GB950872A - Substituted pyridyl-ethyl-piperazines - Google Patents

Substituted pyridyl-ethyl-piperazines

Info

Publication number
GB950872A
GB950872A GB9856/61A GB985661A GB950872A GB 950872 A GB950872 A GB 950872A GB 9856/61 A GB9856/61 A GB 9856/61A GB 985661 A GB985661 A GB 985661A GB 950872 A GB950872 A GB 950872A
Authority
GB
United Kingdom
Prior art keywords
pyridyl
formula
compounds
atoms
piperazines
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB9856/61A
Inventor
Jacques Boissier
Roger Ratouis
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Societe Industrielle pour la Fabrication des Antibiotiques SA SIFA
Original Assignee
Societe Industrielle pour la Fabrication des Antibiotiques SA SIFA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Societe Industrielle pour la Fabrication des Antibiotiques SA SIFA filed Critical Societe Industrielle pour la Fabrication des Antibiotiques SA SIFA
Priority to GB9856/61A priority Critical patent/GB950872A/en
Priority to FR889488A priority patent/FR1769M/en
Priority to FR890422A priority patent/FR1317053A/en
Publication of GB950872A publication Critical patent/GB950872A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/02—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms containing only hydrogen and carbon atoms in addition to the ring hetero elements
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pyridine Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

The invention comprises compounds of general formula: <FORM:0950872/C2/1> in which R represents a 2-pyridyl or 4-pyridyl radical and R1 represents a 2-pyridyl, phenyl, 2-halogenophenyl, 2-alkoxyphenyl (up to 10 C atoms) or 2-alkylphenyl (up to 10 C atoms) radical; and their acid addition salts; and their preparation by heating a compound of formula: <FORM:0950872/C2/2> with a compound of formula: <FORM:0950872/C2/3> in the presence of a polymerisation inhibitor for vinyl pyridines. Pharmaceutical compositions comprise the above compounds and salts with an inert pharmaceutically acceptable carrier. Oral, parenteral and rectal administration are mentioned. The compounds have depressant, hypotensive, antihistamine and antiadrenaline properties.
GB9856/61A 1961-03-17 1961-03-17 Substituted pyridyl-ethyl-piperazines Expired GB950872A (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
GB9856/61A GB950872A (en) 1961-03-17 1961-03-17 Substituted pyridyl-ethyl-piperazines
FR889488A FR1769M (en) 1961-03-17 1962-02-28 New derivatives of piperazine.
FR890422A FR1317053A (en) 1961-03-17 1962-03-08 Novel piperazine derivatives, and method of preparation

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB9856/61A GB950872A (en) 1961-03-17 1961-03-17 Substituted pyridyl-ethyl-piperazines

Publications (1)

Publication Number Publication Date
GB950872A true GB950872A (en) 1964-02-26

Family

ID=9880065

Family Applications (1)

Application Number Title Priority Date Filing Date
GB9856/61A Expired GB950872A (en) 1961-03-17 1961-03-17 Substituted pyridyl-ethyl-piperazines

Country Status (2)

Country Link
FR (1) FR1769M (en)
GB (1) GB950872A (en)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4831030A (en) * 1985-12-12 1989-05-16 Fujisawa Pharmaceutical Co., Ltd. Diphenylpyridine compounds, processes for the preparation thereof and composition comprising the same
JP2010500985A (en) * 2006-08-17 2010-01-14 エフ．ホフマン−ラ ロシュ アーゲー Aryl piperazine derivatives and uses thereof
US7834035B2 (en) 2003-11-06 2010-11-16 Addex Pharma Sa Allosteric modulators of metabotropic glutamate receptors
US7998963B2 (en) 2008-02-15 2011-08-16 Roche Palo Alto Llc Arylpiperazine derivatives and uses thereof

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4831030A (en) * 1985-12-12 1989-05-16 Fujisawa Pharmaceutical Co., Ltd. Diphenylpyridine compounds, processes for the preparation thereof and composition comprising the same
US7834035B2 (en) 2003-11-06 2010-11-16 Addex Pharma Sa Allosteric modulators of metabotropic glutamate receptors
US8030331B2 (en) 2003-11-06 2011-10-04 Addex Pharma Sa Allosteric modulators of metabotropic glutamate receptors
US8163775B2 (en) 2003-11-06 2012-04-24 Addex Pharma Sa Allosteric modulators of metabotropic glutamate receptors
JP2010500985A (en) * 2006-08-17 2010-01-14 エフ．ホフマン−ラ ロシュ アーゲー Aryl piperazine derivatives and uses thereof
US7998963B2 (en) 2008-02-15 2011-08-16 Roche Palo Alto Llc Arylpiperazine derivatives and uses thereof

Also Published As

Publication number Publication date
FR1769M (en) 1963-04-08

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