AR008375A1 - Compuestos fluorenonas alquiloxiaminas sustituidas y derivados de los mismos, procedimiento para la preparacion de compuestos utiles como intermediarios en la preparacion de los mismos y compuestos intermediarios. - Google Patents
Compuestos fluorenonas alquiloxiaminas sustituidas y derivados de los mismos, procedimiento para la preparacion de compuestos utiles como intermediarios en la preparacion de los mismos y compuestos intermediarios.Info
- Publication number
- AR008375A1 AR008375A1 ARP970102266A ARP970102266A AR008375A1 AR 008375 A1 AR008375 A1 AR 008375A1 AR P970102266 A ARP970102266 A AR P970102266A AR P970102266 A ARP970102266 A AR P970102266A AR 008375 A1 AR008375 A1 AR 008375A1
- Authority
- AR
- Argentina
- Prior art keywords
- compounds
- preparation
- substituted
- alkyloxyamins
- fluorenon
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
- C07D295/084—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
- C07D295/088—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
- C07C217/02—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
- C07C217/04—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
- C07C217/06—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one etherified hydroxy group and one amino group bound to the carbon skeleton, which is not further substituted
- C07C217/14—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one etherified hydroxy group and one amino group bound to the carbon skeleton, which is not further substituted the oxygen atom of the etherified hydroxy group being further bound to a carbon atom of a six-membered aromatic ring
- C07C217/24—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one etherified hydroxy group and one amino group bound to the carbon skeleton, which is not further substituted the oxygen atom of the etherified hydroxy group being further bound to a carbon atom of a six-membered aromatic ring the six-membered aromatic ring being part of a condensed ring system containing rings other than six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
- C07C235/42—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton
- C07C235/44—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton with carbon atoms of carboxamide groups and singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2603/00—Systems containing at least three condensed rings
- C07C2603/02—Ortho- or ortho- and peri-condensed systems
- C07C2603/04—Ortho- or ortho- and peri-condensed systems containing three rings
- C07C2603/06—Ortho- or ortho- and peri-condensed systems containing three rings containing at least one ring with less than six ring members
- C07C2603/10—Ortho- or ortho- and peri-condensed systems containing three rings containing at least one ring with less than six ring members containing five-membered rings
- C07C2603/12—Ortho- or ortho- and peri-condensed systems containing three rings containing at least one ring with less than six ring members containing five-membered rings only one five-membered ring
- C07C2603/18—Fluorenes; Hydrogenated fluorenes
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Pulmonology (AREA)
- Vascular Medicine (AREA)
- Urology & Nephrology (AREA)
- Hematology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Dermatology (AREA)
- Diabetes (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
Se describe el uso de compuestos fluorenonas alquiloxiamino sustituídos y derivados de los mismos, caracterizado dicho uso para la preparacion de unmedicamento para el tratamiento de enfermedades mediadas por la proteína Kinasa C, poseyendo dichoscompuestos la formula general I donde: B, es S o NH; R4 esmetilo, etilo, n-propilo o ambos R4 pueden combinarse para dar pirrolidinilo, piperidinilo o morfolino; R5 es alquileno C1-5; V es hidrogeno, metoxi, etoxi,propoxi o butoxi; X es H ometoxi, etoxi, propoxi, fluoro, cloro o alquilamino C1-4; Y es H o NH2, NHR, NHCOR, donde R es alquilo C1-5 o fenilo; Z es H,alquilo C1-5, cloro, fluoro, BR5N(R4)2 donde R4, R5 y B son como se ha definidoantes; con la condicion de que: Z puedaestar prese nte en la posicion 1, 2, 3 o4 y, cuandoesté presente en la posicion 1, 2 o 4, substituya a Y, V o X, respectivamente; o una sal del mismo farmacéuticamente aceptable. También sedescriben nuevos compuestos con la condicion quecuando Z es BR5N (R4)2 entonces al menos uno de Y, V o X no sea hidrogeno o esté sustituído por Z.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US65558496A | 1996-05-30 | 1996-05-30 | |
US65553796A | 1996-05-30 | 1996-05-30 |
Publications (1)
Publication Number | Publication Date |
---|---|
AR008375A1 true AR008375A1 (es) | 2000-01-19 |
Family
ID=27096988
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP970102266A AR008375A1 (es) | 1996-05-30 | 1997-05-28 | Compuestos fluorenonas alquiloxiaminas sustituidas y derivados de los mismos, procedimiento para la preparacion de compuestos utiles como intermediarios en la preparacion de los mismos y compuestos intermediarios. |
Country Status (18)
Country | Link |
---|---|
EP (1) | EP0906268B1 (es) |
JP (1) | JP3897363B2 (es) |
CN (1) | CN1160309C (es) |
AR (1) | AR008375A1 (es) |
AT (1) | ATE209626T1 (es) |
AU (1) | AU737073B2 (es) |
BR (1) | BR9709406B1 (es) |
CA (1) | CA2257136C (es) |
DE (1) | DE69708629T2 (es) |
DK (1) | DK0906268T3 (es) |
ES (1) | ES2170390T3 (es) |
HK (1) | HK1019147A1 (es) |
HU (1) | HUP9901621A3 (es) |
IL (1) | IL126873A (es) |
NO (1) | NO312457B1 (es) |
NZ (1) | NZ332597A (es) |
PT (1) | PT906268E (es) |
WO (1) | WO1997045397A1 (es) |
Families Citing this family (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6103712A (en) * | 1998-03-05 | 2000-08-15 | Eli Lilly And Company | Therapeutic treatment for asthma |
US6103713A (en) * | 1998-03-05 | 2000-08-15 | Eli Lilly And Company | Therapeutic treatment for autoimmune diseases |
DE19908504C2 (de) * | 1999-02-26 | 2003-04-30 | Boehringer Ingelheim Pharma | Großtechnisches Verfahren zur Herstellung von Derivaten der Biphenyl-2-carbonsäure durch Verseifen eines (2-Oxazolinyl)-2-biphenyl-Derivats mit Salzsäure |
DE19917990A1 (de) * | 1999-04-20 | 2000-11-02 | Florian Lang | Arzneimittel enthaltend Hemmstoffe der zellvolumenregulierten humanen Kinase h-sgk |
BR0113258A (pt) | 2000-08-18 | 2003-07-15 | Agouron Pharma | Compostos, pró-drogas, metabólitos ou sais, métodos de tratamento de condição doentia em mamìferos, mediada pela atividade de proteìna cinase e métodos de modulação ou inibição da atividade de um receptor de proteìna cinase |
US20050171079A1 (en) * | 2004-02-04 | 2005-08-04 | Schrimpf Michael R. | Amino-substituted tricyclic derivatives and methods of use |
US7365193B2 (en) | 2004-02-04 | 2008-04-29 | Abbott Laboratories | Amino-substituted tricyclic derivatives and methods of use |
CA2789972A1 (en) * | 2010-01-11 | 2011-07-14 | Healor Ltd. | Method for treatment of inflammatory disease and disorder |
CN103204781B (zh) * | 2013-03-14 | 2015-04-01 | 武汉大学 | 2,7–二取代芴酮衍生物及其制备方法与应用 |
CN109053435A (zh) * | 2018-08-03 | 2018-12-21 | 上海华堇生物技术有限责任公司 | 2,3-二甲氧基苯甲酰氯的制备方法 |
CN115590964A (zh) * | 2022-09-14 | 2023-01-13 | 苏州大学(Cn) | 蛋白激酶c抑制剂在制备抗肿瘤转移药物中的应用 |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IL33573A (en) * | 1968-12-30 | 1973-10-25 | Richardson Merrell Inc | Bis-basic ethers and thioethers of fluorenone,fluorenol and fluorene |
US5034384A (en) * | 1990-08-01 | 1991-07-23 | Merck & Co., Inc. | 2-(9-fluorenonyl)-carbapenem antibacterial agents |
-
1997
- 1997-04-24 JP JP54237197A patent/JP3897363B2/ja not_active Expired - Fee Related
- 1997-04-24 NZ NZ332597A patent/NZ332597A/xx not_active IP Right Cessation
- 1997-04-24 PT PT97921288T patent/PT906268E/pt unknown
- 1997-04-24 AT AT97921288T patent/ATE209626T1/de active
- 1997-04-24 EP EP97921288A patent/EP0906268B1/en not_active Expired - Lifetime
- 1997-04-24 DE DE69708629T patent/DE69708629T2/de not_active Expired - Lifetime
- 1997-04-24 HU HU9901621A patent/HUP9901621A3/hu unknown
- 1997-04-24 ES ES97921288T patent/ES2170390T3/es not_active Expired - Lifetime
- 1997-04-24 IL IL12687397A patent/IL126873A/xx not_active IP Right Cessation
- 1997-04-24 AU AU27365/97A patent/AU737073B2/en not_active Ceased
- 1997-04-24 WO PCT/US1997/006602 patent/WO1997045397A1/en active IP Right Grant
- 1997-04-24 DK DK97921288T patent/DK0906268T3/da active
- 1997-04-24 BR BRPI9709406-4A patent/BR9709406B1/pt not_active IP Right Cessation
- 1997-04-24 CA CA002257136A patent/CA2257136C/en not_active Expired - Fee Related
- 1997-04-24 CN CNB971951411A patent/CN1160309C/zh not_active Expired - Fee Related
- 1997-05-28 AR ARP970102266A patent/AR008375A1/es active IP Right Grant
-
1998
- 1998-11-27 NO NO19985577A patent/NO312457B1/no not_active IP Right Cessation
-
1999
- 1999-10-05 HK HK99104317A patent/HK1019147A1/xx not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
CA2257136C (en) | 2004-07-20 |
DE69708629T2 (de) | 2002-08-01 |
CN1220660A (zh) | 1999-06-23 |
HK1019147A1 (en) | 2000-01-14 |
BR9709406B1 (pt) | 2009-05-05 |
CA2257136A1 (en) | 1997-12-04 |
AU2736597A (en) | 1998-01-05 |
NO312457B1 (no) | 2002-05-13 |
CN1160309C (zh) | 2004-08-04 |
WO1997045397A1 (en) | 1997-12-04 |
IL126873A0 (en) | 1999-09-22 |
ATE209626T1 (de) | 2001-12-15 |
ES2170390T3 (es) | 2002-08-01 |
NO985577D0 (no) | 1998-11-27 |
DE69708629D1 (de) | 2002-01-10 |
HUP9901621A3 (en) | 2002-01-28 |
EP0906268B1 (en) | 2001-11-28 |
PT906268E (pt) | 2002-05-31 |
NZ332597A (en) | 2000-08-25 |
JP3897363B2 (ja) | 2007-03-22 |
JP2000511528A (ja) | 2000-09-05 |
NO985577L (no) | 1999-01-27 |
EP0906268A1 (en) | 1999-04-07 |
IL126873A (en) | 2005-09-25 |
HUP9901621A2 (hu) | 1999-08-30 |
AU737073B2 (en) | 2001-08-09 |
BR9709406A (pt) | 1999-08-10 |
DK0906268T3 (da) | 2002-03-18 |
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