DE3881246D1 - Durch benzhydryl n-substituierte heterocyclische derivate, ihre herstellung und ihre verwendung. - Google Patents

Durch benzhydryl n-substituierte heterocyclische derivate, ihre herstellung und ihre verwendung.

Info

Publication number
DE3881246D1
DE3881246D1 DE8888302414T DE3881246T DE3881246D1 DE 3881246 D1 DE3881246 D1 DE 3881246D1 DE 8888302414 T DE8888302414 T DE 8888302414T DE 3881246 T DE3881246 T DE 3881246T DE 3881246 D1 DE3881246 D1 DE 3881246D1
Authority
DE
Germany
Prior art keywords
benzhydryl
substituted
production
halo
substituted heterocyclic
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE8888302414T
Other languages
English (en)
Other versions
DE3881246T2 (de
Inventor
Koichi C O Sankyo Compan Hirai
Katsumi C O Sankyo Co Fujimoto
Yuji C O Sankyo Company Iwano
Yoshiki C O Sankyo Comp Matsui
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sankyo Co Ltd
Original Assignee
Sankyo Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sankyo Co Ltd filed Critical Sankyo Co Ltd
Application granted granted Critical
Publication of DE3881246D1 publication Critical patent/DE3881246D1/de
Publication of DE3881246T2 publication Critical patent/DE3881246T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/12—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms
    • C07D295/125—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/13—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/04—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to the ring carbon atoms
    • C07D215/08—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to the ring carbon atoms with acylated ring nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/14—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D295/145—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/15—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
DE88302414T 1987-03-18 1988-03-18 Durch Benzhydryl N-substituierte heterocyclische Derivate, ihre Herstellung und ihre Verwendung. Expired - Fee Related DE3881246T2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP6315787 1987-03-18

Publications (2)

Publication Number Publication Date
DE3881246D1 true DE3881246D1 (de) 1993-07-01
DE3881246T2 DE3881246T2 (de) 1994-01-27

Family

ID=13221117

Family Applications (1)

Application Number Title Priority Date Filing Date
DE88302414T Expired - Fee Related DE3881246T2 (de) 1987-03-18 1988-03-18 Durch Benzhydryl N-substituierte heterocyclische Derivate, ihre Herstellung und ihre Verwendung.

Country Status (7)

Country Link
US (1) US5028610A (de)
EP (1) EP0283310B1 (de)
KR (1) KR880011123A (de)
AT (1) ATE89822T1 (de)
CA (1) CA1326027C (de)
DE (1) DE3881246T2 (de)
ES (1) ES2056913T3 (de)

Families Citing this family (44)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5229406A (en) * 1990-09-19 1993-07-20 G. D. Searle & Co. 1,3,5-trisubstituted-1,2,4-triazole compounds for treatment of circulatory disorders
US5140036A (en) * 1990-09-19 1992-08-18 G. D. Searle & Co. 1,3,5-trisubstituted-1,2,4-triazole compounds for treatment of circulatory disorders
EP0553191B1 (de) * 1990-10-10 1995-05-17 Schering Corporation Pyridin- und pyridin-n-oxid-derivate von diarylmethyl- piperidinen oder piperazinen, deren zusammensetzungen und anwendung
US5238952A (en) * 1990-10-31 1993-08-24 G. D. Searle & Co. N-substituted imidazol-2-one compounds for treatment of circulatory disorders
US5087634A (en) * 1990-10-31 1992-02-11 G. D. Searle & Co. N-substituted imidazol-2-one compounds for treatment of circulatory disorders
US5196537A (en) * 1991-03-21 1993-03-23 G. D. Searle & Co. 5-apylheteroarylalkyl-1,3,5-trisubstituted-1,2,4-triazole compounds for treatment of circulatory disorders
US5164403A (en) * 1991-04-05 1992-11-17 G. D. Searle & Co. N-arylheteroarylalkyl imidazol-2-one compounds for treatment of circulatory disorders
TW198008B (de) * 1991-04-08 1993-01-11 Green Cross Corp
CA2067475C (en) * 1991-05-08 2000-10-10 Yasuo Oshiro Carbostyril derivatives and their use
US5378698A (en) * 1991-10-21 1995-01-03 Shionogi & Co., Ltd. Benzothiazepine derivatives
WO1993020080A1 (en) * 1992-03-27 1993-10-14 Schering Corporation Bridged bis-aryl carbinol derivatives, compositions and methods of use
ES2089815T3 (es) * 1992-03-27 1996-10-01 Schering Corp Derivados de bis-aril-carbinol sin enlaces de puente, composiciones y metodos de uso.
FR2693722B1 (fr) * 1992-07-16 1994-10-14 Meram Lab Dérivés de la N-cycloalkylpipérazine, procédé d'obtention et compositions pharmaceutiques les contenant.
US6380254B2 (en) 1994-01-24 2002-04-30 Leigh Biotechnology, Inc. Method and composition for treating and preventing pathogenic effects caused by intracellular calcium overload
SE9504661D0 (sv) * 1995-12-22 1995-12-22 Astra Pharma Inc New compounds
SE9504662D0 (sv) * 1995-12-22 1995-12-22 Astra Pharma Inc New compounds
EP0914319B1 (de) * 1996-05-20 2001-11-21 Teijin Limited Cyclischer diarylalkyl diaminederivate als antogoniste von chemokinerezeptoren
US6063794A (en) 1996-10-11 2000-05-16 Cor Therapeutics Inc. Selective factor Xa inhibitors
US6369080B2 (en) 1996-10-11 2002-04-09 Cor Therapeutics, Inc. Selective factor Xa inhibitors
US6262047B1 (en) 1996-10-11 2001-07-17 Cor Therapeutics, Inc. Selective factor Xa inhibitors
US6194435B1 (en) 1996-10-11 2001-02-27 Cor Therapeutics, Inc. Lactams as selective factor Xa inhibitors
CA2285659A1 (en) 1997-04-14 1998-10-22 Cor Therapeutics, Inc. Selective factor xa inhibitors
EP0975625A1 (de) * 1997-04-14 2000-02-02 Cor Therapeutics, Inc. AUSWÄHLEND Xa KAKTOR INHIBITOREN
WO1998046628A1 (en) * 1997-04-14 1998-10-22 Cor Therapeutics, Inc. SELECTIVE FACTOR Xa INHIBITORS
NZ500353A (en) 1997-04-14 2002-02-01 Cor Therapeutics Inc Cyclic diaza compounds that are selective inhibitors of factor Xa
US6228854B1 (en) 1997-08-11 2001-05-08 Cor Therapeutics, Inc. Selective factor Xa inhibitors
US6218382B1 (en) 1997-08-11 2001-04-17 Cor Therapeutics, Inc Selective factor Xa inhibitors
US6333321B1 (en) 1997-08-11 2001-12-25 Cor Therapeutics, Inc. Selective factor Xa inhibitors
GB9923748D0 (en) * 1999-10-07 1999-12-08 Glaxo Group Ltd Chemical compounds
USRE39921E1 (en) 1999-10-07 2007-11-13 Smithkline Beecham Corporation Chemical compounds
SE9904673D0 (sv) 1999-12-20 1999-12-20 Astra Pharma Inc Novel compounds
SE9904674D0 (sv) 1999-12-20 1999-12-20 Astra Pharma Inc Novel compounds
SE0001209D0 (sv) 2000-04-04 2000-04-04 Astrazeneca Canada Inc Novel compounds
GB0025354D0 (en) * 2000-10-17 2000-11-29 Glaxo Group Ltd Chemical compounds
GB0108594D0 (en) * 2001-04-05 2001-05-23 Glaxo Group Ltd Chemical compounds
WO2002094794A1 (en) 2001-05-18 2002-11-28 Astrazeneca Ab 4 (phenyl-piperazinyl-methyl) benzamide derivatives and their use for the treatment of pain anxiety or gastrointestinal disorders
GB0203020D0 (en) 2002-02-08 2002-03-27 Glaxo Group Ltd Chemical compounds
GB0203022D0 (en) * 2002-02-08 2002-03-27 Glaxo Group Ltd Chemical compounds
US7482365B2 (en) * 2002-02-08 2009-01-27 Glaxo Group Limited Piperidylcarboxamide derivatives and their use in the treatment of tachykinin-mediated diseases
SE0203303D0 (sv) 2002-11-07 2002-11-07 Astrazeneca Ab Novel Compounds
SE0203302D0 (sv) 2002-11-07 2002-11-07 Astrazeneca Ab Novel Compounds
SE0203300D0 (sv) 2002-11-07 2002-11-07 Astrazeneca Ab Novel Compounds
KR101234421B1 (ko) 2004-08-02 2013-02-18 아스트라제네카 아베 디아릴메틸 피페라진 유도체, 이의 제조 방법 및 용도
EP2024364A1 (de) * 2006-05-26 2009-02-18 Neuromed Pharmaceuticals, Ltd. Heterocyclische verbindungen als calciumkanalblocker

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3244718A (en) * 1964-02-17 1966-04-05 Biel John Hans Piperazine derivatives
DE1795375A1 (de) * 1968-09-21 1972-01-05 Boehringer Mannheim Gmbh Basische AEther und Verfahren zur Herstellung derselben
US3953448A (en) * 1972-12-07 1976-04-27 Delmar Chemicals Limited Piperazino-anilido compounds
JPS59118765A (ja) * 1982-12-24 1984-07-09 Fujisawa Pharmaceut Co Ltd ピペラジン誘導体
US4567264A (en) * 1983-05-18 1986-01-28 Syntex (U.S.A.) Inc. Cardioselective aryloxy- and arylthio- hydroxypropylene-piperazinyl acetanilides which affect calcium entry
IT1190375B (it) * 1985-06-20 1988-02-16 Recordati Chem Pharm N-benzidrildiazacicloalchil-alcanilidi ad attivita' antianafilattica ed antibroncospastica
HU196196B (en) * 1986-04-28 1988-10-28 Richter Gedeon Vegyeszet Process for producing new benzhydryl-piperazine derivatives and pharmaceuticals comprising the compounds
US4780495A (en) * 1986-07-21 1988-10-25 The B. F. Goodrich Company N-(substituted)-α-(3,5-dialkyl-4-hydroxyphenyl)-α,α-disubstituted acetamides, and composition stabilized therewith

Also Published As

Publication number Publication date
DE3881246T2 (de) 1994-01-27
EP0283310B1 (de) 1993-05-26
KR880011123A (ko) 1988-10-26
US5028610A (en) 1991-07-02
CA1326027C (en) 1994-01-11
EP0283310A1 (de) 1988-09-21
ES2056913T3 (es) 1994-10-16
ATE89822T1 (de) 1993-06-15

Similar Documents

Publication Publication Date Title
DE3881246D1 (de) Durch benzhydryl n-substituierte heterocyclische derivate, ihre herstellung und ihre verwendung.
DE69120500D1 (de) Azasteroide zur Behandlung prostatischer Hypertrophie, ihre Herstellung und Verwendung
ATE117685T1 (de) Chinoloncarbonsäure-derivate.
IL68075A0 (en) Pyridine and pyrane derivatives,their preparation and pharmaceutical compositions containing them
HUT61742A (en) Process for producing cyclic amide derivatives and pharmaceutical compositions comprising same
HUT47268A (en) Process for production of dihydro-piridine-derivatives and medical compositions containing them as active substance
HUT59394A (en) Process for producing piperazine derivatives and pharmaceutical compositions comprising same
FI914187A0 (fi) Menetelmä valmistaa kaavan /I/ mukaista 1-metyylikarbapeneemijohdosta
NO910804D0 (no) Substituerte beta-diketoner.
HUT50337A (en) Process for producing benzoxazine derivatives and pharmaceutical compositions comprising the compounds
DE69023939T2 (de) Förderung der Osteogenese durch Verwendung von Vitamin D-Derivaten.
DE3472104D1 (en) N-substituted ûbis(hydroxymethyl)-methyl¨-isoquinoline derivatives, process for preparing them and pharmaceutical compositions containing them
DE3569528D1 (en) Penem derivatives, methods of producing them, their use and pharmaceutical compositions
SE8002426L (sv) Nya derivat av 2-(2-pyridyl)tetrahydrotiofen
ATE125256T1 (de) Zwischenprodukte der mureidomycin-gruppe, ihre herstellung und verwendung.
HUT60261A (en) Process for producing piperazine derivatives and pharmaceutical compositions comprising same
ATE86629T1 (de) 4-piperidincarboxamid-derivate.

Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee