CN1036774A - 9α-羟基-17-亚甲基甾类的制备法及该甾类在制备皮质甾类中用途 - Google Patents
9α-羟基-17-亚甲基甾类的制备法及该甾类在制备皮质甾类中用途 Download PDFInfo
- Publication number
- CN1036774A CN1036774A CN89102092A CN89102092A CN1036774A CN 1036774 A CN1036774 A CN 1036774A CN 89102092 A CN89102092 A CN 89102092A CN 89102092 A CN89102092 A CN 89102092A CN 1036774 A CN1036774 A CN 1036774A
- Authority
- CN
- China
- Prior art keywords
- alpha
- hydroxy
- compound
- methyl
- pregnant
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J13/00—Normal steroids containing carbon, hydrogen, halogen or oxygen having a carbon-to-carbon double bond from or to position 17
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J5/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond
- C07J5/0007—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond not substituted in position 17 alfa
- C07J5/0023—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond not substituted in position 17 alfa substituted in position 16
- C07J5/003—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond not substituted in position 17 alfa substituted in position 16 by a saturated or unsaturated hydrocarbon group including 16-alkylidene substitutes
- C07J5/0038—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond not substituted in position 17 alfa substituted in position 16 by a saturated or unsaturated hydrocarbon group including 16-alkylidene substitutes by an alkyl group
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J13/00—Normal steroids containing carbon, hydrogen, halogen or oxygen having a carbon-to-carbon double bond from or to position 17
- C07J13/005—Normal steroids containing carbon, hydrogen, halogen or oxygen having a carbon-to-carbon double bond from or to position 17 with double bond in position 16 (17)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J13/00—Normal steroids containing carbon, hydrogen, halogen or oxygen having a carbon-to-carbon double bond from or to position 17
- C07J13/007—Normal steroids containing carbon, hydrogen, halogen or oxygen having a carbon-to-carbon double bond from or to position 17 with double bond in position 17 (20)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J21/00—Normal steroids containing carbon, hydrogen, halogen or oxygen having an oxygen-containing hetero ring spiro-condensed with the cyclopenta(a)hydrophenanthrene skeleton
- C07J21/005—Ketals
- C07J21/006—Ketals at position 3
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
- C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
- C07J41/005—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 the 17-beta position being substituted by an uninterrupted chain of only two carbon atoms, e.g. pregnane derivatives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J5/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond
- C07J5/0007—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond not substituted in position 17 alfa
- C07J5/0015—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond not substituted in position 17 alfa not substituted in position 16
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J7/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms
- C07J7/0005—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21
- C07J7/001—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21 substituted in position 20 by a keto group
- C07J7/0015—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21 substituted in position 20 by a keto group not substituted in position 17 alfa
- C07J7/002—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21 substituted in position 20 by a keto group not substituted in position 17 alfa not substituted in position 16
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J7/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms
- C07J7/0005—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21
- C07J7/001—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21 substituted in position 20 by a keto group
- C07J7/004—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21 substituted in position 20 by a keto group substituted in position 17 alfa
- C07J7/0045—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21 substituted in position 20 by a keto group substituted in position 17 alfa not substituted in position 16
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J7/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms
- C07J7/008—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms substituted in position 21
- C07J7/009—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms substituted in position 21 by only one oxygen atom doubly bound
Abstract
Description
Claims (21)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
NL88200675.2 | 1988-04-08 | ||
EP88200675 | 1988-04-08 |
Related Child Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CNB951202561A Division CN1187365C (zh) | 1988-04-08 | 1989-04-08 | 9α-羟基-17-亚甲基甾类在制备皮质甾类中的用途 |
Publications (2)
Publication Number | Publication Date |
---|---|
CN1036774A true CN1036774A (zh) | 1989-11-01 |
CN1032211C CN1032211C (zh) | 1996-07-03 |
Family
ID=8199778
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CNB951202561A Expired - Lifetime CN1187365C (zh) | 1988-04-08 | 1989-04-08 | 9α-羟基-17-亚甲基甾类在制备皮质甾类中的用途 |
CN89102092A Expired - Lifetime CN1032211C (zh) | 1988-04-08 | 1989-04-08 | 9α-羟基-17-亚甲基甾类的制备方法 |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CNB951202561A Expired - Lifetime CN1187365C (zh) | 1988-04-08 | 1989-04-08 | 9α-羟基-17-亚甲基甾类在制备皮质甾类中的用途 |
Country Status (18)
Country | Link |
---|---|
US (1) | US5194602A (zh) |
EP (1) | EP0336521B1 (zh) |
JP (1) | JP2812397B2 (zh) |
KR (1) | KR0138777B1 (zh) |
CN (2) | CN1187365C (zh) |
AU (1) | AU618350B2 (zh) |
CA (1) | CA1332409C (zh) |
DE (1) | DE68901104D1 (zh) |
DK (1) | DK175401B1 (zh) |
ES (1) | ES2033516T3 (zh) |
FI (1) | FI108436B (zh) |
GR (1) | GR3004539T3 (zh) |
HU (1) | HU208437B (zh) |
IE (1) | IE62277B1 (zh) |
IL (1) | IL89880A (zh) |
NO (1) | NO300894B1 (zh) |
PT (1) | PT90227B (zh) |
WO (1) | WO1989009781A1 (zh) |
Families Citing this family (21)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
MY105302A (en) * | 1989-11-27 | 1994-09-30 | Schering Corp | Process for dehydrating corticosteroid intermediates. |
FR2677029B1 (fr) * | 1991-05-23 | 1994-01-21 | Roussel Uclaf | Nouveaux derives sterouides de l'andostra-4,9(11),16-trien-3-one. |
FR2677028B1 (fr) * | 1991-05-23 | 1994-01-21 | Roussel Uclaf | Nouveaux derives sterouides du pregna-4,9(11),17(20)-trien-3-one. |
FR2676740B1 (fr) * | 1991-05-23 | 1993-11-05 | Roussel Uclaf | Nouveaux derives sterouides du pregna-4,9(11),17(20)-trie-3-one, leur preparation, leur application a la preparation de composes sterouides de type pregna-4,9(11),16-triene-3,20-dione et nouveaux intermediaires. |
FR2681069B1 (fr) * | 1991-09-06 | 1995-04-28 | Roussel Uclaf | Nouveau procede de preparation de l'hydrocortisone et nouveaux intermediaires. |
FR2683530B1 (fr) * | 1991-11-08 | 1994-01-21 | Roussel Uclaf | Nouveau procede de preparation de derives 20-oxo 17 alpha, 21-dihydroxyles du pregnane et nouveaux intermediaires. |
WO1993015103A2 (en) * | 1992-01-28 | 1993-08-05 | Schering Corporation | Novel steroid intermediates and processes for their preparation |
CN1061984C (zh) * | 1996-04-18 | 2001-02-14 | 上海华联制药有限公司 | 甾体激素化合物中引入9-11双键的一种方法 |
CA2330611A1 (en) | 1998-05-22 | 1999-12-02 | The Board Of Trustees Of The Leland Stanford Junior University | Bifunctional molecules and therapies based thereon |
US6855836B2 (en) * | 2000-10-26 | 2005-02-15 | Jenapharm Gmbh & Co. Kg | 17-Methylene steroids, process for their production and pharmaceutical compositions that contain these compounds |
SI1889198T1 (sl) | 2005-04-28 | 2015-02-27 | Proteus Digital Health, Inc. | Farma-informacijski sistem |
WO2007035716A2 (en) | 2005-09-16 | 2007-03-29 | Raptor Pharmaceutical Inc. | Compositions comprising receptor-associated protein (rap) variants specific for cr-containing proteins and uses thereof |
US20080318870A1 (en) | 2007-06-19 | 2008-12-25 | Kythera Biopharmaceuticals, Inc. | Synthetic bile acid compositions and methods |
MX360094B (es) * | 2007-06-19 | 2018-10-19 | Kythera Biopharmaceuticals Inc Star | Composición, método y preparación del ácido biliar sintético. |
JOP20180077A1 (ar) | 2007-06-19 | 2019-01-30 | Kythera Biopharmaceuticals Inc | تركيبات وطرق لحمض صفراوي تخليقي |
US8242294B2 (en) | 2007-06-19 | 2012-08-14 | Kythera Biopharmaceuticals, Inc. | Synthetic bile acid compositions and methods |
WO2010095940A2 (en) | 2009-02-20 | 2010-08-26 | To-Bbb Holding B.V. | Glutathione-based drug delivery system |
NZ596876A (en) | 2009-05-06 | 2014-01-31 | Lab Skin Care Inc | Dermal delivery compositions comprising active agent-calcium phosphate particle complexes and methods of using the same |
GB2480632A (en) | 2010-05-25 | 2011-11-30 | Kythera Biopharmaceuticals Inc | Preparation of 12-keto and 12-alpha-hydroxy steroids |
BR112013003216A2 (pt) | 2010-08-12 | 2016-05-17 | Kythera Biopharmaceuticals Inc | composições sintéticas de ácido biliar e métodos |
WO2013044119A1 (en) * | 2011-09-22 | 2013-03-28 | Kythera Biopharmaceuticals, Inc. | Compositions and methods related to deoxycholic acid and its polymorphs |
Family Cites Families (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
NL103170C (zh) * | 1958-11-14 | |||
DE1568506A1 (de) * | 1966-03-23 | 1970-07-16 | Hoechst Ag | Verfahren zur Herstellung von delta?-Pregnen-3,21-diol-20-on-21-acylaten |
US3445907A (en) * | 1967-02-16 | 1969-05-27 | Ind Tectonics Inc | Roller retaining method for roller bearing separators |
US4255344A (en) * | 1978-11-08 | 1981-03-10 | Mitsubishi Chemical Industries, Limited | 9-α-Hydroxy steroids |
FR2462445A1 (fr) * | 1979-07-31 | 1981-02-13 | Roussel Uclaf | Nouveaux derives 17-/(hydroxymethyl) (formamido) methylene/steroides, leur procede de preparation et leur application a l'introduction de la chaine laterale hydroxyacetyle |
FR2486947A1 (fr) * | 1980-07-15 | 1982-01-22 | Roussel Uclaf | Nouveaux derives steroides 20-isonitriles 17(20) insatures, leur procede de preparation et leur application a la preparation des steroides 17a-hydroxy 20-ceto |
DE3136917A1 (de) * | 1980-09-27 | 1982-05-19 | Barmag Barmer Maschinenfabrik Ag, 5630 Remscheid | "kraftstoffoerderpumpe" |
FR2493324B1 (zh) * | 1980-11-05 | 1983-01-21 | Roussel Uclaf | |
FR2521567A1 (fr) * | 1982-02-18 | 1983-08-19 | Roussel Uclaf | Nouveaux derives steroides 17(20)nitro, leur procede de preparation et leur application a la preparation de corticosteroides |
EP0123734A1 (en) * | 1983-04-29 | 1984-11-07 | Gist-Brocades N.V. | 17-(Isocyano-sulfonylmethylene)-steroids, 17-(formamido-sulfonylmethylene)-steroids and their preparation |
-
1989
- 1989-04-07 US US07/474,852 patent/US5194602A/en not_active Expired - Lifetime
- 1989-04-07 KR KR1019890702133A patent/KR0138777B1/ko not_active IP Right Cessation
- 1989-04-07 EP EP89200891A patent/EP0336521B1/en not_active Expired - Lifetime
- 1989-04-07 AU AU34313/89A patent/AU618350B2/en not_active Expired
- 1989-04-07 WO PCT/NL1989/000020 patent/WO1989009781A1/en active IP Right Grant
- 1989-04-07 JP JP1504593A patent/JP2812397B2/ja not_active Expired - Lifetime
- 1989-04-07 DE DE8989200891T patent/DE68901104D1/de not_active Expired - Lifetime
- 1989-04-07 HU HU892602A patent/HU208437B/hu unknown
- 1989-04-07 ES ES198989200891T patent/ES2033516T3/es not_active Expired - Lifetime
- 1989-04-07 IL IL8988089A patent/IL89880A/en unknown
- 1989-04-07 PT PT90227A patent/PT90227B/pt not_active IP Right Cessation
- 1989-04-08 CN CNB951202561A patent/CN1187365C/zh not_active Expired - Lifetime
- 1989-04-08 CN CN89102092A patent/CN1032211C/zh not_active Expired - Lifetime
- 1989-04-10 CA CA000596257A patent/CA1332409C/en not_active Expired - Lifetime
- 1989-04-10 IE IE113489A patent/IE62277B1/en not_active IP Right Cessation
-
1990
- 1990-10-03 FI FI904877A patent/FI108436B/fi not_active IP Right Cessation
- 1990-10-05 NO NO904333A patent/NO300894B1/no not_active IP Right Cessation
- 1990-10-05 DK DK199002408A patent/DK175401B1/da not_active IP Right Cessation
-
1992
- 1992-05-08 GR GR920400800T patent/GR3004539T3/el unknown
Also Published As
Publication number | Publication date |
---|---|
IL89880A (en) | 1994-06-24 |
KR0138777B1 (ko) | 1998-04-30 |
JP2812397B2 (ja) | 1998-10-22 |
US5194602A (en) | 1993-03-16 |
DK240890A (da) | 1990-10-05 |
FI904877A0 (fi) | 1990-10-03 |
IL89880A0 (en) | 1989-12-15 |
GR3004539T3 (zh) | 1993-04-28 |
DK240890D0 (da) | 1990-10-05 |
DK175401B1 (da) | 2004-09-27 |
HUT55411A (en) | 1991-05-28 |
IE891134L (en) | 1989-10-08 |
KR900700499A (ko) | 1990-08-13 |
AU618350B2 (en) | 1991-12-19 |
NO904333L (no) | 1990-12-03 |
DE68901104D1 (de) | 1992-05-07 |
NO904333D0 (no) | 1990-10-05 |
PT90227B (pt) | 1994-06-30 |
CN1141301A (zh) | 1997-01-29 |
PT90227A (pt) | 1989-11-10 |
JPH03503645A (ja) | 1991-08-15 |
IE62277B1 (en) | 1995-01-25 |
FI108436B (fi) | 2002-01-31 |
NO300894B1 (no) | 1997-08-11 |
EP0336521A1 (en) | 1989-10-11 |
WO1989009781A1 (en) | 1989-10-19 |
EP0336521B1 (en) | 1992-04-01 |
CN1187365C (zh) | 2005-02-02 |
HU208437B (en) | 1993-10-28 |
AU3431389A (en) | 1989-11-03 |
CA1332409C (en) | 1994-10-11 |
CN1032211C (zh) | 1996-07-03 |
HU892602D0 (en) | 1991-03-28 |
ES2033516T3 (es) | 1993-03-16 |
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C06 | Publication | ||
PB01 | Publication | ||
C10 | Entry into substantive examination | ||
SE01 | Entry into force of request for substantive examination | ||
C53 | Correction of patent of invention or patent application | ||
CB02 | Change of applicant information |
Address after: Paris France Applicant after: Roussel UCLAF Address before: Holland V Woolf. Applicant before: Gist-Brocades N |
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COR | Change of bibliographic data |
Free format text: CORRECT: APPLICANT; FROM: GIST-BROCADES S. A. TO: LU SAIER UCLAF LTD. |
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C53 | Correction of patent of invention or patent application | ||
CB02 | Change of applicant information |
Address after: Paris France Applicant after: Russell Ukraf Co.,Ltd. Address before: Holland V Woolf. Applicant before: Gist-Brocades N |
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COR | Change of bibliographic data |
Free format text: CORRECT: APPLICANT; FROM: GIST-BROCADES S. A. TO: ROUSSEL·WURLKURF CO., LTD. |
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C14 | Grant of patent or utility model | ||
GR01 | Patent grant | ||
C15 | Extension of patent right duration from 15 to 20 years for appl. with date before 31.12.1992 and still valid on 11.12.2001 (patent law change 1993) | ||
OR01 | Other related matters | ||
C56 | Change in the name or address of the patentee |
Owner name: ROUSSEL·WURLKURF CO., LTD. Free format text: FORMER NAME OR ADDRESS: ROUSSEL UCLAF Owner name: AVENTIS PHARMA S.A. Free format text: FORMER NAME OR ADDRESS: HOECHST MARION ROUSSEL, INC. Owner name: HOECHST MARION ROUSSEL, INC. Free format text: FORMER NAME OR ADDRESS: ROUSSEL·WURLKURF CO., LTD. |
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CP01 | Change in the name or title of a patent holder |
Address after: Paris France Patentee after: AVENTIS PHARMA S.A. Address before: Paris France Patentee before: HOECHST MARION ROUSSEL, Inc. Address after: Paris France Patentee after: HOECHST MARION ROUSSEL, Inc. Address before: Paris France Patentee before: Russell Ukraf Co.,Ltd. Address after: Paris France Patentee after: Russell Ukraf Co.,Ltd. Address before: Paris France Patentee before: Roussel Uclaf |
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C17 | Cessation of patent right | ||
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