ES8706110A1 - Un procedimiento para la preparacion de derivados de alfa-aminoalquil-alfa-alquilfenilacetonitrilo. - Google Patents
Un procedimiento para la preparacion de derivados de alfa-aminoalquil-alfa-alquilfenilacetonitrilo.Info
- Publication number
- ES8706110A1 ES8706110A1 ES547930A ES547930A ES8706110A1 ES 8706110 A1 ES8706110 A1 ES 8706110A1 ES 547930 A ES547930 A ES 547930A ES 547930 A ES547930 A ES 547930A ES 8706110 A1 ES8706110 A1 ES 8706110A1
- Authority
- ES
- Spain
- Prior art keywords
- alpha
- aminoalkyl
- novel
- alkylphenylacetonitriles
- cartino
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C255/00—Carboxylic acid nitriles
- C07C255/01—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms
- C07C255/32—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms having cyano groups bound to acyclic carbon atoms of a carbon skeleton containing at least one six-membered aromatic ring
- C07C255/37—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms having cyano groups bound to acyclic carbon atoms of a carbon skeleton containing at least one six-membered aromatic ring the carbon skeleton being further substituted by etherified hydroxy groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C255/00—Carboxylic acid nitriles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/275—Nitriles; Isonitriles
- A61K31/277—Nitriles; Isonitriles having a ring, e.g. verapamil
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C253/00—Preparation of carboxylic acid nitriles
- C07C253/30—Preparation of carboxylic acid nitriles by reactions not involving the formation of cyano groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
PROCEDIMIENTO PARA PREPARAR DERIVADOS DE A-AMINOALQUIL-A-ALQUILFENILACETONITRILO. CONSISTE EN TRATAR A UN ALDEHIDO DE FORMULA (II) CON UNA AMINA DE FORMULA (III), EN PRESENCIA DE HIDRURO SODICO Y EN BUTAMOL, PARA OBTENER UN COMPUESTO DE FORMULA (I) Y SUS SALES. SIENDO: R1, R2 Y R3, H O ALCOXI INFERIOR; R4, ALQUILO INFERIOR DE CADENA LINEAL O RAMIFICADA; R5, H O ALQUILO INFERIOR; R6 Y R7, HAL, H, ALQUILO INFERIOR Y OTRO; K, 1 O 2; Y M Y N, 2 O 3. SE UTILIZAN COMO CARDIOVASCULARES.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP21639984A JPS6197252A (ja) | 1984-10-17 | 1984-10-17 | α−アミノアルキル−α−アルキルフエニルアセトニトリル誘導体 |
JP60160278A JPS6222750A (ja) | 1985-07-22 | 1985-07-22 | α−アミノアルキル−α−アルキルフエニルアセトニトリル誘導体 |
Publications (2)
Publication Number | Publication Date |
---|---|
ES547930A0 ES547930A0 (es) | 1987-06-01 |
ES8706110A1 true ES8706110A1 (es) | 1987-06-01 |
Family
ID=26486832
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES547930A Expired ES8706110A1 (es) | 1984-10-17 | 1985-10-16 | Un procedimiento para la preparacion de derivados de alfa-aminoalquil-alfa-alquilfenilacetonitrilo. |
Country Status (10)
Country | Link |
---|---|
US (1) | US4612329A (es) |
EP (1) | EP0180810B1 (es) |
KR (1) | KR860003205A (es) |
AU (1) | AU584547B2 (es) |
CA (1) | CA1260000A (es) |
DE (1) | DE3564103D1 (es) |
DK (1) | DK476685A (es) |
ES (1) | ES8706110A1 (es) |
HU (1) | HU195476B (es) |
YU (1) | YU165185A (es) |
Families Citing this family (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CS258534B1 (en) * | 1986-07-18 | 1988-08-16 | Ludvik Blaha | Derivatives of valeronitrile and method of their preparation |
DE3642331A1 (de) * | 1986-12-11 | 1988-06-23 | Basf Ag | Basisch substituierte phenylacetonitrile, ihre herstellung und diese enthaltende arzneimittel |
US4981871A (en) * | 1987-05-15 | 1991-01-01 | Abelson Mark B | Treatment of ocular hypertension with class I calcium channel blocking agents |
EP0370712A3 (en) * | 1988-11-18 | 1991-10-02 | Ajinomoto Co., Inc. | Ethylamine derivatives and hypotensives containing the same |
IE904628A1 (en) * | 1989-12-21 | 1991-07-17 | Searle & Co | w-Amino-Ó-Phenylalkanonitrile Derivatives |
DE69131842T2 (de) * | 1990-10-05 | 2000-07-27 | Ajinomoto Kk | Piperidinderivate und ihre Verwendung als antiarrhythmische Wirkstoffe |
FR2717473B1 (fr) * | 1994-03-16 | 1996-06-28 | Esteve Labor Dr | Dérivés de cyclopropylacétonitrile, leur préparation et leur application comme médicaments. |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE1154810B (de) * | 1961-04-01 | 1963-09-26 | Knoll Ag | Verfahren zur Herstellung basisch substituierter Phenylacetonitrile |
DE3034221A1 (de) * | 1980-09-11 | 1982-04-22 | Basf Ag, 6700 Ludwigshafen | Verfahren zur herstellung basisch substituierter phenylacetonitrile |
DE3144150A1 (de) * | 1981-04-10 | 1982-12-09 | Basf Ag, 6700 Ludwigshafen | (omega)-cyan-1,(omega)-diphenyl-azaalkan-derivate, ihre herstellung und diese enthaltende arzneimittel |
DE3121766A1 (de) * | 1981-06-02 | 1982-12-16 | Basf Ag, 6700 Ludwigshafen | Verfahren zur herstellung basisch substituierter phenylacetonitrile |
DE3433383A1 (de) * | 1984-09-12 | 1986-03-20 | Boehringer Mannheim Gmbh, 6800 Mannheim | Neue phenyl-acetonitril-derivate |
-
1985
- 1985-10-11 US US06/786,742 patent/US4612329A/en not_active Expired - Fee Related
- 1985-10-12 DE DE8585112977T patent/DE3564103D1/de not_active Expired
- 1985-10-12 EP EP85112977A patent/EP0180810B1/en not_active Expired
- 1985-10-14 AU AU48738/85A patent/AU584547B2/en not_active Ceased
- 1985-10-16 KR KR1019850007607A patent/KR860003205A/ko not_active Application Discontinuation
- 1985-10-16 HU HU854015A patent/HU195476B/hu not_active IP Right Cessation
- 1985-10-16 YU YU165185A patent/YU165185A/sh unknown
- 1985-10-16 ES ES547930A patent/ES8706110A1/es not_active Expired
- 1985-10-17 DK DK476685A patent/DK476685A/da not_active Application Discontinuation
- 1985-10-17 CA CA000493147A patent/CA1260000A/en not_active Expired
Also Published As
Publication number | Publication date |
---|---|
EP0180810A1 (en) | 1986-05-14 |
HU195476B (en) | 1988-05-30 |
DK476685A (da) | 1986-07-03 |
DE3564103D1 (de) | 1988-09-08 |
ES547930A0 (es) | 1987-06-01 |
DK476685D0 (da) | 1985-10-17 |
HUT40073A (en) | 1986-11-28 |
CA1260000A (en) | 1989-09-26 |
EP0180810B1 (en) | 1988-08-03 |
AU4873885A (en) | 1986-04-24 |
AU584547B2 (en) | 1989-05-25 |
YU165185A (sh) | 1992-09-07 |
US4612329A (en) | 1986-09-16 |
KR860003205A (ko) | 1986-05-21 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FD1A | Patent lapsed |
Effective date: 19970203 |