ATE425162T1 - Thiazolderivate als npy-antagonisten - Google Patents
Thiazolderivate als npy-antagonistenInfo
- Publication number
- ATE425162T1 ATE425162T1 AT04763756T AT04763756T ATE425162T1 AT E425162 T1 ATE425162 T1 AT E425162T1 AT 04763756 T AT04763756 T AT 04763756T AT 04763756 T AT04763756 T AT 04763756T AT E425162 T1 ATE425162 T1 AT E425162T1
- Authority
- AT
- Austria
- Prior art keywords
- thiazole derivatives
- npy antagonists
- npy
- antagonists
- compounds
- Prior art date
Links
- 239000005557 antagonist Substances 0.000 title abstract 2
- 150000007979 thiazole derivatives Chemical class 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 2
- 208000008589 Obesity Diseases 0.000 abstract 1
- 150000002148 esters Chemical class 0.000 abstract 1
- BPGXUIVWLQTVLZ-OFGSCBOVSA-N neuropeptide y(npy) Chemical compound C([C@@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(O)=O)NC(=O)[C@H](CC=1N=CNC=1)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C)NC(=O)[C@H]1N(CCC1)C(=O)[C@H](C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)CNC(=O)[C@H]1N(CCC1)C(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H]1N(CCC1)C(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@H]1N(CCC1)C(=O)[C@@H](N)CC=1C=CC(O)=CC=1)C1=CC=C(O)C=C1 BPGXUIVWLQTVLZ-OFGSCBOVSA-N 0.000 abstract 1
- 235000020824 obesity Nutrition 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Diabetes (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Child & Adolescent Psychology (AREA)
- Immunology (AREA)
- Endocrinology (AREA)
- Rheumatology (AREA)
- Emergency Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Photoreceptors In Electrophotography (AREA)
- Adhesives Or Adhesive Processes (AREA)
- Coloring Foods And Improving Nutritive Qualities (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP03017633 | 2003-08-12 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE425162T1 true ATE425162T1 (de) | 2009-03-15 |
Family
ID=34130065
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT04763756T ATE425162T1 (de) | 2003-08-12 | 2004-08-04 | Thiazolderivate als npy-antagonisten |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US7265109B2 (de) |
| EP (1) | EP1656374B1 (de) |
| JP (1) | JP2007501824A (de) |
| KR (1) | KR20060037436A (de) |
| CN (1) | CN100393718C (de) |
| AT (1) | ATE425162T1 (de) |
| AU (1) | AU2004263312A1 (de) |
| BR (1) | BRPI0413458A (de) |
| CA (1) | CA2533464A1 (de) |
| DE (1) | DE602004019939D1 (de) |
| ES (1) | ES2321299T3 (de) |
| MX (1) | MXPA06001561A (de) |
| RU (1) | RU2321586C2 (de) |
| WO (1) | WO2005014593A1 (de) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1814551A2 (de) * | 2004-09-20 | 2007-08-08 | Xenon Pharmaceuticals Inc. | Pyridazin-derivate zur verhinderung menschlicher stearoyl-coa-desaturase |
| WO2007075852A2 (en) * | 2005-12-22 | 2007-07-05 | Icagen, Inc. | Calcium channel antagonists |
| JP5642661B2 (ja) | 2009-03-05 | 2014-12-17 | 塩野義製薬株式会社 | Ｎｐｙｙ５受容体拮抗作用を有するピペリジンおよびピロリジン誘導体 |
| EP4387965A2 (de) | 2021-08-18 | 2024-06-26 | ChemoCentryx, Inc. | Arylsulfonylverbindungen als ccr6-inhibitoren |
Family Cites Families (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA1247547A (en) * | 1983-06-22 | 1988-12-28 | Paul Hadvary | Leucine derivatives |
| US4776409A (en) * | 1984-09-04 | 1988-10-11 | Manchak Frank | Insitu waste impoundment treating apparatus and method of using same |
| US4844839A (en) * | 1984-09-04 | 1989-07-04 | Manchak Frank | In situ treatment and analysis of wastes |
| CA1328881C (en) * | 1984-12-21 | 1994-04-26 | Pierre Barbier | Process for the manufacture of oxetanones |
| US5246960A (en) * | 1984-12-21 | 1993-09-21 | Hoffmann-La Roche Inc. | Oxetanones |
| CA1270837A (en) | 1984-12-21 | 1990-06-26 | Hoffmann-La Roche Limited | Oxetanones |
| NL8620328A (nl) * | 1985-08-26 | 1987-08-03 | Manchak Frank | Inrichting voor het in situ behandelen van gevaarlijk afval en werkwijze voor het gebruiken daarvan. |
| CA2035972C (en) * | 1990-02-23 | 2006-07-11 | Martin Karpf | Process for the preparation of oxetanones |
| US5274143A (en) | 1991-07-23 | 1993-12-28 | Hoffmann-La Roche Inc. | Process for the preparation of (R)-3-hexyl-5,6-dihydro-4-hydroxy-6-undecyl-2H-pyran-2-one and (R)-5,6-dihydro-6-undecyl-2H-pyran-2,4(3H)-dione |
| US5245960A (en) * | 1992-07-22 | 1993-09-21 | Outboard Marine Corporation | Integral bracket and idler assembly |
| US6004996A (en) * | 1997-02-05 | 1999-12-21 | Hoffman-La Roche Inc. | Tetrahydrolipstatin containing compositions |
| US6267952B1 (en) | 1998-01-09 | 2001-07-31 | Geltex Pharmaceuticals, Inc. | Lipase inhibiting polymers |
| DE19824175A1 (de) * | 1998-05-29 | 1999-12-02 | Novartis Ag | Amino-azol-Verbindungen |
| CN1152680C (zh) | 1998-08-14 | 2004-06-09 | 霍夫曼-拉罗奇有限公司 | 含有脂酶抑制剂和壳聚糖的药物组合物 |
| WO2000009122A1 (en) | 1998-08-14 | 2000-02-24 | F. Hoffmann-La Roche Ag | Pharmaceutical compositions containing lipase inhibitors |
| US6340683B1 (en) * | 1999-04-22 | 2002-01-22 | Synaptic Pharmaceutical Corporation | Selective NPY (Y5) antagonists (triazines) |
| AU2001246494A1 (en) * | 2000-03-03 | 2001-09-12 | Novartis Ag | Condensed thiazolamines and their use as neuropeptide y5 antagonists |
| WO2003011843A1 (en) * | 2001-08-03 | 2003-02-13 | Novo Nordisk A/S | Novel 2,4-diaminothiazole derivatives |
| ES2292992T3 (es) * | 2002-02-28 | 2008-03-16 | F. Hoffmann-La Roche Ag | Derivados de tiazol como antagonistas del receptor npy. |
| WO2004074283A1 (en) * | 2003-02-21 | 2004-09-02 | Pfizer Inc. | N-heterocyclyl-substituted amino-thiazole derivatives as protein kinase inhibitors |
-
2004
- 2004-08-04 WO PCT/EP2004/008699 patent/WO2005014593A1/en active Application Filing
- 2004-08-04 BR BRPI0413458-3A patent/BRPI0413458A/pt not_active IP Right Cessation
- 2004-08-04 MX MXPA06001561A patent/MXPA06001561A/es not_active Application Discontinuation
- 2004-08-04 ES ES04763756T patent/ES2321299T3/es active Active
- 2004-08-04 RU RU2006107448/04A patent/RU2321586C2/ru not_active IP Right Cessation
- 2004-08-04 AU AU2004263312A patent/AU2004263312A1/en not_active Abandoned
- 2004-08-04 AT AT04763756T patent/ATE425162T1/de not_active IP Right Cessation
- 2004-08-04 DE DE602004019939T patent/DE602004019939D1/de active Active
- 2004-08-04 EP EP04763756A patent/EP1656374B1/de not_active Not-in-force
- 2004-08-04 CN CNB200480022677XA patent/CN100393718C/zh not_active Expired - Fee Related
- 2004-08-04 JP JP2006522950A patent/JP2007501824A/ja active Pending
- 2004-08-04 KR KR1020067002853A patent/KR20060037436A/ko active IP Right Grant
- 2004-08-04 CA CA002533464A patent/CA2533464A1/en not_active Abandoned
- 2004-08-10 US US10/915,190 patent/US7265109B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| EP1656374A1 (de) | 2006-05-17 |
| MXPA06001561A (es) | 2006-05-15 |
| DE602004019939D1 (de) | 2009-04-23 |
| CN100393718C (zh) | 2008-06-11 |
| JP2007501824A (ja) | 2007-02-01 |
| US20050038073A1 (en) | 2005-02-17 |
| CN1832947A (zh) | 2006-09-13 |
| AU2004263312A1 (en) | 2005-02-17 |
| CA2533464A1 (en) | 2005-02-17 |
| BRPI0413458A (pt) | 2006-10-17 |
| WO2005014593A1 (en) | 2005-02-17 |
| ES2321299T3 (es) | 2009-06-04 |
| RU2006107448A (ru) | 2007-09-20 |
| US7265109B2 (en) | 2007-09-04 |
| RU2321586C2 (ru) | 2008-04-10 |
| KR20060037436A (ko) | 2006-05-03 |
| EP1656374B1 (de) | 2009-03-11 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |