ATA501280A - Verfahren zur herstellung neuer 1,2,4-oxadiazin -derivate sowie von deren salze - Google Patents
Verfahren zur herstellung neuer 1,2,4-oxadiazin -derivate sowie von deren salzeInfo
- Publication number
- ATA501280A ATA501280A AT0501280A AT501280A ATA501280A AT A501280 A ATA501280 A AT A501280A AT 0501280 A AT0501280 A AT 0501280A AT 501280 A AT501280 A AT 501280A AT A501280 A ATA501280 A AT A501280A
- Authority
- AT
- Austria
- Prior art keywords
- alkyl
- phenyl
- oxadiazine
- derivs
- antiinflammatory
- Prior art date
Links
- 230000003288 anthiarrhythmic effect Effects 0.000 title abstract 2
- 230000003110 anti-inflammatory effect Effects 0.000 title abstract 2
- 230000001882 diuretic effect Effects 0.000 title abstract 2
- 230000005792 cardiovascular activity Effects 0.000 title 1
- 239000002934 diuretic Substances 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 abstract 6
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 4
- 125000003545 alkoxy group Chemical group 0.000 abstract 3
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 2
- 229910052736 halogen Inorganic materials 0.000 abstract 2
- 150000002367 halogens Chemical class 0.000 abstract 2
- PUAQLLVFLMYYJJ-UHFFFAOYSA-N 2-aminopropiophenone Chemical compound CC(N)C(=O)C1=CC=CC=C1 PUAQLLVFLMYYJJ-UHFFFAOYSA-N 0.000 abstract 1
- HPYLZSUEFFQHRS-UHFFFAOYSA-N 2h-1,2,4-oxadiazine Chemical compound N1OC=CN=C1 HPYLZSUEFFQHRS-UHFFFAOYSA-N 0.000 abstract 1
- 208000001953 Hypotension Diseases 0.000 abstract 1
- JCXJVPUVTGWSNB-UHFFFAOYSA-N Nitrogen dioxide Chemical compound O=[N]=O JCXJVPUVTGWSNB-UHFFFAOYSA-N 0.000 abstract 1
- 125000002252 acyl group Chemical group 0.000 abstract 1
- 230000017531 blood circulation Effects 0.000 abstract 1
- 208000021822 hypotensive Diseases 0.000 abstract 1
- 230000001077 hypotensive effect Effects 0.000 abstract 1
- 239000000543 intermediate Substances 0.000 abstract 1
- 239000008267 milk Substances 0.000 abstract 1
- 210000004080 milk Anatomy 0.000 abstract 1
- 235000013336 milk Nutrition 0.000 abstract 1
- 125000001624 naphthyl group Chemical group 0.000 abstract 1
- 239000000810 peripheral vasodilating agent Substances 0.000 abstract 1
- 229960002116 peripheral vasodilator Drugs 0.000 abstract 1
- 230000003389 potentiating effect Effects 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D273/00—Heterocyclic compounds containing rings having nitrogen and oxygen atoms as the only ring hetero atoms, not provided for by groups C07D261/00 - C07D271/00
- C07D273/02—Heterocyclic compounds containing rings having nitrogen and oxygen atoms as the only ring hetero atoms, not provided for by groups C07D261/00 - C07D271/00 having two nitrogen atoms and only one oxygen atom
- C07D273/04—Six-membered rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/10—Antioedematous agents; Diuretics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| AT208083A AT375658B (de) | 1979-10-11 | 1983-06-07 | Verfahren zur herstellung neuer 1,2,4-oxadiazin- derivate sowie von deren salzen |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| HU79CI1914A HU180708B (en) | 1979-10-11 | 1979-10-11 | Process for preparing new 1,2,4-oxadiazine derivatives |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| ATA501280A true ATA501280A (de) | 1983-05-15 |
| AT373247B AT373247B (de) | 1983-12-27 |
Family
ID=10994765
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT0501280A AT373247B (de) | 1979-10-11 | 1980-10-09 | Verfahren zur herstellung neuer 1,2,4-oxadiazin -derivate sowie von deren salzen |
Country Status (25)
| Country | Link |
|---|---|
| US (1) | US4308270A (de) |
| JP (1) | JPS5663970A (de) |
| AT (1) | AT373247B (de) |
| BE (1) | BE885634A (de) |
| CA (1) | CA1159828A (de) |
| CH (1) | CH649540A5 (de) |
| CS (1) | CS249111B2 (de) |
| DD (1) | DD153551A5 (de) |
| DE (1) | DE3037747A1 (de) |
| DK (1) | DK149106C (de) |
| ES (1) | ES495820A0 (de) |
| FR (1) | FR2467204B1 (de) |
| GB (1) | GB2062628B (de) |
| GR (1) | GR71205B (de) |
| HU (1) | HU180708B (de) |
| IL (1) | IL61176A (de) |
| IT (1) | IT1129306B (de) |
| LU (1) | LU82823A1 (de) |
| NL (1) | NL8005587A (de) |
| NO (1) | NO153652C (de) |
| PL (2) | PL129378B1 (de) |
| RO (3) | RO81210A (de) |
| SE (1) | SE448234B (de) |
| SU (1) | SU1087520A1 (de) |
| YU (2) | YU41739B (de) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HU179951B (en) * | 1979-10-11 | 1983-01-28 | Chinoin Gyogyszer Es Vegyeszet | Process for preparing 1,2,4-oxadiazolin-5-one derivatives and pharmaceutical compositions containing thereof |
| US20070232597A1 (en) * | 2003-04-10 | 2007-10-04 | Xiangping Qian | Compounds, Compositions, and Methods |
| US20170050980A1 (en) * | 2015-08-18 | 2017-02-23 | Forum Pharmaceuticals Inc. | Oxadiazine compounds and methods of use thereof |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NL132134C (de) * | 1963-03-22 | |||
| DE1545658C3 (de) * | 1964-03-02 | 1981-04-23 | Chinoin Gyógyszer és Vegyészeti Termékek Gyára RT, 1045 Budapest | Verfahren zur Herstellung von 3,5-disubstituierten 1,2,4-Oxadiazolderivaten |
| DE1795839C3 (de) * | 1964-03-02 | 1981-09-03 | Chinoin Gyógyszer és Vegyészeti Termékek Gyára RT, 1045 Budapest | Verfahren zur Herstellung von 3,5-disubstituierten 1,2,4-Oxadiazolderivaten |
| IT1043838B (it) * | 1971-04-22 | 1980-02-29 | Poli Ind Chimica Spa | 1 2 3 4 tetraidroisochinoline e processo per la loro preparazione |
| US4154598A (en) * | 1975-09-11 | 1979-05-15 | Philagro | Herbicidal 1,2,4-oxadiazin-5-one compositions |
| US4026894A (en) * | 1975-10-14 | 1977-05-31 | Abbott Laboratories | Antihypertensive agents |
| HU179951B (en) * | 1979-10-11 | 1983-01-28 | Chinoin Gyogyszer Es Vegyeszet | Process for preparing 1,2,4-oxadiazolin-5-one derivatives and pharmaceutical compositions containing thereof |
-
1979
- 1979-10-11 HU HU79CI1914A patent/HU180708B/hu not_active IP Right Cessation
-
1980
- 1980-09-30 IL IL61176A patent/IL61176A/xx unknown
- 1980-10-03 LU LU82823A patent/LU82823A1/de unknown
- 1980-10-06 GR GR63060A patent/GR71205B/el unknown
- 1980-10-06 DE DE19803037747 patent/DE3037747A1/de not_active Withdrawn
- 1980-10-06 CS CS806736A patent/CS249111B2/cs unknown
- 1980-10-07 SE SE8007026A patent/SE448234B/sv not_active IP Right Cessation
- 1980-10-09 JP JP14066980A patent/JPS5663970A/ja active Granted
- 1980-10-09 IT IT68556/80A patent/IT1129306B/it active
- 1980-10-09 NL NL8005587A patent/NL8005587A/nl not_active Application Discontinuation
- 1980-10-09 RO RO80102322A patent/RO81210A/ro unknown
- 1980-10-09 FR FR8021625A patent/FR2467204B1/fr not_active Expired
- 1980-10-09 AT AT0501280A patent/AT373247B/de not_active IP Right Cessation
- 1980-10-09 RO RO108149A patent/RO85268B/ro unknown
- 1980-10-09 RO RO108150A patent/RO85269B/ro unknown
- 1980-10-10 DD DD80224477A patent/DD153551A5/de not_active IP Right Cessation
- 1980-10-10 CH CH7600/80A patent/CH649540A5/de not_active IP Right Cessation
- 1980-10-10 PL PL1980232264A patent/PL129378B1/pl unknown
- 1980-10-10 GB GB8032827A patent/GB2062628B/en not_active Expired
- 1980-10-10 CA CA000362230A patent/CA1159828A/en not_active Expired
- 1980-10-10 DK DK429680A patent/DK149106C/da not_active IP Right Cessation
- 1980-10-10 SU SU802993202A patent/SU1087520A1/ru active
- 1980-10-10 YU YU2595/80A patent/YU41739B/xx unknown
- 1980-10-10 US US06/196,034 patent/US4308270A/en not_active Expired - Lifetime
- 1980-10-10 PL PL1980227211A patent/PL129081B1/pl unknown
- 1980-10-10 ES ES495820A patent/ES495820A0/es active Granted
- 1980-10-10 BE BE0/202407A patent/BE885634A/fr not_active IP Right Cessation
- 1980-10-10 NO NO803045A patent/NO153652C/no unknown
-
1982
- 1982-12-29 YU YU2911/82A patent/YU42063B/xx unknown
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| ELJ | Ceased due to non-payment of the annual fee |