AR247205A1 - Procedimiento para la obtencion de compuestos de acidos carboxi-3-alquiloxi-9-oxo-9h-fluoreno o 9h-xanteno alcanoicos y sus sales. - Google Patents

Procedimiento para la obtencion de compuestos de acidos carboxi-3-alquiloxi-9-oxo-9h-fluoreno o 9h-xanteno alcanoicos y sus sales.

Info

Publication number
AR247205A1
AR247205A1 AR91319057A AR31905791A AR247205A1 AR 247205 A1 AR247205 A1 AR 247205A1 AR 91319057 A AR91319057 A AR 91319057A AR 31905791 A AR31905791 A AR 31905791A AR 247205 A1 AR247205 A1 AR 247205A1
Authority
AR
Argentina
Prior art keywords
fluorene
oxo
carboxy
xanthene
alkyloxy
Prior art date
Application number
AR91319057A
Other languages
English (en)
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Application granted granted Critical
Publication of AR247205A1 publication Critical patent/AR247205A1/es

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D311/00Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/78Ring systems having three or more relevant rings
    • C07D311/80Dibenzopyrans; Hydrogenated dibenzopyrans
    • C07D311/82Xanthenes
    • C07D311/84Xanthenes with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 9
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D311/00Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/78Ring systems having three or more relevant rings
    • C07D311/80Dibenzopyrans; Hydrogenated dibenzopyrans
    • C07D311/82Xanthenes
    • C07D311/84Xanthenes with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 9
    • C07D311/88Nitrogen atoms
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • A61P11/08Bronchodilators
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • A61P11/14Antitussive agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/08Antiallergic agents
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D311/00Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/78Ring systems having three or more relevant rings
    • C07D311/80Dibenzopyrans; Hydrogenated dibenzopyrans
    • C07D311/82Xanthenes
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D311/00Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/78Ring systems having three or more relevant rings
    • C07D311/80Dibenzopyrans; Hydrogenated dibenzopyrans
    • C07D311/82Xanthenes
    • C07D311/84Xanthenes with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 9
    • C07D311/86Oxygen atoms, e.g. xanthones

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pulmonology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyrane Compounds (AREA)

Abstract

PREPARACION COMPUESTOS DE CARBOXI-3-ALQUILOXI-9-OXO-9H-FLUORENO O 9H XANTENO-ALCANOICOS DE FORMULA (I), DONDE: Y ES -CO-, -C(=NOH)-, -CHOH-, - CH2- O-C(=CH2)-, A ES UN ENLACE U -O-, UNO DE LOS RADICALES R1 O R2 ES HIDROGENO Y EL OTRO R1 O R2 ES -CH2CH2COOH, P ES 1-16 Y Z ES -H O -G-Q, DONDE G ES UN ENLACE, -O-, -S(O)T-, -NH-, -CH=CH- O -C=C, Q ES FENILO SUSTITUIDO O NO CON UNO O DOS SUSTITUYENTES COMO SER HALO, ALQUILO, ALCOXI ACETILO, NITRO, AMINO, TRIFLUOROMETILO, HIDROXI Y -S(O)T-(ALQUILO) Y CADA SIMBOLO T ES INDEPENDIENTEMENTE 0-2, QUE CONSISTE EN HIDROLIZAR UN COMPUESTO DE FORMULA (II), DONDE UNO DE LOS RADICALES R1 O R2 ES HIDROGENO Y EL OTRO R1 O R2 ES -CH2CH2COOR; Y OPCIONALMENTE CONVERTIR EL PRODUCTO RESULTANTE EN UNA SAL DE ADICION DE BASE FARMACEUTICAMENTE ACEPTABLE.
AR91319057A 1990-02-16 1991-02-14 Procedimiento para la obtencion de compuestos de acidos carboxi-3-alquiloxi-9-oxo-9h-fluoreno o 9h-xanteno alcanoicos y sus sales. AR247205A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/481,413 US4996230A (en) 1990-02-16 1990-02-16 Leukotriene antagonists

Publications (1)

Publication Number Publication Date
AR247205A1 true AR247205A1 (es) 1994-11-30

Family

ID=23911845

Family Applications (1)

Application Number Title Priority Date Filing Date
AR91319057A AR247205A1 (es) 1990-02-16 1991-02-14 Procedimiento para la obtencion de compuestos de acidos carboxi-3-alquiloxi-9-oxo-9h-fluoreno o 9h-xanteno alcanoicos y sus sales.

Country Status (20)

Country Link
US (1) US4996230A (es)
EP (1) EP0442748B1 (es)
JP (1) JPH04211037A (es)
KR (1) KR910015558A (es)
CN (1) CN1028639C (es)
AR (1) AR247205A1 (es)
AT (1) ATE116980T1 (es)
AU (1) AU631482B2 (es)
CA (1) CA2036523A1 (es)
DE (1) DE69106545T2 (es)
FI (1) FI910728A (es)
HU (1) HU208431B (es)
IE (1) IE910531A1 (es)
IL (1) IL97242A0 (es)
NO (1) NO177097C (es)
NZ (1) NZ237124A (es)
PT (1) PT96760A (es)
RU (1) RU2007401C1 (es)
YU (1) YU27691A (es)
ZA (1) ZA911111B (es)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PH30449A (en) * 1991-11-25 1997-05-28 Lilly Co Eli Substituted phenyl phenol leukotriene antagonists
US5352690A (en) * 1992-07-01 1994-10-04 Eli Lilly And Company 1,2,4-trioxygenated benzene derivatives useful as leukotriene antagonists
CA2142735A1 (en) * 1993-06-18 1995-01-05 Tatsuyoshi Tanaka Fluorenone derivatives, process for preparing the same and central or peripheral nerve degeneration repair and protective agent
EP0785930A1 (en) * 1994-10-13 1997-07-30 Pfizer Inc. Benzopyran and benzo-fused compounds, their preparation and their use as leukotriene b 4? (ltb 4?) antagonists
US5939452A (en) * 1994-10-13 1999-08-17 Pfizer Inc Benzopyran and benzo-fused compounds, their preparation and their use as leukotriene B4' (LTB4) antagonists
US5977077A (en) * 1995-08-28 1999-11-02 Interlab Corporation Xanthone analogs for the treatment of infectious diseases
EP0795554A3 (en) * 1996-03-05 1998-01-28 Takeda Chemical Industries, Ltd. (Oxo-)xanthene derivatives, their preparation and their use as immunomodulators
US6613797B2 (en) 1999-12-02 2003-09-02 Interlab, Inc. Xanthone analogs for treating infectious diseases and complexation of heme and porphyrins
US20080293750A1 (en) * 2002-10-17 2008-11-27 Anna Helgadottir Susceptibility Gene for Myocardial Infarction, Stroke, Paod and Methods of Treatment
US20060019269A1 (en) * 2002-10-17 2006-01-26 Decode Genetics, Inc. Susceptibility gene for myocardial infarction, stroke, and PAOD, methods of treatment
US20100216863A1 (en) * 2004-01-30 2010-08-26 Decode Genetics Ehf. Susceptibility Gene for Myocardial Infarction, Stroke, and PAOD; Methods of Treatment
US8158362B2 (en) * 2005-03-30 2012-04-17 Decode Genetics Ehf. Methods of diagnosing susceptibility to myocardial infarction and screening for an LTA4H haplotype
CN112285355B (zh) * 2020-10-20 2023-01-13 四川大学华西医院 Viridiflorin检测试剂在制备COPD诊断试剂盒中的用途

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL7008627A (es) * 1969-06-25 1970-12-29
US3987088A (en) * 1971-09-08 1976-10-19 Burroughs Wellcome Co. Cyclic carbonyl compounds
FR2278331A1 (fr) * 1974-01-24 1976-02-13 Roussel Uclaf Nouveaux acides carboxyliques et leurs derives, leur application comme medicaments et leur procede de preparation
US4166819A (en) * 1975-09-24 1979-09-04 Abbott Laboratories 4-Aroyl substituted phenoxy methylene-5-tetrazoles
GB1543964A (en) * 1976-04-08 1979-04-11 Ici Ltd Method of antagonising herbicides on soyabean and cotton
EP0093381B1 (en) * 1982-04-27 1986-07-23 The Wellcome Foundation Limited Tricyclic compounds, preparation, use and intermediates
SE8400239D0 (sv) * 1984-01-19 1984-01-19 Pharmacia Ab Nya arylettiksyraderivat
US4661607A (en) * 1984-09-21 1987-04-28 Chugai Seiyaku Kabushiki Kaisha Furoxanthone derivatives useful as diuretics
DE3789299T2 (de) * 1986-12-23 1994-08-04 Warner Lambert Co Verbindungen mit antitumoralen und antibakteriellen Eigenschaften.
CA1320490C (en) * 1987-01-12 1993-07-20 Darrel M. Gapinski Anti-inflammatory agents
US5242121A (en) * 1991-08-23 1993-09-07 Roto-Mix Enterprises, Ltd. Bale support and cutter

Also Published As

Publication number Publication date
DE69106545D1 (de) 1995-02-23
AU631482B2 (en) 1992-11-26
IL97242A0 (en) 1992-05-25
HU208431B (en) 1993-10-28
CA2036523A1 (en) 1991-08-17
RU2007401C1 (ru) 1994-02-15
FI910728A (fi) 1991-08-17
NO177097C (no) 1995-07-19
NZ237124A (en) 1992-04-28
KR910015558A (ko) 1991-09-30
FI910728A0 (fi) 1991-02-14
YU27691A (sh) 1994-04-05
ZA911111B (en) 1992-10-28
PT96760A (pt) 1991-11-29
NO910608D0 (no) 1991-02-15
AU7110391A (en) 1991-08-22
IE910531A1 (en) 1991-08-28
NO910608L (no) 1991-08-19
EP0442748B1 (en) 1995-01-11
JPH04211037A (ja) 1992-08-03
NO177097B (no) 1995-04-10
HUT56359A (en) 1991-08-28
CN1028639C (zh) 1995-05-31
US4996230A (en) 1991-02-26
EP0442748A1 (en) 1991-08-21
ATE116980T1 (de) 1995-01-15
DE69106545T2 (de) 1995-06-01
CN1054066A (zh) 1991-08-28

Similar Documents

Publication Publication Date Title
AR247205A1 (es) Procedimiento para la obtencion de compuestos de acidos carboxi-3-alquiloxi-9-oxo-9h-fluoreno o 9h-xanteno alcanoicos y sus sales.
DE69120500T2 (de) Azasteroide zur Behandlung prostatischer Hypertrophie, ihre Herstellung und Verwendung
ZA911403B (en) Derivatives having a naphthalene structure,process for preparing these and pharmaceutical compositions containing them
SE7601205L (sv) Derivat av omettade aminosyror
ES8703881A1 (es) Procedimiento para la fabricacion de derivados del acido &- (oxo-2 hexahidro-2,4,5,6,7,7a tieno (3,2-c)piridil-5) fenil acetico
FI833339A (fi) Foerfarande foer framstaellning av farmakologiskt verksamma diazabicyklo-(3,3,1)-nonaner
SE7601207L (sv) Acetylenderivat av acetyleniska aminosyror
ATE161261T1 (de) Neue acylierte phospholipid-arzneimittel
KR870003107A (ko) 키산틴 유도체의 제조방법
ES8506706A1 (es) Procedimiento para la obtencion de esteres sustituidos de tiazolidimilos de acidos minerales.
FI873443A (fi) Norfloxacinmellanprodukt.
ES8106489A1 (es) Un procedimiento para la preparacion de un derivado de 15 sulfonamidoprostaglandina.
JPS5573677A (en) Thienylbenzoic acid derivative and its production
DK82583A (da) Furyloxazolyleddikesyrederivater og fremgangsmaader til fremstilling deraf
DK452984D0 (da) Fremgangsmaade til fremstilling af quinolin-4-oner
JPS55164671A (en) Azetidine derivative and its preparation
SE8207475L (sv) Nya heterocykliska ettiksyrederivat och ett forfarande for framstellning derav
DK452684A (da) Fremgangsmaade til fremstilling af quinolin-4-oner
JPS557221A (en) Preparation of alethine derivative
SE7900855L (sv) Forfarande for framstellning av monorden och derivat derav
SE8200320L (sv) Nya derivat av spiro-1 isobensofuraner och spiro-1 isobensotiofener, derasframstellningssett och terapeutiska anvendning
ES2032040T3 (es) Nuevos derivados del nonatrieno-1,3,5, su preparacion y su empleo.
ES8601168A1 (es) Procedimiento para la obtencion de amidas del acido 4-hidro-xi-2-metil-2h-1,2-benzotiazina-3-carboxilico-1,1-dioxido
SE408645B (sv) Forfarande for framstellning av nya benso-2,4-tiazepiner med foretredesvis antiarytmisk verkan
ES418803A1 (es) Procedimiento de obtencion de un nuevo derivado de accion antilipemica.