RO87523B - Procedeu pentru prepararea unor derivati de carbonilaminoalchilaminopropanolilor - Google Patents
Procedeu pentru prepararea unor derivati de carbonilaminoalchilaminopropanolilorInfo
- Publication number
- RO87523B RO87523B RO109344A RO10934482A RO87523B RO 87523 B RO87523 B RO 87523B RO 109344 A RO109344 A RO 109344A RO 10934482 A RO10934482 A RO 10934482A RO 87523 B RO87523 B RO 87523B
- Authority
- RO
- Romania
- Prior art keywords
- carbon atoms
- general formula
- alkyl group
- group containing
- defined above
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
- C07D295/20—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carbonic acid, or sulfur or nitrogen analogues thereof
- C07D295/215—Radicals derived from nitrogen analogues of carbonic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C275/00—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
- C07C275/04—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to acyclic carbon atoms
- C07C275/06—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to acyclic carbon atoms of an acyclic and saturated carbon skeleton
- C07C275/14—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to acyclic carbon atoms of an acyclic and saturated carbon skeleton being further substituted by nitrogen atoms not being part of nitro or nitroso groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Peptides Or Proteins (AREA)
Abstract
Inventia se refera la un procedeu pentru prepararea unor derivati de carbonil-aminoalchil-aminopropanoli para-substituiti cu formula generala I: (vezi formula) în care R1 reprezinta un atom hidrogen, o grupa alchil lineara sau ramificata, continînd 1-5 atomi de carbon, o grupa cicloalchil cu 3-6 atomi de carbon sau o grupa cicloalchil-alchil continînd 4-6 atomi de carbon; R2 reprezinta H, Cl, Br sau F, n este 2,3 sau 4, R3 si R4 sunt identici sau diferiti si reprezinta fiecare o grupa alchil continînd 2-4 atomi de carbon, sau R3 si R4 sunt ambii atomi de hidrogen, sau R3 si R4 sunt ambii atomi de hidrogen, sau R3 si R4 împreuna cu atomul de azot adiacent formeaza o grupa morfolino, conform caruia un compus cu formula generala II: (vezi formula) în care R1 si R2 au semnificatiile de mai sus, X reprezinta o grupa hidroxi, Z reprezinta o grupa hidroxi eventual esterificata sau X si Z formeaza împreuna o grupa epoxi, reactioneaza cu o amina cu formula generala III: (vezi formula) în care n, R3 si R4 au semnificatiile de mai sus, în mediu de alcanol inferior drept solvent, la temperatura de reflux, iar compusul obtinut se poate transforma în sarurile acceptabile farmaceutic în mod sine cunoscut.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SE8107574 | 1981-12-17 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| RO87523B true RO87523B (ro) | 1985-08-31 |
| RO87523A RO87523A (ro) | 1985-08-31 |
Family
ID=20345297
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RO82109344A RO87523A (ro) | 1981-12-17 | 1982-12-16 | Procedeu pentru prepararea unor derivati ai carbonilaminoalchilaminopropanoli para-substituiti |
Country Status (26)
| Country | Link |
|---|---|
| US (1) | US4636501A (ro) |
| EP (1) | EP0085286B1 (ro) |
| JP (1) | JPS58110556A (ro) |
| KR (1) | KR840002820A (ro) |
| AT (1) | ATE19510T1 (ro) |
| AU (1) | AU9163782A (ro) |
| CA (1) | CA1178588A (ro) |
| CS (2) | CS239935B2 (ro) |
| DD (1) | DD208799A5 (ro) |
| DE (1) | DE3270905D1 (ro) |
| DK (1) | DK560182A (ro) |
| ES (3) | ES518268A0 (ro) |
| FI (1) | FI824339A7 (ro) |
| GB (1) | GB2111500B (ro) |
| GR (1) | GR77833B (ro) |
| IL (1) | IL67479A0 (ro) |
| MY (1) | MY8600745A (ro) |
| NO (1) | NO154835C (ro) |
| NZ (1) | NZ202817A (ro) |
| OA (1) | OA07279A (ro) |
| PH (1) | PH18107A (ro) |
| PL (1) | PL139609B1 (ro) |
| PT (1) | PT75994B (ro) |
| RO (1) | RO87523A (ro) |
| SU (1) | SU1169533A3 (ro) |
| ZA (1) | ZA829249B (ro) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4692446A (en) * | 1981-11-12 | 1987-09-08 | E. I. Du Pont De Nemours & Co., Inc. | Esters of aryloxypropanolamine derivatives and medicinal uses |
| DE3380093D1 (en) * | 1982-09-30 | 1989-07-27 | William John Louis | 3-aminopropoxyphenyl derivatives, their preparation and pharmaceutical compositions containing them |
| US4594343A (en) * | 1984-10-19 | 1986-06-10 | Shanklin Jr James R | 1-[(aminoalkyl and aminoalkylamino)carbonyl and thiocarbonyl]-α,α-diarylpyrrolidine, piperidine and homopiperidineacetamides and acetonitriles |
| DE3687035T2 (de) * | 1985-05-14 | 1993-03-25 | William John Louis | 3-aminopropyloxyphenylabkoemmlinge, herstellung und arzneitmittel die sie enthalten. |
| AU609788B2 (en) * | 1987-03-16 | 1991-05-09 | University Of Florida | Labile ketone derivatives of 3-substituted-1-alkylamino- 2-propanols and their use as beta-adrenergic blockers |
| AU2061588A (en) * | 1987-09-07 | 1989-03-09 | Imperial Chemical Industries Plc | Phenol ester of xamoterol |
| DE4018070A1 (de) * | 1990-06-06 | 1991-12-12 | Bayer Ag | Morpholinoharnstoff-derivate |
| KR20170013856A (ko) * | 2014-02-18 | 2017-02-07 | 더 보드 어브 트러스티스 어브 더 리랜드 스탠포드 주니어 유니버시티 | 신경계 장애를 갖는 인간에서의 인식 및 사회적 행동을 개선시키기 위한 화합물 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SE372762B (ro) * | 1969-05-21 | 1975-01-13 | Haessle Ab | |
| GB1457876A (en) * | 1972-12-15 | 1976-12-08 | Ici Ltd | Alkanolamine derivatives device for use in |
| GB1455116A (en) * | 1972-12-15 | 1976-11-10 | Ici Ltd | Pharmaceutical compositions |
| FR2368951A2 (fr) * | 1976-10-27 | 1978-05-26 | Synthelabo | Nouveaux ethers de phenol |
| IE47053B1 (en) * | 1977-05-23 | 1983-12-14 | Ici Ltd | Cardiac stimulants |
| GB2002748B (en) * | 1977-05-23 | 1982-01-06 | Ici Ltd | Cardiac stimulants |
| FI76551C (fi) * | 1980-11-06 | 1988-11-10 | Sandoz Ag | Foerfarande foer framstaellning av nya terapeutiskt anvaendbara 3-aminopropoxifenylderivat. |
-
1982
- 1982-12-10 AT AT82850257T patent/ATE19510T1/de not_active IP Right Cessation
- 1982-12-10 DE DE8282850257T patent/DE3270905D1/de not_active Expired
- 1982-12-10 EP EP82850257A patent/EP0085286B1/en not_active Expired
- 1982-12-13 PH PH28269A patent/PH18107A/en unknown
- 1982-12-15 GB GB08235707A patent/GB2111500B/en not_active Expired
- 1982-12-15 IL IL67479A patent/IL67479A0/xx unknown
- 1982-12-15 ZA ZA829249A patent/ZA829249B/xx unknown
- 1982-12-16 NZ NZ202817A patent/NZ202817A/en unknown
- 1982-12-16 CA CA000417848A patent/CA1178588A/en not_active Expired
- 1982-12-16 OA OA57873A patent/OA07279A/xx unknown
- 1982-12-16 RO RO82109344A patent/RO87523A/ro unknown
- 1982-12-16 NO NO824237A patent/NO154835C/no unknown
- 1982-12-16 FI FI824339A patent/FI824339A7/fi not_active Application Discontinuation
- 1982-12-16 CS CS829249A patent/CS239935B2/cs unknown
- 1982-12-16 CS CS828725A patent/CS239948B2/cs unknown
- 1982-12-16 PT PT75994A patent/PT75994B/pt unknown
- 1982-12-16 JP JP57219367A patent/JPS58110556A/ja active Pending
- 1982-12-16 GR GR70092A patent/GR77833B/el unknown
- 1982-12-16 ES ES518268A patent/ES518268A0/es active Granted
- 1982-12-17 AU AU91637/82A patent/AU9163782A/en not_active Abandoned
- 1982-12-17 PL PL1982239591A patent/PL139609B1/pl unknown
- 1982-12-17 DD DD82246176A patent/DD208799A5/de unknown
- 1982-12-17 KR KR1019820005659A patent/KR840002820A/ko not_active Withdrawn
- 1982-12-17 DK DK560182A patent/DK560182A/da not_active Application Discontinuation
-
1983
- 1983-10-31 SU SU833657075A patent/SU1169533A3/ru active
- 1983-11-16 ES ES527314A patent/ES8501738A1/es not_active Expired
-
1984
- 1984-09-01 ES ES535597A patent/ES535597A0/es active Granted
-
1985
- 1985-07-22 US US06/757,763 patent/US4636501A/en not_active Expired - Fee Related
-
1986
- 1986-12-30 MY MY745/86A patent/MY8600745A/xx unknown
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