RO85822B - Procedeu pentru prepararea unor derivati de benzodiazepina - Google Patents

Procedeu pentru prepararea unor derivati de benzodiazepina

Info

Publication number
RO85822B
RO85822B RO108967A RO10896780A RO85822B RO 85822 B RO85822 B RO 85822B RO 108967 A RO108967 A RO 108967A RO 10896780 A RO10896780 A RO 10896780A RO 85822 B RO85822 B RO 85822B
Authority
RO
Romania
Prior art keywords
carbon atoms
formula
alkyl
benzodiazepine derivatives
cycloalkylalkyl
Prior art date
Application number
RO108967A
Other languages
English (en)
Other versions
RO85822A (ro
Inventor
Jiban Kumar Chakrabarti
Terrence Michael Hotten
Original Assignee
Lilly Industries Limited
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Industries Limited filed Critical Lilly Industries Limited
Publication of RO85822A publication Critical patent/RO85822A/ro
Publication of RO85822B publication Critical patent/RO85822B/ro

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D231/38—Nitrogen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Psychiatry (AREA)
  • Anesthesiology (AREA)
  • Hospice & Palliative Care (AREA)
  • Otolaryngology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Inventia se refera la un procedeu pentru prepararea unor derivati de benzodiazepina cu formula generala I: (vezi formula) în care R1, R2, R3 si R4 reprezinta, în mod independent, hidrogen, alchil cu 1...4 atomi de carbon, alchenil cu 2...4 atomi de carbon, cicloalchil cu 3...7 atomi de carbon, cicloalchilalchil cu 3...7, respectiv 1...4 atomi de carbon, halogen, haloalchil cu 1...4 a<tomi de carbon, alcanoil cu 1...4 atomi de carbon, nitro, amino, acilamino cu 2...4 atomi de carbon, ciano, hidroxi, alcoxi cu 1....4 atomi de carbon, haloalchil cu 1...4 atomi de carbon sau o grupare cu formula -SO2(R8)2-, SO2R8 sau -SO3R8 este alchil ,cu 1...4 atomi de carbon, sau fenil, eventual substituit, R5 este o grupare cu formula: (vezi formula) în care R9 este halogen, alchil cu 1...4 atomi de carbon, cicloalchil cu 3...7 atomi de carbon, cicloalchilalchil cu 3...7 atomi de carbon, alchenil cu 2...4 atomi de carbon, alcanoli cu 1..4 atomi de carbon, benzil, ciano, sau fenil, eventual substituit, R10 este hidrogen..................
RO108967A 1979-10-16 1980-10-13 Procedeu pentru prepararea unor derivati de benzodiazepina RO85822B (ro)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB7935846 1979-10-16

Publications (2)

Publication Number Publication Date
RO85822A RO85822A (ro) 1984-11-25
RO85822B true RO85822B (ro) 1984-11-30

Family

ID=10508540

Family Applications (2)

Application Number Title Priority Date Filing Date
RO108967A RO85822B (ro) 1979-10-16 1980-10-13 Procedeu pentru prepararea unor derivati de benzodiazepina
RO102349A RO81351B (ro) 1979-10-16 1980-10-13 Procedeu pentru prepararea unor derivati de benzodiazepinei

Family Applications After (1)

Application Number Title Priority Date Filing Date
RO102349A RO81351B (ro) 1979-10-16 1980-10-13 Procedeu pentru prepararea unor derivati de benzodiazepinei

Country Status (33)

Country Link
US (3) US4404137A (ro)
EP (1) EP0027390B1 (ro)
JP (1) JPS5663987A (ro)
KR (2) KR850000471B1 (ro)
AR (2) AR228041A1 (ro)
AT (1) AT373889B (ro)
AU (1) AU538500B2 (ro)
BE (1) BE885729A (ro)
BG (2) BG35042A3 (ro)
CA (1) CA1159056A (ro)
CH (1) CH646700A5 (ro)
CS (1) CS244409B2 (ro)
DD (1) DD153692A5 (ro)
DE (1) DE3068706D1 (ro)
DK (1) DK437480A (ro)
ES (1) ES495948A0 (ro)
FI (1) FI67550C (ro)
FR (1) FR2467851A1 (ro)
GB (1) GB8327127D0 (ro)
GR (1) GR70720B (ro)
HU (1) HU182213B (ro)
IE (1) IE50358B1 (ro)
IL (1) IL61264A (ro)
IT (1) IT1143047B (ro)
LU (1) LU82853A1 (ro)
MX (1) MX6233E (ro)
NZ (1) NZ195248A (ro)
PH (2) PH16288A (ro)
PL (2) PL135044B1 (ro)
PT (1) PT71913B (ro)
RO (2) RO85822B (ro)
YU (1) YU261580A (ro)
ZA (1) ZA806342B (ro)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4404137A (en) * 1979-10-16 1983-09-13 Lilly Industries Limited Pyrazolo [3,4-b][1,5]benzodiazepine compounds
US4431589A (en) * 1980-12-11 1984-02-14 Lilly House Benzodiazepine compounds and their use as pharmaceuticals
US4596799A (en) * 1985-01-29 1986-06-24 Ciba-Geigy Corporation 9H-pyrrolo[2,1-c]-1,2,4-triazolo[4,3-a][1,4]benzodiazepines
TW219896B (ro) * 1988-07-07 1994-02-01 Duphar Int Res
GB8819059D0 (en) * 1988-08-11 1988-09-14 Lilly Industries Ltd Benzodiazepine compounds & their use as pharmaceuticals
US5631250A (en) * 1995-03-24 1997-05-20 Eli Lilly And Company Process and solvate of 2-methyl-thieno-benzodiazepine
US5637584A (en) * 1995-03-24 1997-06-10 Eli Lilly And Company Solvate of olanzapine
US20050085463A1 (en) * 2003-01-23 2005-04-21 Weiner David M. Use of N-desmethylclozapine to treat human neuropsychiatric disease
US20050250767A1 (en) * 2003-01-23 2005-11-10 Weiner David M Use of N-desmethylclozapine to treat human neuropsychiatric disease
JP2006515628A (ja) * 2003-01-23 2006-06-01 アカディア ファーマシューティカルズ，インコーポレーテッド ヒト神経精神疾患を処置するためのｎ−デスメチルクロザピンの使用
SG133606A1 (en) * 2003-12-22 2007-07-30 Acadia Pharm Inc Amino substituted diaryl [a,d] cycloheptene analogs as muscarinic agonists and methods of treatment of neuropsychiatric disorders
CA2560671A1 (en) * 2004-04-01 2006-01-05 Acadia Pharmaceuticals Inc. Crystalline forms of n-desmethylclozapine
US20070105836A1 (en) * 2005-10-31 2007-05-10 Lars Pettersson Prodrugs of muscarinic agonists and methods of treatment of neuropsychiatric disorders
JP5438482B2 (ja) * 2009-12-03 2014-03-12 Ｊｕｋｉ株式会社 ミシン、ミシンの縫製データ編集装置及びミシンの縫製データ編集プログラム

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3450694A (en) * 1966-02-23 1969-06-17 Abbott Lab Substituted benzoxazepines and benzothiazepines
US3758479A (en) * 1967-03-22 1973-09-11 Sandoz Ag Nitro and sulphamoyl substituted dibenzodiazepines
DE1795183B1 (de) * 1968-08-20 1972-07-20 Thomae Gmbh Dr K 5,11-Dihydro-6H-pyrido[2,3-b][1,4]benzodiazepin-6-on-derivate und Arzneimittel
CA918659A (en) * 1969-07-31 1973-01-09 Yoshitomi Pharmaceutical Industries 11-(4-substituted-1-piperazinyl)-dibenzo (b,f) (1,4) thiazepines
US4172831A (en) * 1974-11-26 1979-10-30 Lilly Industries Limited Thieno-benzodiazepines
US4115568A (en) * 1974-11-26 1978-09-19 Lilly Industries Limited Thieno[3,2-b]-[1,5]benzodiazepines
US3953430A (en) * 1975-02-24 1976-04-27 American Cyanamid Company Substituted benzodiazepin-10-ones and method of use
US3951981A (en) * 1975-02-24 1976-04-20 American Cyanamid Company Substituted benzodiazepines and method of use
DE2707270A1 (de) * 1977-02-19 1978-08-24 Hoechst Ag Pyrazolo-diazepine und verfahren zu ihrer herstellung
DE2707269A1 (de) * 1977-02-19 1978-08-24 Hoechst Ag Heterocyclische stickstoffverbindungen und verfahren zu ihrer herstellung
US4097597A (en) * 1977-02-23 1978-06-27 Abbott Laboratories Dibenzo b,e! 1,4!diazepines
IT7851496A0 (it) * 1977-10-31 1978-10-13 Sandoz Ag Menti pirazinobenzossazepine loro preparazione e loro impiego quali medica
CH643263A5 (de) * 1979-05-11 1984-05-30 Sandoz Ag Benzodiazepine, ihre herstellung und verwendung.
CA1154762A (en) * 1979-08-03 1983-10-04 Georg Rainer Substituted tetraazatricyclic compounds, a process for their preparation, their use and medicaments containing them
US4404137A (en) * 1979-10-16 1983-09-13 Lilly Industries Limited Pyrazolo [3,4-b][1,5]benzodiazepine compounds

Also Published As

Publication number Publication date
LU82853A1 (fr) 1982-05-10
ATA510180A (de) 1983-07-15
FI803253L (fi) 1981-04-17
KR850000471B1 (ko) 1985-04-08
RO81351A (ro) 1983-02-15
IT1143047B (it) 1986-10-22
DE3068706D1 (en) 1984-08-30
PT71913A (en) 1980-11-01
KR830004300A (ko) 1983-07-09
JPS5663987A (en) 1981-05-30
US4404137A (en) 1983-09-13
AU6325280A (en) 1981-04-30
ES8106905A1 (es) 1981-09-16
IL61264A0 (en) 1980-12-31
DK437480A (da) 1981-04-17
EP0027390A1 (en) 1981-04-22
ZA806342B (en) 1982-05-26
US4542131A (en) 1985-09-17
FR2467851B1 (ro) 1985-04-05
NZ195248A (en) 1983-11-18
RO85822A (ro) 1984-11-25
PH16288A (en) 1983-09-05
AR228041A1 (es) 1983-01-14
EP0027390B1 (en) 1984-07-25
GB8327127D0 (en) 1983-11-09
IL61264A (en) 1985-08-30
PL231270A1 (ro) 1981-12-23
BG34907A3 (en) 1983-12-15
AT373889B (de) 1984-02-27
KR850000472B1 (ko) 1985-04-08
PL135044B1 (en) 1985-09-30
IE802135L (en) 1981-04-16
FI67550B (fi) 1984-12-31
MX6233E (es) 1985-01-14
FR2467851A1 (fr) 1981-04-30
GR70720B (ro) 1983-01-18
CA1159056A (en) 1983-12-20
FI67550C (fi) 1985-04-10
PT71913B (en) 1981-08-31
BE885729A (fr) 1981-04-15
AR228101A1 (es) 1983-01-14
ES495948A0 (es) 1981-09-16
IE50358B1 (en) 1986-04-02
HU182213B (en) 1983-12-28
YU261580A (en) 1983-12-31
IT8049899A0 (it) 1980-10-14
DD153692A5 (de) 1982-01-27
CS244409B2 (en) 1986-07-17
PL227306A1 (ro) 1981-09-18
KR850001463A (ko) 1985-03-18
US4486591A (en) 1984-12-04
PH17759A (en) 1984-12-05
RO81351B (ro) 1983-02-28
CH646700A5 (fr) 1984-12-14
BG35042A3 (en) 1983-01-16
AU538500B2 (en) 1984-08-16
PL126824B1 (en) 1983-09-30

Similar Documents

Publication Publication Date Title
RO85822B (ro) Procedeu pentru prepararea unor derivati de benzodiazepina
RO84802B (ro) Procedeu pentru obtinerea unor (1-aril-ciclobutil)-alchilamine
MY101643A (en) Fungicides
TW370450B (en) Substituted 1H-3-aryl-pyrrolidine-2,4-dione derivatives
ES537677A0 (es) Procedimiento para preparar una 1h-imidazo (4, 5-c) quinolin-4-amina
RO82369B (ro) Procedeu pentru prepararea unor derivati de 9-amino-dibenzopiran
NZ503912A (en) Piperidinylaminomethyl trifluoromethyl cyclic ether compounds and their use as substance P antagonists
IL98340A0 (en) Morpholinourea derivatives,their preparation and their use as insect-and mite repellants
AR246962A1 (es) Procedimiento para preparar derivados alquilamino-alquilenicos de ciertos 2h-1-benzopiranos.
FI894061A0 (fi) Menetelmä lääkeaineina käyttökelpoisten , -disubstituoitujen N-sykloalkyylialkyylibentsyyliamiinien valmistamiseksi ja niiden synteesivälituotteita
DK334480A (da) Fremgangsmaade til fremstilling af phenoxypiperidinderivater
RO82507B (ro) Procedeu pentru prepararea unor derivati ai acidului 1, 2, 3-tiadiazol-5-carboxilic
ES466366A1 (es) Un procedimiento para preparar derivados de metasulfonamido-benzamida.
MD422C2 (ro) Derivaţi ai azolului şi compuţi intermediari pentru producerea lor
NO842482L (no) Fremgangsmaate til fremstilling av beta-karbolinderivater
ES2012648A6 (es) Procedimiento para la preparacion de nuevos derivados de 1,4-benzoxazina y 1,4-benzotiazina.
ES2032501T3 (es) Un procedimiento de preparacion de derivados de urileno-2,4,6-triamino-3-oxido.
AR008375A1 (es) Compuestos fluorenonas alquiloxiaminas sustituidas y derivados de los mismos, procedimiento para la preparacion de compuestos utiles como intermediarios en la preparacion de los mismos y compuestos intermediarios.
YU47047B (sh) Supstituisani 3-amino-2-benzoilcikloheks-2-enoni, postupak za njihovo dobijanje i primena za dobijanje herbicica
MY108849A (en) Novel compound
ES463424A1 (es) Procedimiento de preparacion de lactamas sustituidas en n.
DE3061188D1 (en) 2-sulfonyl-quinoxalines, processes for their preparation and their use as microbicides
RO78871B (ro) Procedeu pentru prepararea unor derivati de piridiluree si piridiltiouree
ES8607265A1 (es) Un procedimiento para la preparacion de nuevos derivados de aminoalcoholes
RO72831B (ro) Procedeu pentru prepararea unor fenilpiperazine