DE602004019939D1 - Thiazolderivate als npy-antagonisten - Google Patents
Thiazolderivate als npy-antagonistenInfo
- Publication number
- DE602004019939D1 DE602004019939D1 DE602004019939T DE602004019939T DE602004019939D1 DE 602004019939 D1 DE602004019939 D1 DE 602004019939D1 DE 602004019939 T DE602004019939 T DE 602004019939T DE 602004019939 T DE602004019939 T DE 602004019939T DE 602004019939 D1 DE602004019939 D1 DE 602004019939D1
- Authority
- DE
- Germany
- Prior art keywords
- npy antagonists
- thiazone
- derivatives
- npy
- antagonists
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- 239000005557 antagonist Substances 0.000 title abstract 2
- QAYICIQNSGETAS-UHFFFAOYSA-N dazomet Chemical class CN1CSC(=S)N(C)C1 QAYICIQNSGETAS-UHFFFAOYSA-N 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 2
- 208000008589 Obesity Diseases 0.000 abstract 1
- 150000002148 esters Chemical class 0.000 abstract 1
- BPGXUIVWLQTVLZ-OFGSCBOVSA-N neuropeptide y(npy) Chemical compound C([C@@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(O)=O)NC(=O)[C@H](CC=1N=CNC=1)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C)NC(=O)[C@H]1N(CCC1)C(=O)[C@H](C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)CNC(=O)[C@H]1N(CCC1)C(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H]1N(CCC1)C(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@H]1N(CCC1)C(=O)[C@@H](N)CC=1C=CC(O)=CC=1)C1=CC=C(O)C=C1 BPGXUIVWLQTVLZ-OFGSCBOVSA-N 0.000 abstract 1
- 235000020824 obesity Nutrition 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP03017633 | 2003-08-12 | ||
| PCT/EP2004/008699 WO2005014593A1 (en) | 2003-08-12 | 2004-08-04 | Thiazole derivatives as npy antagonists |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DE602004019939D1 true DE602004019939D1 (de) | 2009-04-23 |
Family
ID=34130065
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE602004019939T Active DE602004019939D1 (de) | 2003-08-12 | 2004-08-04 | Thiazolderivate als npy-antagonisten |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US7265109B2 (de) |
| EP (1) | EP1656374B1 (de) |
| JP (1) | JP2007501824A (de) |
| KR (1) | KR20060037436A (de) |
| CN (1) | CN100393718C (de) |
| AT (1) | ATE425162T1 (de) |
| AU (1) | AU2004263312A1 (de) |
| BR (1) | BRPI0413458A (de) |
| CA (1) | CA2533464A1 (de) |
| DE (1) | DE602004019939D1 (de) |
| ES (1) | ES2321299T3 (de) |
| MX (1) | MXPA06001561A (de) |
| RU (1) | RU2321586C2 (de) |
| WO (1) | WO2005014593A1 (de) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2316458A1 (de) * | 2004-09-20 | 2011-05-04 | Xenon Pharmaceuticals Inc. | Pyridazin-Derivate zur Verhinderung menschlicher Stearoyl-coa-desaturas |
| JP2009521461A (ja) * | 2005-12-22 | 2009-06-04 | アイカジェン， インコーポレイテッド | カルシウムチャネルアンタゴニスト |
| JP5642661B2 (ja) | 2009-03-05 | 2014-12-17 | 塩野義製薬株式会社 | Ｎｐｙｙ５受容体拮抗作用を有するピペリジンおよびピロリジン誘導体 |
Family Cites Families (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA1247547A (en) * | 1983-06-22 | 1988-12-28 | Paul Hadvary | Leucine derivatives |
| US4844839A (en) * | 1984-09-04 | 1989-07-04 | Manchak Frank | In situ treatment and analysis of wastes |
| US4776409A (en) * | 1984-09-04 | 1988-10-11 | Manchak Frank | Insitu waste impoundment treating apparatus and method of using same |
| US5246960A (en) * | 1984-12-21 | 1993-09-21 | Hoffmann-La Roche Inc. | Oxetanones |
| CA1270837A (en) * | 1984-12-21 | 1990-06-26 | Hoffmann-La Roche Limited | Oxetanones |
| CA1328881C (en) | 1984-12-21 | 1994-04-26 | Pierre Barbier | Process for the manufacture of oxetanones |
| DE3690446T1 (de) * | 1985-08-26 | 1987-12-10 | ||
| CA2035972C (en) | 1990-02-23 | 2006-07-11 | Martin Karpf | Process for the preparation of oxetanones |
| US5274143A (en) | 1991-07-23 | 1993-12-28 | Hoffmann-La Roche Inc. | Process for the preparation of (R)-3-hexyl-5,6-dihydro-4-hydroxy-6-undecyl-2H-pyran-2-one and (R)-5,6-dihydro-6-undecyl-2H-pyran-2,4(3H)-dione |
| US5245960A (en) * | 1992-07-22 | 1993-09-21 | Outboard Marine Corporation | Integral bracket and idler assembly |
| US6004996A (en) * | 1997-02-05 | 1999-12-21 | Hoffman-La Roche Inc. | Tetrahydrolipstatin containing compositions |
| US6267952B1 (en) | 1998-01-09 | 2001-07-31 | Geltex Pharmaceuticals, Inc. | Lipase inhibiting polymers |
| DE19824175A1 (de) * | 1998-05-29 | 1999-12-02 | Novartis Ag | Amino-azol-Verbindungen |
| TR200100472T2 (tr) | 1998-08-14 | 2001-07-23 | F.Hoffmann-La Roche Ag | Lipaz inhibitörleri ile sitozan içeren farmasötik bileşimler |
| WO2000009122A1 (en) | 1998-08-14 | 2000-02-24 | F. Hoffmann-La Roche Ag | Pharmaceutical compositions containing lipase inhibitors |
| US6340683B1 (en) * | 1999-04-22 | 2002-01-22 | Synaptic Pharmaceutical Corporation | Selective NPY (Y5) antagonists (triazines) |
| AU2001246494A1 (en) * | 2000-03-03 | 2001-09-12 | Novartis Ag | Condensed thiazolamines and their use as neuropeptide y5 antagonists |
| EP1417188A1 (de) * | 2001-08-03 | 2004-05-12 | Novo Nordisk A/S | Neue 2-4-diaminothiazolderivaten |
| WO2003072577A1 (en) * | 2002-02-28 | 2003-09-04 | F.Hoffmann-La Roche Ag | Thiazole derivatives as npy receptor antagonists |
| MXPA05008878A (es) * | 2003-02-21 | 2005-10-05 | Pfizer | Derivados de aminotiazol sustituidos con cicloalquilo que contiene n y composiciones farmaceuticas para inhibir la proliferacion celular, y metodos para su uso. |
-
2004
- 2004-08-04 JP JP2006522950A patent/JP2007501824A/ja active Pending
- 2004-08-04 KR KR1020067002853A patent/KR20060037436A/ko active IP Right Grant
- 2004-08-04 EP EP04763756A patent/EP1656374B1/de not_active Not-in-force
- 2004-08-04 AT AT04763756T patent/ATE425162T1/de not_active IP Right Cessation
- 2004-08-04 AU AU2004263312A patent/AU2004263312A1/en not_active Abandoned
- 2004-08-04 BR BRPI0413458-3A patent/BRPI0413458A/pt not_active IP Right Cessation
- 2004-08-04 DE DE602004019939T patent/DE602004019939D1/de active Active
- 2004-08-04 RU RU2006107448/04A patent/RU2321586C2/ru not_active IP Right Cessation
- 2004-08-04 CN CNB200480022677XA patent/CN100393718C/zh not_active Expired - Fee Related
- 2004-08-04 ES ES04763756T patent/ES2321299T3/es active Active
- 2004-08-04 CA CA002533464A patent/CA2533464A1/en not_active Abandoned
- 2004-08-04 MX MXPA06001561A patent/MXPA06001561A/es not_active Application Discontinuation
- 2004-08-04 WO PCT/EP2004/008699 patent/WO2005014593A1/en active Application Filing
- 2004-08-10 US US10/915,190 patent/US7265109B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| RU2321586C2 (ru) | 2008-04-10 |
| ES2321299T3 (es) | 2009-06-04 |
| EP1656374A1 (de) | 2006-05-17 |
| JP2007501824A (ja) | 2007-02-01 |
| AU2004263312A1 (en) | 2005-02-17 |
| KR20060037436A (ko) | 2006-05-03 |
| CN100393718C (zh) | 2008-06-11 |
| US20050038073A1 (en) | 2005-02-17 |
| CN1832947A (zh) | 2006-09-13 |
| CA2533464A1 (en) | 2005-02-17 |
| ATE425162T1 (de) | 2009-03-15 |
| EP1656374B1 (de) | 2009-03-11 |
| BRPI0413458A (pt) | 2006-10-17 |
| RU2006107448A (ru) | 2007-09-20 |
| WO2005014593A1 (en) | 2005-02-17 |
| MXPA06001561A (es) | 2006-05-15 |
| US7265109B2 (en) | 2007-09-04 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8364 | No opposition during term of opposition |