RO85385B - Procedeu pentru prepararea unor derivati de tiazol - Google Patents
Procedeu pentru prepararea unor derivati de tiazolInfo
- Publication number
- RO85385B RO85385B RO110351A RO11035183A RO85385B RO 85385 B RO85385 B RO 85385B RO 110351 A RO110351 A RO 110351A RO 11035183 A RO11035183 A RO 11035183A RO 85385 B RO85385 B RO 85385B
- Authority
- RO
- Romania
- Prior art keywords
- sub
- sup
- alkyl
- aryl
- alkynyl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/22—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
- C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
- C07D295/194—Radicals derived from thio- or thiono carboxylic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/22—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C07D277/28—Radicals substituted by nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D277/56—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Thiazole And Isothizaole Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Cephalosporin Compounds (AREA)
- Supply Devices, Intensifiers, Converters, And Telemotors (AREA)
- Fats And Perfumes (AREA)
- Diaphragms For Electromechanical Transducers (AREA)
- Treating Waste Gases (AREA)
- Earth Drilling (AREA)
- Inert Electrodes (AREA)
Abstract
Inventia se refera la un procedeu pentru prepararea unor derivati de tioazol, cu formula generala I: (vezi formula) în care R1 si R2 sînt identici sau diferiti si reprezinta hidrogen, alchil cu 1...4 atomi de carbon sau, împreuna cu atomul de azot la care sînt legati, formeaza un heterocicul, ales dintre piperidino, morfolino si pirolidino, m este 1,2,3 n este 2 sau 3, R3 reprezinta o grupa alchenil cu 2...4 atomi de carbon sau o grupa alchinil cu 2...4 atomi de carbon, R4 si r5 sînt identici sau diferiti si reprezinta hidrogen, metil sau etil, cu conditia ca numarul total de atomi de carbon din grupa C R4R5R3 sa fie mai mic de 7, constînd din aceea ca o amina cu formula generala Ii: (vezi formula) în care substituentii R1 si r2 au semnificatiile de mai sus se trateaza cu un compus cu formula generala II: (vezi formula) în care substituentii R3, R4 si R5 au semnificatiile de mai sus si L1 este o grupa scindabila tioalchil cu 1...4 atomi de carbon, reactia avînd loc în apa, la o temperatura cuprinsa între 40 si 50 degree C.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US06/360,034 US4474794A (en) | 1982-03-19 | 1982-03-19 | N-Thiazolylmethylthioalkyl-N1 -alkenyl (or alkynyl)guanidines and related compounds |
Publications (2)
Publication Number | Publication Date |
---|---|
RO85385A RO85385A (ro) | 1984-11-25 |
RO85385B true RO85385B (ro) | 1984-11-30 |
Family
ID=23416322
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
RO110351A RO85385B (ro) | 1982-03-19 | 1983-03-16 | Procedeu pentru prepararea unor derivati de tiazol |
Country Status (22)
Country | Link |
---|---|
US (1) | US4474794A (ro) |
EP (1) | EP0091220B1 (ro) |
JP (1) | JPS58170773A (ro) |
KR (1) | KR840004091A (ro) |
AT (1) | ATE27156T1 (ro) |
AU (1) | AU1254583A (ro) |
CA (1) | CA1190547A (ro) |
CS (1) | CS236788B2 (ro) |
DD (1) | DD207376A5 (ro) |
DE (1) | DE3371514D1 (ro) |
DK (1) | DK91083A (ro) |
ES (1) | ES8405386A1 (ro) |
FI (1) | FI830879L (ro) |
GB (1) | GB2116973B (ro) |
GR (1) | GR77882B (ro) |
IL (1) | IL68152A0 (ro) |
NZ (1) | NZ203605A (ro) |
PH (1) | PH18504A (ro) |
PL (1) | PL241066A1 (ro) |
PT (1) | PT76397B (ro) |
RO (1) | RO85385B (ro) |
ZA (1) | ZA831882B (ro) |
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IL80961A0 (en) * | 1985-12-18 | 1987-03-31 | Lilly Co Eli | Synthesis of nizatidine |
ES2053462T3 (es) * | 1987-04-06 | 1994-08-01 | Heumann Pharma Gmbh & Co | Procedimiento para la produccion de derivados de nitroetano. |
NL9000132A (nl) * | 1990-01-19 | 1991-08-16 | Cedona Pharm Bv | Nieuwe thiazoolderivaten. |
EP4196793A1 (en) | 2020-08-11 | 2023-06-21 | Université de Strasbourg | H2 blockers targeting liver macrophages for the prevention and treatment of liver disease and cancer |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4200578A (en) * | 1978-12-18 | 1980-04-29 | Bristol-Myers Company | Thiazole derivatives |
US4375547A (en) * | 1980-10-02 | 1983-03-01 | Eli Lilly And Company | N-Methyl-N'-2-([(2-dimethylaminomethyl)-4-thiazolyl]methylthio)ethyl 2-nitro-1,1-ethenediamine |
-
1982
- 1982-03-19 US US06/360,034 patent/US4474794A/en not_active Expired - Fee Related
-
1983
- 1983-02-25 DK DK91083A patent/DK91083A/da not_active Application Discontinuation
- 1983-03-16 GR GR70814A patent/GR77882B/el unknown
- 1983-03-16 CA CA000423708A patent/CA1190547A/en not_active Expired
- 1983-03-16 DE DE8383301461T patent/DE3371514D1/de not_active Expired
- 1983-03-16 GB GB08307201A patent/GB2116973B/en not_active Expired
- 1983-03-16 AT AT83301461T patent/ATE27156T1/de not_active IP Right Cessation
- 1983-03-16 IL IL68152A patent/IL68152A0/xx unknown
- 1983-03-16 RO RO110351A patent/RO85385B/ro unknown
- 1983-03-16 FI FI830879A patent/FI830879L/fi not_active Application Discontinuation
- 1983-03-16 PT PT76397A patent/PT76397B/pt unknown
- 1983-03-16 EP EP83301461A patent/EP0091220B1/en not_active Expired
- 1983-03-17 AU AU12545/83A patent/AU1254583A/en not_active Abandoned
- 1983-03-17 PH PH28661A patent/PH18504A/en unknown
- 1983-03-17 PL PL24106683A patent/PL241066A1/xx unknown
- 1983-03-17 NZ NZ203605A patent/NZ203605A/en unknown
- 1983-03-17 DD DD83248911A patent/DD207376A5/de unknown
- 1983-03-17 JP JP58047005A patent/JPS58170773A/ja active Pending
- 1983-03-17 ZA ZA831882A patent/ZA831882B/xx unknown
- 1983-03-17 KR KR1019830001082A patent/KR840004091A/ko not_active IP Right Cessation
- 1983-03-18 ES ES520791A patent/ES8405386A1/es not_active Expired
-
1984
- 1984-03-16 CS CS831821A patent/CS236788B2/cs unknown
Also Published As
Publication number | Publication date |
---|---|
PL241066A1 (en) | 1985-01-02 |
DE3371514D1 (en) | 1987-06-19 |
DD207376A5 (de) | 1984-02-29 |
JPS58170773A (ja) | 1983-10-07 |
GB2116973B (en) | 1985-08-29 |
KR840004091A (ko) | 1984-10-06 |
GB2116973A (en) | 1983-10-05 |
PH18504A (en) | 1985-08-02 |
AU1254583A (en) | 1983-09-22 |
FI830879A0 (fi) | 1983-03-16 |
PT76397A (en) | 1983-04-01 |
NZ203605A (en) | 1985-10-11 |
EP0091220A3 (en) | 1984-05-23 |
GB8307201D0 (en) | 1983-04-20 |
ZA831882B (en) | 1984-11-28 |
RO85385A (ro) | 1984-11-25 |
DK91083D0 (da) | 1983-02-25 |
EP0091220A2 (en) | 1983-10-12 |
IL68152A0 (en) | 1983-06-15 |
ES520791A0 (es) | 1984-06-01 |
FI830879L (fi) | 1983-09-20 |
ATE27156T1 (de) | 1987-05-15 |
US4474794A (en) | 1984-10-02 |
CS236788B2 (en) | 1985-05-15 |
EP0091220B1 (en) | 1987-05-13 |
CA1190547A (en) | 1985-07-16 |
ES8405386A1 (es) | 1984-06-01 |
PT76397B (en) | 1986-02-04 |
GR77882B (ro) | 1984-09-25 |
DK91083A (da) | 1983-09-20 |
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