ATE143954T1 - Verfahren zur herstellung von pyranonen und pyrandionen - Google Patents

Verfahren zur herstellung von pyranonen und pyrandionen

Info

Publication number
ATE143954T1
ATE143954T1 AT92111663T AT92111663T ATE143954T1 AT E143954 T1 ATE143954 T1 AT E143954T1 AT 92111663 T AT92111663 T AT 92111663T AT 92111663 T AT92111663 T AT 92111663T AT E143954 T1 ATE143954 T1 AT E143954T1
Authority
AT
Austria
Prior art keywords
chem
hydrogen
formula
substituted
compound
Prior art date
Application number
AT92111663T
Other languages
English (en)
Inventor
John Joseph Landi Jr
Keith Marriott Ramig
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Application granted granted Critical
Publication of ATE143954T1 publication Critical patent/ATE143954T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/66—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety
    • C07C69/67—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of saturated acids
    • C07C69/675—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of saturated acids of saturated hydroxy-carboxylic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
    • C07D309/32—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Saccharide Compounds (AREA)
  • Pyrane Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
AT92111663T 1991-07-23 1992-07-09 Verfahren zur herstellung von pyranonen und pyrandionen ATE143954T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US73440891A 1991-07-23 1991-07-23
US07/849,908 US5274143A (en) 1991-07-23 1992-03-12 Process for the preparation of (R)-3-hexyl-5,6-dihydro-4-hydroxy-6-undecyl-2H-pyran-2-one and (R)-5,6-dihydro-6-undecyl-2H-pyran-2,4(3H)-dione

Publications (1)

Publication Number Publication Date
ATE143954T1 true ATE143954T1 (de) 1996-10-15

Family

ID=27112724

Family Applications (1)

Application Number Title Priority Date Filing Date
AT92111663T ATE143954T1 (de) 1991-07-23 1992-07-09 Verfahren zur herstellung von pyranonen und pyrandionen

Country Status (7)

Country Link
US (2) US5274143A (de)
EP (1) EP0524495B1 (de)
JP (1) JP3248760B2 (de)
AT (1) ATE143954T1 (de)
DE (1) DE69214369T2 (de)
DK (1) DK0524495T3 (de)
ES (1) ES2092603T3 (de)

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US5481008A (en) * 1993-09-13 1996-01-02 Hoffmann-La Roche Inc. Process for the preparation of optically active compounds
US6545165B1 (en) * 2000-02-04 2003-04-08 Roche Colorado Corporation Synthesis of 3,6-dialkyl-5,6-dihydro-4-hydroxy-pyran-2-one
BR0112800A (pt) 2000-07-28 2003-07-01 Hoffmann La Roche Utilização de um inibidor de lìpases e de um sequestrante de ácido de bìlis farmaceuticamente aceitáveis e processo para a prevenção e tratamento de enfermidades associadas com altos nìveis de colesterol de plasma
AU1212002A (en) 2000-08-09 2002-02-18 Hoffmann La Roche Use of lipase inhibitors
US6900226B2 (en) 2000-09-06 2005-05-31 Hoffman-La Roche Inc. Neuropeptide Y antagonists
MXPA03003246A (es) 2000-10-16 2003-06-06 Hoffmann La Roche Derivados de indolina y su uso como ligandos del receptor 5-ht2.
GB0030710D0 (en) 2000-12-15 2001-01-31 Hoffmann La Roche Piperazine derivatives
WO2002051844A1 (en) 2000-12-27 2002-07-04 F. Hoffmann-La Roche Ag Indole derivatives and their use as 5-ht2b and 5-ht2c receptor ligands
GB0106177D0 (en) 2001-03-13 2001-05-02 Hoffmann La Roche Piperazine derivatives
ES2300478T3 (es) 2001-05-21 2008-06-16 F. Hoffmann-La Roche Ag Derivados de quinolina como ligandos para el receptor de neuropeptido y.
US20030027786A1 (en) 2001-06-06 2003-02-06 Karsten Maeder Lipase inhibiting composition
US6730319B2 (en) 2001-06-06 2004-05-04 Hoffmann-La Roche Inc. Pharmaceutical compositions having depressed melting points
US6787558B2 (en) 2001-09-28 2004-09-07 Hoffmann-La Roche Inc. Quinoline derivatives
SE0104274D0 (sv) * 2001-12-17 2001-12-17 Astrazeneca Ab Novel process
GB0202015D0 (en) 2002-01-29 2002-03-13 Hoffmann La Roche Piperazine Derivatives
RU2298002C2 (ru) 2002-02-04 2007-04-27 Ф. Хоффманн-Ля Рош Аг Производные хинолина в качестве антагонистов npy
AU2003210305B2 (en) 2002-02-28 2006-07-06 F. Hoffmann-La Roche Ag Thiazole derivatives as NPY receptor antagonists
WO2004005265A1 (en) 2002-07-05 2004-01-15 F. Hoffmann-La Roche Ag Quinazoline derivatives
MXPA05001328A (es) 2002-08-07 2005-04-28 Hoffmann La Roche Derivados de tiazol.
CN100577660C (zh) 2002-09-12 2010-01-06 霍夫曼-拉罗奇有限公司 作为ppar激动剂用于治疗糖尿病的n-取代-1h-吲哚-5-丙酸化合物
ES2312819T3 (es) 2002-11-25 2009-03-01 F. Hoffmann-La Roche Ag Derivados de indolilo.
NZ539546A (en) * 2002-11-26 2007-11-30 Pfizer Prod Inc Phenyl substituted piperidine compounds for use as PPAR activators
GB0314967D0 (en) 2003-06-26 2003-07-30 Hoffmann La Roche Piperazine derivatives
MXPA06001570A (es) 2003-08-12 2006-05-15 Hoffmann La Roche Antagonistas del receptor de neuropeptido y (npy) 2-amino-5-benzoiltiazol.
WO2005014593A1 (en) 2003-08-12 2005-02-17 F. Hoffmann-La Roche Ag Thiazole derivatives as npy antagonists
US7649002B2 (en) 2004-02-04 2010-01-19 Pfizer Inc (3,5-dimethylpiperidin-1yl)(4-phenylpyrrolidin-3-yl)methanone derivatives as MCR4 agonists
EP1819681B1 (de) * 2004-11-23 2009-08-12 Warner-Lambert Company LLC 7-(2h-pyrazol-3-yl)-3,5-dihydroxy-heptansäure-derivate als hmg-co-a-reductase-inhibitoren zur behandlung von lipidemia
CA2609634C (en) 2005-05-03 2011-02-01 F. Hoffmann-La Roche Ag Tetracyclic azapyrazinoindolines as 5-ht2 ligands
JP2009503050A (ja) * 2005-08-04 2009-01-29 ファイザー・リミテッド ピペリジノイル−ピロリジンおよびピペリジノイル−ピペリジン化合物
BRPI0614834A2 (pt) 2005-08-18 2011-04-19 Hoffmann La Roche compostos, processo para a sua manufatura, composições farmacêuticas que os compreendem e usos destas
US7741317B2 (en) 2005-10-21 2010-06-22 Bristol-Myers Squibb Company LXR modulators
US7888376B2 (en) 2005-11-23 2011-02-15 Bristol-Myers Squibb Company Heterocyclic CETP inhibitors
ATE466007T1 (de) 2005-11-30 2010-05-15 Hoffmann La Roche 5-substituierte indol-2-carbonsäureamidderivate
KR101124156B1 (ko) 2005-11-30 2012-03-23 에프. 호프만-라 로슈 아게 1,5-치환된 인돌-2-일 아마이드 유도체
ES2362929T3 (es) 2005-11-30 2011-07-15 F. Hoffmann-La Roche Ag Derivados de 1,1-dioxo-tiomorfolinil-indolil-metanona para uso como moduladores de h3.
WO2007065820A1 (en) 2005-12-09 2007-06-14 F. Hoffmann-La Roche Ag Tricyclic amide derivatives useful for treating obesity
ES2334580T3 (es) 2005-12-15 2010-03-12 F. Hoffmann-La Roche Ag Derivados de pirrolo(2,3-c)piridina.
DE602006014305D1 (de) 2005-12-16 2010-06-24 Hoffmann La Roche Pyrroloä2,3-büpyridinderivate als modulatoren des h3-rezeptors
ES2402581T3 (es) * 2006-02-23 2013-05-06 Pfizer Limited Piperidinoilpirrolidinas como agonistas del receptor de melanocortina tipo 4
US7432255B2 (en) * 2006-05-16 2008-10-07 Hoffmann-La Roche Inc. 1H-indol-5-yl-piperazin-1-yl-methanone derivatives
CN101448820A (zh) 2006-05-30 2009-06-03 霍夫曼-拉罗奇有限公司 哌啶基嘧啶衍生物
US7514433B2 (en) 2006-08-03 2009-04-07 Hoffmann-La Roche Inc. 1H-indole-6-yl-piperazin-1-yl-methanone derivatives
US20100210633A1 (en) * 2006-10-12 2010-08-19 Epix Delaware, Inc. Carboxamide compounds and their use
JP2010509392A (ja) 2006-11-13 2010-03-25 ファイザー・プロダクツ・インク ジアリール、ジピリジニルおよびアリール−ピリジニル誘導体ならびにその使用
US20080182851A1 (en) * 2006-11-20 2008-07-31 Glenmark Pharmaceuticals S.A. Acetylene derivatives as stearoyl coa desaturase inhibitors
CN101663262B (zh) 2006-12-01 2014-03-26 百时美施贵宝公司 用于治疗动脉粥样硬化和心血管疾病的作为cetp抑制剂的n-(3-苄基)-2,2-(二苯基)-丙-1胺衍生物
US20080146559A1 (en) 2006-12-08 2008-06-19 Li Chen 4,5,6,7-Tetrahydro-Thieno [2,3-C] Pyridine Derivatives
WO2009013195A1 (en) * 2007-07-25 2009-01-29 F. Hoffmann-La Roche Ag Benzofuran- and benzo[b]thiophene-2-carboxylic acid amide derivatives and use thereof as histamine 3 receptor modulators
WO2009037542A2 (en) 2007-09-20 2009-03-26 Glenmark Pharmaceuticals, S.A. Spirocyclic compounds as stearoyl coa desaturase inhibitors
KR101076680B1 (ko) * 2007-11-01 2011-10-26 한미홀딩스 주식회사 (6ｒ)-3-헥실-4-히드록시-6-운데실-5,6-다이히드로피란-2-온의 제조방법 및 이에 사용되는 중간체
JP2011506466A (ja) 2007-12-11 2011-03-03 株式会社サイトパスファインダー カルボキサミド化合物ならびにケモカイン受容体アゴニストとしてのそれらの使用
WO2010015972A1 (en) * 2008-08-06 2010-02-11 Pfizer Limited Diazepine and diazocane compounds as mc4 agonists
US20130072519A1 (en) 2010-05-21 2013-03-21 Edward Lee Conn 2-phenyl benzoylamides
JP2014513923A (ja) 2011-03-04 2014-06-19 ファイザー・インク Ｅｄｎ３様ペプチドおよびその使用
MX2015014666A (es) 2013-04-17 2016-03-01 Pfizer Derivados de n-piperidin-3-ilbenzamida para tratar enfermedades cardiovasculares.
WO2016055901A1 (en) 2014-10-08 2016-04-14 Pfizer Inc. Substituted amide compounds
EP3911648A4 (de) 2019-01-18 2022-10-26 Astrazeneca AB Pcsk9-inhibitoren und verfahren zur verwendung davon

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US2542849A (en) * 1948-10-22 1951-02-20 Gen Aniline & Film Corp Diazotypes containing pyronones
US4206222A (en) * 1977-06-23 1980-06-03 Societe Civile Particuliere De Brevets Suffren Method for preparing a substance having properties against collagen diseases and products obtained
CA2035972C (en) * 1990-02-23 2006-07-11 Martin Karpf Process for the preparation of oxetanones

Also Published As

Publication number Publication date
EP0524495B1 (de) 1996-10-09
DE69214369T2 (de) 1997-03-27
ES2092603T3 (es) 1996-12-01
EP0524495A1 (de) 1993-01-27
DE69214369D1 (de) 1996-11-14
DK0524495T3 (da) 1996-11-25
US5274143A (en) 1993-12-28
JPH05194471A (ja) 1993-08-03
JP3248760B2 (ja) 2002-01-21
US5420305A (en) 1995-05-30

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Legal Events

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UEP Publication of translation of european patent specification