RO93388B - Procedeu pentru prepararea unor derivati de aminoalcooli - Google Patents
Procedeu pentru prepararea unor derivati de aminoalcooliInfo
- Publication number
- RO93388B RO93388B RO120221A RO12022185A RO93388B RO 93388 B RO93388 B RO 93388B RO 120221 A RO120221 A RO 120221A RO 12022185 A RO12022185 A RO 12022185A RO 93388 B RO93388 B RO 93388B
- Authority
- RO
- Romania
- Prior art keywords
- general formula
- compound
- alkyl radical
- atom
- radical
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/12—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms
- C07D295/125—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
- C07D295/13—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Neurosurgery (AREA)
- Pharmacology & Pharmacy (AREA)
- Neurology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biomedical Technology (AREA)
- Hospice & Palliative Care (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Psychiatry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
Abstract
Inventia se refera la un procedeu pentru prepararea unor derivati de aminoalcooli cu formula generala I: (vezi formula) în care R reprezinta un atom de hidrogen, R1 reprezinta un radical alchil liniar sau ramificat cu 3...8 atomi de carbon, R2 si R3 reprezinta un radical alchil inferior sau formeaza împreuna cu atomul de azot învecinat un inel cu 5...7 membri la care se ataseaza eventual, un atom de oxigen, R4 reprezinta un atom de hidrogen sau un radical alchil inferior, X reprezinta un atom de hidrogen sau halogen sau un radical alchil inferior sau alcoxi inferior si n reprezinta un numar întreg cu 2 sau 3, caracterizat prin aceea ca, în scopul obtinerii unor compusi cu efecte farmacologige superioare, un compus cu formula generala: (vezi formula) în care R, R1, R4 si X sunt definiti mai sus, reactioneaza cu un compus cu formula generala III: în care Y1 reprezinta un atom de hidrogen sau un radical toxiloxi si R2 si R3 au semnificatiile susmentionate, în raport echimolar la o temperatura cuprinsa între 70...130 degree C, eventual în mediu de solvent inert ales dintre benzen, toluen sau alcanol inferior si daca se doreste prin metode cunoscute, compusul obtinut se transforma în saruri farmacologice acceptabile sau în compus cu formula generala I în care R reprezinta un radical alchil.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP59203623A JPS6183147A (ja) | 1984-09-28 | 1984-09-28 | 新規なアミノアルコール誘導体およびその製造法並びにそれを有効成分とするグルタミン酸遮断剤 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| RO93388A RO93388A (ro) | 1987-12-31 |
| RO93388B true RO93388B (ro) | 1988-01-03 |
Family
ID=16477107
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RO120221A RO93388B (ro) | 1984-09-28 | 1985-09-27 | Procedeu pentru prepararea unor derivati de aminoalcooli |
Country Status (21)
| Country | Link |
|---|---|
| EP (1) | EP0177245B1 (ro) |
| JP (1) | JPS6183147A (ro) |
| KR (1) | KR910002671B1 (ro) |
| AR (1) | AR242776A1 (ro) |
| AT (1) | ATE62480T1 (ro) |
| AU (1) | AU578737B2 (ro) |
| BR (1) | BR8504879A (ro) |
| CA (1) | CA1260467A (ro) |
| CS (1) | CS264332B2 (ro) |
| DE (1) | DE3582466D1 (ro) |
| DK (1) | DK167117B1 (ro) |
| ES (1) | ES8706610A1 (ro) |
| HU (1) | HU199774B (ro) |
| IN (1) | IN162767B (ro) |
| MX (1) | MX162733A (ro) |
| MY (1) | MY102921A (ro) |
| NZ (1) | NZ213628A (ro) |
| PH (1) | PH21169A (ro) |
| RO (1) | RO93388B (ro) |
| SU (1) | SU1433409A3 (ro) |
| ZA (1) | ZA857449B (ro) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5070196A (en) * | 1986-02-01 | 1991-12-03 | Nippon Chemiphar Co., Ltd. | Alkylenediamine derivatives |
| EP0235942B1 (en) * | 1986-02-01 | 1994-03-23 | Nippon Chemiphar Co., Ltd. | Alkylenediamine derivatives |
| JPH0314562A (ja) * | 1988-04-11 | 1991-01-23 | Nippon Chemiphar Co Ltd | 新規なアルキレンジアミン誘導体およびグルタミン酸遮断剤 |
| WO1992022279A2 (en) * | 1991-06-06 | 1992-12-23 | G.D. Searle & Co. | N-[arylethyl]-n-alkyl-2-(1-pyrrolidinyl)ethylamine derivatives for cns disorders |
| IT1271623B (it) * | 1994-03-21 | 1997-06-04 | Lifegroup Spa | N-acilderivati di aminoalcoli con acidi monocarbossilici e bicarbossilici con attivita' neuroprotettiva nelle patologie neurologiche correlate ad eccitotossicita' |
| CA2231013A1 (en) * | 1997-04-30 | 1998-10-30 | Eli Lilly And Company | Process for preparing benzoic acid derivative intermediates and benzothiophene pharmaceuticals |
| DE10251170A1 (de) * | 2002-10-31 | 2004-05-13 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Neue Beta-Agonisten, Verfahren zu deren Herstellung und deren Verwendung als Arzneimittel |
| US20040127733A1 (en) | 2002-10-31 | 2004-07-01 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | New beta-agonists, processes for preparing them and their use as pharmaceutical compositions |
| DE102004021779A1 (de) | 2004-04-30 | 2005-11-24 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Neue Beta-Agonisten, Verfahren zu deren Herstellung und deren Verwendung als Arzneimittel |
| DE102005052127A1 (de) | 2005-10-28 | 2007-05-03 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Neue indol-haltige Beta-Agonisten, Verfahren zu deren Herstellung und deren Verwendung als Arzneimittel |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2600217A (en) * | 1948-06-22 | 1952-06-10 | American Cyanamid Co | Diaryl-hydroxyalkyl-diamino compounds and preparation thereof |
| US3092636A (en) * | 1959-10-21 | 1963-06-04 | Upjohn Co | Alpha-[2-(1-alkyleneimino) ethylamino]-alkanophenones and the corresponding alcohols |
| GB1200886A (en) * | 1966-09-23 | 1970-08-05 | Allen & Hanburys Ltd | Phenylaminoethanol derivatives |
| US3517000A (en) * | 1968-08-08 | 1970-06-23 | American Home Prod | Alpha-aminomethyl benzyl alcohols |
| FR2370472A2 (fr) * | 1976-11-10 | 1978-06-09 | Continental Pharma | Amino-alcool heterocyclique, son sel et son procede de preparation |
| JPS6183170A (ja) * | 1984-09-28 | 1986-04-26 | Nippon Chemiphar Co Ltd | 新規な１，３−オキサゾリジン−２−オン誘導体およびその製造法 |
-
1984
- 1984-09-28 JP JP59203623A patent/JPS6183147A/ja active Granted
-
1985
- 1985-09-17 IN IN724/MAS/85A patent/IN162767B/en unknown
- 1985-09-23 AU AU47689/85A patent/AU578737B2/en not_active Ceased
- 1985-09-24 EP EP85306767A patent/EP0177245B1/en not_active Expired - Lifetime
- 1985-09-24 DE DE8585306767T patent/DE3582466D1/de not_active Expired - Fee Related
- 1985-09-24 AT AT85306767T patent/ATE62480T1/de active
- 1985-09-24 CA CA000491405A patent/CA1260467A/en not_active Expired
- 1985-09-25 ES ES547283A patent/ES8706610A1/es not_active Expired
- 1985-09-26 KR KR1019850007117A patent/KR910002671B1/ko not_active IP Right Cessation
- 1985-09-26 CS CS856904A patent/CS264332B2/cs unknown
- 1985-09-26 ZA ZA857449A patent/ZA857449B/xx unknown
- 1985-09-27 NZ NZ213628A patent/NZ213628A/xx unknown
- 1985-09-27 PH PH32860A patent/PH21169A/en unknown
- 1985-09-27 AR AR85301762A patent/AR242776A1/es active
- 1985-09-27 RO RO120221A patent/RO93388B/ro unknown
- 1985-09-27 HU HU853744A patent/HU199774B/hu not_active IP Right Cessation
- 1985-09-27 SU SU853957801A patent/SU1433409A3/ru active
- 1985-09-27 DK DK439285A patent/DK167117B1/da not_active IP Right Cessation
- 1985-09-30 BR BR8504879A patent/BR8504879A/pt not_active IP Right Cessation
- 1985-10-01 MX MX64A patent/MX162733A/es unknown
-
1987
- 1987-09-29 MY MYPI87002216A patent/MY102921A/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CS264332B2 (en) | 1989-07-12 |
| DK167117B1 (da) | 1993-08-30 |
| ZA857449B (en) | 1986-06-25 |
| ES8706610A1 (es) | 1987-07-01 |
| MX162733A (es) | 1991-06-24 |
| JPH0517900B2 (ro) | 1993-03-10 |
| JPS6183147A (ja) | 1986-04-26 |
| HU199774B (en) | 1990-03-28 |
| ES547283A0 (es) | 1987-07-01 |
| KR910002671B1 (ko) | 1991-05-03 |
| RO93388A (ro) | 1987-12-31 |
| IN162767B (ro) | 1988-07-09 |
| AR242776A1 (es) | 1993-05-31 |
| NZ213628A (en) | 1989-03-29 |
| CS690485A2 (en) | 1988-11-15 |
| PH21169A (en) | 1987-08-07 |
| MY102921A (en) | 1993-03-31 |
| CA1260467A (en) | 1989-09-26 |
| DK439285D0 (da) | 1985-09-27 |
| KR860002450A (ko) | 1986-04-26 |
| BR8504879A (pt) | 1986-07-22 |
| HUT40613A (en) | 1987-01-28 |
| AU4768985A (en) | 1986-04-10 |
| AU578737B2 (en) | 1988-11-03 |
| EP0177245A3 (en) | 1987-07-01 |
| ATE62480T1 (de) | 1991-04-15 |
| DE3582466D1 (de) | 1991-05-16 |
| EP0177245A2 (en) | 1986-04-09 |
| SU1433409A3 (ru) | 1988-10-23 |
| EP0177245B1 (en) | 1991-04-10 |
| DK439285A (da) | 1986-03-29 |
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