ES8405371A1 - Un procedimiento para la preparacion de derivados del indol. - Google Patents
Un procedimiento para la preparacion de derivados del indol.Info
- Publication number
- ES8405371A1 ES8405371A1 ES513934A ES513934A ES8405371A1 ES 8405371 A1 ES8405371 A1 ES 8405371A1 ES 513934 A ES513934 A ES 513934A ES 513934 A ES513934 A ES 513934A ES 8405371 A1 ES8405371 A1 ES 8405371A1
- Authority
- ES
- Spain
- Prior art keywords
- group
- alkyl
- hydrogen atom
- cycloalkyl
- represent
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 150000002391 heterocyclic compounds Chemical class 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 abstract 5
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 4
- 125000003710 aryl alkyl group Chemical group 0.000 abstract 3
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 3
- 125000006273 (C1-C3) alkyl group Chemical group 0.000 abstract 2
- 101100134927 Gallus gallus COR8 gene Proteins 0.000 abstract 2
- 125000003118 aryl group Chemical group 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 208000019695 Migraine disease Diseases 0.000 abstract 1
- 229910006074 SO2NH2 Inorganic materials 0.000 abstract 1
- 125000003342 alkenyl group Chemical group 0.000 abstract 1
- 125000002947 alkylene group Chemical group 0.000 abstract 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 1
- 206010027599 migraine Diseases 0.000 abstract 1
- 125000002950 monocyclic group Chemical group 0.000 abstract 1
- 229910052757 nitrogen Inorganic materials 0.000 abstract 1
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 239000012453 solvate Substances 0.000 abstract 1
- 125000000565 sulfonamide group Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/44—Iso-indoles; Hydrogenated iso-indoles
- C07D209/48—Iso-indoles; Hydrogenated iso-indoles with oxygen atoms in positions 1 and 3, e.g. phthalimide
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
- C07D209/16—Tryptamines
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Indole Compounds (AREA)
Abstract
PROCEDIMIENTO PARA LA PREPARACION DE DERIVADOS DEL INDOL.CONSISTE EN REDUCIR UN COMPUESTO DE FORMULA (II) CON HIDROGENO EN PRESENCIA DE UN CATALIZADOR COMO PD, EN UN DISOLVENTE TAL COMO ALCOHOL, ETANOL, ETER Y OTROS Y A TEMPERATURA ENTRE -10JC A 50JC, PARA OBTENER UN COMPUESTO DE FORMULA (I) O UNA SAL DERIVADA DEL MISMO, DONDE W ES UN GRUPO CAPAZ DE SER REDUCIDO PARA DAR EL GRUPO ALKNR4R5 O UN DERIVADO PROTEGIDO DEL MISMO, ALK REPRESENTA UNA CADENA ALQUILENICA QUE CONTIENE C 2 A 3 QUE PUEDEN SER O NO SUSTITUIDOS O ESTAR SUSTITUIDOS POR DOS GRUPOS ALQUILO C1 A 3; R2, R3, R4, R6, R7 PUEDEN SER IGUALES O DIFERENTES REPRESENTAN HIDROGENO O UN GRUPO ALQUILO C 1 A 3, R5 REPRESENTA UN GRUPO HIDROGENO, ALQUILO, CICLOALQUILO Y OTROS, R1 REPRESENTA COR8, CONR9R10, CSNR9R10 Y OTROS; R8 REPRESENTA UN GRUPO ALQUILO, CICLOALQUILO Y OTROS, R9 ES UN ATOMO DE HIDROGENO O UN GRUPO ALQUILO, R10 ES UN ATOMO DE HIDROGENO O UN GRUPO ALQUILO, CICLOALQUILO Y N ES 0 O 1.SON UTILES PARA EL TRATAMIENTO DE LA MIGRAINA.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB8026287 | 1980-08-12 | ||
GB8026288 | 1980-08-12 |
Publications (2)
Publication Number | Publication Date |
---|---|
ES8405371A1 true ES8405371A1 (es) | 1984-06-01 |
ES513934A0 ES513934A0 (es) | 1984-06-01 |
Family
ID=26276534
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES504694A Granted ES504694A0 (es) | 1980-08-12 | 1981-08-11 | Procedimiento para la preparacion de derivados del indol. |
ES513934A Granted ES513934A0 (es) | 1980-08-12 | 1982-07-13 | Un procedimiento para la preparacion de derivados del indol. |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES504694A Granted ES504694A0 (es) | 1980-08-12 | 1981-08-11 | Procedimiento para la preparacion de derivados del indol. |
Country Status (12)
Country | Link |
---|---|
AU (1) | AU550010B2 (es) |
CH (1) | CH652394A5 (es) |
DE (1) | DE3131752A1 (es) |
DK (1) | DK157995C (es) |
ES (2) | ES504694A0 (es) |
FR (1) | FR2488606A1 (es) |
GB (1) | GB2083463B (es) |
IE (1) | IE51493B1 (es) |
IT (1) | IT1171450B (es) |
NL (1) | NL8103764A (es) |
NZ (1) | NZ197998A (es) |
SE (1) | SE454777B (es) |
Families Citing this family (20)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GR79215B (es) * | 1982-06-07 | 1984-10-22 | Glaxo Group Ltd | |
PT78358B (en) * | 1983-04-07 | 1986-05-30 | Smith Kline French Lab | Chemical process |
GB8332437D0 (en) * | 1983-12-06 | 1984-01-11 | Glaxo Group Ltd | Chemical compounds |
GB8332435D0 (en) * | 1983-12-06 | 1984-01-11 | Glaxo Group Ltd | Chemical compounds |
GB8419575D0 (en) * | 1984-08-01 | 1984-09-05 | Glaxo Group Ltd | Chemical compounds |
GB8600397D0 (en) * | 1986-01-08 | 1986-02-12 | Glaxo Group Ltd | Chemical compounds |
GB8600398D0 (en) * | 1986-01-08 | 1986-02-12 | Glaxo Group Ltd | Chemical compounds |
GB8607824D0 (en) * | 1986-03-27 | 1986-04-30 | Glaxo Group Ltd | Chemical compounds |
US5225431A (en) * | 1987-10-23 | 1993-07-06 | Burroughs Wellcome Co. | Therapeutic substituted indole compounds and compositions thereof |
CZ283018B6 (cs) * | 1991-02-01 | 1997-12-17 | Merck Sharp And Dohme Limited | Deriváty imidazolu, triazolu a tetrazolu a farmaceutické přípravky na jejich bázi |
GB9104136D0 (en) * | 1991-02-27 | 1991-04-17 | Merck Sharp & Dohme | Therapeutic agents |
UA34452C2 (uk) * | 1992-04-10 | 2001-03-15 | Пфайзер Інк. | Похідні ациламіноіндолу, що проявляють серотонінову 5-нт1 агоністичну активність та похідні аміноіндолу як проміжні сполуки |
GB9207930D0 (en) * | 1992-04-10 | 1992-05-27 | Pfizer Ltd | Indoles |
GB9209882D0 (en) * | 1992-05-07 | 1992-06-24 | Glaxo Lab Sa | Compositions |
GB9211277D0 (en) | 1992-05-28 | 1992-07-15 | Glaxo Group Inc | Pharmaceutical compositions |
IL106445A (en) * | 1992-07-30 | 1998-01-04 | Merck Sharp & Dohme | History of 1,2,4-Trans-Triazole 4-Transform, Preparation and Pharmaceutical Preparations Containing Them |
ES2070772B1 (es) * | 1993-08-09 | 1996-02-16 | Pfizer | Derivados de acilaminoindol |
CA2207201A1 (en) * | 1994-12-06 | 1996-06-13 | Caroline Henry | Azetidine, pyrrolidine and piperidine derivatives as 5ht1 receptor agonists |
FR2731224B1 (fr) * | 1995-03-02 | 1997-05-30 | Pf Medicament | Nouveaux derives bi-tryptaminiques sulfonamides, leur procede de preparation et leur utilisation a titre de medicaments |
US7189753B1 (en) | 1997-11-06 | 2007-03-13 | Cady Roger K | Preemptive prophylaxis of migraine |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2870162A (en) * | 1954-04-28 | 1959-01-20 | Upjohn Co | Production of certain tryptamines and compounds produced in the process |
FR1203195A (fr) * | 1958-07-25 | 1960-01-15 | Chimiotherapie Lab Franc | Procédé de préparation d'un nouveau dérivé de la tryptamine |
NL7316677A (es) * | 1972-12-21 | 1974-06-25 | ||
ZA795239B (en) * | 1978-10-12 | 1980-11-26 | Glaxo Group Ltd | Heterocyclic compounds |
-
1981
- 1981-08-11 GB GB8124478A patent/GB2083463B/en not_active Expired
- 1981-08-11 CH CH5161/81A patent/CH652394A5/fr not_active IP Right Cessation
- 1981-08-11 FR FR8115515A patent/FR2488606A1/fr active Granted
- 1981-08-11 SE SE8104783A patent/SE454777B/sv not_active IP Right Cessation
- 1981-08-11 DK DK357281A patent/DK157995C/da not_active IP Right Cessation
- 1981-08-11 ES ES504694A patent/ES504694A0/es active Granted
- 1981-08-11 DE DE19813131752 patent/DE3131752A1/de active Granted
- 1981-08-11 NL NL8103764A patent/NL8103764A/nl not_active Application Discontinuation
- 1981-08-11 NZ NZ197998A patent/NZ197998A/en unknown
- 1981-08-11 IE IE1832/81A patent/IE51493B1/en unknown
- 1981-08-11 IT IT49085/81A patent/IT1171450B/it active
- 1981-08-11 AU AU73995/81A patent/AU550010B2/en not_active Ceased
-
1982
- 1982-07-13 ES ES513934A patent/ES513934A0/es active Granted
Also Published As
Publication number | Publication date |
---|---|
CH652394A5 (fr) | 1985-11-15 |
ES513934A0 (es) | 1984-06-01 |
AU7399581A (en) | 1982-02-18 |
AU550010B2 (en) | 1986-02-27 |
DK157995B (da) | 1990-03-12 |
IT1171450B (it) | 1987-06-10 |
SE454777B (sv) | 1988-05-30 |
NZ197998A (en) | 1985-08-16 |
GB2083463B (en) | 1984-05-10 |
IE51493B1 (en) | 1987-01-07 |
NL8103764A (nl) | 1982-03-01 |
FR2488606A1 (fr) | 1982-02-19 |
GB2083463A (en) | 1982-03-24 |
DK357281A (da) | 1982-02-13 |
FR2488606B1 (es) | 1984-10-26 |
DE3131752C2 (es) | 1992-04-23 |
ES8300699A1 (es) | 1982-11-01 |
ES504694A0 (es) | 1982-11-01 |
IE811832L (en) | 1982-02-12 |
DE3131752A1 (de) | 1982-06-16 |
IT8149085A0 (it) | 1981-08-11 |
SE8104783L (sv) | 1982-02-13 |
DK157995C (da) | 1990-08-06 |
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