ES2091426T3 - Nuevo procedimiento de preparacion de derivados 20-oxo-17-alfa,21-dihidroxilados del pregnano y nuevos productos intermedios. - Google Patents

Nuevo procedimiento de preparacion de derivados 20-oxo-17-alfa,21-dihidroxilados del pregnano y nuevos productos intermedios.

Info

Publication number
ES2091426T3
ES2091426T3 ES92402996T ES92402996T ES2091426T3 ES 2091426 T3 ES2091426 T3 ES 2091426T3 ES 92402996 T ES92402996 T ES 92402996T ES 92402996 T ES92402996 T ES 92402996T ES 2091426 T3 ES2091426 T3 ES 2091426T3
Authority
ES
Spain
Prior art keywords
carbon atoms
compound
formula
new
preparation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES92402996T
Other languages
English (en)
Inventor
Jean Buendia
Michel Vivat
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sanofi Aventis France
Original Assignee
Roussel Uclaf SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Roussel Uclaf SA filed Critical Roussel Uclaf SA
Application granted granted Critical
Publication of ES2091426T3 publication Critical patent/ES2091426T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J7/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J5/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond
    • C07J5/0046—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa
    • C07J5/0053—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa not substituted in position 16
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
    • C07J41/005—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 the 17-beta position being substituted by an uninterrupted chain of only two carbon atoms, e.g. pregnane derivatives
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Abstract

LA INVENCION SE REFIERE A UN PROCESO DE PREPARACION DE LOS COMPUESTOS (I): DONDE R1 ES PARTICULARMENTE HIDROGENO O ALQUILO, R2 ES ALQUILO Y LOS NUCLEOS A, B, C Y D LLEVAN EVENTUALMENTE UN O VARIOS ENLACES DOBLES, UNA O VARIAS FUNCIONES HIDROXI O CETONA EVENTUALMENTE PROTEGIDAS, UNO O VARIOS ATOMOS DE HALOGENO O UNO O VARIOS RADICALES ALQUILO, ALQUILOXI, ALQUENILO O ALQUINILO, PROCESO QUE CONSISTE EN OXIDAR UN COMPUESTO 20-FORMMIDO 21HIDROXI 17(20)-ENO CORRESPONDIENTE, EN PRESENCIA DE AGUA Y A CONTINUACION EN HIDROLIZAR EL 21-FORMIATO OBTENIDO. LA INVENCION SE REFIERE TAMBIEN A INTERMEDIOS NUEVOS ASI OBTENIDOS.
ES92402996T 1991-11-08 1992-11-05 Nuevo procedimiento de preparacion de derivados 20-oxo-17-alfa,21-dihidroxilados del pregnano y nuevos productos intermedios. Expired - Lifetime ES2091426T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9113777A FR2683530B1 (fr) 1991-11-08 1991-11-08 Nouveau procede de preparation de derives 20-oxo 17 alpha, 21-dihydroxyles du pregnane et nouveaux intermediaires.

Publications (1)

Publication Number Publication Date
ES2091426T3 true ES2091426T3 (es) 1996-11-01

Family

ID=9418742

Family Applications (1)

Application Number Title Priority Date Filing Date
ES92402996T Expired - Lifetime ES2091426T3 (es) 1991-11-08 1992-11-05 Nuevo procedimiento de preparacion de derivados 20-oxo-17-alfa,21-dihidroxilados del pregnano y nuevos productos intermedios.

Country Status (19)

Country Link
US (1) US5352808A (es)
EP (1) EP0546875B1 (es)
JP (1) JP3492717B2 (es)
KR (1) KR100220541B1 (es)
CN (1) CN1036719C (es)
AT (1) ATE142637T1 (es)
AU (1) AU666504B2 (es)
CA (1) CA2082284C (es)
DE (1) DE69213680T2 (es)
DK (1) DK0546875T3 (es)
ES (1) ES2091426T3 (es)
FR (2) FR2683530B1 (es)
GR (1) GR3021336T3 (es)
HU (1) HU213610B (es)
MX (1) MX9206354A (es)
PL (2) PL173273B1 (es)
RU (1) RU2106354C1 (es)
TW (1) TW228525B (es)
ZA (1) ZA928577B (es)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20070225510A1 (en) * 2006-03-27 2007-09-27 Henri John T Convergent Process for the Synthesis of Taxane Derivatives
CN102532230B (zh) * 2011-12-31 2013-02-13 赵云现 17a,21－二羟基黄体酮的制备方法

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR58097E (fr) * 1948-03-16 1953-09-21 Balai-brosse en caoutchouc, de forme et d'aspect variables, destiné au nettoyage intégral de toutes cuvettes, baignoires, lavabos, bidets, w.c.
FR1167928A (fr) * 1956-06-25 1958-12-03 Chimiotherapie Lab Franc Procédé de préparation de dérivés acyloxylés de stéroïdes
GB1440063A (en) * 1972-08-11 1976-06-23 Glaxo Lab Ltd 17alpha-esters of 17alpha,21-dihydroxy-20-oxo-steroids
DE2603266A1 (de) * 1976-01-29 1977-08-11 Hoechst Ag 17-hydroxyacetylsteroide und verfahren zu ihrer herstellung
FR2462445A1 (fr) * 1979-07-31 1981-02-13 Roussel Uclaf Nouveaux derives 17-/(hydroxymethyl) (formamido) methylene/steroides, leur procede de preparation et leur application a l'introduction de la chaine laterale hydroxyacetyle
FR2498607A1 (fr) * 1981-01-29 1982-07-30 Roussel Uclaf Nouveau procede de preparation de 17a-hydroxy 17b-hydroxyacetyle steroides, produits intermediaires correspondants et produits finals obtenus
FR2552766B1 (fr) * 1983-10-04 1987-06-26 Theramex Nouveau procede de preparation de derives de la serie du 17 a-hydroxy 19-nor progesterone
US4600538A (en) * 1984-08-02 1986-07-15 The Upjohn Company Corticosteroids from 17-keto steroids via 20-cyano-Δ17 (20)-pregnanes
US4568492A (en) * 1984-09-14 1986-02-04 The Upjohn Company Δ16-20-Keto steroid conversion to 17α-hydroxy-20-keto steroids
DE68901104D1 (de) * 1988-04-08 1992-05-07 Roussel Uclaf 9-alpha-hydroxy-17-methylen-steroidderivate, verfahren zu deren herstellung und ihre anwendung in der herstellung von corticosteroiden.
FR2681069B1 (fr) * 1991-09-06 1995-04-28 Roussel Uclaf Nouveau procede de preparation de l'hydrocortisone et nouveaux intermediaires.

Also Published As

Publication number Publication date
CA2082284C (fr) 2000-02-15
CA2082284A1 (fr) 1993-05-09
AU666504B2 (en) 1996-02-15
US5352808A (en) 1994-10-04
AU2819092A (en) 1993-05-13
EP0546875B1 (fr) 1996-09-11
FR2683530A1 (fr) 1993-05-14
HU9203491D0 (en) 1993-01-28
FR2683820A1 (fr) 1993-05-21
HUT64360A (en) 1993-12-28
ZA928577B (en) 1993-11-08
TW228525B (es) 1994-08-21
FR2683530B1 (fr) 1994-01-21
KR100220541B1 (ko) 1999-10-01
EP0546875A3 (en) 1994-05-18
CN1072182A (zh) 1993-05-19
EP0546875A2 (fr) 1993-06-16
JPH05194583A (ja) 1993-08-03
GR3021336T3 (en) 1997-01-31
MX9206354A (es) 1993-05-01
HU213610B (en) 1997-08-28
DE69213680T2 (de) 1997-03-06
PL296513A1 (en) 1993-07-12
RU2106354C1 (ru) 1998-03-10
PL173451B1 (pl) 1998-03-31
CN1036719C (zh) 1997-12-17
DE69213680D1 (de) 1996-10-17
PL173273B1 (pl) 1998-02-27
DK0546875T3 (da) 1996-11-25
KR930010054A (ko) 1993-06-21
JP3492717B2 (ja) 2004-02-03
ATE142637T1 (de) 1996-09-15
FR2683820B1 (fr) 1995-05-19

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