ES2053527T3 - Derivados de alquilendiamina. - Google Patents

Derivados de alquilendiamina.

Info

Publication number
ES2053527T3
ES2053527T3 ES87300850T ES87300850T ES2053527T3 ES 2053527 T3 ES2053527 T3 ES 2053527T3 ES 87300850 T ES87300850 T ES 87300850T ES 87300850 T ES87300850 T ES 87300850T ES 2053527 T3 ES2053527 T3 ES 2053527T3
Authority
ES
Spain
Prior art keywords
group
formula
integer
alkylendiamine
same meaning
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES87300850T
Other languages
English (en)
Inventor
Mitsuo Masaki
Haruhiko Shinozaki
Masaru Satoh
Naoya Mortioh
Koichi Hashimoto
Toshiro Kamishiro
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Nippon Chemiphar Co Ltd
Original Assignee
Nippon Chemiphar Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nippon Chemiphar Co Ltd filed Critical Nippon Chemiphar Co Ltd
Application granted granted Critical
Publication of ES2053527T3 publication Critical patent/ES2053527T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/12—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/12—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms
    • C07D295/125—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/13—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A61P21/02—Muscle relaxants, e.g. for tetanus or cramps

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pain & Pain Management (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Neurology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

LA INVENCION SE REFIERE A NUEVOS DERIVADOS DE ALQUILENDIAMINA DE FORMULA (I): EN LA QUE A ES UN GRUPO DE FORMULA (II): SIENDO R1 UN GRUPO HIDROCARBONADO ALIFATICO, ALICICLICO, ARILO O ARILALQUILICO; R2 UN GRUPO HIDROCARBONADO ALIFATICO, ALCOXI, ARILOXI O HIDROCARBONADO ALIFATICO CONTENIENDO UN ENLACE ESTER O ETER; Y N Y M TIENEN COMO VALOR 0, 1 O 2, SIEMPRE QUE M+N NO SEA MAYOR DE 3; Y B ES HIDROGENO, O BIEN A ES UN GRUPO III: EN EL QUE R3 TIENE EL MISMO SIGNIFICADO DE R1 Y K ES UN ENTERO DE 0 A 3, Y B ES UN GRUPO REPRESENTADO POR LA FORMULA (IV): EN LA QUE R4 TIENE CASI EL MISMO SIGNIFICADO QUE R2, P ES UN NUMERO ENTERO DE 2 A 6 Y Q ES UN ENTERO DE 4 A 7. ESTOS COMPUESTOS SON UTILES COMO BLOQUEANTES DE GLUTAMATO.
ES87300850T 1986-02-01 1987-01-30 Derivados de alquilendiamina. Expired - Lifetime ES2053527T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2049886 1986-02-01
JP2049786 1986-02-01

Publications (1)

Publication Number Publication Date
ES2053527T3 true ES2053527T3 (es) 1994-08-01

Family

ID=26357459

Family Applications (1)

Application Number Title Priority Date Filing Date
ES87300850T Expired - Lifetime ES2053527T3 (es) 1986-02-01 1987-01-30 Derivados de alquilendiamina.

Country Status (16)

Country Link
EP (1) EP0235942B1 (es)
KR (1) KR940010177B1 (es)
CN (1) CN1018829B (es)
AR (1) AR242199A1 (es)
AU (1) AU608211B2 (es)
BR (1) BR8700457A (es)
CA (1) CA1318913C (es)
CS (1) CS270556B2 (es)
DE (1) DE3789395T2 (es)
DK (1) DK50287A (es)
ES (1) ES2053527T3 (es)
HU (1) HU199817B (es)
IN (2) IN164200B (es)
NZ (1) NZ219124A (es)
RO (1) RO105572B1 (es)
SU (2) SU1590043A3 (es)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5217979A (en) * 1989-09-22 1993-06-08 Merrell Dow Pharmaceuticals Inc. Substituted alkyl piperidines
CA2025490C (en) * 1989-09-22 2003-09-16 James R. Mccarthy Novel substituted alkyl piperidines and their use as inhibitors of cholesterol synthesis
AU2159692A (en) * 1991-06-06 1993-01-12 G.D. Searle & Co. N-(arylethyl)-n-alkyl-2-(1-pyrrolidinyl)ethylamine derivatives for cns disorders
US5350758A (en) * 1992-07-08 1994-09-27 Merrell Dow Pharmaceuticals Inc. Piperidyl sulfonamides and sulfoxamides as inhibitors of cholesterol biosynthesis
US6025355A (en) 1997-05-19 2000-02-15 Cambridge Neuroscience, Inc. Pharmaceutically active compounds and methods of use
US6242198B1 (en) 1996-07-25 2001-06-05 Cambridge Neuroscience, Inc. Methods of treatment of eye trauma and disorders
US6756389B2 (en) 1996-08-09 2004-06-29 Cambridge Neuroscience, Inc. Pharmaceutically active compounds and methods of use
CN105591523B (zh) * 2016-01-08 2018-12-18 中国科学院电工研究所 永磁电磁复合盘式涡流制动装置
CN111491914B (zh) * 2017-12-20 2024-04-26 罗地亚经营管理公司 新的阳离子季铵化合物和包含其的组合物及其制造方法

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6183147A (ja) * 1984-09-28 1986-04-26 Nippon Chemiphar Co Ltd 新規なアミノアルコール誘導体およびその製造法並びにそれを有効成分とするグルタミン酸遮断剤

Also Published As

Publication number Publication date
HUT44527A (en) 1988-03-28
DK50287A (da) 1987-08-02
CA1318913C (en) 1993-06-08
KR870007881A (ko) 1987-09-22
IN170699B (es) 1992-05-02
CS61587A2 (en) 1989-11-14
DE3789395T2 (de) 1994-08-04
IN164200B (es) 1989-01-28
SU1590043A3 (ru) 1990-08-30
DE3789395D1 (de) 1994-04-28
DK50287D0 (da) 1987-01-30
KR940010177B1 (ko) 1994-10-22
EP0235942A1 (en) 1987-09-09
RO105572B1 (ro) 1992-09-25
EP0235942B1 (en) 1994-03-23
CN1018829B (zh) 1992-10-28
NZ219124A (en) 1990-04-26
SU1563594A3 (ru) 1990-05-07
CN87101762A (zh) 1987-10-07
CS270556B2 (en) 1990-07-12
AR242199A1 (es) 1993-03-31
AU6819087A (en) 1987-08-06
AU608211B2 (en) 1991-03-28
HU199817B (en) 1990-03-28
BR8700457A (pt) 1987-12-08

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