DK165447C - 2-pyrimidinyl-1-piperazin-derivater, fremgangsmaader til deres fremstilling og laegemidler indeholdende dem - Google Patents

2-pyrimidinyl-1-piperazin-derivater, fremgangsmaader til deres fremstilling og laegemidler indeholdende dem

Info

Publication number
DK165447C
DK165447C DK295984A DK295984A DK165447C DK 165447 C DK165447 C DK 165447C DK 295984 A DK295984 A DK 295984A DK 295984 A DK295984 A DK 295984A DK 165447 C DK165447 C DK 165447C
Authority
DK
Denmark
Prior art keywords
pyrimidinyl
piperazine derivatives
procedures
preparation
formula
Prior art date
Application number
DK295984A
Other languages
English (en)
Other versions
DK295984D0 (da
DK165447B (da
DK295984A (da
Inventor
Peter-Rudolf Seidel
Harald Horstmann
Joerg Traber
Wolfgang Dompert
Thomas Glaser
Teunis Schuurman
Original Assignee
Troponwerke Gmbh & Co Kg
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Troponwerke Gmbh & Co Kg filed Critical Troponwerke Gmbh & Co Kg
Publication of DK295984D0 publication Critical patent/DK295984D0/da
Publication of DK295984A publication Critical patent/DK295984A/da
Publication of DK165447B publication Critical patent/DK165447B/da
Application granted granted Critical
Publication of DK165447C publication Critical patent/DK165447C/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/32—One oxygen, sulfur or nitrogen atom
    • C07D239/42—One nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72—Quinazolines; Hydrogenated quinazolines
    • C07D239/95—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in positions 2 and 4
    • C07D239/96—Two oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Neurosurgery (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Neurology (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Anesthesiology (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
DK295984A 1983-06-18 1984-06-15 2-pyrimidinyl-1-piperazin-derivater, fremgangsmaader til deres fremstilling og laegemidler indeholdende dem DK165447C (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19833321969 DE3321969A1 (de) 1983-06-18 1983-06-18 2-pyrimidinyl-1-piperazin-derivate, verfahren zu ihrer herstellung und diese enthaltende arzneimittel
DE3321969 1983-06-18

Publications (4)

Publication Number Publication Date
DK295984D0 DK295984D0 (da) 1984-06-15
DK295984A DK295984A (da) 1984-12-19
DK165447B DK165447B (da) 1992-11-30
DK165447C true DK165447C (da) 1993-04-13

Family

ID=6201759

Family Applications (2)

Application Number Title Priority Date Filing Date
DK295984A DK165447C (da) 1983-06-18 1984-06-15 2-pyrimidinyl-1-piperazin-derivater, fremgangsmaader til deres fremstilling og laegemidler indeholdende dem
DK031092A DK168740B1 (da) 1983-06-18 1992-03-06 2-Pyrimidinyl-1-piperazin-derivater

Family Applications After (1)

Application Number Title Priority Date Filing Date
DK031092A DK168740B1 (da) 1983-06-18 1992-03-06 2-Pyrimidinyl-1-piperazin-derivater

Country Status (18)

Country Link
US (4) US4818756A (da)
EP (1) EP0129128B1 (da)
JP (1) JPH0660165B2 (da)
KR (1) KR920000761B1 (da)
AT (1) ATE58534T1 (da)
AU (1) AU569086B2 (da)
CA (1) CA1300624C (da)
DE (2) DE3321969A1 (da)
DK (2) DK165447C (da)
ES (6) ES533338A0 (da)
FI (1) FI82936C (da)
GR (1) GR82211B (da)
HU (1) HU196391B (da)
IL (1) IL72120A (da)
NZ (1) NZ208529A (da)
PH (1) PH22960A (da)
PT (1) PT78751B (da)
ZA (1) ZA844585B (da)

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US4732984A (en) * 1985-10-17 1988-03-22 American Home Products Corporation Piperazinoisothiazolones with psychotropic activity
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AR242678A1 (es) * 1986-03-05 1993-04-30 Gonzalez Jorge Alberto Mejoras en instrumentos musicales de cuerda de arco.
US4771053A (en) * 1987-03-02 1988-09-13 Bristol-Myers Company Method for alleviation of primary depressive disorders
DE3720074A1 (de) * 1987-06-16 1988-12-29 Bayer Ag Mittel zur verhinderung von rangkaempfen bei schweinen
US4994455A (en) * 1987-10-26 1991-02-19 Pfizer Inc. Anti-anxiety agents
DE3736974A1 (de) * 1987-10-31 1989-05-11 Troponwerke Gmbh & Co Kg Verwendung von 2-pyrimidinyl-1-piperazin-derivaten
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JP2556722B2 (ja) * 1988-02-18 1996-11-20 興和株式会社 新規なスルホンアミド化合物
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US5278160A (en) * 1988-05-24 1994-01-11 American Home Products Corporation Use of aryl- and heteroaryl piperazinyl carboxamides in the treatment of various central nervous system disorders
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US5482940A (en) * 1988-05-24 1996-01-09 American Home Products Corporation Use of aryl- and heteroaryl piperazinyl carboxamides in the treatment of various central nervous system disorders
US5106849A (en) * 1988-05-24 1992-04-21 American Home Products Corporation Use of aryl- and heteroaryl piperazinyl carboxamides in the treatment of various central nervous system disorders
FI895821A0 (fi) * 1988-12-07 1989-12-05 Wellcome Found Farmaceutiskt aktiva cns foereningar.
MX19222A (es) * 1989-01-23 1993-12-01 Pfizer Agentes ansioliticos bis-aza-biciclicos
FR2642759B1 (fr) * 1989-02-09 1991-05-17 Laboratorios Esteve Sa Derives de pyrimidyl-piperazinyl-alkyl azoles avec activite anxiolytique et/ou tranquillisante
US5364849A (en) * 1989-04-22 1994-11-15 John Wyeth & Brother, Limited 1-[3 or 4-[1-[4-piperazinyl]]-2 arylpropionyl or butryl]-heterocyclic derivatives
US5382583A (en) * 1989-04-22 1995-01-17 John Wyeth & Brother, Limited Piperazine derivatives
FR2654934B1 (fr) * 1989-11-29 1994-09-30 Midy Spa Utilisation de derive [4-(2-pyrimidinyl)-1-piperazinyl] butyliques pour la preparation de medicaments destines a combattre les troubles de la motricite intestinale.
US5096908A (en) * 1990-05-04 1992-03-17 Eli Lilly And Company Method of inhibiting gastric acid secretion
US5258379A (en) * 1990-05-04 1993-11-02 Eli Lilly And Company Method of inhibiting gastric acid secretion with n-arylpiperazines
US5021569A (en) * 1990-06-12 1991-06-04 American Home Products Corporation 4-azatricyclo[4.3.1.1(3,8)]undecylarylpiperazines with anxiolytic activity
US5077293A (en) * 1990-06-29 1991-12-31 Bristol-Myers Squibb Co. 1-indolyalkyl-4-(alkoxypyrimidinyl)piperazines
US5204465A (en) * 1990-12-18 1993-04-20 Lonza Ltd. Process for the production of piperazinylpyrimidine derivatives
US5200520A (en) * 1990-12-18 1993-04-06 Lonza Ltd. Process for the production of piperazinylpyrimidine derivatives
US5140018A (en) * 1991-05-07 1992-08-18 Abbott Laboratories 1,3,2-benzodithiazole-1-oxide compounds
FR2701260B1 (fr) * 1993-02-05 1995-05-05 Esteve Labor Dr Dérivés de 2-[4-(4-azolylbutyl)-1-pipérazinyl]-5-hydroxypyrimidine, leur préparation et leur application en tant que médicaments.
US5681954A (en) * 1993-05-14 1997-10-28 Daiichi Pharmaceutical Co., Ltd. Piperazine derivatives
US5849148A (en) * 1993-08-12 1998-12-15 Ancon Chemical Pty. Ltd. Distributor plate and evaporator
CA2146593A1 (en) * 1994-05-05 1995-11-06 Jack Melton Large-scale process for azapirone synthesis
CA2196510C (en) * 1996-02-01 2000-08-01 Masashi Komatsu Process for producing dioxoquinazolines
US6312717B1 (en) 1998-07-07 2001-11-06 Bristol-Myers Squibb Company Method for treatment of anxiety and depression
US6566361B2 (en) 1999-06-30 2003-05-20 Laboratories, Upsa Azapirone pain treatment
US6864262B2 (en) * 2000-11-29 2005-03-08 Eli Lilly And Company 1-(2-m-methanesulfonamidophenylethyl)-4-(m-trifluoromethylphenyl) piperazine and pharmaceutically acceptable salts and solvents thereof
US20050192220A1 (en) * 2001-02-05 2005-09-01 Gevys Pharmaceuticas Ltd. Composition and method for potentiating drugs
US6833377B2 (en) * 2001-02-05 2004-12-21 Gevys Pharmaceuticals Ltd. Composition and method for potentiating drugs
EP1758583A2 (en) * 2004-05-31 2007-03-07 Ranbaxy Laboratories Limited Arylpiperazine derivatives useful as adrenergic receptor antagonists
EP2393785A4 (en) 2009-01-28 2013-10-30 Univ Vanderbilt SUBSTITUTED 1,1,3,3-TETRAOXIDOBENZO [D] [1,3,2] DITHIAZOLE AS ALLOSTERIC MGLUR4 POTENTIATORS, COMPOSITIONS AND METHODS OF TREATING NEUROLOGICAL DYSFUNCTIONS

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US4668687A (en) * 1984-07-23 1987-05-26 Bristol-Myers Company Psychogeriatric 1-(2-pyrimidinyl)piperazinyl derivatives of 1-pyrrolidin-2-ones
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Also Published As

Publication number Publication date
EP0129128B1 (de) 1990-11-22
ES8603465A1 (es) 1985-12-16
KR920000761B1 (ko) 1992-01-21
ES8603466A1 (es) 1985-12-16
HU196391B (en) 1988-11-28
DK168740B1 (da) 1994-05-30
EP0129128A3 (en) 1985-05-22
ZA844585B (en) 1985-02-27
DK295984D0 (da) 1984-06-15
EP0129128A2 (de) 1984-12-27
ES8603467A1 (es) 1985-12-16
CA1300624C (en) 1992-05-12
PT78751A (en) 1984-07-01
ES542319A0 (es) 1986-06-01
NZ208529A (en) 1989-01-27
KR850000433A (ko) 1985-02-27
FI842419A0 (fi) 1984-06-14
US5314884A (en) 1994-05-24
AU2929384A (en) 1984-12-20
PT78751B (en) 1986-07-14
IL72120A0 (en) 1984-10-31
ES542320A0 (es) 1985-12-16
FI842419A (fi) 1984-12-19
US4937343A (en) 1990-06-26
ES8603464A1 (es) 1985-12-16
DK165447B (da) 1992-11-30
ES8607285A1 (es) 1986-06-01
ES8600275A1 (es) 1985-08-01
DE3483629D1 (de) 1991-01-03
DE3321969A1 (de) 1984-12-20
ES533338A0 (es) 1985-08-01
FI82936C (fi) 1991-05-10
DK295984A (da) 1984-12-19
ES542323A0 (es) 1985-12-16
AU569086B2 (en) 1988-01-21
US4988809A (en) 1991-01-29
JPH0660165B2 (ja) 1994-08-10
HUT34746A (en) 1985-04-28
JPS6023373A (ja) 1985-02-05
FI82936B (fi) 1991-01-31
DK31092A (da) 1992-03-06
ES542321A0 (es) 1985-12-16
ES542322A0 (es) 1985-12-16
PH22960A (en) 1989-02-03
ATE58534T1 (de) 1990-12-15
DK31092D0 (da) 1992-03-06
IL72120A (en) 1989-09-28
GR82211B (da) 1984-12-13
US4818756A (en) 1989-04-04

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