RO82013B - Procedeu pentru prepararea unor derivati de carbostiril - Google Patents

Procedeu pentru prepararea unor derivati de carbostiril

Info

Publication number
RO82013B
RO82013B RO103556A RO10355679A RO82013B RO 82013 B RO82013 B RO 82013B RO 103556 A RO103556 A RO 103556A RO 10355679 A RO10355679 A RO 10355679A RO 82013 B RO82013 B RO 82013B
Authority
RO
Romania
Prior art keywords
group
carbon atoms
phenyl
alkyl
halogen
Prior art date
Application number
RO103556A
Other languages
English (en)
Other versions
RO82013A (ro
Inventor
Erich Muller
Josef Nickl
Josef Roch
Berthold Narr
Walter Haarmann
Johannes Maximilian Weisenberger
Original Assignee
Dr. Karl Thomae
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE19782806721 external-priority patent/DE2806721A1/de
Priority claimed from DE19782853314 external-priority patent/DE2853314A1/de
Application filed by Dr. Karl Thomae filed Critical Dr. Karl Thomae
Publication of RO82013B publication Critical patent/RO82013B/ro
Publication of RO82013A publication Critical patent/RO82013A/ro

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/20—Oxygen atoms
    • C07D215/22—Oxygen atoms attached in position 2 or 4
    • C07D215/227—Oxygen atoms attached in position 2 or 4 only one oxygen atom which is attached in position 2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/32—Oxygen atoms
    • C07D209/34—Oxygen atoms in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/20—Oxygen atoms
    • C07D215/24—Oxygen atoms attached in position 8
    • C07D215/26—Alcohols; Ethers thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/36—Sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/38—Nitrogen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Cardiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Diabetes (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Hematology (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Quinoline Compounds (AREA)
  • Indole Compounds (AREA)

Abstract

Inventia se refera la un procedeu pentru prepararea unor derivati de carbostiril cu formula generala I: (vezi formula) în care substituentii R1 si R2 reprezinta hidrogen sau o grupa metil, R3 reprezinta hidrogen, brom, nitro, sau acetilamino, linia pinctata arata ca în pozitia 3,4 legatura simpla sau dubla, substituentul A reprezinta o grupa alchilen liniara cu 2...6 atomi de carbon, hidroxipropilen, 0-xilen sau p-xilen, substituentul R4 reprezinta o grupa alchil cu 1...4 atomi de carbon, o grupa fenil, eventual substituita cu alchil cu 1...4 atomi de carbon, halogen, hidroxi, metoxi, carboxi, nitro, acetamido, fenil sau ciclohexil, o grupa fenil disubstituita cu halogen, metoxi si/sau alchil cu 1...4 atomi de carbon, o grupa hidroxi-fenil, halogenfenil sau aminofenil substituita prin doi atomi de halogen sau prin doua grupe alchil cu cîte 1...4 atomi de carbon, o grupa benzil...
RO79103556A 1978-02-17 1979-02-14 7rocedeu pentru prepararea unor derivati de carbostiril RO82013A (ro)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19782806721 DE2806721A1 (de) 1978-02-17 1978-02-17 Neue carbostyril-derivate
DE19782853314 DE2853314A1 (de) 1978-12-09 1978-12-09 Neue carbostyril- und oxindolderivate, ihre herstellung und ihre verwendung als arzneimittel

Publications (2)

Publication Number Publication Date
RO82013B true RO82013B (ro) 1983-05-30
RO82013A RO82013A (ro) 1983-06-01

Family

ID=25773852

Family Applications (2)

Application Number Title Priority Date Filing Date
RO79103556A RO82013A (ro) 1978-02-17 1979-02-14 7rocedeu pentru prepararea unor derivati de carbostiril
RO7996613A RO76683A (ro) 1978-02-17 1979-02-14 Procedeu de preparare a unor derivati de carbostiril

Family Applications After (1)

Application Number Title Priority Date Filing Date
RO7996613A RO76683A (ro) 1978-02-17 1979-02-14 Procedeu de preparare a unor derivati de carbostiril

Country Status (24)

Country Link
EP (1) EP0003771B1 (ro)
JP (1) JPS54132581A (ro)
AT (1) AT374183B (ro)
AU (1) AU523147B2 (ro)
CA (1) CA1116600A (ro)
CS (1) CS227005B2 (ro)
DD (1) DD141829A5 (ro)
DE (1) DE2963868D1 (ro)
DK (1) DK157017C (ro)
ES (3) ES477517A1 (ro)
FI (1) FI69064C (ro)
GR (1) GR66565B (ro)
HK (1) HK50485A (ro)
HU (1) HU177522B (ro)
IE (1) IE48179B1 (ro)
IL (1) IL56677A (ro)
NO (1) NO152839C (ro)
NZ (1) NZ189685A (ro)
PH (1) PH16698A (ro)
PL (3) PL119177B1 (ro)
PT (1) PT69244A (ro)
RO (2) RO82013A (ro)
SU (2) SU843739A3 (ro)
YU (1) YU41146B (ro)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1171624B (it) * 1980-11-12 1987-06-10 Thomae Gmbh Dr K Indolinoni dotati di proprieta' farmaceutiche e procedimento per la loro produzione
US4442111A (en) * 1981-07-25 1984-04-10 Dr. Karl Thomae Gesellschaft Mit Beschrankter Haftung Antithrombotic sulfimino and sulfoximino indolinones-2
DE3217012A1 (de) * 1982-05-06 1983-11-10 Dr. Karl Thomae Gmbh, 7950 Biberach Benzoxazin-2-one, deren herstellung und diese verbindungen enthaltende arzneimittel
CA2093633A1 (en) * 1991-08-23 1993-02-24 Seiji Sato Carbostyril derivative and platelets aggregation inhibitory agent
JP2004529110A (ja) 2001-03-06 2004-09-24 アストラゼネカ アクチボラグ 脈管損傷活性を有するインドール誘導体
MY129350A (en) 2001-04-25 2007-03-30 Bristol Myers Squibb Co Aripiprazole oral solution

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5082218A (ro) * 1973-11-10 1975-07-03
US3904761A (en) * 1974-01-25 1975-09-09 Hoechst Co American Method of preventing thrombosis
US4070470A (en) * 1974-06-24 1978-01-24 Otsuka Pharmaceutical Co., Ltd. Platelet aggregation inhibiting carbostyrils, their compositions and method of use
JPS5321176A (en) * 1976-08-09 1978-02-27 Otsuka Pharmaceut Co Ltd Carbostyryl derivatives
NZ187452A (en) * 1977-06-10 1980-05-27 Otsuka Pharma Co Ltd N- substituted-aminocarbonylpropoxy-carbostyrils and their preparation

Also Published As

Publication number Publication date
PH16698A (en) 1984-01-16
PL117771B1 (en) 1981-08-31
IL56677A (en) 1982-09-30
SU843739A3 (ru) 1981-06-30
CA1116600A (en) 1982-01-19
NZ189685A (en) 1984-07-06
SU852170A3 (ru) 1981-07-30
FI69064B (fi) 1985-08-30
RO76683A (ro) 1981-05-30
NO152839B (no) 1985-08-19
CS227005B2 (en) 1984-04-16
RO82013A (ro) 1983-06-01
YU41146B (en) 1986-12-31
ES477517A1 (es) 1980-01-16
HU177522B (en) 1981-10-28
DK69679A (da) 1979-08-18
ES484633A1 (es) 1980-05-16
PL119423B1 (en) 1981-12-31
DK157017B (da) 1989-10-30
DK157017C (da) 1990-03-26
NO790521L (no) 1979-08-20
PL119177B1 (en) 1981-12-31
IE790313L (en) 1979-08-17
FI69064C (fi) 1985-12-10
HK50485A (en) 1985-07-12
ES484634A1 (es) 1980-05-16
YU36679A (en) 1983-02-28
AU523147B2 (en) 1982-07-15
ATA93379A (de) 1983-08-15
EP0003771A1 (de) 1979-09-05
PL213471A1 (ro) 1980-02-25
JPS6331464B2 (ro) 1988-06-23
FI790507A (fi) 1979-08-18
NO152839C (no) 1985-11-27
PT69244A (de) 1979-03-01
IE48179B1 (en) 1984-10-17
GR66565B (ro) 1981-03-27
DE2963868D1 (en) 1982-11-25
IL56677A0 (en) 1979-05-31
AT374183B (de) 1984-03-26
AU4432979A (en) 1979-08-23
DD141829A5 (de) 1980-05-21
JPS54132581A (en) 1979-10-15
EP0003771B1 (de) 1982-10-20

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