GB1217427A - Cinchona alkaloid derivatives - Google Patents
Cinchona alkaloid derivativesInfo
- Publication number
- GB1217427A GB1217427A GB6031768A GB6031768A GB1217427A GB 1217427 A GB1217427 A GB 1217427A GB 6031768 A GB6031768 A GB 6031768A GB 6031768 A GB6031768 A GB 6031768A GB 1217427 A GB1217427 A GB 1217427A
- Authority
- GB
- United Kingdom
- Prior art keywords
- alkyl
- aryl
- formulμ
- haloalkenyl
- haloalkyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
- C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems
- C07D453/04—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems having a quinolyl-4, a substituted quinolyl-4 or a alkylenedioxy-quinolyl-4 radical linked through only one carbon atom, attached in position 2, e.g. quinine
Abstract
1,217,427. Cinchona alkaloid derivatives. AMERICAN HOME PRODUCTS CORP. 19 Dec., 1968 [21 Dec., 1967], No. 60317/68. Heading C2C. Novel compounds of Formulµ I and II and their acid addition salts in which Q is a radical R 1 is H or methoxy; R<SP>2</SP> is C 1-6 alkyl, C 2-6 alkenyl, C 2-6 alkynyl, di-C 1-0 alkyl-N-(CH 2 ) n - in which n is 3-10, C 3-6 cycloalkyl, C 1-0 haloalkyl, C 2-6 haloalkenyl, aryl or aryl substituted by 1-5 halo, C 1-6 alkyl, C 2-6 alkenyl, C 2-6 alkynyl, C 1-6 haloalkyl, C 1-6 alkoxy, or C 2-6 haloalkenyl; and R 3 is ethyl or vinyl, provided that when R<SP>1</SP> is methoxy in Formula I R<SP>2</SP> is not aryl are prepared by reacting the N-oxides of formulµ with R<SP>2</SP>MgX or R<SP>2</SP>Li where X is halo and decomposing the organic complex formed, followed where necessary by salt formation. Pharmaceutical compositions comprise the compounds I or II together with suitable excipients for oral or parenteral application as anti-malarials and anti-arrhythmic agents.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US69227767A | 1967-12-21 | 1967-12-21 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1217427A true GB1217427A (en) | 1970-12-31 |
Family
ID=24779930
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB6031768A Expired GB1217427A (en) | 1967-12-21 | 1968-12-19 | Cinchona alkaloid derivatives |
Country Status (6)
| Country | Link |
|---|---|
| BE (1) | BE725838A (en) |
| CH (1) | CH505099A (en) |
| DE (1) | DE1816122A1 (en) |
| FR (2) | FR1596270A (en) |
| GB (1) | GB1217427A (en) |
| NL (1) | NL6818449A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2578579A1 (en) | 2010-07-14 | 2013-04-10 | National Institute of Immunology | Benzothiophene carboxamide compounds, composition and applications thereof |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CH605916A5 (en) * | 1973-12-07 | 1978-10-13 | Hoffmann La Roche |
-
1968
- 1968-12-19 GB GB6031768A patent/GB1217427A/en not_active Expired
- 1968-12-20 DE DE19681816122 patent/DE1816122A1/en active Pending
- 1968-12-20 NL NL6818449A patent/NL6818449A/xx unknown
- 1968-12-20 FR FR1596270D patent/FR1596270A/fr not_active Expired
- 1968-12-20 BE BE725838D patent/BE725838A/xx unknown
- 1968-12-20 FR FR179699A patent/FR8186M/fr not_active Expired
- 1968-12-23 CH CH1919468A patent/CH505099A/en not_active IP Right Cessation
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2578579A1 (en) | 2010-07-14 | 2013-04-10 | National Institute of Immunology | Benzothiophene carboxamide compounds, composition and applications thereof |
Also Published As
| Publication number | Publication date |
|---|---|
| DE1816122A1 (en) | 1969-07-24 |
| BE725838A (en) | 1969-06-20 |
| CH505099A (en) | 1971-03-31 |
| FR8186M (en) | 1970-09-07 |
| NL6818449A (en) | 1969-06-24 |
| FR1596270A (en) | 1970-06-15 |
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