AR247205A1 - Procedimiento para la obtencion de compuestos de acidos carboxi-3-alquiloxi-9-oxo-9h-fluoreno o 9h-xanteno alcanoicos y sus sales. - Google Patents

Procedimiento para la obtencion de compuestos de acidos carboxi-3-alquiloxi-9-oxo-9h-fluoreno o 9h-xanteno alcanoicos y sus sales.

Info

Publication number
AR247205A1
AR247205A1 AR91319057A AR31905791A AR247205A1 AR 247205 A1 AR247205 A1 AR 247205A1 AR 91319057 A AR91319057 A AR 91319057A AR 31905791 A AR31905791 A AR 31905791A AR 247205 A1 AR247205 A1 AR 247205A1
Authority
AR
Argentina
Prior art keywords
fluorene
oxo
carboxy
xanthene
alkyloxy
Prior art date
Application number
AR91319057A
Other languages
English (en)
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Application granted granted Critical
Publication of AR247205A1 publication Critical patent/AR247205A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/78—Ring systems having three or more relevant rings
    • C07D311/80—Dibenzopyrans; Hydrogenated dibenzopyrans
    • C07D311/82—Xanthenes
    • C07D311/84—Xanthenes with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 9
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/78—Ring systems having three or more relevant rings
    • C07D311/80—Dibenzopyrans; Hydrogenated dibenzopyrans
    • C07D311/82—Xanthenes
    • C07D311/84—Xanthenes with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 9
    • C07D311/88—Nitrogen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/14—Antitussive agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/78—Ring systems having three or more relevant rings
    • C07D311/80—Dibenzopyrans; Hydrogenated dibenzopyrans
    • C07D311/82—Xanthenes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/78—Ring systems having three or more relevant rings
    • C07D311/80—Dibenzopyrans; Hydrogenated dibenzopyrans
    • C07D311/82—Xanthenes
    • C07D311/84—Xanthenes with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 9
    • C07D311/86—Oxygen atoms, e.g. xanthones

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pulmonology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyrane Compounds (AREA)

Abstract

PREPARACION COMPUESTOS DE CARBOXI-3-ALQUILOXI-9-OXO-9H-FLUORENO O 9H XANTENO-ALCANOICOS DE FORMULA (I), DONDE: Y ES -CO-, -C(=NOH)-, -CHOH-, - CH2- O-C(=CH2)-, A ES UN ENLACE U -O-, UNO DE LOS RADICALES R1 O R2 ES HIDROGENO Y EL OTRO R1 O R2 ES -CH2CH2COOH, P ES 1-16 Y Z ES -H O -G-Q, DONDE G ES UN ENLACE, -O-, -S(O)T-, -NH-, -CH=CH- O -C=C, Q ES FENILO SUSTITUIDO O NO CON UNO O DOS SUSTITUYENTES COMO SER HALO, ALQUILO, ALCOXI ACETILO, NITRO, AMINO, TRIFLUOROMETILO, HIDROXI Y -S(O)T-(ALQUILO) Y CADA SIMBOLO T ES INDEPENDIENTEMENTE 0-2, QUE CONSISTE EN HIDROLIZAR UN COMPUESTO DE FORMULA (II), DONDE UNO DE LOS RADICALES R1 O R2 ES HIDROGENO Y EL OTRO R1 O R2 ES -CH2CH2COOR; Y OPCIONALMENTE CONVERTIR EL PRODUCTO RESULTANTE EN UNA SAL DE ADICION DE BASE FARMACEUTICAMENTE ACEPTABLE.
AR91319057A 1990-02-16 1991-02-14 Procedimiento para la obtencion de compuestos de acidos carboxi-3-alquiloxi-9-oxo-9h-fluoreno o 9h-xanteno alcanoicos y sus sales. AR247205A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/481,413 US4996230A (en) 1990-02-16 1990-02-16 Leukotriene antagonists

Publications (1)

Publication Number Publication Date
AR247205A1 true AR247205A1 (es) 1994-11-30

Family

ID=23911845

Family Applications (1)

Application Number Title Priority Date Filing Date
AR91319057A AR247205A1 (es) 1990-02-16 1991-02-14 Procedimiento para la obtencion de compuestos de acidos carboxi-3-alquiloxi-9-oxo-9h-fluoreno o 9h-xanteno alcanoicos y sus sales.

Country Status (20)

Country Link
US (1) US4996230A (es)
EP (1) EP0442748B1 (es)
JP (1) JPH04211037A (es)
KR (1) KR910015558A (es)
CN (1) CN1028639C (es)
AR (1) AR247205A1 (es)
AT (1) ATE116980T1 (es)
AU (1) AU631482B2 (es)
CA (1) CA2036523A1 (es)
DE (1) DE69106545T2 (es)
FI (1) FI910728A (es)
HU (1) HU208431B (es)
IE (1) IE910531A1 (es)
IL (1) IL97242A0 (es)
NO (1) NO177097C (es)
NZ (1) NZ237124A (es)
PT (1) PT96760A (es)
RU (1) RU2007401C1 (es)
YU (1) YU27691A (es)
ZA (1) ZA911111B (es)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PH30449A (en) * 1991-11-25 1997-05-28 Lilly Co Eli Substituted phenyl phenol leukotriene antagonists
US5352690A (en) * 1992-07-01 1994-10-04 Eli Lilly And Company 1,2,4-trioxygenated benzene derivatives useful as leukotriene antagonists
DK0655992T3 (da) * 1993-06-18 1999-07-19 Otsuka Pharma Co Ltd Fluorenonderivater, fremgangsmåde til deres fremstilling samt regenererings- og beskyttelsesmiddel mod central eller perife
KR100232341B1 (ko) * 1994-10-13 2000-07-01 디. 제이. 우드 류코트리엔 b4(ltb4) 길항물질로서의 벤조피란 및 벤조-축합된 화합물
MX9702734A (es) * 1994-10-13 1997-06-28 Pfizer Benzopirano y compuestos benzocondensados, su preparacion y su uso como antagonistas de leucotrieno b4 (ltb4).
US5977077A (en) * 1995-08-28 1999-11-02 Interlab Corporation Xanthone analogs for the treatment of infectious diseases
US6221637B1 (en) 1996-03-05 2001-04-24 Takeda Chemical Industries, Ltd. Xanthene derivatives, their production and use
US6613797B2 (en) 1999-12-02 2003-09-02 Interlab, Inc. Xanthone analogs for treating infectious diseases and complexation of heme and porphyrins
US20060019269A1 (en) * 2002-10-17 2006-01-26 Decode Genetics, Inc. Susceptibility gene for myocardial infarction, stroke, and PAOD, methods of treatment
US20080293750A1 (en) * 2002-10-17 2008-11-27 Anna Helgadottir Susceptibility Gene for Myocardial Infarction, Stroke, Paod and Methods of Treatment
US20100216863A1 (en) * 2004-01-30 2010-08-26 Decode Genetics Ehf. Susceptibility Gene for Myocardial Infarction, Stroke, and PAOD; Methods of Treatment
US8158362B2 (en) * 2005-03-30 2012-04-17 Decode Genetics Ehf. Methods of diagnosing susceptibility to myocardial infarction and screening for an LTA4H haplotype
CN112285355B (zh) * 2020-10-20 2023-01-13 四川大学华西医院 Viridiflorin检测试剂在制备COPD诊断试剂盒中的用途

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL7008627A (es) * 1969-06-25 1970-12-29
US3987088A (en) * 1971-09-08 1976-10-19 Burroughs Wellcome Co. Cyclic carbonyl compounds
FR2278331A1 (fr) * 1974-01-24 1976-02-13 Roussel Uclaf Nouveaux acides carboxyliques et leurs derives, leur application comme medicaments et leur procede de preparation
US4166819A (en) * 1975-09-24 1979-09-04 Abbott Laboratories 4-Aroyl substituted phenoxy methylene-5-tetrazoles
GB1543964A (en) * 1976-04-08 1979-04-11 Ici Ltd Method of antagonising herbicides on soyabean and cotton
NZ204003A (en) * 1982-04-27 1986-05-09 Wellcome Found Substituted xanthenes and xanthones and pharmaceutical compositions
SE8400239D0 (sv) * 1984-01-19 1984-01-19 Pharmacia Ab Nya arylettiksyraderivat
US4661607A (en) * 1984-09-21 1987-04-28 Chugai Seiyaku Kabushiki Kaisha Furoxanthone derivatives useful as diuretics
DE3789299T2 (de) * 1986-12-23 1994-08-04 Warner Lambert Co Verbindungen mit antitumoralen und antibakteriellen Eigenschaften.
CA1320490C (en) * 1987-01-12 1993-07-20 Darrel M. Gapinski Anti-inflammatory agents
US5242121A (en) * 1991-08-23 1993-09-07 Roto-Mix Enterprises, Ltd. Bale support and cutter

Also Published As

Publication number Publication date
RU2007401C1 (ru) 1994-02-15
DE69106545D1 (de) 1995-02-23
YU27691A (sh) 1994-04-05
ZA911111B (en) 1992-10-28
PT96760A (pt) 1991-11-29
JPH04211037A (ja) 1992-08-03
NO910608L (no) 1991-08-19
CN1028639C (zh) 1995-05-31
CA2036523A1 (en) 1991-08-17
NO910608D0 (no) 1991-02-15
FI910728A0 (fi) 1991-02-14
AU631482B2 (en) 1992-11-26
US4996230A (en) 1991-02-26
EP0442748B1 (en) 1995-01-11
CN1054066A (zh) 1991-08-28
KR910015558A (ko) 1991-09-30
IL97242A0 (en) 1992-05-25
NO177097C (no) 1995-07-19
EP0442748A1 (en) 1991-08-21
HU208431B (en) 1993-10-28
FI910728A (fi) 1991-08-17
HUT56359A (en) 1991-08-28
AU7110391A (en) 1991-08-22
DE69106545T2 (de) 1995-06-01
NZ237124A (en) 1992-04-28
IE910531A1 (en) 1991-08-28
ATE116980T1 (de) 1995-01-15
NO177097B (no) 1995-04-10

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