DE3877470T2 - Oxazole und thiazole zur behandlung seniler demenz. - Google Patents

Oxazole und thiazole zur behandlung seniler demenz.

Info

Publication number
DE3877470T2
DE3877470T2 DE19883877470 DE3877470T DE3877470T2 DE 3877470 T2 DE3877470 T2 DE 3877470T2 DE 19883877470 DE19883877470 DE 19883877470 DE 3877470 T DE3877470 T DE 3877470T DE 3877470 T2 DE3877470 T2 DE 3877470T2
Authority
DE
Germany
Prior art keywords
oxazoles
thiazoles
senile dementia
treating senile
treating
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE19883877470
Other languages
English (en)
Other versions
DE3877470D1 (de
Inventor
Raymond Baker
Roger J Snow
John Saunders
Graham A Showell
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Organon Pharma UK Ltd
Original Assignee
Merck Sharp and Dohme Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB878721343A external-priority patent/GB8721343D0/en
Priority claimed from GB888801759A external-priority patent/GB8801759D0/en
Application filed by Merck Sharp and Dohme Ltd filed Critical Merck Sharp and Dohme Ltd
Application granted granted Critical
Publication of DE3877470D1 publication Critical patent/DE3877470D1/de
Publication of DE3877470T2 publication Critical patent/DE3877470T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/46—8-Azabicyclo [3.2.1] octane; Derivatives thereof, e.g. atropine, cocaine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
    • C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems
DE19883877470 1987-09-10 1988-09-01 Oxazole und thiazole zur behandlung seniler demenz. Expired - Fee Related DE3877470T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB878721343A GB8721343D0 (en) 1987-09-10 1987-09-10 Therapeutic agents
GB888801759A GB8801759D0 (en) 1988-01-27 1988-01-27 Therapeutic agents

Publications (2)

Publication Number Publication Date
DE3877470D1 DE3877470D1 (de) 1993-02-25
DE3877470T2 true DE3877470T2 (de) 1993-06-24

Family

ID=26292711

Family Applications (1)

Application Number Title Priority Date Filing Date
DE19883877470 Expired - Fee Related DE3877470T2 (de) 1987-09-10 1988-09-01 Oxazole und thiazole zur behandlung seniler demenz.

Country Status (5)

Country Link
EP (1) EP0307141B1 (de)
JP (1) JPH01151576A (de)
DE (1) DE3877470T2 (de)
DK (1) DK503288A (de)
ES (1) ES2053748T3 (de)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0261763B1 (de) * 1986-06-27 1994-02-09 Beecham Group Plc Verbrückte bicyclische N-heterocyclische Verbindungen
ATE133415T1 (de) * 1987-04-15 1996-02-15 Beecham Group Plc Am brückenkopf substituierte azabicyclenderivate
IE63906B1 (en) * 1987-11-13 1995-06-14 Novo Nordisk As Azabicyclic compounds and their preparation and use
EP0322182A3 (de) * 1987-12-22 1992-01-02 Beecham Group Plc Azabicyclische-Verbindungen, Verfahren zu ihrer Herstellung und diese enthaltende pharmazeutische Zubereitungen
CA2000041A1 (en) * 1988-10-13 1990-04-13 Barry S. Orlek Compounds
GB8830226D0 (en) * 1988-12-23 1989-02-22 Beecham Group Plc Novel compounds
IT1229491B (it) * 1988-12-28 1991-09-03 Roussel Maestretti S P A Ora R Derivati della 1,2,5,6-tetraidropiridina, loro procedimento di preparazione e loro impiego come sostanze medicinali
EP0413545B1 (de) * 1989-08-16 1997-05-14 Beecham Group Plc Azabicyclische Verbindungen
DE69026197T2 (de) * 1989-10-07 1997-01-09 Beecham Group Plc Azabizyklische Verbindungen, Verfahren und Zwischenprodukte zu ihrer Herstellung und diese enthaltende pharmazeutische Zubereitungen
MX9100517A (es) * 1990-08-06 1992-04-01 Smith Kline French Lab Compuestos
JPH06503563A (ja) * 1990-11-29 1994-04-21 アラーガン、インコーポレイテッド 高眼圧の処置におけるピリジン誘導体の用途
IE922270A1 (en) * 1991-07-26 1993-01-27 Akzo Nv Pyrazole derivatives
SE9201478D0 (sv) * 1992-05-11 1992-05-11 Kabi Pharmacia Ab Heteroaromatic quinuclidinenes, their use and preparation
AU686340B2 (en) * 1994-03-11 1998-02-05 Yamanouchi Pharmaceutical Co., Ltd. 5-HT3 receptor agonist, novel thiazole derivative, and intermediate therefor
US5733912A (en) * 1997-02-19 1998-03-31 Abbott Laboratories 7A-heterocycle substituted hexahydro-1H-pyrrolizine compounds useful in controlling chemical synaptic transmission
WO2000073288A1 (en) * 1999-05-28 2000-12-07 Vertex Pharmaceuticals Incorporated Method for preparing 5-substituted oxazoles
GB0516313D0 (en) * 2005-08-08 2005-09-14 Argenta Discovery Ltd Azole derivatives and their uses
WO2008017827A2 (en) * 2006-08-08 2008-02-14 Argenta Discovery Limited Azole and thiazole derivatives and their uses
KR20090119757A (ko) * 2007-02-07 2009-11-19 아젠터 디스커버리 리미티드 무스카린성 ｍ3 길항제의 나파디실레이트 염
GB0702382D0 (en) * 2007-02-07 2007-03-21 Argenta Discovery Ltd New salt
GB0702385D0 (en) * 2007-02-07 2007-03-21 Argenta Discovery Ltd New combination
GB0702416D0 (en) * 2007-02-07 2007-03-21 Argenta Discovery Ltd New combination

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5511677B2 (de) * 1971-12-09 1980-03-26
JPS6183170A (ja) * 1984-09-28 1986-04-26 Nippon Chemiphar Co Ltd 新規な１，３−オキサゾリジン−２−オン誘導体およびその製造法
NL8601494A (nl) * 1985-06-22 1987-01-16 Sandoz Ag Thiazolen, hun bereiding en farmaceutische preparaten die ze bevatten.
US4650805A (en) * 1985-12-02 1987-03-17 Warner-Lambert Company 4-(1,2,5,6-Tetrahydro-1-alkyl-3-pyridinyl)-2-thiazolamines and 4-(hexahydro-1-alkyl-3-pyridinyl)-2-thiazolamines having anti-psychotic activity
NZ219646A (en) * 1986-03-27 1990-10-26 Merck Sharp & Dohme Oxadiazole derivatives of azacyclics for treating cns disorders
GB8610432D0 (en) * 1986-04-29 1986-06-04 Akzo Nv Amino-thiazole & oxazole derivatives
EP0261763B1 (de) * 1986-06-27 1994-02-09 Beecham Group Plc Verbrückte bicyclische N-heterocyclische Verbindungen
ATE133415T1 (de) * 1987-04-15 1996-02-15 Beecham Group Plc Am brückenkopf substituierte azabicyclenderivate
GB8714789D0 (en) * 1987-06-24 1987-07-29 Lundbeck & Co As H Heterocyclic compounds
JP3353406B2 (ja) * 1993-08-16 2002-12-03 富士電機株式会社 燃料電池発電装置

Also Published As

Publication number Publication date
EP0307141A3 (en) 1989-04-12
DK503288A (da) 1989-04-28
DK503288D0 (da) 1988-09-09
JPH01151576A (ja) 1989-06-14
EP0307141A2 (de) 1989-03-15
ES2053748T3 (es) 1994-08-01
DE3877470D1 (de) 1993-02-25
EP0307141B1 (de) 1993-01-13

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee