RO81210B - Procedeu pentru prepararea unor derivati de 1, 2, 4-oxadiazina - Google Patents
Procedeu pentru prepararea unor derivati de 1, 2, 4-oxadiazinaInfo
- Publication number
- RO81210B RO81210B RO102322A RO10232280A RO81210B RO 81210 B RO81210 B RO 81210B RO 102322 A RO102322 A RO 102322A RO 10232280 A RO10232280 A RO 10232280A RO 81210 B RO81210 B RO 81210B
- Authority
- RO
- Romania
- Prior art keywords
- group
- preparing
- alkyl
- optionally substituted
- carbon atoms
- Prior art date
Links
- 150000005065 1,2,4-oxadiazines Chemical class 0.000 title 1
- 238000004519 manufacturing process Methods 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- 125000004432 carbon atom Chemical group C* 0.000 abstract 2
- 125000004435 hydrogen atom Chemical class [H]* 0.000 abstract 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 2
- 125000000229 (C1-C4)alkoxy group Chemical group 0.000 abstract 1
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical group 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D273/00—Heterocyclic compounds containing rings having nitrogen and oxygen atoms as the only ring hetero atoms, not provided for by groups C07D261/00 - C07D271/00
- C07D273/02—Heterocyclic compounds containing rings having nitrogen and oxygen atoms as the only ring hetero atoms, not provided for by groups C07D261/00 - C07D271/00 having two nitrogen atoms and only one oxygen atom
- C07D273/04—Six-membered rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/10—Antioedematous agents; Diuretics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Abstract
Inventia se refera la un procede pentru prepararea unor compusi cu formula generala I: (vezi formula) în care R1 reprezinta hidrogen, o grupa fenil, eventual substituita cu halogen sau alchil cu 1 la 5 atomi de carbon, o grupa benzil, o grupa alchil cu 1 la 5 atomi de carbon, eventual substituita cu una sau doua grupe fenil sau o grupa neftilmetil, R2 reprezinta un atom de hidrogen sau o grupa alchil cu 1 la 4 atomi de carbon, R3 reprezinta cicloalchil cu 5 la 6 atom de carbon, sau R2 si r3 luati împreuna reprezinta o grupa cu formula generala II: (vezi formula) în care R4 si R5 reprezinta sau o grupa alcoxi cu 1 la 4 atomi de carbon.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| HU79CI1914A HU180708B (en) | 1979-10-11 | 1979-10-11 | Process for preparing new 1,2,4-oxadiazine derivatives |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| RO81210B true RO81210B (ro) | 1983-01-30 |
| RO81210A RO81210A (ro) | 1983-02-01 |
Family
ID=10994765
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RO80102322A RO81210A (ro) | 1979-10-11 | 1980-10-09 | Procedeu pentru prepararea unor derivati de 1,2,4-oxadiazina |
| RO108149A RO85268B (ro) | 1979-10-11 | 1980-10-09 | Procedeu pentru prepararea unor derivati de 1, 2, 4-oxa-diazina |
| RO108150A RO85269B (ro) | 1979-10-11 | 1980-10-09 | Procedeu de preparare a unor derivati de 1, 2, 4-oxadiazina |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RO108149A RO85268B (ro) | 1979-10-11 | 1980-10-09 | Procedeu pentru prepararea unor derivati de 1, 2, 4-oxa-diazina |
| RO108150A RO85269B (ro) | 1979-10-11 | 1980-10-09 | Procedeu de preparare a unor derivati de 1, 2, 4-oxadiazina |
Country Status (25)
| Country | Link |
|---|---|
| US (1) | US4308270A (ro) |
| JP (1) | JPS5663970A (ro) |
| AT (1) | AT373247B (ro) |
| BE (1) | BE885634A (ro) |
| CA (1) | CA1159828A (ro) |
| CH (1) | CH649540A5 (ro) |
| CS (1) | CS249111B2 (ro) |
| DD (1) | DD153551A5 (ro) |
| DE (1) | DE3037747A1 (ro) |
| DK (1) | DK149106C (ro) |
| ES (1) | ES8106714A1 (ro) |
| FR (1) | FR2467204B1 (ro) |
| GB (1) | GB2062628B (ro) |
| GR (1) | GR71205B (ro) |
| HU (1) | HU180708B (ro) |
| IL (1) | IL61176A (ro) |
| IT (1) | IT1129306B (ro) |
| LU (1) | LU82823A1 (ro) |
| NL (1) | NL8005587A (ro) |
| NO (1) | NO153652C (ro) |
| PL (2) | PL129378B1 (ro) |
| RO (3) | RO81210A (ro) |
| SE (1) | SE448234B (ro) |
| SU (1) | SU1087520A1 (ro) |
| YU (2) | YU41739B (ro) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HU179951B (en) * | 1979-10-11 | 1983-01-28 | Chinoin Gyogyszer Es Vegyeszet | Process for preparing 1,2,4-oxadiazolin-5-one derivatives and pharmaceutical compositions containing thereof |
| JP2006523232A (ja) * | 2003-04-10 | 2006-10-12 | サイトキネティクス・インコーポレーテッド | 化合物、組成物、および方法 |
| US20170050980A1 (en) * | 2015-08-18 | 2017-02-23 | Forum Pharmaceuticals Inc. | Oxadiazine compounds and methods of use thereof |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NL302339A (ro) * | 1963-03-22 | |||
| DE1545658C3 (de) * | 1964-03-02 | 1981-04-23 | Chinoin Gyógyszer és Vegyészeti Termékek Gyára RT, 1045 Budapest | Verfahren zur Herstellung von 3,5-disubstituierten 1,2,4-Oxadiazolderivaten |
| DE1795839C3 (de) * | 1964-03-02 | 1981-09-03 | Chinoin Gyógyszer és Vegyészeti Termékek Gyára RT, 1045 Budapest | Verfahren zur Herstellung von 3,5-disubstituierten 1,2,4-Oxadiazolderivaten |
| IT1043838B (it) * | 1971-04-22 | 1980-02-29 | Poli Ind Chimica Spa | 1 2 3 4 tetraidroisochinoline e processo per la loro preparazione |
| US4154598A (en) * | 1975-09-11 | 1979-05-15 | Philagro | Herbicidal 1,2,4-oxadiazin-5-one compositions |
| US4026894A (en) * | 1975-10-14 | 1977-05-31 | Abbott Laboratories | Antihypertensive agents |
| HU179951B (en) * | 1979-10-11 | 1983-01-28 | Chinoin Gyogyszer Es Vegyeszet | Process for preparing 1,2,4-oxadiazolin-5-one derivatives and pharmaceutical compositions containing thereof |
-
1979
- 1979-10-11 HU HU79CI1914A patent/HU180708B/hu not_active IP Right Cessation
-
1980
- 1980-09-30 IL IL61176A patent/IL61176A/xx unknown
- 1980-10-03 LU LU82823A patent/LU82823A1/de unknown
- 1980-10-06 CS CS806736A patent/CS249111B2/cs unknown
- 1980-10-06 DE DE19803037747 patent/DE3037747A1/de not_active Withdrawn
- 1980-10-06 GR GR63060A patent/GR71205B/el unknown
- 1980-10-07 SE SE8007026A patent/SE448234B/sv not_active IP Right Cessation
- 1980-10-09 FR FR8021625A patent/FR2467204B1/fr not_active Expired
- 1980-10-09 RO RO80102322A patent/RO81210A/ro unknown
- 1980-10-09 NL NL8005587A patent/NL8005587A/nl not_active Application Discontinuation
- 1980-10-09 IT IT68556/80A patent/IT1129306B/it active
- 1980-10-09 RO RO108149A patent/RO85268B/ro unknown
- 1980-10-09 JP JP14066980A patent/JPS5663970A/ja active Granted
- 1980-10-09 AT AT0501280A patent/AT373247B/de not_active IP Right Cessation
- 1980-10-09 RO RO108150A patent/RO85269B/ro unknown
- 1980-10-10 PL PL1980232264A patent/PL129378B1/pl unknown
- 1980-10-10 US US06/196,034 patent/US4308270A/en not_active Expired - Lifetime
- 1980-10-10 CA CA000362230A patent/CA1159828A/en not_active Expired
- 1980-10-10 DK DK429680A patent/DK149106C/da not_active IP Right Cessation
- 1980-10-10 YU YU2595/80A patent/YU41739B/xx unknown
- 1980-10-10 ES ES495820A patent/ES8106714A1/es not_active Expired
- 1980-10-10 GB GB8032827A patent/GB2062628B/en not_active Expired
- 1980-10-10 SU SU802993202A patent/SU1087520A1/ru active
- 1980-10-10 PL PL1980227211A patent/PL129081B1/pl unknown
- 1980-10-10 CH CH7600/80A patent/CH649540A5/de not_active IP Right Cessation
- 1980-10-10 DD DD80224477A patent/DD153551A5/de not_active IP Right Cessation
- 1980-10-10 BE BE0/202407A patent/BE885634A/fr not_active IP Right Cessation
- 1980-10-10 NO NO803045A patent/NO153652C/no unknown
-
1982
- 1982-12-29 YU YU2911/82A patent/YU42063B/xx unknown
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| RO84802B (ro) | Procedeu pentru obtinerea unor (1-aril-ciclobutil)-alchilamine | |
| RO82370B (ro) | Procedeu pentru prepararea unor derivati de 9-aminodibenzopiran | |
| DE69021502D1 (de) | Benzimidazolderivate, Verfahren zu deren Herstellung und Anwendung. | |
| SE8101409L (sv) | Karbostyrilderivat och forfarande for framstellning derav | |
| ES455294A1 (es) | Un procedimiento de preparacion de una fenilamidina sustituida. | |
| RO70771B (ro) | Procedeu pentru prepararea unor compusi heterociclici aminoacilati | |
| RO84317B (ro) | Procedeu de preparare a unor derivati de difenileter cu activitate erbicida | |
| RO80925B (ro) | Procedeu pentru prepararea unor derivati de nitrotiofen | |
| NO840595L (no) | Fremgangsmaate ved fremstilling av nye carbacycliner | |
| RO82507B (ro) | Procedeu pentru prepararea unor derivati ai acidului 1, 2, 3-tiadiazol-5-carboxilic | |
| RO81351B (ro) | Procedeu pentru prepararea unor derivati de benzodiazepinei | |
| RO81210B (ro) | Procedeu pentru prepararea unor derivati de 1, 2, 4-oxadiazina | |
| AU534746B2 (en) | Oxime derivatives | |
| MY108849A (en) | Novel compound | |
| RO72831B (ro) | Procedeu pentru prepararea unor fenilpiperazine | |
| RO78871B (ro) | Procedeu pentru prepararea unor derivati de piridiluree si piridiltiouree | |
| RO82013B (ro) | Procedeu pentru prepararea unor derivati de carbostiril | |
| HUT35253A (en) | Process for preparing 4-/3-alkynyl-oxy-2-hydroxy-propyl/-piperazin-1-y1-n-phenyl-acetamide derivatives | |
| RO83713B (ro) | Procedeu pentru prepararea unor haloacilamide | |
| YU150690A (sh) | Benzotiazinski derivati i postupak za njihovo dobijanje | |
| RO82505B (ro) | Procedeu pentru prepararea unor derivati de chinoxalinil-1, 4-dioxizi | |
| RO82375B1 (ro) | Procedeu pentru prepararea unor derivati de 9-amino-dibenzopiran | |
| ATE51151T1 (de) | Prostaglandine zur behandlung von gehirnanoxie. | |
| MA20461A1 (fr) | Procede de preparation de nouveaux derives de l'isoxazoloquinoleine | |
| EP0033098A3 (en) | N-methyl-n-silyl-carbamates, process for their preparation and their use as pesticides |