GB1416412A - Piperazinyl-and monopiperazinyl monoalkanol esters and a process of production thereof - Google Patents
Piperazinyl-and monopiperazinyl monoalkanol esters and a process of production thereofInfo
- Publication number
- GB1416412A GB1416412A GB58874A GB58874A GB1416412A GB 1416412 A GB1416412 A GB 1416412A GB 58874 A GB58874 A GB 58874A GB 58874 A GB58874 A GB 58874A GB 1416412 A GB1416412 A GB 1416412A
- Authority
- GB
- United Kingdom
- Prior art keywords
- monopiperazinyl
- monoalkanol
- piperazinyl
- esters
- production
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
- C07D295/084—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
- C07D295/088—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Pain & Pain Management (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Pyridine Compounds (AREA)
Abstract
1416412 Piperazine and homopiperazine derivatives HOKURIKU PHARMACEUTICAL CO Ltd 7 Jan 1974 [8 Oct 1973 (3)] 00588/74 Heading C2C Novel compounds I (in which R is phenyl substituted with one or more of C 1-6 alkyl, C 1-6 alkoxy and halogen; or styryl or pyridyl optionally substituted with one or more C 1-6 alkoxy groups and n and m are 2 or 3) and salts thereof, are prepared by esterification of an alcohol of Formula (II) or a salt thereof, with an appropriate acid. Pharmaceutical compositions having analgesic, coronary vasodilative, anti-convulsant and blood pressure decreasing properties comprise one of the above novel compounds together with a pharmaceutically acceptable vehicle or diluent.
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP47111219A JPS5210877B2 (en) | 1972-11-08 | 1972-11-08 | |
JP11229173A JPS5224032B2 (en) | 1973-10-08 | 1973-10-08 | |
JP11229073A JPS5246235B2 (en) | 1973-10-08 | 1973-10-08 | |
JP48112289A JPS5224031B2 (en) | 1972-11-08 | 1973-10-08 |
Publications (1)
Publication Number | Publication Date |
---|---|
GB1416412A true GB1416412A (en) | 1975-12-03 |
Family
ID=27469891
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
GB58874A Expired GB1416412A (en) | 1972-11-08 | 1974-01-07 | Piperazinyl-and monopiperazinyl monoalkanol esters and a process of production thereof |
Country Status (10)
Country | Link |
---|---|
JP (2) | JPS5210877B2 (en) |
AT (1) | AT333287B (en) |
BE (1) | BE807031A (en) |
CA (1) | CA1055492A (en) |
CH (1) | CH591465A5 (en) |
DE (1) | DE2355420A1 (en) |
FR (1) | FR2205515B1 (en) |
GB (1) | GB1416412A (en) |
NL (1) | NL7400278A (en) |
SE (1) | SE398502B (en) |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
HU173380B (en) * | 1977-02-25 | 1979-04-28 | Richter Gedeon Vegyeszet | Process for producing new pyridyl-piperazine derivatives and acid additional salts thereof |
JPS53144591A (en) * | 1977-05-20 | 1978-12-15 | Asutaabueruke Ag Chem Fuaburii | Process for preparing homopirerazine |
DE3403778A1 (en) * | 1984-02-03 | 1985-08-08 | Degussa Ag, 6000 Frankfurt | CYANOMETHYL- (2-CYANO-ETHYL) - (3-HYDROXY-PROPYL) -AMINE HIS USE FOR PRODUCING 1- (3-HYDROXY-PROPYL) -1,4-DIAZEPANE AND 1,4-BIS (3- (3rd , 4,5-TRIMETHOXYBENZOYLOXY) -PROPYL) -DIAZEPAN |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2088018A1 (en) * | 1970-05-03 | 1972-01-07 | Rabot Ets David | Vasodilatory, substd nicotinic acid amino ester derivs |
FR2088019A1 (en) * | 1970-05-08 | 1972-01-07 | Rabot Ets David | Esters of 2 and 6-substituted nicotinic acids - with vasomotor active |
FR2134121A1 (en) * | 1971-04-20 | 1972-12-08 | Penciolelli Madeleine | Piperazino ethyl phloroglucates prepn - useful as vasodilators |
-
1972
- 1972-11-08 JP JP47111219A patent/JPS5210877B2/ja not_active Expired
-
1973
- 1973-10-08 JP JP48112289A patent/JPS5224031B2/ja not_active Expired
- 1973-11-06 DE DE19732355420 patent/DE2355420A1/en not_active Ceased
- 1973-11-07 BE BE137507A patent/BE807031A/en unknown
- 1973-11-07 FR FR7340568A patent/FR2205515B1/fr not_active Expired
-
1974
- 1974-01-07 GB GB58874A patent/GB1416412A/en not_active Expired
- 1974-01-07 CA CA189,574A patent/CA1055492A/en not_active Expired
- 1974-01-08 SE SE7400215A patent/SE398502B/en unknown
- 1974-01-09 NL NL7400278A patent/NL7400278A/en not_active Application Discontinuation
- 1974-01-09 AT AT13574*#A patent/AT333287B/en not_active IP Right Cessation
- 1974-02-12 CH CH191374A patent/CH591465A5/xx not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
DE2355420A1 (en) | 1974-07-04 |
JPS5224031B2 (en) | 1977-06-28 |
SE7400215L (en) | 1975-04-16 |
FR2205515B1 (en) | 1978-11-17 |
BE807031A (en) | 1974-03-01 |
JPS5210877B2 (en) | 1977-03-26 |
CH591465A5 (en) | 1977-09-15 |
SE398502B (en) | 1977-12-27 |
AT333287B (en) | 1976-11-10 |
JPS5062983A (en) | 1975-05-29 |
JPS49132088A (en) | 1974-12-18 |
NL7400278A (en) | 1975-04-10 |
ATA13574A (en) | 1976-03-15 |
CA1055492A (en) | 1979-05-29 |
FR2205515A1 (en) | 1974-05-31 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
PS | Patent sealed [section 19, patents act 1949] | ||
PCNP | Patent ceased through non-payment of renewal fee |