RO91422B - Procedeu pentru prepararea unor derivati de 1,3-oxazolidin-2-ona - Google Patents
Procedeu pentru prepararea unor derivati de 1,3-oxazolidin-2-onaInfo
- Publication number
- RO91422B RO91422B RO118984A RO11898485A RO91422B RO 91422 B RO91422 B RO 91422B RO 118984 A RO118984 A RO 118984A RO 11898485 A RO11898485 A RO 11898485A RO 91422 B RO91422 B RO 91422B
- Authority
- RO
- Romania
- Prior art keywords
- general formula
- carbon atoms
- compound
- alkoxy group
- group
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
- C07D263/08—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D263/16—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D263/18—Oxygen atoms
- C07D263/20—Oxygen atoms attached in position 2
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
- C07D263/08—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D263/16—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D263/18—Oxygen atoms
- C07D263/20—Oxygen atoms attached in position 2
- C07D263/22—Oxygen atoms attached in position 2 with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to other ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Neurology (AREA)
- General Health & Medical Sciences (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Pain & Pain Management (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
Inventia se refera la un procedeu pentru prepararea unor derivati de 1,3-oxazolidin-2-ona cu formula generala I: (vezi formula) în care R este o grupa alchil liniara sau ramificata cu 3...8 atomi de carbon, X este un atom de hidrogen sau halogen, o grupa alchill cu 1...3 atomi de carbon sau o grupa alcoxi cu 1...3 atomi de carbon si n este un numar întreg de la 4 la 6 constînd din aceea ca un compus cu formula generala II: (vezi formula) în care R, X si n au semnificatiile de mai sus, se trateaza un derivat carbonilic cu formula generala III: (vezi formula) în care Ra este un atom de clor sau o grupa alcoxi cu 1...3 atomi de carbon si R6 este un atom de clor, o grupa alcoxi cu 1...3 atomi de carbon sau o grupa triclormetiloxi, reactia avînd loc la o temperatura cuprinsa între -15 degree C si +95 degree C, în prezenta unui agent bazic eventual, în prezenta unui amestec de apa si solvent organic inert. Compusul intermedia obtinut, în cazul în care se foloseste cloralchilcarbonat în calitate de compus cu formula generala III se ciclizeaza, în prezenta unei baze eventual, într-o hidrocarbura aromatica drept solvent, dupa care, daca se doreste, compusul obtinut cu formula generala I se transforma într-o sare de aditie acida prin procedee în sine cunoscute.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP59203624A JPS6183170A (ja) | 1984-09-28 | 1984-09-28 | 新規な１，３−オキサゾリジン−２−オン誘導体およびその製造法 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| RO91422A RO91422A (ro) | 1987-06-30 |
| RO91422B true RO91422B (ro) | 1987-07-02 |
Family
ID=16477122
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RO118984A RO91422B (ro) | 1984-09-28 | 1985-05-30 | Procedeu pentru prepararea unor derivati de 1,3-oxazolidin-2-ona |
Country Status (27)
| Country | Link |
|---|---|
| US (1) | US4644063A (ro) |
| JP (1) | JPS6183170A (ro) |
| KR (1) | KR900004323B1 (ro) |
| AR (1) | AR240924A1 (ro) |
| AT (1) | AT392069B (ro) |
| AU (1) | AU566419B2 (ro) |
| BR (1) | BR8502707A (ro) |
| CA (1) | CA1252092A (ro) |
| CH (1) | CH663207A5 (ro) |
| CS (1) | CS273606B2 (ro) |
| DE (1) | DE3519261C2 (ro) |
| DK (1) | DK165952C (ro) |
| ES (2) | ES8800571A1 (ro) |
| FR (1) | FR2571052B1 (ro) |
| GB (2) | GB8512975D0 (ro) |
| HU (1) | HU199132B (ro) |
| IN (1) | IN162060B (ro) |
| IT (1) | IT1208807B (ro) |
| MX (2) | MX161397A (ro) |
| MY (1) | MY102081A (ro) |
| NL (1) | NL193191C (ro) |
| NZ (1) | NZ212143A (ro) |
| PH (1) | PH20852A (ro) |
| RO (1) | RO91422B (ro) |
| SE (1) | SE463100B (ro) |
| SU (2) | SU1402263A3 (ro) |
| ZA (1) | ZA854001B (ro) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS6183147A (ja) * | 1984-09-28 | 1986-04-26 | Nippon Chemiphar Co Ltd | 新規なアミノアルコール誘導体およびその製造法並びにそれを有効成分とするグルタミン酸遮断剤 |
| JPH0759570B2 (ja) * | 1986-05-06 | 1995-06-28 | 三井東圧化学株式会社 | ２−オキサゾリジノン類の製造方法 |
| JPH0713017B2 (ja) * | 1986-06-18 | 1995-02-15 | 日本ケミファ株式会社 | 脳細胞保護作用を有する医薬組成物 |
| EP0307141B1 (en) * | 1987-09-10 | 1993-01-13 | MERCK SHARP & DOHME LTD. | Oxazoles and thiazoles for the treatment of senile dementia |
| DE68915595T2 (de) * | 1988-03-24 | 1994-09-15 | Sankyo Co | Verwendung von Isoxazolinonen als cerebro-aktive Medikamente. |
| JPH0314562A (ja) * | 1988-04-11 | 1991-01-23 | Nippon Chemiphar Co Ltd | 新規なアルキレンジアミン誘導体およびグルタミン酸遮断剤 |
| US5187171A (en) * | 1989-01-09 | 1993-02-16 | G. D. Searle & Co. | Use of a glycine b partial agonist as an antipsychotic |
| DK0579169T3 (da) * | 1992-07-14 | 1999-05-31 | Nippon Chemiphar Co | Alkylendiaminderivater |
| JPH09504272A (ja) * | 1993-09-15 | 1997-04-28 | メルク シヤープ エンド ドーム リミテツド | ドーパミンアンタゴニストとしてのイミダゾロン及びオキサゾロン誘導体 |
| DE4425613A1 (de) * | 1994-07-20 | 1996-01-25 | Bayer Ag | 5-gliedrige Heteroaryl-oxazolidinone |
| US6037354A (en) | 1997-06-18 | 2000-03-14 | Merck & Co., Inc. | Alpha 1a adrenergic receptor antagonists |
| PL2967029T3 (pl) | 2013-03-14 | 2017-10-31 | Akzo Nobel Chemicals Int Bv | Eter celulozy jako środek kontrolujący znoszenie i środek odporności na deszcz |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2437389A (en) * | 1948-03-09 | Oxazoeidones and erocesstok | ||
| DE1135461B (de) * | 1959-05-08 | 1962-08-30 | Knoll Ag | Verfahren zur Herstellung von basisch substituierten Phthalimidinen |
| FR1301267A (fr) * | 1961-04-04 | 1962-08-17 | Science Union Et Compagnie Soc | Nouveaux dérivés de l'oxazolidinone-2 et leurs procédés de préparation |
| US3131197A (en) * | 1963-03-13 | 1964-04-28 | Smith Kline French Lab | 5-(3, 4-carbonyldioxyphenyl)-3-isopropyl-2-oxazolidone |
| US3576808A (en) * | 1967-09-15 | 1971-04-27 | Miles Lab | N-4-phenyl-1-piperazinylalkyl-5-phenyl-oxazolidinones |
| GB1222708A (en) * | 1968-10-22 | 1971-02-17 | Delalande Sa | Novel 5-(n-substituted aminomethyl)-2-oxazolidinones and their process of preparation |
| FR2179582B1 (ro) * | 1972-04-13 | 1975-10-10 | Synthelabo |
-
1984
- 1984-09-28 JP JP59203624A patent/JPS6183170A/ja active Granted
-
1985
- 1985-05-21 NZ NZ212143A patent/NZ212143A/en unknown
- 1985-05-22 SE SE8502525A patent/SE463100B/sv not_active IP Right Cessation
- 1985-05-22 GB GB858512975A patent/GB8512975D0/en active Pending
- 1985-05-23 IN IN382/MAS/85A patent/IN162060B/en unknown
- 1985-05-23 DK DK230185A patent/DK165952C/da not_active IP Right Cessation
- 1985-05-24 PH PH32310A patent/PH20852A/en unknown
- 1985-05-24 DE DE3519261A patent/DE3519261C2/de not_active Expired - Fee Related
- 1985-05-27 ES ES543517A patent/ES8800571A1/es not_active Expired
- 1985-05-27 ZA ZA854001A patent/ZA854001B/xx unknown
- 1985-05-28 CA CA000482506A patent/CA1252092A/en not_active Expired
- 1985-05-29 KR KR1019850003726A patent/KR900004323B1/ko not_active IP Right Cessation
- 1985-05-29 US US06/739,059 patent/US4644063A/en not_active Expired - Lifetime
- 1985-05-30 GB GB08513685A patent/GB2165237B/en not_active Expired
- 1985-05-30 RO RO118984A patent/RO91422B/ro unknown
- 1985-05-30 FR FR8508128A patent/FR2571052B1/fr not_active Expired
- 1985-05-30 SU SU853902250A patent/SU1402263A3/ru active
- 1985-05-30 IT IT8567500A patent/IT1208807B/it active
- 1985-05-30 HU HU852082A patent/HU199132B/hu not_active IP Right Cessation
- 1985-05-31 BR BR8502707A patent/BR8502707A/pt not_active IP Right Cessation
- 1985-05-31 NL NL8501579A patent/NL193191C/nl not_active IP Right Cessation
- 1985-05-31 CH CH2317/85A patent/CH663207A5/fr not_active IP Right Cessation
- 1985-05-31 MX MX205493A patent/MX161397A/es unknown
- 1985-05-31 CS CS392785A patent/CS273606B2/cs unknown
- 1985-05-31 AR AR300604A patent/AR240924A1/es active
- 1985-05-31 AT AT0165685A patent/AT392069B/de not_active IP Right Cessation
- 1985-07-09 AU AU44697/85A patent/AU566419B2/en not_active Ceased
-
1986
- 1986-05-13 SU SU864027452A patent/SU1431679A3/ru active
- 1986-09-18 ES ES557075A patent/ES8802152A1/es not_active Expired
-
1987
- 1987-09-29 MY MYPI87002215A patent/MY102081A/en unknown
-
1990
- 1990-07-16 MX MX2159290A patent/MX21592A/es unknown
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| DE69214369D1 (de) | Verfahren zur Herstellung von Pyranonen und Pyrandionen | |
| RO91422B (ro) | Procedeu pentru prepararea unor derivati de 1,3-oxazolidin-2-ona | |
| RO82962B (ro) | Procedeu pentru prepararea unor derivati de cefalosporina | |
| GB1464583A (en) | Preparation of quinazoline derivatives | |
| DE68924237D1 (de) | Verfahren zur Herstellung von Verbindungen zur Behandlung der gutartigen Prostatahypertrophie. | |
| KR850000442A (ko) | 7-피페리디노-1,2,3,5-테트라하이드로 이미다조[2,1-b] 퀴나졸린-2-온의 제조방법 | |
| GB1500255A (en) | Process for the preparation of 2,4-dioxo-1,2,3,4-tetrahydro-s-triazine-(1,2-a)-benzimidazoles | |
| DE3764018D1 (de) | Chemisches verfahren zur herstellung von abkoemmlingen von oxamid. | |
| ATE45720T1 (de) | Verfahren zur herstellung von 2(hydroxyalkyl)acrylverbindungen. | |
| KR840007417A (ko) | 오르토 용해된 피롤 유도체의 제조방법 | |
| DE69032752D1 (de) | Verfahren zur Herstellung von Metallkomplexen von Thiolactamen | |
| GB1430926A (en) | 2-amino-3,4-dihydropyridines their production and their medicinal use | |
| DE69800073D1 (de) | Verfahren zur Herstellung von 2-Cyanobiphenyl-Verbindungen | |
| DE69733716D1 (de) | Verfahren zur herstellung von imidazolderivaten | |
| ES8104182A1 (es) | Procedimiento para preparar diaminas alquiladas | |
| ATE195132T1 (de) | Katalysator für ethylen-(co)-polymerisation mit verbesserter aktivität | |
| DE69001852D1 (de) | Herstellung von derivaten der glutarsaeure. | |
| RO85313B (ro) | Procedeu pentru prepararea unor anilide ale ergolinei | |
| MX9204872A (es) | Un metodo y compuestos intermedios para la preparacion de 6-fluorobenzisotiazoles. | |
| ES8105261A1 (es) | Procedimiento para preparar aminas alcoxiladas | |
| DE69024114D1 (de) | Verfahren zur Herstellung von Penemen | |
| GB1545077A (en) | Process for purifying water using bis-isothiouronium salts | |
| MX9206354A (es) | Nuevo procedimiento de preparacion de derivados 20-oxo-dihidroxilados en 17a, 21 del pregnano, y nuevos compuestos intermedios | |
| KR910019976A (ko) | N-아릴테트라히드로프탈이미드 | |
| KR900016112A (ko) | 제초제 화합물 및 그의 제조방법 |