JPS557221A - Preparation of alethine derivative - Google Patents

Preparation of alethine derivative

Info

Publication number
JPS557221A
JPS557221A JP7889578A JP7889578A JPS557221A JP S557221 A JPS557221 A JP S557221A JP 7889578 A JP7889578 A JP 7889578A JP 7889578 A JP7889578 A JP 7889578A JP S557221 A JPS557221 A JP S557221A
Authority
JP
Japan
Prior art keywords
substituted
alethine
tertiary
cystamine
cysteamine
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP7889578A
Other languages
Japanese (ja)
Other versions
JPS6210981B2 (en
Inventor
Masahiro Kamata
Akihiko Miyadera
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Daiichi Pharmaceutical Co Ltd
Original Assignee
Daiichi Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Daiichi Pharmaceutical Co Ltd filed Critical Daiichi Pharmaceutical Co Ltd
Priority to JP7889578A priority Critical patent/JPS557221A/en
Publication of JPS557221A publication Critical patent/JPS557221A/en
Publication of JPS6210981B2 publication Critical patent/JPS6210981B2/ja
Granted legal-status Critical Current

Links

Classifications

    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

PURPOSE: To prepare an N-substituted alethine in high yield and purity, by reacting an N-substituted-β-alanine with cystamine or cysteamine in the presence of a deacidifying agent, a halogen compound, a tertiary phosphine or a tertiary phosphite.
CONSTITUTION: An N-substituted alethine is prepared by the direct condensation of an N-substituted-β-alanine with cystamine or cysteamine, or their salts, in the presence of a halogen compound such as halogen molecule, alkyl halide, etc., a tertiary phosphine such as triphenyl phosphine, or a tertiary phosphite. The N- substitution group is an amino-protecting group such as acyl group. The reaction is pref. carried out in an organic base as a solvent to remove the by-produced hydrogen halide from the system.
EFFECT: The objective compound can be obtained economically, by a simple process.
USE: Pharmacenticals or their intermediates.
COPYRIGHT: (C)1980,JPO&Japio
JP7889578A 1978-06-29 1978-06-29 Preparation of alethine derivative Granted JPS557221A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP7889578A JPS557221A (en) 1978-06-29 1978-06-29 Preparation of alethine derivative

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP7889578A JPS557221A (en) 1978-06-29 1978-06-29 Preparation of alethine derivative

Publications (2)

Publication Number Publication Date
JPS557221A true JPS557221A (en) 1980-01-19
JPS6210981B2 JPS6210981B2 (en) 1987-03-10

Family

ID=13674537

Family Applications (1)

Application Number Title Priority Date Filing Date
JP7889578A Granted JPS557221A (en) 1978-06-29 1978-06-29 Preparation of alethine derivative

Country Status (1)

Country Link
JP (1) JPS557221A (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4461781A (en) * 1982-05-03 1984-07-24 Societe D'assistance Technique Pour Produits Nestle, S.A. Freezing of vegetables
JPS63291546A (en) * 1987-05-25 1988-11-29 Nissin Food Prod Co Ltd Food for cooking in microwave oven and preparation thereof

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5132607A (en) * 1974-10-18 1976-03-19 Beltek Corp MAKIMODOSHI HAYAOKURISOSASOCHI

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5132607A (en) * 1974-10-18 1976-03-19 Beltek Corp MAKIMODOSHI HAYAOKURISOSASOCHI

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4461781A (en) * 1982-05-03 1984-07-24 Societe D'assistance Technique Pour Produits Nestle, S.A. Freezing of vegetables
JPS63291546A (en) * 1987-05-25 1988-11-29 Nissin Food Prod Co Ltd Food for cooking in microwave oven and preparation thereof

Also Published As

Publication number Publication date
JPS6210981B2 (en) 1987-03-10

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