GB1416412A - Piperazinyl-and monopiperazinyl monoalkanol esters and a process of production thereof - Google Patents

Piperazinyl-and monopiperazinyl monoalkanol esters and a process of production thereof

Info

Publication number
GB1416412A
GB1416412A GB58874A GB58874A GB1416412A GB 1416412 A GB1416412 A GB 1416412A GB 58874 A GB58874 A GB 58874A GB 58874 A GB58874 A GB 58874A GB 1416412 A GB1416412 A GB 1416412A
Authority
GB
United Kingdom
Prior art keywords
monopiperazinyl
monoalkanol
piperazinyl
esters
production
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB58874A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Abbott Japan Co Ltd
Original Assignee
Hokuriku Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from JP11229173A external-priority patent/JPS5224032B2/ja
Priority claimed from JP11229073A external-priority patent/JPS5246235B2/ja
Application filed by Hokuriku Pharmaceutical Co Ltd filed Critical Hokuriku Pharmaceutical Co Ltd
Publication of GB1416412A publication Critical patent/GB1416412A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
    • C07D295/084—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/088—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Pain & Pain Management (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pyridine Compounds (AREA)

Abstract

1416412 Piperazine and homopiperazine derivatives HOKURIKU PHARMACEUTICAL CO Ltd 7 Jan 1974 [8 Oct 1973 (3)] 00588/74 Heading C2C Novel compounds I (in which R is phenyl substituted with one or more of C 1-6 alkyl, C 1-6 alkoxy and halogen; or styryl or pyridyl optionally substituted with one or more C 1-6 alkoxy groups and n and m are 2 or 3) and salts thereof, are prepared by esterification of an alcohol of Formula (II) or a salt thereof, with an appropriate acid. Pharmaceutical compositions having analgesic, coronary vasodilative, anti-convulsant and blood pressure decreasing properties comprise one of the above novel compounds together with a pharmaceutically acceptable vehicle or diluent.
GB58874A 1972-11-08 1974-01-07 Piperazinyl-and monopiperazinyl monoalkanol esters and a process of production thereof Expired GB1416412A (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
JP47111219A JPS5210877B2 (en) 1972-11-08 1972-11-08
JP11229173A JPS5224032B2 (en) 1973-10-08 1973-10-08
JP48112289A JPS5224031B2 (en) 1972-11-08 1973-10-08
JP11229073A JPS5246235B2 (en) 1973-10-08 1973-10-08

Publications (1)

Publication Number Publication Date
GB1416412A true GB1416412A (en) 1975-12-03

Family

ID=27469891

Family Applications (1)

Application Number Title Priority Date Filing Date
GB58874A Expired GB1416412A (en) 1972-11-08 1974-01-07 Piperazinyl-and monopiperazinyl monoalkanol esters and a process of production thereof

Country Status (10)

Country Link
JP (2) JPS5210877B2 (en)
AT (1) AT333287B (en)
BE (1) BE807031A (en)
CA (1) CA1055492A (en)
CH (1) CH591465A5 (en)
DE (1) DE2355420A1 (en)
FR (1) FR2205515B1 (en)
GB (1) GB1416412A (en)
NL (1) NL7400278A (en)
SE (1) SE398502B (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HU173380B (en) * 1977-02-25 1979-04-28 Richter Gedeon Vegyeszet Process for producing new pyridyl-piperazine derivatives and acid additional salts thereof
JPS53144591A (en) * 1977-05-20 1978-12-15 Asutaabueruke Ag Chem Fuaburii Process for preparing homopirerazine
DE3403778A1 (en) * 1984-02-03 1985-08-08 Degussa Ag, 6000 Frankfurt CYANOMETHYL- (2-CYANO-ETHYL) - (3-HYDROXY-PROPYL) -AMINE HIS USE FOR PRODUCING 1- (3-HYDROXY-PROPYL) -1,4-DIAZEPANE AND 1,4-BIS (3- (3rd , 4,5-TRIMETHOXYBENZOYLOXY) -PROPYL) -DIAZEPAN

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2088018A1 (en) * 1970-05-03 1972-01-07 Rabot Ets David Vasodilatory, substd nicotinic acid amino ester derivs
FR2088019A1 (en) * 1970-05-08 1972-01-07 Rabot Ets David Esters of 2 and 6-substituted nicotinic acids - with vasomotor active
FR2134121A1 (en) * 1971-04-20 1972-12-08 Penciolelli Madeleine Piperazino ethyl phloroglucates prepn - useful as vasodilators

Also Published As

Publication number Publication date
JPS5062983A (en) 1975-05-29
FR2205515A1 (en) 1974-05-31
AT333287B (en) 1976-11-10
SE7400215L (en) 1975-04-16
FR2205515B1 (en) 1978-11-17
ATA13574A (en) 1976-03-15
BE807031A (en) 1974-03-01
SE398502B (en) 1977-12-27
JPS5210877B2 (en) 1977-03-26
JPS49132088A (en) 1974-12-18
CA1055492A (en) 1979-05-29
NL7400278A (en) 1975-04-10
JPS5224031B2 (en) 1977-06-28
CH591465A5 (en) 1977-09-15
DE2355420A1 (en) 1974-07-04

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Legal Events

Date Code Title Description
PS Patent sealed [section 19, patents act 1949]
PCNP Patent ceased through non-payment of renewal fee