DE69214369D1 - Verfahren zur Herstellung von Pyranonen und Pyrandionen - Google Patents
Verfahren zur Herstellung von Pyranonen und PyrandionenInfo
- Publication number
- DE69214369D1 DE69214369D1 DE69214369T DE69214369T DE69214369D1 DE 69214369 D1 DE69214369 D1 DE 69214369D1 DE 69214369 T DE69214369 T DE 69214369T DE 69214369 T DE69214369 T DE 69214369T DE 69214369 D1 DE69214369 D1 DE 69214369D1
- Authority
- DE
- Germany
- Prior art keywords
- chem
- hydrogen
- formula
- substituted
- preparation
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
- C07C69/66—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety
- C07C69/67—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of saturated acids
- C07C69/675—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of saturated acids of saturated hydroxy-carboxylic acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
- C07D309/32—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Saccharide Compounds (AREA)
- Pyrane Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US73440891A | 1991-07-23 | 1991-07-23 | |
US07/849,908 US5274143A (en) | 1991-07-23 | 1992-03-12 | Process for the preparation of (R)-3-hexyl-5,6-dihydro-4-hydroxy-6-undecyl-2H-pyran-2-one and (R)-5,6-dihydro-6-undecyl-2H-pyran-2,4(3H)-dione |
Publications (2)
Publication Number | Publication Date |
---|---|
DE69214369D1 true DE69214369D1 (de) | 1996-11-14 |
DE69214369T2 DE69214369T2 (de) | 1997-03-27 |
Family
ID=27112724
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69214369T Expired - Lifetime DE69214369T2 (de) | 1991-07-23 | 1992-07-09 | Verfahren zur Herstellung von Pyranonen und Pyrandionen |
Country Status (7)
Country | Link |
---|---|
US (2) | US5274143A (de) |
EP (1) | EP0524495B1 (de) |
JP (1) | JP3248760B2 (de) |
AT (1) | ATE143954T1 (de) |
DE (1) | DE69214369T2 (de) |
DK (1) | DK0524495T3 (de) |
ES (1) | ES2092603T3 (de) |
Families Citing this family (57)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5481008A (en) * | 1993-09-13 | 1996-01-02 | Hoffmann-La Roche Inc. | Process for the preparation of optically active compounds |
US6545165B1 (en) | 2000-02-04 | 2003-04-08 | Roche Colorado Corporation | Synthesis of 3,6-dialkyl-5,6-dihydro-4-hydroxy-pyran-2-one |
AU2001289696B2 (en) | 2000-07-28 | 2006-07-06 | Cheplapharm Arzneimittel Gmbh | New use of lipase inhibitors |
PT1311260E (pt) | 2000-08-09 | 2008-05-02 | Hoffmann La Roche | Utilização de inibidores de lipase para o tratamento da dispepsia |
US6900226B2 (en) | 2000-09-06 | 2005-05-31 | Hoffman-La Roche Inc. | Neuropeptide Y antagonists |
BR0114708A (pt) | 2000-10-16 | 2003-07-01 | Hoffmann La Roche | Compostos, composições farmacêuticas que compreendem os mesmos, utilização dos compostos, processo de tratamento de distúrbios e de obesidade, e processos para a preparação dos compostos e de uma composição |
GB0030710D0 (en) | 2000-12-15 | 2001-01-31 | Hoffmann La Roche | Piperazine derivatives |
CA2432085C (en) | 2000-12-27 | 2009-02-24 | F. Hoffmann-La Roche Ag | Indole derivatives and their use as 5-ht2b and 5-ht2c receptor ligands |
GB0106177D0 (en) | 2001-03-13 | 2001-05-02 | Hoffmann La Roche | Piperazine derivatives |
WO2002094789A1 (en) | 2001-05-21 | 2002-11-28 | F. Hoffmann-La Roche Ag | Quinoline derivatives as ligands for the neuropeptide y receptor |
US20030027786A1 (en) | 2001-06-06 | 2003-02-06 | Karsten Maeder | Lipase inhibiting composition |
US6730319B2 (en) | 2001-06-06 | 2004-05-04 | Hoffmann-La Roche Inc. | Pharmaceutical compositions having depressed melting points |
US6787558B2 (en) | 2001-09-28 | 2004-09-07 | Hoffmann-La Roche Inc. | Quinoline derivatives |
SE0104274D0 (sv) * | 2001-12-17 | 2001-12-17 | Astrazeneca Ab | Novel process |
GB0202015D0 (en) | 2002-01-29 | 2002-03-13 | Hoffmann La Roche | Piperazine Derivatives |
EP1474145B1 (de) | 2002-02-04 | 2008-04-23 | F. Hoffmann-La Roche Ag | Chinolinderivate als npy antagonisten |
WO2003072577A1 (en) | 2002-02-28 | 2003-09-04 | F.Hoffmann-La Roche Ag | Thiazole derivatives as npy receptor antagonists |
JP2005535648A (ja) | 2002-07-05 | 2005-11-24 | エフ.ホフマン−ラ ロシュ アーゲー | キナゾリン誘導体 |
MXPA05001328A (es) | 2002-08-07 | 2005-04-28 | Hoffmann La Roche | Derivados de tiazol. |
CN100577660C (zh) | 2002-09-12 | 2010-01-06 | 霍夫曼-拉罗奇有限公司 | 作为ppar激动剂用于治疗糖尿病的n-取代-1h-吲哚-5-丙酸化合物 |
PL377320A1 (pl) | 2002-11-25 | 2006-01-23 | F. Hoffmann-La Roche Ag | Pochodne indolilowe |
BR0316521A (pt) * | 2002-11-26 | 2005-10-04 | Pfizer Prod Inc | Ativadores de ppar |
GB0314967D0 (en) | 2003-06-26 | 2003-07-30 | Hoffmann La Roche | Piperazine derivatives |
DE602004019939D1 (de) | 2003-08-12 | 2009-04-23 | Hoffmann La Roche | Thiazolderivate als npy-antagonisten |
DE602004010529T2 (de) | 2003-08-12 | 2008-11-27 | F. Hoffmann-La Roche Ag | 2-amino-5-benzoylthiazol npy-antagonisten |
US7649002B2 (en) | 2004-02-04 | 2010-01-19 | Pfizer Inc | (3,5-dimethylpiperidin-1yl)(4-phenylpyrrolidin-3-yl)methanone derivatives as MCR4 agonists |
MX2007005137A (es) * | 2004-11-23 | 2007-06-22 | Warner Lambert Co | Derivados del acido 7-(2h-pyrazol-3-il)-3, 5-dihidroxi-heptanoico como inhibidores de hmg co-a reductasa para el tratamiento de lipidemia. |
EP1888585B1 (de) | 2005-05-03 | 2011-06-29 | F. Hoffmann-La Roche AG | Tetracyclische azapyrazinoindoline als 5-ht2-liganden |
CA2617654A1 (en) * | 2005-08-04 | 2007-02-08 | Pfizer Limited | Piperidinoyl-pyrrolidine and piperidinoyl-piperidine compounds |
MX2008002061A (es) | 2005-08-18 | 2008-04-16 | Hoffmann La Roche | Derivados de tiazolil piperidina utiles como moduladores del receptor h3. |
US7741317B2 (en) | 2005-10-21 | 2010-06-22 | Bristol-Myers Squibb Company | LXR modulators |
US7888376B2 (en) | 2005-11-23 | 2011-02-15 | Bristol-Myers Squibb Company | Heterocyclic CETP inhibitors |
ES2359739T3 (es) | 2005-11-30 | 2011-05-26 | F. Hoffmann-La Roche Ag | Derivados de indol-2-il-amida 1,5-sustituida. |
ATE507222T1 (de) | 2005-11-30 | 2011-05-15 | Hoffmann La Roche | 1,1-dioxo-thiomorpholinyl-indolyl-methanon- derivate zur verwendung als h3-modulatoren |
BRPI0619233A2 (pt) | 2005-11-30 | 2011-09-20 | Hoffmann La Roche | compostos, processo para a sua manufatura, método para o tratamento e/ou prevenção de enfermidades que estão associadas com a modulação de receptores de h3, uso dos compostos e método para o tratamento ou prevenção de obesidade e de diabetes do tipo ii em um ser humano ou animal |
ES2333672T3 (es) | 2005-12-09 | 2010-02-25 | F. Hoffmann-La Roche Ag | Derivados de amida triciclica para tratamiento de obesidad. |
AU2006326135A1 (en) | 2005-12-15 | 2007-06-21 | F. Hoffmann-La Roche Ag | Pyrrolo[2,3-c]pyridine derivatives |
KR101015666B1 (ko) | 2005-12-16 | 2011-02-22 | 에프. 호프만-라 로슈 아게 | H3 수용체 조절제로서 피롤로[2,3-b]피리딘 유도체 |
MX2008010899A (es) * | 2006-02-23 | 2008-11-27 | Pfizer Ltd | Piperidinoilpirrolidinas agonistas del receptor de melanocortina tipo 4. |
US7432255B2 (en) * | 2006-05-16 | 2008-10-07 | Hoffmann-La Roche Inc. | 1H-indol-5-yl-piperazin-1-yl-methanone derivatives |
BRPI0711740A2 (pt) | 2006-05-30 | 2011-12-06 | Hoffmann La Roche | compostos, processo para a sua manufatura,composições farmacêuticas que os compreendem, método para o tratamento e/ou prevenção de enfermidades que estão associadas com a modulação de receptores de h3, método para o tratamento ou prevenção de obesidade, de diabetes do tipo ii, e uso dos compostos na manufatura de medicamentos |
US7514433B2 (en) | 2006-08-03 | 2009-04-07 | Hoffmann-La Roche Inc. | 1H-indole-6-yl-piperazin-1-yl-methanone derivatives |
TW200831497A (en) * | 2006-10-12 | 2008-08-01 | Epix Delaware Inc | Carboxamide compounds and their use |
WO2008059335A1 (en) | 2006-11-13 | 2008-05-22 | Pfizer Products Inc. | Diaryl, dipyridinyl and aryl-pyridinyl derivatives and uses thereof |
US20080182851A1 (en) * | 2006-11-20 | 2008-07-31 | Glenmark Pharmaceuticals S.A. | Acetylene derivatives as stearoyl coa desaturase inhibitors |
US8404896B2 (en) | 2006-12-01 | 2013-03-26 | Bristol-Myers Squibb Company | N-((3-benzyl)-2,2-(bis-phenyl)-propan-1-amine derivatives as CETP inhibitors for the treatment of atherosclerosis and cardiovascular diseases |
US20080146559A1 (en) | 2006-12-08 | 2008-06-19 | Li Chen | 4,5,6,7-Tetrahydro-Thieno [2,3-C] Pyridine Derivatives |
KR20100027231A (ko) * | 2007-07-25 | 2010-03-10 | 에프. 호프만-라 로슈 아게 | 벤조퓨란- 및 벤조[b]티오펜-2-카복실산 아마이드 유도체 및 이의 히스타민 3 수용체 조절제로서의 용도 |
WO2009037542A2 (en) | 2007-09-20 | 2009-03-26 | Glenmark Pharmaceuticals, S.A. | Spirocyclic compounds as stearoyl coa desaturase inhibitors |
KR101076680B1 (ko) * | 2007-11-01 | 2011-10-26 | 한미홀딩스 주식회사 | (6r)-3-헥실-4-히드록시-6-운데실-5,6-다이히드로피란-2-온의 제조방법 및 이에 사용되는 중간체 |
US8569282B2 (en) | 2007-12-11 | 2013-10-29 | Cytopathfinder, Inc. | Carboxamide compounds and their use |
EP2326638B9 (de) * | 2008-08-06 | 2013-11-13 | Pfizer Limited | Diazepin- und diazocanverbindungen als mc4-agonisten |
JP2013528172A (ja) | 2010-05-21 | 2013-07-08 | ファイザー・インク | 2−フェニルベンゾイルアミド |
CA2828343A1 (en) | 2011-03-04 | 2012-09-13 | The Scripps Research Institute | Edn3-like peptides and uses thereof |
AU2014255381A1 (en) | 2013-04-17 | 2015-10-08 | Pfizer Inc. | N-piperidin-3-ylbenzamide derivatives for treating cardiovascular diseases |
WO2016055901A1 (en) | 2014-10-08 | 2016-04-14 | Pfizer Inc. | Substituted amide compounds |
AU2020209215B2 (en) | 2019-01-18 | 2023-02-02 | Astrazeneca Ab | PCSK9 inhibitors and methods of use thereof |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2542849A (en) * | 1948-10-22 | 1951-02-20 | Gen Aniline & Film Corp | Diazotypes containing pyronones |
US4206222A (en) * | 1977-06-23 | 1980-06-03 | Societe Civile Particuliere De Brevets Suffren | Method for preparing a substance having properties against collagen diseases and products obtained |
CA2035972C (en) * | 1990-02-23 | 2006-07-11 | Martin Karpf | Process for the preparation of oxetanones |
-
1992
- 1992-03-12 US US07/849,908 patent/US5274143A/en not_active Expired - Lifetime
- 1992-07-09 EP EP92111663A patent/EP0524495B1/de not_active Expired - Lifetime
- 1992-07-09 ES ES92111663T patent/ES2092603T3/es not_active Expired - Lifetime
- 1992-07-09 DK DK92111663.8T patent/DK0524495T3/da active
- 1992-07-09 AT AT92111663T patent/ATE143954T1/de active
- 1992-07-09 DE DE69214369T patent/DE69214369T2/de not_active Expired - Lifetime
- 1992-07-22 JP JP21573492A patent/JP3248760B2/ja not_active Expired - Lifetime
-
1993
- 1993-10-04 US US08/131,843 patent/US5420305A/en not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
JPH05194471A (ja) | 1993-08-03 |
US5274143A (en) | 1993-12-28 |
ATE143954T1 (de) | 1996-10-15 |
US5420305A (en) | 1995-05-30 |
DE69214369T2 (de) | 1997-03-27 |
EP0524495B1 (de) | 1996-10-09 |
JP3248760B2 (ja) | 2002-01-21 |
ES2092603T3 (es) | 1996-12-01 |
EP0524495A1 (de) | 1993-01-27 |
DK0524495T3 (da) | 1996-11-25 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8327 | Change in the person/name/address of the patent owner |
Owner name: F. HOFFMANN-LA ROCHE AG, BASEL, CH |
|
8364 | No opposition during term of opposition | ||
R071 | Expiry of right |
Ref document number: 524495 Country of ref document: EP |