ES2170390T3 - Fluorenonas alquiloxiamino-substituidas y su uso como inhibidores de la proteina kinasa-c. - Google Patents
Fluorenonas alquiloxiamino-substituidas y su uso como inhibidores de la proteina kinasa-c.Info
- Publication number
- ES2170390T3 ES2170390T3 ES97921288T ES97921288T ES2170390T3 ES 2170390 T3 ES2170390 T3 ES 2170390T3 ES 97921288 T ES97921288 T ES 97921288T ES 97921288 T ES97921288 T ES 97921288T ES 2170390 T3 ES2170390 T3 ES 2170390T3
- Authority
- ES
- Spain
- Prior art keywords
- fluorenonas
- protein
- compounds
- substituidas
- alquiloxiamino
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
- C07D295/084—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
- C07D295/088—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
- C07C217/02—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
- C07C217/04—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
- C07C217/06—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one etherified hydroxy group and one amino group bound to the carbon skeleton, which is not further substituted
- C07C217/14—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one etherified hydroxy group and one amino group bound to the carbon skeleton, which is not further substituted the oxygen atom of the etherified hydroxy group being further bound to a carbon atom of a six-membered aromatic ring
- C07C217/24—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one etherified hydroxy group and one amino group bound to the carbon skeleton, which is not further substituted the oxygen atom of the etherified hydroxy group being further bound to a carbon atom of a six-membered aromatic ring the six-membered aromatic ring being part of a condensed ring system containing rings other than six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
- C07C235/42—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton
- C07C235/44—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton with carbon atoms of carboxamide groups and singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2603/00—Systems containing at least three condensed rings
- C07C2603/02—Ortho- or ortho- and peri-condensed systems
- C07C2603/04—Ortho- or ortho- and peri-condensed systems containing three rings
- C07C2603/06—Ortho- or ortho- and peri-condensed systems containing three rings containing at least one ring with less than six ring members
- C07C2603/10—Ortho- or ortho- and peri-condensed systems containing three rings containing at least one ring with less than six ring members containing five-membered rings
- C07C2603/12—Ortho- or ortho- and peri-condensed systems containing three rings containing at least one ring with less than six ring members containing five-membered rings only one five-membered ring
- C07C2603/18—Fluorenes; Hydrogenated fluorenes
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Pulmonology (AREA)
- Urology & Nephrology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Vascular Medicine (AREA)
- Dermatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
EN LA PRESENTE INVENCION SE DESCRIBEN CIERTAS FLUORENONAS SUSTITUIDAS POR ALQUILOXIAMINOS QUE INHIBEN LA PROTEINA C QUINASA, ASI COMO COMPOSICIONES FARMACEUTICAS QUE CONTIENEN ESTOS COMPUESTOS Y METODOS DE USO DE ESTOS COMPUESTOS PARA CONTROLAR LA ACTIVIDAD DE LA PROTEINA C QUINASA EN MAMIFEROS, INCLUIDOS LOS SERES HUMANOS. DE MANERA ESPECIFICA, LOS PRESENTES COMPUESTOS SON UTILES EN EL TRATAMIENTO DE ESTADOS DE DOLENCIAS NEOPLASICAS, TRASTORNOS ASOCIADOS A UN FLUJO SANGUINEO ANORMAL (INCLUIDAS LA HIPERTENSION, ISQUEMIA, ATEROSCLEROSIS, DEFICIENCIAS COAGULATIVAS) Y ENFERMEDADES INFLAMATORIAS (INCLUIDAS LAS INMUNODEFICIENCIAS, ASMA, FIBROSIS PULMONAR Y PSORIASIS).
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US65558496A | 1996-05-30 | 1996-05-30 | |
US65553796A | 1996-05-30 | 1996-05-30 |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2170390T3 true ES2170390T3 (es) | 2002-08-01 |
Family
ID=27096988
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES97921288T Expired - Lifetime ES2170390T3 (es) | 1996-05-30 | 1997-04-24 | Fluorenonas alquiloxiamino-substituidas y su uso como inhibidores de la proteina kinasa-c. |
Country Status (18)
Country | Link |
---|---|
EP (1) | EP0906268B1 (es) |
JP (1) | JP3897363B2 (es) |
CN (1) | CN1160309C (es) |
AR (1) | AR008375A1 (es) |
AT (1) | ATE209626T1 (es) |
AU (1) | AU737073B2 (es) |
BR (1) | BR9709406B1 (es) |
CA (1) | CA2257136C (es) |
DE (1) | DE69708629T2 (es) |
DK (1) | DK0906268T3 (es) |
ES (1) | ES2170390T3 (es) |
HK (1) | HK1019147A1 (es) |
HU (1) | HUP9901621A3 (es) |
IL (1) | IL126873A (es) |
NO (1) | NO312457B1 (es) |
NZ (1) | NZ332597A (es) |
PT (1) | PT906268E (es) |
WO (1) | WO1997045397A1 (es) |
Families Citing this family (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6103713A (en) * | 1998-03-05 | 2000-08-15 | Eli Lilly And Company | Therapeutic treatment for autoimmune diseases |
US6103712A (en) * | 1998-03-05 | 2000-08-15 | Eli Lilly And Company | Therapeutic treatment for asthma |
DE19908504C2 (de) * | 1999-02-26 | 2003-04-30 | Boehringer Ingelheim Pharma | Großtechnisches Verfahren zur Herstellung von Derivaten der Biphenyl-2-carbonsäure durch Verseifen eines (2-Oxazolinyl)-2-biphenyl-Derivats mit Salzsäure |
DE19917990A1 (de) * | 1999-04-20 | 2000-11-02 | Florian Lang | Arzneimittel enthaltend Hemmstoffe der zellvolumenregulierten humanen Kinase h-sgk |
EP1309563B1 (en) * | 2000-08-18 | 2005-05-11 | Agouron Pharmaceuticals, Inc. | Heterocyclic-hydroxyimino-fluorenes and their use for inhibiting protein kinases |
US20050171079A1 (en) * | 2004-02-04 | 2005-08-04 | Schrimpf Michael R. | Amino-substituted tricyclic derivatives and methods of use |
US7365193B2 (en) | 2004-02-04 | 2008-04-29 | Abbott Laboratories | Amino-substituted tricyclic derivatives and methods of use |
RU2012134041A (ru) * | 2010-01-11 | 2014-02-20 | Хилор Лтд. | Способ лечения воспалительного заболевания и расстройства |
CN103204781B (zh) * | 2013-03-14 | 2015-04-01 | 武汉大学 | 2,7–二取代芴酮衍生物及其制备方法与应用 |
CN109053435A (zh) * | 2018-08-03 | 2018-12-21 | 上海华堇生物技术有限责任公司 | 2,3-二甲氧基苯甲酰氯的制备方法 |
CN115590964A (zh) * | 2022-09-14 | 2023-01-13 | 苏州大学(Cn) | 蛋白激酶c抑制剂在制备抗肿瘤转移药物中的应用 |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IL33573A (en) * | 1968-12-30 | 1973-10-25 | Richardson Merrell Inc | Bis-basic ethers and thioethers of fluorenone,fluorenol and fluorene |
US5034384A (en) * | 1990-08-01 | 1991-07-23 | Merck & Co., Inc. | 2-(9-fluorenonyl)-carbapenem antibacterial agents |
-
1997
- 1997-04-24 AT AT97921288T patent/ATE209626T1/de active
- 1997-04-24 BR BRPI9709406-4A patent/BR9709406B1/pt not_active IP Right Cessation
- 1997-04-24 WO PCT/US1997/006602 patent/WO1997045397A1/en active IP Right Grant
- 1997-04-24 DK DK97921288T patent/DK0906268T3/da active
- 1997-04-24 IL IL12687397A patent/IL126873A/xx not_active IP Right Cessation
- 1997-04-24 NZ NZ332597A patent/NZ332597A/xx not_active IP Right Cessation
- 1997-04-24 AU AU27365/97A patent/AU737073B2/en not_active Ceased
- 1997-04-24 CA CA002257136A patent/CA2257136C/en not_active Expired - Fee Related
- 1997-04-24 ES ES97921288T patent/ES2170390T3/es not_active Expired - Lifetime
- 1997-04-24 EP EP97921288A patent/EP0906268B1/en not_active Expired - Lifetime
- 1997-04-24 DE DE69708629T patent/DE69708629T2/de not_active Expired - Lifetime
- 1997-04-24 CN CNB971951411A patent/CN1160309C/zh not_active Expired - Fee Related
- 1997-04-24 HU HU9901621A patent/HUP9901621A3/hu unknown
- 1997-04-24 JP JP54237197A patent/JP3897363B2/ja not_active Expired - Fee Related
- 1997-04-24 PT PT97921288T patent/PT906268E/pt unknown
- 1997-05-28 AR ARP970102266A patent/AR008375A1/es active IP Right Grant
-
1998
- 1998-11-27 NO NO19985577A patent/NO312457B1/no not_active IP Right Cessation
-
1999
- 1999-10-05 HK HK99104317A patent/HK1019147A1/xx not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
CA2257136A1 (en) | 1997-12-04 |
JP3897363B2 (ja) | 2007-03-22 |
NO312457B1 (no) | 2002-05-13 |
DK0906268T3 (da) | 2002-03-18 |
JP2000511528A (ja) | 2000-09-05 |
AU737073B2 (en) | 2001-08-09 |
BR9709406A (pt) | 1999-08-10 |
NO985577L (no) | 1999-01-27 |
CN1220660A (zh) | 1999-06-23 |
NO985577D0 (no) | 1998-11-27 |
AR008375A1 (es) | 2000-01-19 |
DE69708629D1 (de) | 2002-01-10 |
EP0906268A1 (en) | 1999-04-07 |
HK1019147A1 (en) | 2000-01-14 |
DE69708629T2 (de) | 2002-08-01 |
IL126873A (en) | 2005-09-25 |
NZ332597A (en) | 2000-08-25 |
CN1160309C (zh) | 2004-08-04 |
WO1997045397A1 (en) | 1997-12-04 |
PT906268E (pt) | 2002-05-31 |
EP0906268B1 (en) | 2001-11-28 |
IL126873A0 (en) | 1999-09-22 |
ATE209626T1 (de) | 2001-12-15 |
CA2257136C (en) | 2004-07-20 |
BR9709406B1 (pt) | 2009-05-05 |
AU2736597A (en) | 1998-01-05 |
HUP9901621A3 (en) | 2002-01-28 |
HUP9901621A2 (hu) | 1999-08-30 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG2A | Definitive protection |
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