ES484634A1 - Procedimiento para la preparacion de nuevos derivados car- bostirilicos y oxindolicos - Google Patents

Procedimiento para la preparacion de nuevos derivados car- bostirilicos y oxindolicos

Info

Publication number
ES484634A1
ES484634A1 ES484634A ES484634A ES484634A1 ES 484634 A1 ES484634 A1 ES 484634A1 ES 484634 A ES484634 A ES 484634A ES 484634 A ES484634 A ES 484634A ES 484634 A1 ES484634 A1 ES 484634A1
Authority
ES
Spain
Prior art keywords
group
carbon atoms
methyl
pyridyl
whilst
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES484634A
Other languages
English (en)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Boehringer Ingelheim Pharma GmbH and Co KG
Original Assignee
Dr Karl Thomae GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE19782806721 external-priority patent/DE2806721A1/de
Priority claimed from DE19782853314 external-priority patent/DE2853314A1/de
Application filed by Dr Karl Thomae GmbH filed Critical Dr Karl Thomae GmbH
Publication of ES484634A1 publication Critical patent/ES484634A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/20—Oxygen atoms
    • C07D215/22—Oxygen atoms attached in position 2 or 4
    • C07D215/227—Oxygen atoms attached in position 2 or 4 only one oxygen atom which is attached in position 2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/32—Oxygen atoms
    • C07D209/34—Oxygen atoms in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/20—Oxygen atoms
    • C07D215/24—Oxygen atoms attached in position 8
    • C07D215/26—Alcohols; Ethers thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/36—Sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/38—Nitrogen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Cardiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Hospice & Palliative Care (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Quinoline Compounds (AREA)
  • Indole Compounds (AREA)

Abstract

Procedimiento para la preparación de nuevos derivados carbostirílicos y oxindólicos de la fórmula general **(Fórmula)** en donde W significa un grupo vinileno eventualmente sustituido con un grupo metilo, el grupo metileno o etileno, D significa un grupo alcohileno de cadena recta o ramificado con 2 hasta 6 átomos de carbono, un grupo hidroxialcohileno de cadena recta o ramificado con 3 hasta 6 átomos de carbono o un grupo xilileno; R1 significa un átomo de hidrógeno o un grupo alcohilo con 1 hasta 3 átomos de carbono, R2 significa un grupo cicloalcohilo con 3 hasta 6 átomos de carbono, un grupo arilo con 6 hasta 10 átomos de carbono, un grupo aralcohilo con 7 hasta 11 átomos de carbono, un grupo heteroarilo con 4 hasta 9 átomos de carbono, que contiene un átomo de nitrógeno y/o un átomo de oxígeno o un átomo de azufre o dos átomos de nitrógeno o un grupo heteroaralcohilo con 5 hasta 10 átomos de carbono.
ES484634A 1978-02-17 1979-10-01 Procedimiento para la preparacion de nuevos derivados car- bostirilicos y oxindolicos Expired ES484634A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19782806721 DE2806721A1 (de) 1978-02-17 1978-02-17 Neue carbostyril-derivate
DE19782853314 DE2853314A1 (de) 1978-12-09 1978-12-09 Neue carbostyril- und oxindolderivate, ihre herstellung und ihre verwendung als arzneimittel

Publications (1)

Publication Number Publication Date
ES484634A1 true ES484634A1 (es) 1980-05-16

Family

ID=25773852

Family Applications (3)

Application Number Title Priority Date Filing Date
ES477517A Expired ES477517A1 (es) 1978-02-17 1979-02-07 Procedimiento para la preparacion de nuevos derivados car- bostirilicos y oxindolicos.
ES484634A Expired ES484634A1 (es) 1978-02-17 1979-10-01 Procedimiento para la preparacion de nuevos derivados car- bostirilicos y oxindolicos
ES484633A Expired ES484633A1 (es) 1978-02-17 1979-10-01 Procedimiento para la preparacion de nuevos derivados car- bostirilicos y oxindolicos

Family Applications Before (1)

Application Number Title Priority Date Filing Date
ES477517A Expired ES477517A1 (es) 1978-02-17 1979-02-07 Procedimiento para la preparacion de nuevos derivados car- bostirilicos y oxindolicos.

Family Applications After (1)

Application Number Title Priority Date Filing Date
ES484633A Expired ES484633A1 (es) 1978-02-17 1979-10-01 Procedimiento para la preparacion de nuevos derivados car- bostirilicos y oxindolicos

Country Status (24)

Country Link
EP (1) EP0003771B1 (es)
JP (1) JPS54132581A (es)
AT (1) AT374183B (es)
AU (1) AU523147B2 (es)
CA (1) CA1116600A (es)
CS (1) CS227005B2 (es)
DD (1) DD141829A5 (es)
DE (1) DE2963868D1 (es)
DK (1) DK157017C (es)
ES (3) ES477517A1 (es)
FI (1) FI69064C (es)
GR (1) GR66565B (es)
HK (1) HK50485A (es)
HU (1) HU177522B (es)
IE (1) IE48179B1 (es)
IL (1) IL56677A (es)
NO (1) NO152839C (es)
NZ (1) NZ189685A (es)
PH (1) PH16698A (es)
PL (3) PL117771B1 (es)
PT (1) PT69244A (es)
RO (2) RO76683A (es)
SU (2) SU843739A3 (es)
YU (1) YU41146B (es)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1171624B (it) * 1980-11-12 1987-06-10 Thomae Gmbh Dr K Indolinoni dotati di proprieta' farmaceutiche e procedimento per la loro produzione
US4442111A (en) * 1981-07-25 1984-04-10 Dr. Karl Thomae Gesellschaft Mit Beschrankter Haftung Antithrombotic sulfimino and sulfoximino indolinones-2
DE3217012A1 (de) * 1982-05-06 1983-11-10 Dr. Karl Thomae Gmbh, 7950 Biberach Benzoxazin-2-one, deren herstellung und diese verbindungen enthaltende arzneimittel
WO1993004042A1 (fr) * 1991-08-23 1993-03-04 Otsuka Pharmaceutical Co., Ltd. Derive de carbostyrile et antiagregant plaquettaire
JP2004529110A (ja) 2001-03-06 2004-09-24 アストラゼネカ アクチボラグ 脈管損傷活性を有するインドール誘導体
MY129350A (en) 2001-04-25 2007-03-30 Bristol Myers Squibb Co Aripiprazole oral solution

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5082218A (es) * 1973-11-10 1975-07-03
US3904761A (en) * 1974-01-25 1975-09-09 Hoechst Co American Method of preventing thrombosis
FI59246C (fi) * 1974-06-24 1981-07-10 Otsuka Pharma Co Ltd Foerfarande foer framstaellning av benscykloamidderivat anvaendbara vid trombos- och emboliterapin
JPS5321176A (en) * 1976-08-09 1978-02-27 Otsuka Pharmaceut Co Ltd Carbostyryl derivatives
NZ187452A (en) * 1977-06-10 1980-05-27 Otsuka Pharma Co Ltd N- substituted-aminocarbonylpropoxy-carbostyrils and their preparation

Also Published As

Publication number Publication date
PL119423B1 (en) 1981-12-31
AU4432979A (en) 1979-08-23
RO76683A (ro) 1981-05-30
PL119177B1 (en) 1981-12-31
ES477517A1 (es) 1980-01-16
FI69064B (fi) 1985-08-30
IL56677A (en) 1982-09-30
PL117771B1 (en) 1981-08-31
DE2963868D1 (en) 1982-11-25
IL56677A0 (en) 1979-05-31
RO82013A (ro) 1983-06-01
EP0003771A1 (de) 1979-09-05
NO152839B (no) 1985-08-19
DD141829A5 (de) 1980-05-21
ES484633A1 (es) 1980-05-16
HU177522B (en) 1981-10-28
PT69244A (de) 1979-03-01
PH16698A (en) 1984-01-16
GR66565B (es) 1981-03-27
CA1116600A (en) 1982-01-19
DK157017B (da) 1989-10-30
HK50485A (en) 1985-07-12
IE48179B1 (en) 1984-10-17
DK157017C (da) 1990-03-26
JPS54132581A (en) 1979-10-15
AT374183B (de) 1984-03-26
FI69064C (fi) 1985-12-10
RO82013B (ro) 1983-05-30
SU843739A3 (ru) 1981-06-30
YU36679A (en) 1983-02-28
JPS6331464B2 (es) 1988-06-23
DK69679A (da) 1979-08-18
SU852170A3 (ru) 1981-07-30
YU41146B (en) 1986-12-31
IE790313L (en) 1979-08-17
ATA93379A (de) 1983-08-15
NO152839C (no) 1985-11-27
AU523147B2 (en) 1982-07-15
NO790521L (no) 1979-08-20
EP0003771B1 (de) 1982-10-20
PL213471A1 (es) 1980-02-25
FI790507A (fi) 1979-08-18
NZ189685A (en) 1984-07-06
CS227005B2 (en) 1984-04-16

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