ES8106905A1 - Procedimiento para preparar derivados de benzodiazepina - Google Patents

Procedimiento para preparar derivados de benzodiazepina

Info

Publication number
ES8106905A1
ES8106905A1 ES495948A ES495948A ES8106905A1 ES 8106905 A1 ES8106905 A1 ES 8106905A1 ES 495948 A ES495948 A ES 495948A ES 495948 A ES495948 A ES 495948A ES 8106905 A1 ES8106905 A1 ES 8106905A1
Authority
ES
Spain
Prior art keywords
alkyl
preparation
cycloalkyl
haloalkyl
hydrogen
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES495948A
Other languages
English (en)
Other versions
ES495948A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Lilly Industries Ltd
Original Assignee
Lilly Industries Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Industries Ltd filed Critical Lilly Industries Ltd
Publication of ES8106905A1 publication Critical patent/ES8106905A1/es
Publication of ES495948A0 publication Critical patent/ES495948A0/es
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D231/38—Nitrogen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Psychiatry (AREA)
  • Anesthesiology (AREA)
  • Hospice & Palliative Care (AREA)
  • Otolaryngology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

PROCEDIMIENTO PARA LA OBTENCION DE DERIVADOS DE BENZODIAZEPINA DE FORMULA (I) O UNA SAL DE ADICION DE ACIDO DE LOS MISMOS, DONDE R ELEVADO A 1, R CUADRADO, R CUBO, R ELEVADO A 4 A 6 Y A 7 PUEDEN SER DIFERENTES COMPUESTOS, Y R ELEVADO A 5 ES UN GRUPO DE FORMULA (II), SIENDO N 0 O 1 Y R ELEVADO A 9 Y A 10 DIFERENTES COMPUESTOS. CONSISTE EN HACER REACCIONAR UNA AMINA DE FORMULA R ELEVADO A 5 H CON UN COMPUESTO DE FORMULA (II), DONDE Q ES UN RADICAL CAPAZ DE DISOCIARSE CON EL ATOMO DE HIDROGENO DE DICHA AMINA. OTRA FORMA DE OBTENCION ES POR EL CIERRE DE UN ANILLO DE UN COMPUESTO DE FORMULA (IV). EN AMBOS CASOS SE EMPLEA COMO CATALIZADOR UNA AMINA TERCIARIA Y LA REACCION SE LLEVA A CABO EN UN MEDIO DISOLVENTE ORGANICO Y A UNA TEMPERATURA ENTRE 100 Y 200GC. LOS COMPUESTOS OBTENIDOS TIENEN APLICACION EN EL TRATAMIENTO DE DESORDENES DEL SISTEMA NERVIOSO CENTRAL. *FORMULA*
ES495948A 1979-10-16 1980-10-15 Procedimiento para preparar derivados de benzodiazepina Granted ES495948A0 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB7935846 1979-10-16

Publications (2)

Publication Number Publication Date
ES8106905A1 true ES8106905A1 (es) 1981-09-16
ES495948A0 ES495948A0 (es) 1981-09-16

Family

ID=10508540

Family Applications (1)

Application Number Title Priority Date Filing Date
ES495948A Granted ES495948A0 (es) 1979-10-16 1980-10-15 Procedimiento para preparar derivados de benzodiazepina

Country Status (33)

Country Link
US (3) US4404137A (es)
EP (1) EP0027390B1 (es)
JP (1) JPS5663987A (es)
KR (2) KR850000471B1 (es)
AR (2) AR228041A1 (es)
AT (1) AT373889B (es)
AU (1) AU538500B2 (es)
BE (1) BE885729A (es)
BG (2) BG35042A3 (es)
CA (1) CA1159056A (es)
CH (1) CH646700A5 (es)
CS (1) CS244409B2 (es)
DD (1) DD153692A5 (es)
DE (1) DE3068706D1 (es)
DK (1) DK437480A (es)
ES (1) ES495948A0 (es)
FI (1) FI67550C (es)
FR (1) FR2467851A1 (es)
GB (1) GB8327127D0 (es)
GR (1) GR70720B (es)
HU (1) HU182213B (es)
IE (1) IE50358B1 (es)
IL (1) IL61264A (es)
IT (1) IT1143047B (es)
LU (1) LU82853A1 (es)
MX (1) MX6233E (es)
NZ (1) NZ195248A (es)
PH (2) PH16288A (es)
PL (2) PL126824B1 (es)
PT (1) PT71913B (es)
RO (2) RO81351B (es)
YU (1) YU261580A (es)
ZA (1) ZA806342B (es)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4404137A (en) * 1979-10-16 1983-09-13 Lilly Industries Limited Pyrazolo [3,4-b][1,5]benzodiazepine compounds
US4431589A (en) * 1980-12-11 1984-02-14 Lilly House Benzodiazepine compounds and their use as pharmaceuticals
US4596799A (en) * 1985-01-29 1986-06-24 Ciba-Geigy Corporation 9H-pyrrolo[2,1-c]-1,2,4-triazolo[4,3-a][1,4]benzodiazepines
TW219896B (es) * 1988-07-07 1994-02-01 Duphar Int Res
GB8819059D0 (en) * 1988-08-11 1988-09-14 Lilly Industries Ltd Benzodiazepine compounds & their use as pharmaceuticals
US5637584A (en) * 1995-03-24 1997-06-10 Eli Lilly And Company Solvate of olanzapine
US5631250A (en) * 1995-03-24 1997-05-20 Eli Lilly And Company Process and solvate of 2-methyl-thieno-benzodiazepine
US20050085463A1 (en) * 2003-01-23 2005-04-21 Weiner David M. Use of N-desmethylclozapine to treat human neuropsychiatric disease
BRPI0406592A (pt) * 2003-01-23 2005-12-20 Acadia Pharm Inc Usos de n-desmetilclozapina, métodos para o tratamento de psicose, de distúrbios afetivos, de demência, de dor neuropática e de glaucoma e composição farmacêutica
US20050250767A1 (en) * 2003-01-23 2005-11-10 Weiner David M Use of N-desmethylclozapine to treat human neuropsychiatric disease
US7550454B2 (en) * 2003-12-22 2009-06-23 Acadia Pharmaceuticals, Inc. Amino substituted diaryl[a,d]cycloheptene analogs as muscarinic agonists and methods of treatment of neuropsychiatric disorders
JP2007536216A (ja) * 2004-04-01 2007-12-13 アカディア ファーマシューティカルズ，インコーポレーテッド 固体ｎ−デスメチルクロザピンおよびその結晶形を合成および単離する方法
US20070105836A1 (en) * 2005-10-31 2007-05-10 Lars Pettersson Prodrugs of muscarinic agonists and methods of treatment of neuropsychiatric disorders
JP5438482B2 (ja) * 2009-12-03 2014-03-12 Ｊｕｋｉ株式会社 ミシン、ミシンの縫製データ編集装置及びミシンの縫製データ編集プログラム

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3450694A (en) * 1966-02-23 1969-06-17 Abbott Lab Substituted benzoxazepines and benzothiazepines
US3758479A (en) * 1967-03-22 1973-09-11 Sandoz Ag Nitro and sulphamoyl substituted dibenzodiazepines
DE1795183B1 (de) * 1968-08-20 1972-07-20 Thomae Gmbh Dr K 5,11-Dihydro-6H-pyrido[2,3-b][1,4]benzodiazepin-6-on-derivate und Arzneimittel
CA918659A (en) * 1969-07-31 1973-01-09 Yoshitomi Pharmaceutical Industries 11-(4-substituted-1-piperazinyl)-dibenzo (b,f) (1,4) thiazepines
US4115568A (en) * 1974-11-26 1978-09-19 Lilly Industries Limited Thieno[3,2-b]-[1,5]benzodiazepines
US4172831A (en) * 1974-11-26 1979-10-30 Lilly Industries Limited Thieno-benzodiazepines
US3951981A (en) * 1975-02-24 1976-04-20 American Cyanamid Company Substituted benzodiazepines and method of use
US3953430A (en) * 1975-02-24 1976-04-27 American Cyanamid Company Substituted benzodiazepin-10-ones and method of use
DE2707270A1 (de) * 1977-02-19 1978-08-24 Hoechst Ag Pyrazolo-diazepine und verfahren zu ihrer herstellung
DE2707269A1 (de) * 1977-02-19 1978-08-24 Hoechst Ag Heterocyclische stickstoffverbindungen und verfahren zu ihrer herstellung
US4097597A (en) * 1977-02-23 1978-06-27 Abbott Laboratories Dibenzo b,e! 1,4!diazepines
IT7851496A0 (it) * 1977-10-31 1978-10-13 Sandoz Ag Menti pirazinobenzossazepine loro preparazione e loro impiego quali medica
CH643263A5 (de) * 1979-05-11 1984-05-30 Sandoz Ag Benzodiazepine, ihre herstellung und verwendung.
CA1154762A (en) * 1979-08-03 1983-10-04 Georg Rainer Substituted tetraazatricyclic compounds, a process for their preparation, their use and medicaments containing them
US4404137A (en) * 1979-10-16 1983-09-13 Lilly Industries Limited Pyrazolo [3,4-b][1,5]benzodiazepine compounds

Also Published As

Publication number Publication date
DD153692A5 (de) 1982-01-27
US4486591A (en) 1984-12-04
IL61264A (en) 1985-08-30
RO85822A (ro) 1984-11-25
US4542131A (en) 1985-09-17
AR228041A1 (es) 1983-01-14
JPS5663987A (en) 1981-05-30
FI67550C (fi) 1985-04-10
AU6325280A (en) 1981-04-30
IL61264A0 (en) 1980-12-31
RO85822B (ro) 1984-11-30
MX6233E (es) 1985-01-14
CS244409B2 (en) 1986-07-17
PL231270A1 (es) 1981-12-23
FR2467851A1 (fr) 1981-04-30
ZA806342B (en) 1982-05-26
YU261580A (en) 1983-12-31
DK437480A (da) 1981-04-17
FI67550B (fi) 1984-12-31
HU182213B (en) 1983-12-28
GB8327127D0 (en) 1983-11-09
PH17759A (en) 1984-12-05
FI803253L (fi) 1981-04-17
RO81351B (ro) 1983-02-28
IT8049899A0 (it) 1980-10-14
KR850001463A (ko) 1985-03-18
LU82853A1 (fr) 1982-05-10
PL135044B1 (en) 1985-09-30
PH16288A (en) 1983-09-05
PT71913B (en) 1981-08-31
US4404137A (en) 1983-09-13
GR70720B (es) 1983-01-18
ES495948A0 (es) 1981-09-16
EP0027390A1 (en) 1981-04-22
RO81351A (ro) 1983-02-15
IE802135L (en) 1981-04-16
DE3068706D1 (en) 1984-08-30
FR2467851B1 (es) 1985-04-05
PL126824B1 (en) 1983-09-30
KR830004300A (ko) 1983-07-09
BG35042A3 (en) 1983-01-16
IE50358B1 (en) 1986-04-02
CA1159056A (en) 1983-12-20
AU538500B2 (en) 1984-08-16
BE885729A (fr) 1981-04-15
AT373889B (de) 1984-02-27
IT1143047B (it) 1986-10-22
PT71913A (en) 1980-11-01
ATA510180A (de) 1983-07-15
EP0027390B1 (en) 1984-07-25
AR228101A1 (es) 1983-01-14
NZ195248A (en) 1983-11-18
PL227306A1 (es) 1981-09-18
BG34907A3 (en) 1983-12-15
KR850000472B1 (ko) 1985-04-08
CH646700A5 (fr) 1984-12-14
KR850000471B1 (ko) 1985-04-08

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