 1983-09-12 | 1985-06-18 | Mead Johnson & Company | 1-Heteroaryl-4-(2,5-pyrrolidinedion-1-yl)alkyl)piperazine derivatives |
| US4605655A (en) * | 1984-03-06 | 1986-08-12 | Bristol-Myers Company | Antipsychotic 1-fluorophenylbutyl-4-(2-pyrimidinyl)piperazine derivatives |
| JPH0625181B2 (ja) | 1985-03-27 | 1994-04-06 | 住友製薬株式会社 | 新規なイミド誘導体 |
| NL8601494A (nl) * | 1985-06-22 | 1987-01-16 | Sandoz Ag | Thiazolen, hun bereiding en farmaceutische preparaten die ze bevatten. |
| US4732984A (en) * | 1985-10-17 | 1988-03-22 | American Home Products Corporation | Piperazinoisothiazolones with psychotropic activity |
| US4748182A (en) * | 1986-03-05 | 1988-05-31 | Merrell Dow Pharmaceuticals Inc. | Aromatic 2-aminoalkyl-1,2-benzoisothiazol-3(2H)one-1,1-dioxide derivatives and their use as anti-hypertensive and anxiolytic agents |
| AR242678A1 (es) * | 1986-03-05 | 1993-04-30 | Gonzalez Jorge Alberto | Mejoras en instrumentos musicales de cuerda de arco. |
| US4771053A (en) * | 1987-03-02 | 1988-09-13 | Bristol-Myers Company | Method for alleviation of primary depressive disorders |
| DE3720074A1 (de) * | 1987-06-16 | 1988-12-29 | Bayer Ag | Mittel zur verhinderung von rangkaempfen bei schweinen |
| HU206109B (en) * | 1987-10-26 | 1992-08-28 | Pfizer | Process for producing heterocyclic carbonylpropyl pyrimidinyl piperazine derivatives and pharmaceutical compositions comprising same |
| DE3736974A1 (de) * | 1987-10-31 | 1989-05-11 | Troponwerke Gmbh & Co Kg | Verwendung von 2-pyrimidinyl-1-piperazin-derivaten |
| AU2717288A (en) * | 1987-11-12 | 1989-06-01 | American Home Products Corporation | Polycyclicamines with psychotropic activity |
| ATA39088A (de) * | 1988-02-18 | 1990-06-15 | Binder Dieter Dr | Basisch substituierte thienoisothiazol-3(2h)-on-1,1-dioxide und ihre pharmazeutisch vertraeglichen salze, verfahren zu ihrer herstellung und ihre verwendung |
| JP2556722B2 (ja) * | 1988-02-18 | 1996-11-20 | 興和株式会社 | 新規なスルホンアミド化合物 |
| EP0330263A1 (en) * | 1988-02-25 | 1989-08-30 | Merck & Co. Inc. | Piperazinylalkylpyrimidines as hypoglycemic agents |
| US5482940A (en) * | 1988-05-24 | 1996-01-09 | American Home Products Corporation | Use of aryl- and heteroaryl piperazinyl carboxamides in the treatment of various central nervous system disorders |
| US5010078A (en) * | 1988-05-24 | 1991-04-23 | American Home Products Corporation | Aryl- and heteroaryl piperazinyl carboxamides having central nervous system activity |
| US5106849A (en) * | 1988-05-24 | 1992-04-21 | American Home Products Corporation | Use of aryl- and heteroaryl piperazinyl carboxamides in the treatment of various central nervous system disorders |
| US5278160A (en) * | 1988-05-24 | 1994-01-11 | American Home Products Corporation | Use of aryl- and heteroaryl piperazinyl carboxamides in the treatment of various central nervous system disorders |
| FI895821A0 (fi) * | 1988-12-07 | 1989-12-05 | Wellcome Found | Farmaceutiskt aktiva cns foereningar. |
| MX19222A (es) * | 1989-01-23 | 1993-12-01 | Pfizer | Agentes ansioliticos bis-aza-biciclicos |
| FR2642759B1 (fr) * | 1989-02-09 | 1991-05-17 | Laboratorios Esteve Sa | Derives de pyrimidyl-piperazinyl-alkyl azoles avec activite anxiolytique et/ou tranquillisante |
| US5382583A (en) * | 1989-04-22 | 1995-01-17 | John Wyeth & Brother, Limited | Piperazine derivatives |
| US5364849A (en) * | 1989-04-22 | 1994-11-15 | John Wyeth & Brother, Limited | 1-[3 or 4-[1-[4-piperazinyl]]-2 arylpropionyl or butryl]-heterocyclic derivatives |
| FR2654934B1 (fr) * | 1989-11-29 | 1994-09-30 | Midy Spa | Utilisation de derive [4-(2-pyrimidinyl)-1-piperazinyl] butyliques pour la preparation de medicaments destines a combattre les troubles de la motricite intestinale. |
| US5096908A (en) * | 1990-05-04 | 1992-03-17 | Eli Lilly And Company | Method of inhibiting gastric acid secretion |
| US5258379A (en) * | 1990-05-04 | 1993-11-02 | Eli Lilly And Company | Method of inhibiting gastric acid secretion with n-arylpiperazines |
| US5021569A (en) * | 1990-06-12 | 1991-06-04 | American Home Products Corporation | 4-azatricyclo[4.3.1.1(3,8)]undecylarylpiperazines with anxiolytic activity |
| US5077293A (en) * | 1990-06-29 | 1991-12-31 | Bristol-Myers Squibb Co. | 1-indolyalkyl-4-(alkoxypyrimidinyl)piperazines |
| US5200520A (en) * | 1990-12-18 | 1993-04-06 | Lonza Ltd. | Process for the production of piperazinylpyrimidine derivatives |
| US5204465A (en) * | 1990-12-18 | 1993-04-20 | Lonza Ltd. | Process for the production of piperazinylpyrimidine derivatives |
| US5140018A (en) * | 1991-05-07 | 1992-08-18 | Abbott Laboratories | 1,3,2-benzodithiazole-1-oxide compounds |
| FR2701260B1 (fr) * | 1993-02-05 | 1995-05-05 | Esteve Labor Dr | Dérivés de 2-[4-(4-azolylbutyl)-1-pipérazinyl]-5-hydroxypyrimidine, leur préparation et leur application en tant que médicaments. |
| US5681954A (en) * | 1993-05-14 | 1997-10-28 | Daiichi Pharmaceutical Co., Ltd. | Piperazine derivatives |
| WO1995005226A1 (en) * | 1993-08-12 | 1995-02-23 | Ancon Chemicals Pty. Ltd. | Distributor plate and evaporator |
| CA2146593A1 (en) * | 1994-05-05 | 1995-11-06 | Jack Melton | Large-scale process for azapirone synthesis |
| DE69701647T2 (de) * | 1996-02-01 | 2000-09-07 | Sumitomo Chemical Co | Verfahren zur Herstellung von Dioxochinazolinen |
| US6312717B1 (en) | 1998-07-07 | 2001-11-06 | Bristol-Myers Squibb Company | Method for treatment of anxiety and depression |
| US6566361B2 (en) | 1999-06-30 | 2003-05-20 | Laboratories, Upsa | Azapirone pain treatment |
| JP2004517081A (ja) * | 2000-11-29 | 2004-06-10 | イーライ・リリー・アンド・カンパニー | １−（２−ｍ−メタンスルホンアミドフェニルエチル）−４−（ｍ−トリフルオロメチルフェニル）ピペラジンならびにその医薬的に許容しうる塩および溶媒和物 |
| US20050192220A1 (en) * | 2001-02-05 | 2005-09-01 | Gevys Pharmaceuticas Ltd. | Composition and method for potentiating drugs |
| US6833377B2 (en) * | 2001-02-05 | 2004-12-21 | Gevys Pharmaceuticals Ltd. | Composition and method for potentiating drugs |
| WO2005118537A2 (en) * | 2004-05-31 | 2005-12-15 | Ranbaxy Laboratories Limited | Arylpiperazine derivatives as adrenergic receptor antagonists |
| CA2751176A1 (en) | 2009-01-28 | 2010-08-05 | Vanderbilt University | Substituted 1,1,3,3-tetraoxidobenzo[d][1,3,2]dithiazoles as mglur4 allosteric potentiators, compositions, and methods of treating neurological dysfunction |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2519715A (en) * | 1947-11-12 | 1950-08-22 | American Cyanamid Co | 1-carbamyl-4-heterocyclopiperazines |
| US2672460A (en) * | 1952-06-24 | 1954-03-16 | American Cyanamid Co | Disubstituted piperazines and methods of preparing the same |
| GB1279843A (en) * | 1969-05-23 | 1972-06-28 | Science Union & Cie | Benzamidoethyl-piperazines and process for their preparation |
| OA06083A (fr) * | 1977-11-09 | 1981-06-30 | Science Union & Cie Ste Franca | Nouvelles pipérazines disubstituées, leurs procédés de préparation et les compositions pharmaceutiques les renfermant. |
| US4405622A (en) * | 1980-10-16 | 1983-09-20 | Syntex (U.S.A.) Inc. | [1-(1,4-Benzodioxan-2-yl)-4-(4-aminopyrimidin-2-yl]piperazines useful as anti-depressants |
| FR2503162A1 (fr) * | 1981-04-07 | 1982-10-08 | Pharmindustrie | Nouveaux derives de piperazino-2 pyrimidine, procedes pour leur preparation et leur utilisation comme medicaments ou comme intermediaires pour la fabrication de medicaments |
| JPS57197265A (en) * | 1981-05-29 | 1982-12-03 | Eisai Co Ltd | Carboxylic acid imide derivative, its preparation and medicament containing the same |
| US4507303A (en) * | 1981-12-22 | 1985-03-26 | Sumitomo Chemical Company, Limited | Succinimide derivatives, compositions and method of use |
| US4423049A (en) * | 1981-12-28 | 1983-12-27 | Mead Johnson & Company | 2-[4-[(4,4-Dialkyl-2,6-piperidinedion-1-yl)butyl]-1-piperazinyl]pyrimidines |
| US4620006A (en) * | 1982-08-11 | 1986-10-28 | Eastman Kodak Company | Acid salts of 1-(cyanoalkyl)-4-guanylpiperazines |
| US4620002A (en) * | 1982-08-11 | 1986-10-28 | Eastman Kodak Company | 2-pyrimidyl alkanesulfonates |
| JPS5995267A (ja) * | 1982-11-25 | 1984-06-01 | Eisai Co Ltd | カルボン酸イミド誘導体およびその製造方法 |
| US4581357A (en) * | 1983-02-07 | 1986-04-08 | Mead Johnson & Company | Antipsychotic 5-fluoro-pyrimidin-2-yl piperazine compound |
| US4524206A (en) * | 1983-09-12 | 1985-06-18 | Mead Johnson & Company | 1-Heteroaryl-4-(2,5-pyrrolidinedion-1-yl)alkyl)piperazine derivatives |
| US4668687A (en) * | 1984-07-23 | 1987-05-26 | Bristol-Myers Company | Psychogeriatric 1-(2-pyrimidinyl)piperazinyl derivatives of 1-pyrrolidin-2-ones |
| US4732984A (en) * | 1985-10-17 | 1988-03-22 | American Home Products Corporation | Piperazinoisothiazolones with psychotropic activity |
-
1983
- 1983-06-18 DE DE19833321969 patent/DE3321969A1/de not_active Withdrawn
-
1984
- 1984-06-04 DE DE8484106336T patent/DE3483629D1/de not_active Expired - Lifetime
- 1984-06-04 EP EP84106336A patent/EP0129128B1/de not_active Expired - Lifetime
- 1984-06-04 AT AT84106336T patent/ATE58534T1/de not_active IP Right Cessation
- 1984-06-12 ES ES533338A patent/ES8600275A1/es not_active Expired
- 1984-06-12 AU AU29293/84A patent/AU569086B2/en not_active Ceased
- 1984-06-13 PH PH30816A patent/PH22960A/en unknown
- 1984-06-14 FI FI842419A patent/FI82936C/fi not_active IP Right Cessation
- 1984-06-15 IL IL72120A patent/IL72120A/xx not_active IP Right Cessation
- 1984-06-15 GR GR75034A patent/GR82211B/el unknown
- 1984-06-15 PT PT78751A patent/PT78751B/pt not_active IP Right Cessation
- 1984-06-15 DK DK295984A patent/DK165447C/da not_active IP Right Cessation
- 1984-06-15 CA CA000456741A patent/CA1300624C/en not_active Expired - Lifetime
- 1984-06-15 HU HU842325A patent/HU196391B/hu not_active IP Right Cessation
- 1984-06-15 NZ NZ208529A patent/NZ208529A/xx unknown
- 1984-06-18 KR KR1019840003418A patent/KR920000761B1/ko not_active IP Right Cessation
- 1984-06-18 ZA ZA844585A patent/ZA844585B/xx unknown
- 1984-06-18 JP JP59123884A patent/JPH0660165B2/ja not_active Expired - Lifetime
-
1985
- 1985-04-16 ES ES542323A patent/ES8603467A1/es not_active Expired
- 1985-04-16 ES ES542322A patent/ES542322A0/es active Granted
- 1985-04-16 ES ES542320A patent/ES542320A0/es active Granted
- 1985-04-16 ES ES542319A patent/ES8607285A1/es not_active Expired
- 1985-04-16 ES ES542321A patent/ES542321A0/es active Granted
-
1986
- 1986-03-10 US US06/838,238 patent/US4818756A/en not_active Expired - Lifetime
-
1988
- 1988-09-22 US US07/247,813 patent/US4937343A/en not_active Expired - Fee Related
-
1990
- 1990-02-21 US US07/482,580 patent/US4988809A/en not_active Expired - Fee Related
-
1992
- 1992-03-06 DK DK031092A patent/DK168740B1/da not_active IP Right Cessation
- 1992-08-31 US US07/938,187 patent/US5314884A/en not_active Expired - Fee Related
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