DE68901104D1 - 9-alpha-hydroxy-17-methylen-steroidderivate, verfahren zu deren herstellung und ihre anwendung in der herstellung von corticosteroiden. - Google Patents

9-alpha-hydroxy-17-methylen-steroidderivate, verfahren zu deren herstellung und ihre anwendung in der herstellung von corticosteroiden.

Info

Publication number
DE68901104D1
DE68901104D1 DE8989200891T DE68901104T DE68901104D1 DE 68901104 D1 DE68901104 D1 DE 68901104D1 DE 8989200891 T DE8989200891 T DE 8989200891T DE 68901104 T DE68901104 T DE 68901104T DE 68901104 D1 DE68901104 D1 DE 68901104D1
Authority
DE
Germany
Prior art keywords
production
corticosteroids
alpha
hydroxy
application
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE8989200891T
Other languages
English (en)
Inventor
Jacobus Nicolaas Maria Batist
Arthur Friedrich Marx
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Aventis Pharma SA
Original Assignee
Roussel Uclaf SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Roussel Uclaf SA filed Critical Roussel Uclaf SA
Application granted granted Critical
Publication of DE68901104D1 publication Critical patent/DE68901104D1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J13/00—Normal steroids containing carbon, hydrogen, halogen or oxygen having a carbon-to-carbon double bond from or to position 17
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J5/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond
    • C07J5/0007—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond not substituted in position 17 alfa
    • C07J5/0023—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond not substituted in position 17 alfa substituted in position 16
    • C07J5/003—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond not substituted in position 17 alfa substituted in position 16 by a saturated or unsaturated hydrocarbon group including 16-alkylidene substitutes
    • C07J5/0038—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond not substituted in position 17 alfa substituted in position 16 by a saturated or unsaturated hydrocarbon group including 16-alkylidene substitutes by an alkyl group
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J13/00—Normal steroids containing carbon, hydrogen, halogen or oxygen having a carbon-to-carbon double bond from or to position 17
    • C07J13/005—Normal steroids containing carbon, hydrogen, halogen or oxygen having a carbon-to-carbon double bond from or to position 17 with double bond in position 16 (17)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J13/00—Normal steroids containing carbon, hydrogen, halogen or oxygen having a carbon-to-carbon double bond from or to position 17
    • C07J13/007—Normal steroids containing carbon, hydrogen, halogen or oxygen having a carbon-to-carbon double bond from or to position 17 with double bond in position 17 (20)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J21/00—Normal steroids containing carbon, hydrogen, halogen or oxygen having an oxygen-containing hetero ring spiro-condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C07J21/005—Ketals
    • C07J21/006—Ketals at position 3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
    • C07J41/005—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 the 17-beta position being substituted by an uninterrupted chain of only two carbon atoms, e.g. pregnane derivatives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J5/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond
    • C07J5/0007—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond not substituted in position 17 alfa
    • C07J5/0015—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond not substituted in position 17 alfa not substituted in position 16
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J7/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms
    • C07J7/0005—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21
    • C07J7/001—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21 substituted in position 20 by a keto group
    • C07J7/0015—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21 substituted in position 20 by a keto group not substituted in position 17 alfa
    • C07J7/002—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21 substituted in position 20 by a keto group not substituted in position 17 alfa not substituted in position 16
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J7/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms
    • C07J7/0005—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21
    • C07J7/001—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21 substituted in position 20 by a keto group
    • C07J7/004—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21 substituted in position 20 by a keto group substituted in position 17 alfa
    • C07J7/0045—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21 substituted in position 20 by a keto group substituted in position 17 alfa not substituted in position 16
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J7/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms
    • C07J7/008—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms substituted in position 21
    • C07J7/009—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms substituted in position 21 by only one oxygen atom doubly bound
DE8989200891T 1988-04-08 1989-04-07 9-alpha-hydroxy-17-methylen-steroidderivate, verfahren zu deren herstellung und ihre anwendung in der herstellung von corticosteroiden. Expired - Lifetime DE68901104D1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP88200675 1988-04-08

Publications (1)

Publication Number Publication Date
DE68901104D1 true DE68901104D1 (de) 1992-05-07

Family

ID=8199778

Family Applications (1)

Application Number Title Priority Date Filing Date
DE8989200891T Expired - Lifetime DE68901104D1 (de) 1988-04-08 1989-04-07 9-alpha-hydroxy-17-methylen-steroidderivate, verfahren zu deren herstellung und ihre anwendung in der herstellung von corticosteroiden.

Country Status (18)

Country Link
US (1) US5194602A (de)
EP (1) EP0336521B1 (de)
JP (1) JP2812397B2 (de)
KR (1) KR0138777B1 (de)
CN (2) CN1187365C (de)
AU (1) AU618350B2 (de)
CA (1) CA1332409C (de)
DE (1) DE68901104D1 (de)
DK (1) DK175401B1 (de)
ES (1) ES2033516T3 (de)
FI (1) FI108436B (de)
GR (1) GR3004539T3 (de)
HU (1) HU208437B (de)
IE (1) IE62277B1 (de)
IL (1) IL89880A (de)
NO (1) NO300894B1 (de)
PT (1) PT90227B (de)
WO (1) WO1989009781A1 (de)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PT95988A (pt) * 1989-11-27 1991-09-13 Schering Corp Processo para a desidratacao de intermediarios corticoesteroides
FR2677028B1 (fr) * 1991-05-23 1994-01-21 Roussel Uclaf Nouveaux derives sterouides du pregna-4,9(11),17(20)-trien-3-one.
FR2677029B1 (fr) * 1991-05-23 1994-01-21 Roussel Uclaf Nouveaux derives sterouides de l'andostra-4,9(11),16-trien-3-one.
FR2676740B1 (fr) * 1991-05-23 1993-11-05 Roussel Uclaf Nouveaux derives sterouides du pregna-4,9(11),17(20)-trie-3-one, leur preparation, leur application a la preparation de composes sterouides de type pregna-4,9(11),16-triene-3,20-dione et nouveaux intermediaires.
FR2681069B1 (fr) * 1991-09-06 1995-04-28 Roussel Uclaf Nouveau procede de preparation de l'hydrocortisone et nouveaux intermediaires.
FR2683530B1 (fr) * 1991-11-08 1994-01-21 Roussel Uclaf Nouveau procede de preparation de derives 20-oxo 17 alpha, 21-dihydroxyles du pregnane et nouveaux intermediaires.
DE69321099D1 (de) * 1992-01-28 1998-10-22 Schering Corp Neue steroid-zwischenprodukte und verfahren zu ihrer herstellung
CN1061984C (zh) * 1996-04-18 2001-02-14 上海华联制药有限公司 甾体激素化合物中引入9-11双键的一种方法
ATE473759T1 (de) 1998-05-22 2010-07-15 Univ Leland Stanford Junior Bifunktionelle moleküle sowie darauf basierende therapien.
US6855836B2 (en) * 2000-10-26 2005-02-15 Jenapharm Gmbh & Co. Kg 17-Methylene steroids, process for their production and pharmaceutical compositions that contain these compounds
PL1889198T3 (pl) 2005-04-28 2015-04-30 Proteus Digital Health Inc System farmakologiczno-informatyczny
US9062126B2 (en) 2005-09-16 2015-06-23 Raptor Pharmaceuticals Inc. Compositions comprising receptor-associated protein (RAP) variants specific for CR-containing proteins and uses thereof
US20080318870A1 (en) 2007-06-19 2008-12-25 Kythera Biopharmaceuticals, Inc. Synthetic bile acid compositions and methods
US8242294B2 (en) 2007-06-19 2012-08-14 Kythera Biopharmaceuticals, Inc. Synthetic bile acid compositions and methods
TWI503396B (zh) * 2007-06-19 2015-10-11 Kythera Biopharmaceuticals Inc 合成膽汁酸組合物，方法及製備
JOP20180077A1 (ar) 2007-06-19 2019-01-30 Kythera Biopharmaceuticals Inc تركيبات وطرق لحمض صفراوي تخليقي
ES2919563T3 (es) 2009-02-20 2022-07-27 Enhanx Biopharm Inc Sistema de administración de medicamentos a base de glutatión
JP2012526144A (ja) 2009-05-06 2012-10-25 ラボラトリー スキン ケア インコーポレイテッド 活性物質−リン酸カルシウム粒子複合体を含む経皮送達組成物およびその使用方法
GB2480632A (en) 2010-05-25 2011-11-30 Kythera Biopharmaceuticals Inc Preparation of 12-keto and 12-alpha-hydroxy steroids
MX2013001704A (es) 2010-08-12 2013-06-28 Kythera Biopharmaceuticals Inc Composiciones sinteticas de acido biliar y metodos.
WO2013044119A1 (en) * 2011-09-22 2013-03-28 Kythera Biopharmaceuticals, Inc. Compositions and methods related to deoxycholic acid and its polymorphs

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL103170C (de) * 1958-11-14
DE1568506A1 (de) * 1966-03-23 1970-07-16 Hoechst Ag Verfahren zur Herstellung von delta?-Pregnen-3,21-diol-20-on-21-acylaten
US3445907A (en) * 1967-02-16 1969-05-27 Ind Tectonics Inc Roller retaining method for roller bearing separators
US4255344A (en) * 1978-11-08 1981-03-10 Mitsubishi Chemical Industries, Limited 9-α-Hydroxy steroids
FR2462445A1 (fr) * 1979-07-31 1981-02-13 Roussel Uclaf Nouveaux derives 17-/(hydroxymethyl) (formamido) methylene/steroides, leur procede de preparation et leur application a l'introduction de la chaine laterale hydroxyacetyle
FR2486947A1 (fr) * 1980-07-15 1982-01-22 Roussel Uclaf Nouveaux derives steroides 20-isonitriles 17(20) insatures, leur procede de preparation et leur application a la preparation des steroides 17a-hydroxy 20-ceto
DE3136917A1 (de) * 1980-09-27 1982-05-19 Barmag Barmer Maschinenfabrik Ag, 5630 Remscheid "kraftstoffoerderpumpe"
FR2493324B1 (de) * 1980-11-05 1983-01-21 Roussel Uclaf
FR2521567A1 (fr) * 1982-02-18 1983-08-19 Roussel Uclaf Nouveaux derives steroides 17(20)nitro, leur procede de preparation et leur application a la preparation de corticosteroides
EP0123734A1 (de) * 1983-04-29 1984-11-07 Gist-Brocades N.V. 17-(Isocyano-sulfonylmethylen)-Steroide, 17-(Formamido-sulfonylmethylen)-Steroide und ihre Herstellung

Also Published As

Publication number Publication date
NO904333L (no) 1990-12-03
FI108436B (fi) 2002-01-31
DK240890D0 (da) 1990-10-05
AU618350B2 (en) 1991-12-19
NO904333D0 (no) 1990-10-05
JPH03503645A (ja) 1991-08-15
DK240890A (da) 1990-10-05
IL89880A0 (en) 1989-12-15
CN1141301A (zh) 1997-01-29
JP2812397B2 (ja) 1998-10-22
IE891134L (en) 1989-10-08
IL89880A (en) 1994-06-24
DK175401B1 (da) 2004-09-27
NO300894B1 (no) 1997-08-11
PT90227A (pt) 1989-11-10
FI904877A0 (fi) 1990-10-03
US5194602A (en) 1993-03-16
IE62277B1 (en) 1995-01-25
CN1187365C (zh) 2005-02-02
CA1332409C (en) 1994-10-11
HU208437B (en) 1993-10-28
HU892602D0 (en) 1991-03-28
GR3004539T3 (de) 1993-04-28
CN1032211C (zh) 1996-07-03
PT90227B (pt) 1994-06-30
EP0336521A1 (de) 1989-10-11
WO1989009781A1 (en) 1989-10-19
KR0138777B1 (ko) 1998-04-30
CN1036774A (zh) 1989-11-01
EP0336521B1 (de) 1992-04-01
AU3431389A (en) 1989-11-03
KR900700499A (ko) 1990-08-13
ES2033516T3 (es) 1993-03-16
HUT55411A (en) 1991-05-28

Similar Documents

Publication Publication Date Title
DE68901104D1 (de) 9-alpha-hydroxy-17-methylen-steroidderivate, verfahren zu deren herstellung und ihre anwendung in der herstellung von corticosteroiden.
DE3686649T2 (de) Pyrazol-oxim-derivate, verfahren zu deren herstellung und anwendung.
DE68905267T2 (de) Halbleiteranordnung von metallhoecker-typ und verfahren zu deren herstellung.
DE3860769D1 (de) Polymer-zusammensetzung, verfahren zu deren herstellung und deren anwendung.
DE3680859D1 (de) Chinolinderivate und verfahren zu deren herstellung.
DE68917798T2 (de) Anschlussstruktur und Verfahren zu deren Herstellung.
ATE103603T1 (de) Benzimidazolderivate, verfahren zu deren herstellung und deren therapeutische anwendung.
DE3783706D1 (de) Feinteilchen-cellulose und verfahren zu deren herstellung.
DE3862937D1 (de) 3-oxo-propannitril heteroarylderivate und verfahren zu deren herstellung.
DE3877709T2 (de) Indan-derivate und verfahren zu deren herstellung.
DE3480704D1 (de) 1,4-dihydropyridine derivate, verfahren zu deren herstellung und verwendung in der pharmazie.
DE69111327T2 (de) Block von Mikroverbindungsstiften und Verfahren zu dessen Herstellung.
DE68907031D1 (de) Verbindung, zusammensetzung, verfahren und anwendung.
DE68910523D1 (de) Trizyklische 3-oxo-propannitril-derivate und verfahren zu deren herstellung.
DE3865927D1 (de) Tetrahydroindazolyl-benzoxazine, verfahren zu deren herstellung und deren anwendung.
DE3779881D1 (de) Steroid-derivate und verfahren zu ihrer herstellung.
DE3784185D1 (de) Mehrschichtiger mikrowellenabsorber und verfahren zu seiner herstellung.
DE3583803D1 (de) Rhodanin-derivate und verfahren zu deren herstellung.
DE69706157T2 (de) Diarylmethylidenefuran-derivate, verfahren zu deren herstellung und ihre verwendungen in therapie
DE3873223D1 (de) Benzoxazinyl-triazol-oxide, verfahren zu deren herstellung und deren anwendung.
DE3877124T2 (de) Imidazol-derivate, verfahren zu deren herstellung und deren anwendung als alpha-2-adrenoceptor-antagonisten.
DE3583449D1 (de) Lieferschein und verfahren zu seiner herstellung.
DE3675271D1 (de) 1,4-dihydropyridinderivate verwendbar in der behandlung von kardiovaskulaeren stoerungen und verfahren zu ihrer herstellung.
DE68903918D1 (de) Pyrazolverbindungen, verfahren zu deren herstellung, deren anwendung und zwischenprodukte fuer deren herstellung.
DE68914224D1 (de) Benzimidazol-Derivate und Verfahren zu deren Herstellung und deren Anwendung.

Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8327 Change in the person/name/address of the patent owner

Owner name: HOECHST MARION ROUSSEL, PUTEAUX, FR

8327 Change in the person/name/address of the patent owner

Owner name: AVENTIS PHARMA S.A., ANTONY, FR

8328 Change in the person/name/address of the agent

Representative=s name: PFENNING MEINIG & PARTNER GBR, 80339 MUENCHEN