ES8301221A1 - Un procedimiento para la preparacion de derivados de imida- zol - Google Patents

Un procedimiento para la preparacion de derivados de imida- zol

Info

Publication number
ES8301221A1
ES8301221A1 ES505556A ES505556A ES8301221A1 ES 8301221 A1 ES8301221 A1 ES 8301221A1 ES 505556 A ES505556 A ES 505556A ES 505556 A ES505556 A ES 505556A ES 8301221 A1 ES8301221 A1 ES 8301221A1
Authority
ES
Spain
Prior art keywords
alkyl
image
represents hydrogen
antihistaminic
imidazoles
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES505556A
Other languages
English (en)
Other versions
ES505556A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Glaxo Group Ltd
Original Assignee
Glaxo Group Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glaxo Group Ltd filed Critical Glaxo Group Ltd
Publication of ES505556A0 publication Critical patent/ES505556A0/es
Publication of ES8301221A1 publication Critical patent/ES8301221A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

UN PROCEDIMIENTO PARA LA PREPARACION DE DERIVADOS DE IMIDAZOL. CONSISTE EN HACER REACCIONAR UN 2-BENZOILIMIDAZOL DE FORMULA GENERAL (I) CON UN BROMURO DE TRIFENILFOSFONIO DE FORMULA R R NCH CH PPH BR, SE ELIMINA A CONTINUACION EL GRUPO PROTECTOR R SI ES NECESARIO, PARA OBTENER EL CORRESPONDIENTE COMPUESTO (II) DONDE X-Y ES =C=CH. OPCIONALMENTE PUEDE REDUCIRSE EL COMPUESTO OBTENIDO PARA OBTENER EL COMPUESTO (II) EN QUE X-Y ES =CH<024>CH . R ES HALOGENO, HIDROGENO, ALCOXI C <003> , HIDROXI, ALQUILO, R CHOH, CIANO O R CONH; R Y R PUEDEN SER IGUALES O DIFERENTES, REPRESENTANDO CADA UNO UN GRUPO ALQUILO O ALQUENILO O BIEN JUNTO AL ATOMO DE NITROGENO, PUEDEN FORMAR UN ANILLO HETEROCICLICO SATURADO DE 5 A 7 MIEMBROS, QUE OPCIONALMENTE PUEDE CONTENER UN ATOMO DE OXIGENO. >ACTIVIDAD ANTAGONISTA H .
ES505556A 1979-10-03 1981-09-16 Un procedimiento para la preparacion de derivados de imida- zol Expired ES8301221A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB7934347 1979-10-03

Publications (2)

Publication Number Publication Date
ES505556A0 ES505556A0 (es) 1982-12-01
ES8301221A1 true ES8301221A1 (es) 1982-12-01

Family

ID=10508267

Family Applications (3)

Application Number Title Priority Date Filing Date
ES495589A Expired ES8203855A1 (es) 1979-10-03 1980-10-02 Un procedimiento para la preparacion de derivados de imida- lol.
ES505555A Granted ES505555A0 (es) 1979-10-03 1981-09-16 Un procedimiento para la preparacion de derivados de imida- zol
ES505556A Expired ES8301221A1 (es) 1979-10-03 1981-09-16 Un procedimiento para la preparacion de derivados de imida- zol

Family Applications Before (2)

Application Number Title Priority Date Filing Date
ES495589A Expired ES8203855A1 (es) 1979-10-03 1980-10-02 Un procedimiento para la preparacion de derivados de imida- lol.
ES505555A Granted ES505555A0 (es) 1979-10-03 1981-09-16 Un procedimiento para la preparacion de derivados de imida- zol

Country Status (15)

Country Link
US (1) US4324792A (es)
JP (1) JPS5690063A (es)
AU (1) AU6294580A (es)
BE (1) BE885507A (es)
DE (1) DE3037313A1 (es)
DK (1) DK420480A (es)
ES (3) ES8203855A1 (es)
FI (1) FI803127L (es)
FR (1) FR2466461A1 (es)
GB (1) GB2062626B (es)
IT (1) IT1144007B (es)
NL (1) NL8005491A (es)
NZ (1) NZ195144A (es)
SE (1) SE8006953L (es)
ZA (1) ZA806146B (es)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4532331A (en) * 1983-04-12 1985-07-30 Smithkline Beckman Corporation 1-Benzyl-2-aminomethyl imidazole derivatives
PT78388B (en) * 1983-04-12 1986-09-15 Smithkline Beckman Corp Dopamine-beta-hydroxylase inhibitors
US4602093A (en) * 1984-02-08 1986-07-22 Merck & Co., Inc. Novel substituted imidazoles, their preparation and use
US4661602A (en) * 1985-03-29 1987-04-28 G. D. Searle & Co. Substituted alkyl imidazole derivatives
NZ238688A (en) * 1990-06-28 1992-05-26 Smithkline Beecham Corp Substituted histidines: pharmaceutical compositions, preparation and uses thereof
US5807872A (en) * 1992-12-16 1998-09-15 Schering Corporation Imidazoylalkyl substituted with a six membered nitrogen containing heterocyclic ring
US5972984A (en) * 1995-06-06 1999-10-26 Merck & Co., Inc. Inhibitors of farnesyl-protein transferase
US6410539B1 (en) * 1997-10-22 2002-06-25 Astrazenca Uk Limited Imidazole derivatives and their use as farnesyl protein transferase inhibitors
DK1025088T3 (da) 1997-10-22 2001-11-12 Astrazeneca Ab Imidazolderivater og deres anvendelse som farnesylproteintransferaseinhibitorer
EP2447263A1 (en) * 2010-09-27 2012-05-02 Bioprojet Benzazole derivatives as histamine H4 receptor ligands

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2532547A (en) * 1950-12-05 Z-aminoalkyl-glyoxaline derivatives
GB1421792A (en) * 1973-05-17 1976-01-21 Smith Kline French Lab Heterocyclic substituted-1, 1-diamino-ethylene derivatives methods for their preparation and compositions containing them
US4152443A (en) * 1973-07-13 1979-05-01 Smith Kline & French Laboratories Limited Imidazolyl thioureas, ureas and guanidines
US4006137A (en) * 1975-08-21 1977-02-01 E. R. Squibb & Sons, Inc. 2-Ethenyl imidazolium derivatives

Also Published As

Publication number Publication date
FR2466461A1 (fr) 1981-04-10
ES8205204A1 (es) 1982-06-01
IT8049815A0 (it) 1980-10-03
JPS5690063A (en) 1981-07-21
FI803127L (fi) 1981-04-04
ES495589A0 (es) 1981-12-16
US4324792A (en) 1982-04-13
ES505556A0 (es) 1982-12-01
DK420480A (da) 1981-04-04
GB2062626B (en) 1983-10-05
IT1144007B (it) 1986-10-29
BE885507A (fr) 1981-04-02
FR2466461B1 (es) 1983-05-20
DE3037313A1 (de) 1981-04-23
NZ195144A (en) 1983-02-15
GB2062626A (en) 1981-05-28
SE8006953L (sv) 1981-04-04
ES8203855A1 (es) 1981-12-16
NL8005491A (nl) 1981-04-07
ZA806146B (en) 1982-01-27
AU6294580A (en) 1981-04-16
ES505555A0 (es) 1982-06-01

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