ES8405371A1 - Un procedimiento para la preparacion de derivados del indol. - Google Patents

Un procedimiento para la preparacion de derivados del indol.

Info

Publication number
ES8405371A1
ES8405371A1 ES513934A ES513934A ES8405371A1 ES 8405371 A1 ES8405371 A1 ES 8405371A1 ES 513934 A ES513934 A ES 513934A ES 513934 A ES513934 A ES 513934A ES 8405371 A1 ES8405371 A1 ES 8405371A1
Authority
ES
Spain
Prior art keywords
group
alkyl
hydrogen atom
cycloalkyl
represent
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES513934A
Other languages
English (en)
Other versions
ES513934A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Glaxo Group Ltd
Original Assignee
Glaxo Group Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glaxo Group Ltd filed Critical Glaxo Group Ltd
Publication of ES513934A0 publication Critical patent/ES513934A0/es
Publication of ES8405371A1 publication Critical patent/ES8405371A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/44—Iso-indoles; Hydrogenated iso-indoles
    • C07D209/48—Iso-indoles; Hydrogenated iso-indoles with oxygen atoms in positions 1 and 3, e.g. phthalimide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
    • C07D209/16—Tryptamines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Indole Compounds (AREA)

Abstract

PROCEDIMIENTO PARA LA PREPARACION DE DERIVADOS DEL INDOL.CONSISTE EN REDUCIR UN COMPUESTO DE FORMULA (II) CON HIDROGENO EN PRESENCIA DE UN CATALIZADOR COMO PD, EN UN DISOLVENTE TAL COMO ALCOHOL, ETANOL, ETER Y OTROS Y A TEMPERATURA ENTRE -10JC A 50JC, PARA OBTENER UN COMPUESTO DE FORMULA (I) O UNA SAL DERIVADA DEL MISMO, DONDE W ES UN GRUPO CAPAZ DE SER REDUCIDO PARA DAR EL GRUPO ALKNR4R5 O UN DERIVADO PROTEGIDO DEL MISMO, ALK REPRESENTA UNA CADENA ALQUILENICA QUE CONTIENE C 2 A 3 QUE PUEDEN SER O NO SUSTITUIDOS O ESTAR SUSTITUIDOS POR DOS GRUPOS ALQUILO C1 A 3; R2, R3, R4, R6, R7 PUEDEN SER IGUALES O DIFERENTES REPRESENTAN HIDROGENO O UN GRUPO ALQUILO C 1 A 3, R5 REPRESENTA UN GRUPO HIDROGENO, ALQUILO, CICLOALQUILO Y OTROS, R1 REPRESENTA COR8, CONR9R10, CSNR9R10 Y OTROS; R8 REPRESENTA UN GRUPO ALQUILO, CICLOALQUILO Y OTROS, R9 ES UN ATOMO DE HIDROGENO O UN GRUPO ALQUILO, R10 ES UN ATOMO DE HIDROGENO O UN GRUPO ALQUILO, CICLOALQUILO Y N ES 0 O 1.SON UTILES PARA EL TRATAMIENTO DE LA MIGRAINA.
ES513934A 1980-08-12 1982-07-13 Un procedimiento para la preparacion de derivados del indol. Expired ES8405371A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB8026287 1980-08-12
GB8026288 1980-08-12

Publications (2)

Publication Number Publication Date
ES513934A0 ES513934A0 (es) 1984-06-01
ES8405371A1 true ES8405371A1 (es) 1984-06-01

Family

ID=26276534

Family Applications (2)

Application Number Title Priority Date Filing Date
ES504694A Expired ES8300699A1 (es) 1980-08-12 1981-08-11 Procedimiento para la preparacion de derivados del indol.
ES513934A Expired ES8405371A1 (es) 1980-08-12 1982-07-13 Un procedimiento para la preparacion de derivados del indol.

Family Applications Before (1)

Application Number Title Priority Date Filing Date
ES504694A Expired ES8300699A1 (es) 1980-08-12 1981-08-11 Procedimiento para la preparacion de derivados del indol.

Country Status (12)

Country Link
AU (1) AU550010B2 (es)
CH (1) CH652394A5 (es)
DE (1) DE3131752A1 (es)
DK (1) DK157995C (es)
ES (2) ES8300699A1 (es)
FR (1) FR2488606A1 (es)
GB (1) GB2083463B (es)
IE (1) IE51493B1 (es)
IT (1) IT1171450B (es)
NL (1) NL8103764A (es)
NZ (1) NZ197998A (es)
SE (1) SE454777B (es)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GR79215B (es) * 1982-06-07 1984-10-22 Glaxo Group Ltd
PT78358B (en) * 1983-04-07 1986-05-30 Smith Kline French Lab Chemical process
GB8332437D0 (en) * 1983-12-06 1984-01-11 Glaxo Group Ltd Chemical compounds
HU196752B (en) * 1983-12-06 1989-01-30 Glaxo Group Ltd Process for production of medical compositions containing indole-derivatives and these compounds
GB8419575D0 (en) * 1984-08-01 1984-09-05 Glaxo Group Ltd Chemical compounds
GB8600397D0 (en) * 1986-01-08 1986-02-12 Glaxo Group Ltd Chemical compounds
GB8600398D0 (en) * 1986-01-08 1986-02-12 Glaxo Group Ltd Chemical compounds
GB8607824D0 (en) * 1986-03-27 1986-04-30 Glaxo Group Ltd Chemical compounds
US5225431A (en) * 1987-10-23 1993-07-06 Burroughs Wellcome Co. Therapeutic substituted indole compounds and compositions thereof
CZ283018B6 (cs) * 1991-02-01 1997-12-17 Merck Sharp And Dohme Limited Deriváty imidazolu, triazolu a tetrazolu a farmaceutické přípravky na jejich bázi
GB9104136D0 (en) * 1991-02-27 1991-04-17 Merck Sharp & Dohme Therapeutic agents
AU670270B2 (en) * 1992-04-10 1996-07-11 Pfizer Inc. Acylaminoindole derivatives as 5-HT1 agonists
GB9207930D0 (en) * 1992-04-10 1992-05-27 Pfizer Ltd Indoles
GB9209882D0 (en) * 1992-05-07 1992-06-24 Glaxo Lab Sa Compositions
GB9211277D0 (en) 1992-05-28 1992-07-15 Glaxo Group Inc Pharmaceutical compositions
IL106445A (en) * 1992-07-30 1998-01-04 Merck Sharp & Dohme History of 1,2,4-Trans-Triazole 4-Transform, Preparation and Pharmaceutical Preparations Containing Them
ES2070772B1 (es) * 1993-08-09 1996-02-16 Pfizer Derivados de acilaminoindol
CA2207201A1 (en) * 1994-12-06 1996-06-13 Caroline Henry Azetidine, pyrrolidine and piperidine derivatives as 5ht1 receptor agonists
FR2731224B1 (fr) * 1995-03-02 1997-05-30 Pf Medicament Nouveaux derives bi-tryptaminiques sulfonamides, leur procede de preparation et leur utilisation a titre de medicaments
US7189753B1 (en) 1997-11-06 2007-03-13 Cady Roger K Preemptive prophylaxis of migraine

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2870162A (en) * 1954-04-28 1959-01-20 Upjohn Co Production of certain tryptamines and compounds produced in the process
FR1203195A (fr) * 1958-07-25 1960-01-15 Chimiotherapie Lab Franc Procédé de préparation d'un nouveau dérivé de la tryptamine
NL7316677A (es) * 1972-12-21 1974-06-25
ZA795239B (en) * 1978-10-12 1980-11-26 Glaxo Group Ltd Heterocyclic compounds

Also Published As

Publication number Publication date
DK357281A (da) 1982-02-13
IE811832L (en) 1982-02-12
IT1171450B (it) 1987-06-10
NZ197998A (en) 1985-08-16
CH652394A5 (fr) 1985-11-15
DK157995C (da) 1990-08-06
ES504694A0 (es) 1982-11-01
NL8103764A (nl) 1982-03-01
FR2488606A1 (fr) 1982-02-19
GB2083463B (en) 1984-05-10
DK157995B (da) 1990-03-12
ES8300699A1 (es) 1982-11-01
ES513934A0 (es) 1984-06-01
AU550010B2 (en) 1986-02-27
IT8149085A0 (it) 1981-08-11
DE3131752A1 (de) 1982-06-16
SE454777B (sv) 1988-05-30
IE51493B1 (en) 1987-01-07
DE3131752C2 (es) 1992-04-23
FR2488606B1 (es) 1984-10-26
SE8104783L (sv) 1982-02-13
GB2083463A (en) 1982-03-24
AU7399581A (en) 1982-02-18

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