ES2089815T3 - Derivados de bis-aril-carbinol sin enlaces de puente, composiciones y metodos de uso. - Google Patents
Derivados de bis-aril-carbinol sin enlaces de puente, composiciones y metodos de uso.Info
- Publication number
- ES2089815T3 ES2089815T3 ES93908326T ES93908326T ES2089815T3 ES 2089815 T3 ES2089815 T3 ES 2089815T3 ES 93908326 T ES93908326 T ES 93908326T ES 93908326 T ES93908326 T ES 93908326T ES 2089815 T3 ES2089815 T3 ES 2089815T3
- Authority
- ES
- Spain
- Prior art keywords
- group
- aril
- carbinol
- bis
- derivatives
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Pulmonology (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Immunology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Saccharide Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
Abstract
SE DESCRIBE UN COMPUESTO DE FORMULA (1.0) O UNA SAL FARMACEUTICAMENTE ACEPTABLE O DISOLUCION DE ELLA, EN DONDE AR1 REPRESENTA (A), AR2 REPRESENTA (B) O UN GRUPO AROMATICO HETEROCICLICO DE CINCO MIEMBROS SELECCIONADO DEL GRUPO COMPUESTO DE FORMULAS (I A XII), EN DONDE LOS ATOMOS DE CARBONO SUSTITUIBLES DEL GRUPO HETEROCICLICO DE CINCO MIEMBROS PUEDE OPCIONALMENTE ESTAR SUSTITUIDO CON UN GRUPO R1. TAMBIEN SE DESCRIBEN COMPOSICIONES FARMACEUTICAS QUE CONTIENEN COMPUESTOS DE FORMULA (1.0). ADEMAS SE DESCRIBE UN METODO PARA TRATAR ASMA, ALERGIA E INFLAMACION MEDIANTE ADMINISTRACION DE UNA CANTIDAD EFECTIVA ANTI-ASMATICA, ANTI-ALERGICA O ANTI-INFLAMATORIA, RESPECTIVAMENTE DE UN COMPUESTO DE FORMULA (1.0).
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US85891992A | 1992-03-27 | 1992-03-27 |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2089815T3 true ES2089815T3 (es) | 1996-10-01 |
Family
ID=25329500
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES93908326T Expired - Lifetime ES2089815T3 (es) | 1992-03-27 | 1993-03-22 | Derivados de bis-aril-carbinol sin enlaces de puente, composiciones y metodos de uso. |
Country Status (13)
Country | Link |
---|---|
US (2) | US5679692A (es) |
EP (1) | EP0635012B1 (es) |
JP (1) | JPH07505393A (es) |
AT (1) | ATE140224T1 (es) |
AU (1) | AU3918993A (es) |
CA (1) | CA2132848A1 (es) |
DE (1) | DE69303605T2 (es) |
DK (1) | DK0635012T3 (es) |
ES (1) | ES2089815T3 (es) |
GR (1) | GR3021194T3 (es) |
HK (1) | HK31197A (es) |
MX (1) | MX9301721A (es) |
WO (1) | WO1993020063A1 (es) |
Families Citing this family (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
NZ249286A (en) * | 1992-02-13 | 1996-02-27 | Merrell Dow Pharma | Piperidine-4-ylmethyl thiophene and thiazole derivatives and pharmaceutical compositions |
WO2002089802A2 (en) | 2001-05-08 | 2002-11-14 | Schering Corporation | Use of neurokinin receptor antagonists to treat androgen-dependent diseases |
DK1423381T3 (da) | 2001-09-06 | 2007-05-07 | Schering Corp | 17beta-hydroxysteroid-dehydrogenase type 3-inhibitorer til behandling af androgenafhængige sygdomme |
AR036812A1 (es) * | 2001-10-17 | 2004-10-06 | Schering Corp | Inhibidores de la 17beta-hidroxiesteroide deshidrogenasa tipo 3, composiciones farmaceuticas y el uso de dichos compuestos para la fabricacion de medicamentos para el tratamiento de enfermedades androgeno-dependientes |
GB0302094D0 (en) | 2003-01-29 | 2003-02-26 | Pharmagene Lab Ltd | EP4 receptor antagonists |
GB0324269D0 (en) * | 2003-10-16 | 2003-11-19 | Pharmagene Lab Ltd | EP4 receptor antagonists |
US7338967B2 (en) * | 2004-09-10 | 2008-03-04 | Syngenta Limited | Substituted isoxazoles as fungicides |
Family Cites Families (44)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA780443A (en) * | 1968-03-12 | Sandoz Patents Limited | 10 h-(1) benzothiopyrano (3,2-b) pyridine derivatives | |
NL88063C (es) * | 1950-12-05 | |||
US2898339A (en) * | 1957-07-29 | 1959-08-04 | Wm S Merrell Co | N-substituted benzhydrol, benzhydryl, and benzhydrylidene piperidine |
GB1046543A (en) * | 1963-02-22 | 1966-10-26 | Sandoz Ag | Improvements in or relating to azathiaxanthene derivatives |
NL132137C (es) * | 1963-04-24 | |||
BE638971A (es) * | 1963-10-21 | |||
US3325501A (en) * | 1964-02-18 | 1967-06-13 | Sandoz Ltd | 9-[piperidylidene(4')]-1-aza-thiaxanthene-10-oxides and derivatives |
US3803154A (en) * | 1969-08-07 | 1974-04-09 | Colgate Palmolive Co | 11-cyclicaminoalkylidenemorphanthridines |
US3803153A (en) * | 1970-11-16 | 1974-04-09 | Schering Corp | Benzopyrano pyridines |
US3717647A (en) * | 1971-04-09 | 1973-02-20 | Schering Corp | Alpha-nicotinoyl phenylacetonitriles |
US4105849A (en) * | 1974-09-30 | 1978-08-08 | G. D. Searle & Co. | [(Substituted )phenyl]phenylmethyl-1-(dialkylaminoalkyl)piperidines |
US3922276A (en) * | 1974-12-11 | 1975-11-25 | Robins Co Inc A H | 1-Substituted-4-benzylidenepiperidines |
US3956296A (en) * | 1974-12-11 | 1976-05-11 | A. H. Robins Company, Incorporated | 1-Substituted-4-benzylpiperidines |
US4032642A (en) * | 1974-12-11 | 1977-06-28 | A. H. Robins Company, Incorporated | 1-Substituted-4-benzylpiperidines |
US3966944A (en) * | 1975-05-19 | 1976-06-29 | Abbott Laboratories | 10 (N-methyl-4-piperidylidene)-10H[1]-benzopyrano[3,2-b]-pyridine as an analgesic, anti-inflammatory and agent against type III hypersensitivity disease |
US4282233B1 (en) * | 1980-06-19 | 2000-09-05 | Schering Corp | Antihistaminic 11-(4-piperidylidene)-5h-benzoÄ5,6Ü-cyclohepta-Ä1,2Ü-pyridines |
US4355036A (en) * | 1980-06-19 | 1982-10-19 | Schering Corporation | Tricyclic-substituted piperidine antihistamines |
ATE13297T1 (de) * | 1980-09-02 | 1985-06-15 | Sandoz Ag | Piperidyliden-derivate, deren herstellung und diese enthaltende pharmazeutische zusammensetzungen. |
US4360483A (en) * | 1981-08-10 | 1982-11-23 | Ppg Industries, Inc. | Apparatus for and method of pressing plastic sheets |
JPS58171918A (ja) * | 1982-04-01 | 1983-10-08 | Asahi Chem Ind Co Ltd | 強靭なるアクリルシ−ト |
JPS59118765A (ja) * | 1982-12-24 | 1984-07-09 | Fujisawa Pharmaceut Co Ltd | ピペラジン誘導体 |
US4540780A (en) * | 1983-06-02 | 1985-09-10 | Warner-Lambert Company | Diphenylmethylene piperidines |
JPS61501205A (ja) * | 1984-02-15 | 1986-06-19 | シェリング・コ−ポレ−ション | 8↓−クロル↓−6,11↓−ジヒドロ↓−11↓−(4↓−ピペリジリデン)↓−5H↓−ベンゾ〔5,6〕シクロヘプタ〔1,2−b〕ピリジンおよびその塩、これらの化合物の製造方法、ならびにこれらの化合物を含有する医薬組成物 |
US4628095A (en) * | 1985-06-05 | 1986-12-09 | G. D. Searle & Co. | Substituted N-benzyl-4-(benzhydryl) piperidines |
US4632925A (en) * | 1985-10-07 | 1986-12-30 | Hoffmann-La Roche Inc. | N-substituted diphenylpiperidines and antiobesity use thereof |
US4810713A (en) * | 1985-12-20 | 1989-03-07 | A. H. Robins Company, Incorporated | Arylalkyl-heterocyclic amines, n-substituted by aryloxyalkyl groups used in a method for allergy treatment |
EP0235463A3 (en) * | 1985-12-20 | 1990-01-17 | A.H. ROBINS COMPANY, INCORPORATED (a Delaware corporation) | N-substituted-arylalkyl and arylalkylene piperidines as cardiovascular antihistaminic and antisecretory agents |
IL78939A (en) * | 1986-01-17 | 1990-04-29 | Robins Co Inc A H | Pharmaceutical compositions containing n-substituted arylalkyl-and arylalkylene-piperidines and tetrahydropyridines and certain such novel compounds |
US4826853A (en) * | 1986-10-31 | 1989-05-02 | Schering Corporation | 6,11-Dihydro-11-(N-substituted-4-piperidylidene)-5H-benzo(5,6)cyclohepta(1,2-B)pyridines and compositions and methods of use |
US5089496A (en) * | 1986-10-31 | 1992-02-18 | Schering Corporation | Benzo[5,6]cycloheptapyridine compounds, compositions and method of treating allergies |
US5028610A (en) * | 1987-03-18 | 1991-07-02 | Sankyo Company Limited | N-benzhydryl-substituted heterocyclic derivatives, their preparation and their use |
US4797489A (en) * | 1987-12-02 | 1989-01-10 | American Home Products Corp. | Adamantyl- and fluorenyl-arylpiperazines and -arylpiperidines |
US4835157A (en) * | 1988-03-15 | 1989-05-30 | Ortho Pharmaceutical Corporation | Thieno- and furopyrimidine-2,4-dione piperidine derivatives as serotonin antagonists and alpha adrenergic blocking agents |
NZ228888A (en) * | 1988-04-28 | 1991-12-23 | Schering Corp | Derivatives of piperidine, piperidylidene and piperazine and pharmaceutical compositions |
ES2091195T3 (es) * | 1988-04-28 | 1996-11-01 | Schering Corp | Compuestos policiclicos condensados, composiciones, metodos de preparacion y su uso como agentes antagonistas de paf, antihistaminicos y/o antiinflamatorios. |
CA2004211A1 (en) * | 1988-11-30 | 1990-05-31 | Masataka Syoji | Piperidine derivatives and hyportensives containing the same |
US4994456A (en) * | 1989-03-01 | 1991-02-19 | Nisshin Flour Milling Co., Ltd. | Pyridinecarboxylic acid amide derivatives and pharmaceutical compositions comprising same |
GB9000304D0 (en) * | 1990-01-06 | 1990-03-07 | Pfizer Ltd | Muscarinic receptor antagonists |
DE69027197T2 (de) * | 1990-01-19 | 1996-11-21 | Pharmacia Ab | Intraoculare Linse mit Haltebügeln hoher Festigkeit |
US5037435A (en) * | 1990-03-02 | 1991-08-06 | Optical Radiation Corporation | Haptics for intraocular lenses having high fracture toughness |
FR2665160A1 (fr) * | 1990-07-26 | 1992-01-31 | Esteve Labor Dr | Nouveaux derives de 1-diphenylmethylpiperazine, leur preparation et leur application en tant que medicaments. |
DK0553191T3 (da) * | 1990-10-10 | 1995-08-07 | Schering Corp | Pyridin- og pyridin-N-oxidderivater af diarylmethylpiperidiner eller -piperaziner, præparater og an vendelse deraf |
FR2673574B1 (fr) * | 1991-03-06 | 1994-11-04 | Pierre Delamare | Procede de fabrication de disques de polissage et disques ainsi obtenus. |
US5169569A (en) * | 1991-08-05 | 1992-12-08 | Richard Ingram | Method of making a one-piece intraocular lens |
-
1993
- 1993-03-22 ES ES93908326T patent/ES2089815T3/es not_active Expired - Lifetime
- 1993-03-22 AU AU39189/93A patent/AU3918993A/en not_active Abandoned
- 1993-03-22 JP JP5517464A patent/JPH07505393A/ja active Pending
- 1993-03-22 US US08/307,801 patent/US5679692A/en not_active Expired - Lifetime
- 1993-03-22 AT AT93908326T patent/ATE140224T1/de not_active IP Right Cessation
- 1993-03-22 CA CA002132848A patent/CA2132848A1/en not_active Abandoned
- 1993-03-22 DK DK93908326.7T patent/DK0635012T3/da active
- 1993-03-22 DE DE69303605T patent/DE69303605T2/de not_active Expired - Fee Related
- 1993-03-22 WO PCT/US1993/002289 patent/WO1993020063A1/en active IP Right Grant
- 1993-03-22 EP EP93908326A patent/EP0635012B1/en not_active Expired - Lifetime
- 1993-03-26 MX MX9301721A patent/MX9301721A/es not_active IP Right Cessation
-
1995
- 1995-06-02 US US08/459,149 patent/US5665735A/en not_active Expired - Lifetime
-
1996
- 1996-09-30 GR GR960402549T patent/GR3021194T3/el unknown
-
1997
- 1997-03-13 HK HK31197A patent/HK31197A/xx not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
GR3021194T3 (en) | 1996-12-31 |
WO1993020063A1 (en) | 1993-10-14 |
DE69303605D1 (de) | 1996-08-14 |
EP0635012A1 (en) | 1995-01-25 |
EP0635012B1 (en) | 1996-07-10 |
DK0635012T3 (da) | 1996-08-19 |
MX9301721A (es) | 1993-09-01 |
CA2132848A1 (en) | 1993-10-14 |
DE69303605T2 (de) | 1997-01-23 |
US5679692A (en) | 1997-10-21 |
HK31197A (en) | 1997-03-21 |
ATE140224T1 (de) | 1996-07-15 |
US5665735A (en) | 1997-09-09 |
AU3918993A (en) | 1993-11-08 |
JPH07505393A (ja) | 1995-06-15 |
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