RO85556B - Procedeu pentru prepararea unor derivati de aminoacizi - Google Patents
Procedeu pentru prepararea unor derivati de aminoaciziInfo
- Publication number
- RO85556B RO85556B RO108294A RO10829481A RO85556B RO 85556 B RO85556 B RO 85556B RO 108294 A RO108294 A RO 108294A RO 10829481 A RO10829481 A RO 10829481A RO 85556 B RO85556 B RO 85556B
- Authority
- RO
- Romania
- Prior art keywords
- general formula
- alkyl
- carbon atoms
- integer ranging
- formula
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C227/02—Formation of carboxyl groups in compounds containing amino groups, e.g. by oxidation of amino alcohols
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C229/38—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino groups bound to acyclic carbon atoms and carboxyl groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Heart & Thoracic Surgery (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Cardiology (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Steroid Compounds (AREA)
Abstract
Procedeu pentru prepararea unor derivati de aminoacizi cu formula generala I (vezi formula) în care Ar este fenil sau naftil eventual substituit cu alchil inferior, alchenil inferior, alchinil inferior, alcoxi, amino, nitro, alchilamino inferior, hidroxi, hidroxialchil inferior, cian sau o grupa cu formula ( vezi formula9 în care n reprezinta un numar întreg cuprins între 0 si 10, Y este o catena liniara sau ramificata de carbon avînd 1 pîna la 10 atomi de carbon sau arlchil cu 8 pîna la 20 atomi de carbon; R reprezinta un alchil inferior, alchenil inferior, alchinil inferior, aril sau arlachil; X reprezinta un numar întreg cu valori între 1 la circa 3, cu conditia ca atunci cînd x este mai mare de 1, grupele -COOR pot fi identice sau diferite, caracterizat prin aceea ca un arilepoxid cu formula generalp II (vezi formula) în care Ar are semnificatiile de mai sus, reactioneaza cu o amina cu formula generala III: H2n-Y-COOR în care R si Y au semnificatiile de mai sus, în canitati echimolare, la temperatura de reflux, în mediu de alcanol inferior, dupa care produsul se poate transforma într-o sare acceptabila farmaceutic.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US21134080A | 1980-11-28 | 1980-11-28 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| RO85556A RO85556A (ro) | 1985-03-15 |
| RO85556B true RO85556B (ro) | 1985-03-30 |
Family
ID=22786520
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RO108294A RO85556B (ro) | 1980-11-28 | 1981-11-16 | Procedeu pentru prepararea unor derivati de aminoacizi |
Country Status (13)
| Country | Link |
|---|---|
| EP (2) | EP0053434B1 (ro) |
| JP (1) | JPH0617345B2 (ro) |
| KR (1) | KR880001827B1 (ro) |
| AU (1) | AU546152B2 (ro) |
| CA (1) | CA1183148A (ro) |
| DK (1) | DK152491C (ro) |
| EG (1) | EG15685A (ro) |
| GR (1) | GR76307B (ro) |
| IL (1) | IL64346A (ro) |
| NZ (1) | NZ198945A (ro) |
| RO (1) | RO85556B (ro) |
| WO (1) | WO1982001870A1 (ro) |
| ZA (1) | ZA817931B (ro) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0053434B1 (en) * | 1980-11-28 | 1986-08-27 | American Hospital Supply Corporation | Compounds and method for treatment or prophylaxis of cardiac disorders |
| US4455317A (en) * | 1981-06-23 | 1984-06-19 | American Hospital Supply Corporation | Method for treating glaucoma by the topical administration of selectively metabolized beta-blocking agents |
| US4472301A (en) * | 1982-05-27 | 1984-09-18 | Miles Laboratories, Inc. | Propranolol immunogen and antibodies |
| ATE39245T1 (de) * | 1983-02-03 | 1988-12-15 | Univ California | Beta-adrenergisch antagonistische verbindungen und derivate von beta-adrenergischen antagonisten. |
| US4687873A (en) * | 1983-02-03 | 1987-08-18 | The Regents Of The University Of California | Derivatives of β-adrenergic antagonists |
| DE3836987A1 (de) * | 1988-10-31 | 1990-05-23 | Goedecke Ag | 2-aminocarbonsaeuren und deren derivate, verfahren zu deren herstellung und deren verwendung als arzneimittel |
| DE19943635A1 (de) | 1999-09-13 | 2001-03-15 | Bayer Ag | Neuartige Aminodicarbonsäurederivate mit pharmazeutischen Eigenschaften |
| CN115536537B (zh) * | 2022-09-21 | 2023-09-22 | 华中农业大学 | 普萘洛尔衍生物及其在抑制植物病原菌中的应用 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE1922003C3 (de) * | 1969-04-30 | 1979-10-11 | Boehringer Mannheim Gmbh, 6800 Mannheim | N-(3-Aryloxy-2-hydroxypropyl)-aminocarbonsäuren, deren Ester, Amide und Salze, Verfahren zur Herstellung dieser Verbindungen und deren Verwendung bei der Bekämpfung von Herzinsuffizienz |
| DE2324584A1 (de) * | 1972-06-08 | 1974-01-10 | Ciba Geigy Ag | Neue amine und verfahren zu ihrer herstellung |
| CH580057A5 (ro) * | 1973-04-17 | 1976-09-30 | Ciba Geigy Ag | |
| US4146638A (en) * | 1976-02-17 | 1979-03-27 | Boehringer Ingelheim Gmbh | N-(3-phenoxy-2-hydroxy-propyl)-n-(2-phenyl-2-hydroxy-ethyl)-amines |
| US4241177A (en) * | 1978-08-28 | 1980-12-23 | Syva Company | Propanolol antigen conjugates and antibodies |
| SE8004088L (sv) * | 1980-06-02 | 1981-12-03 | Haessle Ab | Nya substituerade 3-fenoxi-l-alkoxikarbonylalkylamino-propanol-2-er med beta-receptorblockerande egenskaper samt forfarande for deras framstellning, farmaceutiska beredningar innehallande desamma och metod att ... |
| EP0053434B1 (en) * | 1980-11-28 | 1986-08-27 | American Hospital Supply Corporation | Compounds and method for treatment or prophylaxis of cardiac disorders |
-
1981
- 1981-10-29 EP EP81305128A patent/EP0053434B1/en not_active Expired
- 1981-11-11 NZ NZ198945A patent/NZ198945A/en unknown
- 1981-11-16 RO RO108294A patent/RO85556B/ro unknown
- 1981-11-16 JP JP56503727A patent/JPH0617345B2/ja not_active Expired - Lifetime
- 1981-11-16 WO PCT/US1981/001515 patent/WO1982001870A1/en active IP Right Grant
- 1981-11-16 AU AU78920/81A patent/AU546152B2/en not_active Expired
- 1981-11-16 EP EP81903189A patent/EP0065963B1/en not_active Expired
- 1981-11-16 ZA ZA817931A patent/ZA817931B/xx unknown
- 1981-11-24 IL IL64346A patent/IL64346A/xx not_active IP Right Cessation
- 1981-11-26 CA CA000390968A patent/CA1183148A/en not_active Expired
- 1981-11-26 GR GR66621A patent/GR76307B/el unknown
- 1981-11-28 EG EG695/81A patent/EG15685A/xx active
- 1981-11-28 KR KR1019810004621A patent/KR880001827B1/ko active
-
1982
- 1982-07-27 DK DK334982A patent/DK152491C/da active
Also Published As
| Publication number | Publication date |
|---|---|
| JPH0617345B2 (ja) | 1994-03-09 |
| EP0065963A4 (en) | 1983-04-25 |
| DK334982A (da) | 1982-07-27 |
| NZ198945A (en) | 1985-09-13 |
| GR76307B (ro) | 1984-08-04 |
| CA1183148A (en) | 1985-02-26 |
| EP0053434A1 (en) | 1982-06-09 |
| IL64346A (en) | 1988-12-30 |
| KR830007510A (ko) | 1983-10-21 |
| EP0065963A1 (en) | 1982-12-08 |
| RO85556A (ro) | 1985-03-15 |
| AU546152B2 (en) | 1985-08-15 |
| DK152491C (da) | 1988-07-25 |
| EG15685A (en) | 1986-12-30 |
| AU7892081A (en) | 1982-06-17 |
| JPS57502124A (ro) | 1982-12-02 |
| WO1982001870A1 (en) | 1982-06-10 |
| EP0065963B1 (en) | 1986-01-29 |
| DK152491B (da) | 1988-03-07 |
| KR880001827B1 (ko) | 1988-09-20 |
| EP0053434B1 (en) | 1986-08-27 |
| ZA817931B (en) | 1983-03-30 |
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