DE69213680T2 - Neues Verfahren zur Herstellung von 20-Oxo, 17-Alpha, 21-Dihydroxy Derivaten von Pregnan und neue Zwischenprodukte dafür - Google Patents

Neues Verfahren zur Herstellung von 20-Oxo, 17-Alpha, 21-Dihydroxy Derivaten von Pregnan und neue Zwischenprodukte dafür

Info

Publication number
DE69213680T2
DE69213680T2 DE69213680T DE69213680T DE69213680T2 DE 69213680 T2 DE69213680 T2 DE 69213680T2 DE 69213680 T DE69213680 T DE 69213680T DE 69213680 T DE69213680 T DE 69213680T DE 69213680 T2 DE69213680 T2 DE 69213680T2
Authority
DE
Germany
Prior art keywords
carbon atoms
compound
formula
new
pregnan
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69213680T
Other languages
English (en)
Other versions
DE69213680D1 (de
Inventor
Jean Buendia
Michel Vivat
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Aventis Pharma SA
Original Assignee
Roussel Uclaf SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Roussel Uclaf SA filed Critical Roussel Uclaf SA
Publication of DE69213680D1 publication Critical patent/DE69213680D1/de
Application granted granted Critical
Publication of DE69213680T2 publication Critical patent/DE69213680T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J7/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J5/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond
    • C07J5/0046—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa
    • C07J5/0053—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa not substituted in position 16
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
    • C07J41/005—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 the 17-beta position being substituted by an uninterrupted chain of only two carbon atoms, e.g. pregnane derivatives
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
DE69213680T 1991-11-08 1992-11-05 Neues Verfahren zur Herstellung von 20-Oxo, 17-Alpha, 21-Dihydroxy Derivaten von Pregnan und neue Zwischenprodukte dafür Expired - Lifetime DE69213680T2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9113777A FR2683530B1 (fr) 1991-11-08 1991-11-08 Nouveau procede de preparation de derives 20-oxo 17 alpha, 21-dihydroxyles du pregnane et nouveaux intermediaires.

Publications (2)

Publication Number Publication Date
DE69213680D1 DE69213680D1 (de) 1996-10-17
DE69213680T2 true DE69213680T2 (de) 1997-03-06

Family

ID=9418742

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69213680T Expired - Lifetime DE69213680T2 (de) 1991-11-08 1992-11-05 Neues Verfahren zur Herstellung von 20-Oxo, 17-Alpha, 21-Dihydroxy Derivaten von Pregnan und neue Zwischenprodukte dafür

Country Status (19)

Country Link
US (1) US5352808A (de)
EP (1) EP0546875B1 (de)
JP (1) JP3492717B2 (de)
KR (1) KR100220541B1 (de)
CN (1) CN1036719C (de)
AT (1) ATE142637T1 (de)
AU (1) AU666504B2 (de)
CA (1) CA2082284C (de)
DE (1) DE69213680T2 (de)
DK (1) DK0546875T3 (de)
ES (1) ES2091426T3 (de)
FR (2) FR2683530B1 (de)
GR (1) GR3021336T3 (de)
HU (1) HU213610B (de)
MX (1) MX9206354A (de)
PL (2) PL173451B1 (de)
RU (1) RU2106354C1 (de)
TW (1) TW228525B (de)
ZA (1) ZA928577B (de)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20070225510A1 (en) * 2006-03-27 2007-09-27 Henri John T Convergent Process for the Synthesis of Taxane Derivatives
CN102532230B (zh) * 2011-12-31 2013-02-13 赵云现 17a,21－二羟基黄体酮的制备方法

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR58097E (fr) * 1948-03-16 1953-09-21 Balai-brosse en caoutchouc, de forme et d'aspect variables, destiné au nettoyage intégral de toutes cuvettes, baignoires, lavabos, bidets, w.c.
FR1167928A (fr) * 1956-06-25 1958-12-03 Chimiotherapie Lab Franc Procédé de préparation de dérivés acyloxylés de stéroïdes
GB1440063A (en) * 1972-08-11 1976-06-23 Glaxo Lab Ltd 17alpha-esters of 17alpha,21-dihydroxy-20-oxo-steroids
DE2603266A1 (de) * 1976-01-29 1977-08-11 Hoechst Ag 17-hydroxyacetylsteroide und verfahren zu ihrer herstellung
FR2462445A1 (fr) * 1979-07-31 1981-02-13 Roussel Uclaf Nouveaux derives 17-/(hydroxymethyl) (formamido) methylene/steroides, leur procede de preparation et leur application a l'introduction de la chaine laterale hydroxyacetyle
FR2498607A1 (fr) * 1981-01-29 1982-07-30 Roussel Uclaf Nouveau procede de preparation de 17a-hydroxy 17b-hydroxyacetyle steroides, produits intermediaires correspondants et produits finals obtenus
FR2552766B1 (fr) * 1983-10-04 1987-06-26 Theramex Nouveau procede de preparation de derives de la serie du 17 a-hydroxy 19-nor progesterone
US4600538A (en) * 1984-08-02 1986-07-15 The Upjohn Company Corticosteroids from 17-keto steroids via 20-cyano-Δ17 (20)-pregnanes
US4568492A (en) * 1984-09-14 1986-02-04 The Upjohn Company Δ16-20-Keto steroid conversion to 17α-hydroxy-20-keto steroids
US5194602A (en) * 1988-04-08 1993-03-16 Gist-Brocades N.V. 9α-hydroxy-17-methylene steroids, process for their preparation and their use in the preparation of corticosteroids
FR2681069B1 (fr) * 1991-09-06 1995-04-28 Roussel Uclaf Nouveau procede de preparation de l'hydrocortisone et nouveaux intermediaires.

Also Published As

Publication number Publication date
CN1036719C (zh) 1997-12-17
EP0546875B1 (de) 1996-09-11
ES2091426T3 (es) 1996-11-01
JPH05194583A (ja) 1993-08-03
CN1072182A (zh) 1993-05-19
HUT64360A (en) 1993-12-28
JP3492717B2 (ja) 2004-02-03
MX9206354A (es) 1993-05-01
DK0546875T3 (da) 1996-11-25
TW228525B (de) 1994-08-21
ATE142637T1 (de) 1996-09-15
PL296513A1 (en) 1993-07-12
FR2683530B1 (fr) 1994-01-21
HU9203491D0 (en) 1993-01-28
FR2683530A1 (fr) 1993-05-14
AU2819092A (en) 1993-05-13
AU666504B2 (en) 1996-02-15
CA2082284A1 (fr) 1993-05-09
KR100220541B1 (ko) 1999-10-01
FR2683820A1 (fr) 1993-05-21
EP0546875A3 (en) 1994-05-18
RU2106354C1 (ru) 1998-03-10
ZA928577B (en) 1993-11-08
HU213610B (en) 1997-08-28
PL173451B1 (pl) 1998-03-31
GR3021336T3 (en) 1997-01-31
DE69213680D1 (de) 1996-10-17
FR2683820B1 (fr) 1995-05-19
CA2082284C (fr) 2000-02-15
PL173273B1 (pl) 1998-02-27
KR930010054A (ko) 1993-06-21
EP0546875A2 (de) 1993-06-16
US5352808A (en) 1994-10-04

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8327 Change in the person/name/address of the patent owner

Owner name: HOECHST MARION ROUSSEL, PUTEAUX, FR

8327 Change in the person/name/address of the patent owner

Owner name: AVENTIS PHARMA S.A., ANTONY, FR

8328 Change in the person/name/address of the agent

Representative=s name: PFENNING MEINIG & PARTNER GBR, 80339 MUENCHEN

8328 Change in the person/name/address of the agent

Representative=s name: MAIWALD PATENTANWALTSGESELLSCHAFT MBH, 80335 MUENC

R071 Expiry of right

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