ATE140224T1 - Unverbrückte bis-aryl-carbinol-derivate, zusammensetzungen und ihre verwendung - Google Patents

Unverbrückte bis-aryl-carbinol-derivate, zusammensetzungen und ihre verwendung

Info

Publication number
ATE140224T1
ATE140224T1 AT93908326T AT93908326T ATE140224T1 AT E140224 T1 ATE140224 T1 AT E140224T1 AT 93908326 T AT93908326 T AT 93908326T AT 93908326 T AT93908326 T AT 93908326T AT E140224 T1 ATE140224 T1 AT E140224T1
Authority
AT
Austria
Prior art keywords
pct
formula
image
group
aryl
Prior art date
Application number
AT93908326T
Other languages
English (en)
Inventor
Richard Friary
John J Piwinski
Jesse K Wong
Original Assignee
Schering Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Corp filed Critical Schering Corp
Application granted granted Critical
Publication of ATE140224T1 publication Critical patent/ATE140224T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Pulmonology (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Immunology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Saccharide Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
AT93908326T 1992-03-27 1993-03-22 Unverbrückte bis-aryl-carbinol-derivate, zusammensetzungen und ihre verwendung ATE140224T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US85891992A 1992-03-27 1992-03-27

Publications (1)

Publication Number Publication Date
ATE140224T1 true ATE140224T1 (de) 1996-07-15

Family

ID=25329500

Family Applications (1)

Application Number Title Priority Date Filing Date
AT93908326T ATE140224T1 (de) 1992-03-27 1993-03-22 Unverbrückte bis-aryl-carbinol-derivate, zusammensetzungen und ihre verwendung

Country Status (13)

Country Link
US (2) US5679692A (de)
EP (1) EP0635012B1 (de)
JP (1) JPH07505393A (de)
AT (1) ATE140224T1 (de)
AU (1) AU3918993A (de)
CA (1) CA2132848A1 (de)
DE (1) DE69303605T2 (de)
DK (1) DK0635012T3 (de)
ES (1) ES2089815T3 (de)
GR (1) GR3021194T3 (de)
HK (1) HK31197A (de)
MX (1) MX9301721A (de)
WO (1) WO1993020063A1 (de)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100269756B1 (ko) * 1992-02-13 2000-10-16 슈테펜엘.네스비트 피페리디닐티아시클릭유도체(Piperidinyl Thiacyclic Derivatives)
AU2002259147A1 (en) 2001-05-08 2002-11-18 Schering Corporation Use of neurokinin receptor antagonists to treat androgen-dependent diseases
BR0212378A (pt) 2001-09-06 2004-10-19 Schering Corp Inibidores de 17beta-hidroxiesteróide desidrogenase tipo 3 para o tratamento de doenças dependentes de androgênio
CA2463626C (en) 2001-10-17 2011-05-24 Schering Corporation Piperidine- and piperazineacetamines as 17beta-hydroxysteroid dehydrogenase type 3 inhibitors for the treatment of androgen dependent diseases
GB0302094D0 (en) 2003-01-29 2003-02-26 Pharmagene Lab Ltd EP4 receptor antagonists
GB0324269D0 (en) * 2003-10-16 2003-11-19 Pharmagene Lab Ltd EP4 receptor antagonists
US7338967B2 (en) * 2004-09-10 2008-03-04 Syngenta Limited Substituted isoxazoles as fungicides

Family Cites Families (44)

* Cited by examiner, † Cited by third party
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NL88063C (de) * 1950-12-05
US2898339A (en) * 1957-07-29 1959-08-04 Wm S Merrell Co N-substituted benzhydrol, benzhydryl, and benzhydrylidene piperidine
GB1046543A (en) * 1963-02-22 1966-10-26 Sandoz Ag Improvements in or relating to azathiaxanthene derivatives
NL132137C (de) * 1963-04-24
BE638971A (de) * 1963-10-21
US3325501A (en) * 1964-02-18 1967-06-13 Sandoz Ltd 9-[piperidylidene(4')]-1-aza-thiaxanthene-10-oxides and derivatives
US3803154A (en) * 1969-08-07 1974-04-09 Colgate Palmolive Co 11-cyclicaminoalkylidenemorphanthridines
US3803153A (en) * 1970-11-16 1974-04-09 Schering Corp Benzopyrano pyridines
US3717647A (en) * 1971-04-09 1973-02-20 Schering Corp Alpha-nicotinoyl phenylacetonitriles
US4105849A (en) * 1974-09-30 1978-08-08 G. D. Searle & Co. [(Substituted )phenyl]phenylmethyl-1-(dialkylaminoalkyl)piperidines
US4032642A (en) * 1974-12-11 1977-06-28 A. H. Robins Company, Incorporated 1-Substituted-4-benzylpiperidines
US3956296A (en) * 1974-12-11 1976-05-11 A. H. Robins Company, Incorporated 1-Substituted-4-benzylpiperidines
US3922276A (en) * 1974-12-11 1975-11-25 Robins Co Inc A H 1-Substituted-4-benzylidenepiperidines
US3966944A (en) * 1975-05-19 1976-06-29 Abbott Laboratories 10 (N-methyl-4-piperidylidene)-10H[1]-benzopyrano[3,2-b]-pyridine as an analgesic, anti-inflammatory and agent against type III hypersensitivity disease
US4355036A (en) * 1980-06-19 1982-10-19 Schering Corporation Tricyclic-substituted piperidine antihistamines
US4282233B1 (en) * 1980-06-19 2000-09-05 Schering Corp Antihistaminic 11-(4-piperidylidene)-5h-benzoÄ5,6Ü-cyclohepta-Ä1,2Ü-pyridines
ATE13297T1 (de) * 1980-09-02 1985-06-15 Sandoz Ag Piperidyliden-derivate, deren herstellung und diese enthaltende pharmazeutische zusammensetzungen.
US4360483A (en) * 1981-08-10 1982-11-23 Ppg Industries, Inc. Apparatus for and method of pressing plastic sheets
JPS58171918A (ja) * 1982-04-01 1983-10-08 Asahi Chem Ind Co Ltd 強靭なるアクリルシ−ト
JPS59118765A (ja) * 1982-12-24 1984-07-09 Fujisawa Pharmaceut Co Ltd ピペラジン誘導体
US4540780A (en) * 1983-06-02 1985-09-10 Warner-Lambert Company Diphenylmethylene piperidines
WO1985003707A1 (en) * 1984-02-15 1985-08-29 Schering Corporation 8-CHLORO-6,11-DIHYDRO-11-(4-PIPERIDYLIDENE)-5H-BENZO AD5,6 BDCYCLOHEPTA AD1,2-b BDPYRIDINE AND ITS SALTS, PROCESSES FOR THE PRODUCTION THEREOF AND PHARMACEUTICAL COMPOSITIONS CONTAINING THESE COMPOUNDS
US4628095A (en) * 1985-06-05 1986-12-09 G. D. Searle & Co. Substituted N-benzyl-4-(benzhydryl) piperidines
US4632925A (en) * 1985-10-07 1986-12-30 Hoffmann-La Roche Inc. N-substituted diphenylpiperidines and antiobesity use thereof
US4810713A (en) * 1985-12-20 1989-03-07 A. H. Robins Company, Incorporated Arylalkyl-heterocyclic amines, n-substituted by aryloxyalkyl groups used in a method for allergy treatment
EP0235463A3 (de) * 1985-12-20 1990-01-17 A.H. ROBINS COMPANY, INCORPORATED (a Delaware corporation) N-substituierte Arylalkyl- und Arylalkylen-Piperidine und Anwendung als kardiovaskulär antihistaminische und antisekretorische Mittel
IN163948B (de) * 1986-01-17 1988-12-10 Robins Co Inc A H
US5089496A (en) * 1986-10-31 1992-02-18 Schering Corporation Benzo[5,6]cycloheptapyridine compounds, compositions and method of treating allergies
US4826853A (en) * 1986-10-31 1989-05-02 Schering Corporation 6,11-Dihydro-11-(N-substituted-4-piperidylidene)-5H-benzo(5,6)cyclohepta(1,2-B)pyridines and compositions and methods of use
US5028610A (en) * 1987-03-18 1991-07-02 Sankyo Company Limited N-benzhydryl-substituted heterocyclic derivatives, their preparation and their use
US4797489A (en) * 1987-12-02 1989-01-10 American Home Products Corp. Adamantyl- and fluorenyl-arylpiperazines and -arylpiperidines
US4835157A (en) * 1988-03-15 1989-05-30 Ortho Pharmaceutical Corporation Thieno- and furopyrimidine-2,4-dione piperidine derivatives as serotonin antagonists and alpha adrenergic blocking agents
JP2511550B2 (ja) * 1988-04-28 1996-06-26 シェリング・コーポレーション 融合多環式化合物、組成物、製造方法およびｐａｆ拮抗、抗ヒスタミンおよび／または抗炎症剤としてのその使用
DE68916699T2 (de) * 1988-04-28 1994-12-01 Schering Corp Benzopyridopiperidin, -piperidyliden und -piperazin-Verbindungen, Zusammensetzungen, Methoden zur Herstellung und Verwendung.
CA2004211A1 (en) * 1988-11-30 1990-05-31 Masataka Syoji Piperidine derivatives and hyportensives containing the same
US4994456A (en) * 1989-03-01 1991-02-19 Nisshin Flour Milling Co., Ltd. Pyridinecarboxylic acid amide derivatives and pharmaceutical compositions comprising same
GB9000304D0 (en) * 1990-01-06 1990-03-07 Pfizer Ltd Muscarinic receptor antagonists
ATE138553T1 (de) * 1990-01-19 1996-06-15 Pharmacia Ab Intraoculare linse mit haltebügeln hoher festigkeit
US5037435A (en) * 1990-03-02 1991-08-06 Optical Radiation Corporation Haptics for intraocular lenses having high fracture toughness
FR2665160A1 (fr) * 1990-07-26 1992-01-31 Esteve Labor Dr Nouveaux derives de 1-diphenylmethylpiperazine, leur preparation et leur application en tant que medicaments.
CA2093798C (en) * 1990-10-10 2000-02-01 John J. Piwinski Pyridine and pyridine n-oxide derivatives of diaryl methyl piperidines or piperazines, and compositions and methods of use thereof
FR2673574B1 (fr) * 1991-03-06 1994-11-04 Pierre Delamare Procede de fabrication de disques de polissage et disques ainsi obtenus.
US5169569A (en) * 1991-08-05 1992-12-08 Richard Ingram Method of making a one-piece intraocular lens

Also Published As

Publication number Publication date
CA2132848A1 (en) 1993-10-14
ES2089815T3 (es) 1996-10-01
US5679692A (en) 1997-10-21
DE69303605T2 (de) 1997-01-23
DE69303605D1 (de) 1996-08-14
JPH07505393A (ja) 1995-06-15
GR3021194T3 (en) 1996-12-31
AU3918993A (en) 1993-11-08
EP0635012A1 (de) 1995-01-25
DK0635012T3 (da) 1996-08-19
US5665735A (en) 1997-09-09
MX9301721A (es) 1993-09-01
HK31197A (en) 1997-03-21
WO1993020063A1 (en) 1993-10-14
EP0635012B1 (de) 1996-07-10

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Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification
REN Ceased due to non-payment of the annual fee