ES2093301T3 - Nuevos oxialquinos, medicamentos que los contienen y procedimiento de preparacion de ambos. - Google Patents

Nuevos oxialquinos, medicamentos que los contienen y procedimiento de preparacion de ambos.

Info

Publication number
ES2093301T3
ES2093301T3 ES93104595T ES93104595T ES2093301T3 ES 2093301 T3 ES2093301 T3 ES 2093301T3 ES 93104595 T ES93104595 T ES 93104595T ES 93104595 T ES93104595 T ES 93104595T ES 2093301 T3 ES2093301 T3 ES 2093301T3
Authority
ES
Spain
Prior art keywords
denotes
oxialquines
medicines
contain
new
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES93104595T
Other languages
English (en)
Inventor
Ulrich Dr Seipp
Werner Dr Vollenberg
Werner Dr Englberger
Cornelia Dr Geist
Michael Dr Haurand
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Gruenenthal GmbH
Original Assignee
Gruenenthal GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gruenenthal GmbH filed Critical Gruenenthal GmbH
Application granted granted Critical
Publication of ES2093301T3 publication Critical patent/ES2093301T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/36—Radicals substituted by singly-bound nitrogen atoms
    • C07D213/42—Radicals substituted by singly-bound nitrogen atoms having hetero atoms attached to the substituent nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C259/00—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups
    • C07C259/04—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups without replacement of the other oxygen atom of the carboxyl group, e.g. hydroxamic acids
    • C07C259/06—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups without replacement of the other oxygen atom of the carboxyl group, e.g. hydroxamic acids having carbon atoms of hydroxamic groups bound to hydrogen atoms or to acyclic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C275/00—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
    • C07C275/64—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups singly-bound to oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
    • C07D333/14—Radicals substituted by singly bound hetero atoms other than halogen
    • C07D333/20—Radicals substituted by singly bound hetero atoms other than halogen by nitrogen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Valve Device For Special Equipments (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Valve-Gear Or Valve Arrangements (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)

Abstract

SE DESCRIBEN NUEVAS OXIALQUINAS, DE FORMULA GENERAL I EN LA QUE Y SOPORTA EL SUSTITUYENTE META O PARA R1 EQUIVALE CH3 O NH2, R2 EQUIVALE A H O CH3, Y R3 EQUIVALE A H, C1 LO O COCH3, Y AR REPRESENTA A UN RESTO AROMATICO DEL GRUPO, CON LA MEDIDA DE QUE R4, R5 Y R6 SEAN IGUALES O DIFERENTES, Y EQUIVALGAN RESPECTIVAMENTE A H, F, CL, BR, C1 O C1 CF3, COMO RACEMATOS O COMPUESTOS DIASTEREOMEROS O EN FORMA OPTICA ACTIVA, ASI COMO UN PROCEDIMIENTO PARA SU OBTENCION. LAS OXIALQUINAS INHIBEN LA 5 Y SON UTILIZADOS COMO MEDICAMENTOS.
ES93104595T 1992-03-30 1993-03-20 Nuevos oxialquinos, medicamentos que los contienen y procedimiento de preparacion de ambos. Expired - Lifetime ES2093301T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE4210322 1992-03-30

Publications (1)

Publication Number Publication Date
ES2093301T3 true ES2093301T3 (es) 1996-12-16

Family

ID=6455382

Family Applications (1)

Application Number Title Priority Date Filing Date
ES93104595T Expired - Lifetime ES2093301T3 (es) 1992-03-30 1993-03-20 Nuevos oxialquinos, medicamentos que los contienen y procedimiento de preparacion de ambos.

Country Status (7)

Country Link
US (1) US5273006A (es)
EP (1) EP0563715B1 (es)
JP (1) JP3612082B2 (es)
AT (1) ATE141257T1 (es)
DE (2) DE4308535A1 (es)
ES (1) ES2093301T3 (es)
HK (1) HK1005178A1 (es)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0663042B1 (de) * 1993-08-03 1997-04-23 FEV Motorentechnik GmbH & Co. KG Hybridgesteuerter viertakt-ottomotor
JP3464698B2 (ja) * 1994-01-25 2003-11-10 本田技研工業株式会社 多気筒内燃機関における触媒活性化装置
JP3388634B2 (ja) * 1994-06-15 2003-03-24 本田技研工業株式会社 内燃機関の動弁装置
JP3402853B2 (ja) * 1995-04-12 2003-05-06 ヤマハ発動機株式会社 エンジンの動弁装置
EP0979929B1 (de) * 1998-08-11 2004-12-15 Wenko AG Burgdorf Hubkolbenmotor mit Kipphebel-Ventilsteuerung
GB2348246B (en) * 1999-03-25 2002-11-13 Ricardo Inc Automotive valve rocker arms
US6354254B1 (en) * 1999-04-14 2002-03-12 Diesel Engine Retarders, Inc. Exhaust and intake rocker arm assemblies for modifying valve lift and timing during positive power
US6230676B1 (en) 1999-04-23 2001-05-15 Toledo Technologies Inc. Interchangeable rocker arm assembly
US7347178B2 (en) * 2006-01-12 2008-03-25 Ford Global Technologies, Llc System and method for controlling auto-ignition
IT201900016271A1 (it) * 2019-09-13 2021-03-13 Piaggio & C Spa Motore a combustione con dispositivo di variazione della fase delle valvole di un albero a camme
DE102021005779A1 (de) 2021-11-22 2023-05-25 Daimler Truck AG Ventilbetrieb für eine Verbrennungskraftmaschine, insbesondere eines Kraftfahrzeugs, sowie Verbrennungskraftmaschine

Family Cites Families (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5261618A (en) * 1975-11-17 1977-05-21 Nissan Motor Co Ltd Open and close time control mechanism for inlet or exhaust valve of in ternal combustion engine
DE2737601C2 (de) * 1977-08-20 1983-01-27 M.A.N. Maschinenfabrik Augsburg-Nürnberg AG, 8500 Nürnberg Einrichtung zum Anlassen einer luftverdichtenden Viertakt-Brennkraftmaschine
JPS54140015A (en) * 1978-04-21 1979-10-30 Toyota Motor Corp Variable valve engine
EP0040121B1 (fr) * 1980-05-08 1983-10-05 Regie Nationale Des Usines Renault Dispositif culbuteur de soupape déconnectable
FR2493915B1 (fr) * 1980-11-13 1985-12-06 Renault Dispositif de distribution variable pour moteur a combustion interne
US4584974A (en) * 1982-07-27 1986-04-29 Nissan Motor Co., Ltd. Valve operation changing system of internal combustion engine
DE3519471A1 (de) * 1984-06-23 1986-01-02 Volkswagenwerk Ag, 3180 Wolfsburg Hubkolben-brennkraftmaschine
JPS6131610A (ja) * 1984-07-24 1986-02-14 Honda Motor Co Ltd 内燃機関の弁作動休止装置
DE3701609A1 (de) * 1986-01-31 1987-08-06 Volkswagen Ag Ventilbetaetigungseinrichtung
JPS62203913A (ja) * 1986-02-28 1987-09-08 Fuji Heavy Ind Ltd 自動車用エンジンの動弁装置
CA1308977C (en) * 1986-08-27 1992-10-20 Tsuneo Konno Valve operating device for internal combustion engine
JPS63106307A (ja) * 1986-10-23 1988-05-11 Honda Motor Co Ltd 内燃機関の弁作動特性可変装置
JPH036801Y2 (es) * 1986-11-18 1991-02-20
EP0276531B1 (en) * 1987-01-30 1992-07-22 Honda Giken Kogyo Kabushiki Kaisha Valve operating mechanism for internal combustion engine
US4897422A (en) * 1987-02-10 1990-01-30 Abbott Laboratories Lipoxygenase inhibiting compounds
EP0292699B1 (en) * 1987-04-24 1994-03-23 Abbott Laboratories Urea based lipoxygenase inhibiting compounds
US5220059A (en) * 1990-04-19 1993-06-15 Abbott Laboratories Lipoxygenase-inhibiting compounds derived from non-steroidal antiinflammatory carboxylic acids
JP2849939B2 (ja) * 1990-05-07 1999-01-27 本田技研工業株式会社 Ｓｏｈｃ型内燃機関
DE4023742A1 (de) * 1990-07-26 1992-01-30 Gruenenthal Gmbh Substituierte phenylacetylene, diese enthaltende arzneimittel und verfahren zur herstellung dieser verbindungen und arzneimittel

Also Published As

Publication number Publication date
EP0563715A2 (de) 1993-10-06
HK1005178A1 (en) 1998-12-24
ATE141257T1 (de) 1996-08-15
DE59303396D1 (de) 1996-09-19
JP3612082B2 (ja) 2005-01-19
DE4308535A1 (de) 1993-10-07
US5273006A (en) 1993-12-28
EP0563715B1 (de) 1996-08-14
EP0563715A3 (en) 1993-11-24
JPH0610636A (ja) 1994-01-18

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