ES2110454T3 - Compuestos de 6-oxo-azepinoindol, asi como procedimiento y productos intermedios para su preparacion y medicamentos que contienen estos compuestos. - Google Patents

Compuestos de 6-oxo-azepinoindol, asi como procedimiento y productos intermedios para su preparacion y medicamentos que contienen estos compuestos.

Info

Publication number
ES2110454T3
ES2110454T3 ES92112431T ES92112431T ES2110454T3 ES 2110454 T3 ES2110454 T3 ES 2110454T3 ES 92112431 T ES92112431 T ES 92112431T ES 92112431 T ES92112431 T ES 92112431T ES 2110454 T3 ES2110454 T3 ES 2110454T3
Authority
ES
Spain
Prior art keywords
lower alkyl
compounds
cycloalkyl
alkyl group
optionally substituted
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES92112431T
Other languages
English (en)
Inventor
Werner Benson
Charldorp Karin Van
Peter Colin Gregory
Klaus-Ullrich Wolf
Ulf Preuschoff
Martin Tulp
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Abbott Products GmbH
Original Assignee
Solvay Pharmaceuticals GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Solvay Pharmaceuticals GmbH filed Critical Solvay Pharmaceuticals GmbH
Application granted granted Critical
Publication of ES2110454T3 publication Critical patent/ES2110454T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/06—Peri-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pain & Pain Management (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Nutrition Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Indole Compounds (AREA)

Abstract

SE DESCRIBEN COMPUESTOS EFICACES FARMACOLOGICAMENTE CON LA FORMULA GENERAL I DONDE R1 REPRESENTA HIDROGENO, UN GRUPO BAJO ALQUILO O CICLOALQUILALQUILO O BIEN UN GRUPO FENILALQUILO BAJO SUSTITUIDO DADO EL CASO, R2 SIGNIFICA HIDROGENO O UN GRUPO ALQUILO BAJO SUSTITUIDO DADO EL CASO POR ALCOXI BAJO EN LA POSICION O RESPECTO AL ATOMO DE NITROGENO, R3 SIGNIFICA HIDROGENO, ALQUILO BAJO, ALCOXI BAJO, HALOGENO O HIDROXI, N REPRESENTA 1 O EN CASO DE QUE LA CADENA NO, ALQUILO BAJO, CICLOALQUILO, CICLOALQUILALQUILO BAJO O UN GRUPO FENILALQUILO BAJO SUSTITUIDO DADO EL CASO, Y R5 SIGNIFICA HIDROGENO, ALQUILO BAJO, CICLOALQUILO, CICLOALQUILALQUILO BAJO O UN GRUPO FENILALQUILO BAJO SUSTITUIDO DADO EL CASO, O R4 Y R5 FORMAN UN HETEROCICLO CONJUNTAMENTE CON EL ATOMO DE NITROGENO AL QUE ESTAN ENLAZADOS Y D REPRESENTA UN ENLACE O, DE CASO DE QUE R4 Y R5 NO SIGNIFIQUE HIDROGENO, REPRESENTA TAMBIEN AL GRUPO TOLERABLES FISIOLOGICAMENTE ASI COMO PROCEDIMIENTO Y PRODUCTOS INTERMEDIOS PARA SU PRODUCCION.
ES92112431T 1991-07-31 1992-07-21 Compuestos de 6-oxo-azepinoindol, asi como procedimiento y productos intermedios para su preparacion y medicamentos que contienen estos compuestos. Expired - Lifetime ES2110454T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE4125292A DE4125292A1 (de) 1991-07-31 1991-07-31 6-oxo-azepinoindol-verbindungen sowie verfahren und zwischenprodukte zu ihrer herstellung und diese verbindungen enthaltende arzneimittel

Publications (1)

Publication Number Publication Date
ES2110454T3 true ES2110454T3 (es) 1998-02-16

Family

ID=6437366

Family Applications (1)

Application Number Title Priority Date Filing Date
ES92112431T Expired - Lifetime ES2110454T3 (es) 1991-07-31 1992-07-21 Compuestos de 6-oxo-azepinoindol, asi como procedimiento y productos intermedios para su preparacion y medicamentos que contienen estos compuestos.

Country Status (21)

Country Link
US (1) US5272143A (es)
EP (1) EP0525584B1 (es)
JP (1) JP3174158B2 (es)
KR (1) KR930002353A (es)
CN (2) CN1069733A (es)
AT (1) ATE161012T1 (es)
AU (1) AU649153B2 (es)
CA (1) CA2075102A1 (es)
CZ (1) CZ239392A3 (es)
DE (2) DE4125292A1 (es)
ES (1) ES2110454T3 (es)
FI (1) FI923440A (es)
HU (2) HU211105B (es)
IE (1) IE922310A1 (es)
IL (1) IL102503A (es)
MX (1) MX9204457A (es)
NO (1) NO300375B1 (es)
NZ (1) NZ243715A (es)
RU (1) RU2078765C1 (es)
TW (1) TW207541B (es)
ZA (1) ZA925093B (es)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5414130A (en) * 1993-12-23 1995-05-09 The Dow Chemical Company Process for the preparation of diaminoresorcinol
AP1538A (en) * 1999-01-11 2006-01-10 Agouron Pharma Tricyclic inhibitors of poly (adp-ribose) polymerases.
ECSP003637A (es) 1999-08-31 2002-03-25 Agouron Pharma Inhibidores triciclicos de poli (adp-ribosa) polimerasas
MX2010012807A (es) * 2008-05-29 2010-12-21 Albany Molecular Res Inc Moduladores del rceptor 5-hidroxitriptamina 3, metodos de fabricacion y uso de los mismos.
PT3150610T (pt) * 2010-02-12 2019-11-11 Pfizer Sais e polrmorfos de 8-fluor0-2-{4- [(metilamino}metil]fenil}-1,3,4,5-tetrahidr0-6hazepin0[ 5,4,3-cd]indol-6-0na
US10513515B2 (en) 2017-08-25 2019-12-24 Biotheryx, Inc. Ether compounds and uses thereof
US11236103B2 (en) 2018-07-27 2022-02-01 Biotheryx, Inc. Bifunctional compounds
EP4143329A4 (en) 2020-04-28 2024-10-16 Anwita Biosciences Inc INTERLEUKIN-2 POLYPEPTIDES AND FUSION PROTEINS THEREOF, AS WELL AS THEIR PHARMACEUTICAL COMPOSITIONS AND THERAPEUTIC APPLICATIONS

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4910193A (en) * 1985-12-16 1990-03-20 Sandoz Ltd. Treatment of gastrointestinal disorders

Also Published As

Publication number Publication date
CA2075102A1 (en) 1993-02-01
EP0525584A1 (de) 1993-02-03
US5272143A (en) 1993-12-21
NO300375B1 (no) 1997-05-20
DE59209055D1 (de) 1998-01-22
IE922310A1 (en) 1993-02-10
KR930002353A (ko) 1993-02-23
JP3174158B2 (ja) 2001-06-11
HU210217A9 (en) 1995-02-28
HU211105B (en) 1995-10-30
HUT65453A (en) 1994-06-28
NO923004L (no) 1993-02-01
RU2078765C1 (ru) 1997-05-10
MX9204457A (es) 1993-05-01
DE4125292A1 (de) 1993-02-04
FI923440A0 (fi) 1992-07-30
CN1069733A (zh) 1993-03-10
JPH05202052A (ja) 1993-08-10
IL102503A0 (en) 1993-01-14
ATE161012T1 (de) 1997-12-15
TW207541B (es) 1993-06-11
EP0525584B1 (de) 1997-12-10
FI923440A (fi) 1993-02-01
HU9202430D0 (en) 1992-10-28
AU2067792A (en) 1993-02-04
CN1141773A (zh) 1997-02-05
CZ239392A3 (en) 1993-04-14
NZ243715A (en) 1995-03-28
AU649153B2 (en) 1994-05-12
NO923004D0 (no) 1992-07-30
ZA925093B (en) 1993-04-28
IL102503A (en) 1995-12-31

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