GB1426200A - Nahpthyridine derivatives - Google Patents
Nahpthyridine derivativesInfo
- Publication number
- GB1426200A GB1426200A GB5612873A GB5612873A GB1426200A GB 1426200 A GB1426200 A GB 1426200A GB 5612873 A GB5612873 A GB 5612873A GB 5612873 A GB5612873 A GB 5612873A GB 1426200 A GB1426200 A GB 1426200A
- Authority
- GB
- United Kingdom
- Prior art keywords
- prepared
- methyl
- methylnicotinate
- alkyl
- reacting
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/79—Acids; Esters
- C07D213/80—Acids; Esters in position 3
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyridine Compounds (AREA)
Abstract
1426200 Naphthyridines AMERICAN HOME PRODUCTS CORP 4 Dec 1973 [7 Dec 1972] 56128/73 Heading C2C Novel compounds of Formula 1 in which R = straight-chain C 1-6 alkyl, R<SP>1</SP> and R<SP>2</SP>=C 1-6 alkyl and Z=O, Na or K; and, when Z=H, pharmaceutically acceptable, acid addition salts thereof, are prepared by cyclizing, e.g. in the presence of a strong base, a compound of Formula IV in which -COR<SP>3</SP>=an ester or di-(C 1-6 alkyl)- amido function, and, if required acidifying the product formed to the free enol, and simultaneously or, as an after step, forming a pharmaceutically acceptacle, acid addition salt thereof. Compounds IV are prepared by reacting a compound II in which Y is a replaceable substituent with a compound of formula HN(R)CH 2 CH 2 COOR<SP>1</SP>. Methyl 2-chloro-6-methylnicotinate is prepared by reacting 2-hydroxy-6-methyl-nicotinic acid with POCl 3 and esterifying the resulting acid. Methyl 2 - benzenesulphonyloxy - 6 - methylnicotinate is prepared by reacting methyl 2- hydroxy-6-methylnicotinate with benzenesulphonyl chloride. Pharmaceutical compositions having antibacterial activity, for oral or parenteral administration, comprise one of the above novel compounds together with a pharmaceutical carriers.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US00313048A US3853864A (en) | 1972-12-07 | 1972-12-07 | 1,7-dialkyl-1,2-dihydro-4-hydroxy-1,8-naphthyridine-3-carboxylic acid alkyl esters |
Publications (1)
Publication Number | Publication Date |
---|---|
GB1426200A true GB1426200A (en) | 1976-02-25 |
Family
ID=23214151
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
GB5612873A Expired GB1426200A (en) | 1972-12-07 | 1973-12-04 | Nahpthyridine derivatives |
Country Status (6)
Country | Link |
---|---|
US (1) | US3853864A (en) |
JP (1) | JPS5653554B2 (en) |
CA (1) | CA1017341A (en) |
DE (1) | DE2360329A1 (en) |
FR (1) | FR2209568B1 (en) |
GB (1) | GB1426200A (en) |
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4273930A (en) * | 1977-06-20 | 1981-06-16 | Sandoz, Inc. | 4-Hydroxy-2-quinolinone-3-carboxylic acid esters |
US4281131A (en) * | 1977-06-20 | 1981-07-28 | Sandoz, Inc. | 4-Hydroxy-2-quinolinone-3-carboxylic acids and salts thereof |
US4128649A (en) * | 1977-06-29 | 1978-12-05 | Sandoz, Inc. | 4-Hydroxy-pyrido[2,3-b]pyridine-2(1H)-one-3-carboxylic acids and esters |
DE2808070A1 (en) * | 1978-02-24 | 1979-08-30 | Bayer Ag | PROCESS FOR THE PRODUCTION OF 4-PYRIDONE-3-CARBONIC ACIDS AND / OR DERIVATIVES |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3590036A (en) * | 1968-11-18 | 1971-06-29 | George Y Lesher | Naphthyridine-3-carboxylic acids,their derivatives and preparation thereof |
BE762804A (en) * | 1970-02-20 | 1971-08-11 | Koei Chemical Co | PROCESS FOR PREPARING DERIVATIVES OF ALKYL-1 NAPHTYRIDINE (-1.8) |
US3786043A (en) * | 1972-06-19 | 1974-01-15 | Sterling Drug Inc | 7-methyl-4-chloro (or -4-lower-alkoxy)-1,8-naphthyridine-3-carboxylates |
-
1972
- 1972-12-07 US US00313048A patent/US3853864A/en not_active Expired - Lifetime
-
1973
- 1973-11-27 CA CA186,799A patent/CA1017341A/en not_active Expired
- 1973-12-04 DE DE2360329A patent/DE2360329A1/en not_active Ceased
- 1973-12-04 GB GB5612873A patent/GB1426200A/en not_active Expired
- 1973-12-05 FR FR7343444A patent/FR2209568B1/fr not_active Expired
- 1973-12-06 JP JP13855973A patent/JPS5653554B2/ja not_active Expired
Also Published As
Publication number | Publication date |
---|---|
CA1017341A (en) | 1977-09-13 |
FR2209568B1 (en) | 1978-07-28 |
US3853864A (en) | 1974-12-10 |
DE2360329A1 (en) | 1974-06-20 |
JPS4987699A (en) | 1974-08-22 |
JPS5653554B2 (en) | 1981-12-19 |
FR2209568A1 (en) | 1974-07-05 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
PS | Patent sealed [section 19, patents act 1949] | ||
PCNP | Patent ceased through non-payment of renewal fee |