FI904877A0 - 9a-hydroxi-17-metylensteroider, foerfarande foer deras framstaellning och deras anvaendning vid framstaellning av kortikosteroider. - Google Patents

9a-hydroxi-17-metylensteroider, foerfarande foer deras framstaellning och deras anvaendning vid framstaellning av kortikosteroider.

Info

Publication number
FI904877A0
FI904877A0 FI904877A FI904877A FI904877A0 FI 904877 A0 FI904877 A0 FI 904877A0 FI 904877 A FI904877 A FI 904877A FI 904877 A FI904877 A FI 904877A FI 904877 A0 FI904877 A0 FI 904877A0
Authority
FI
Finland
Prior art keywords
framstaellning
deras
methylensteroider
kortikosteroider
hydroxi
Prior art date
Application number
FI904877A
Other languages
English (en)
Other versions
FI108436B (fi
Inventor
Jacobus Nicolaas Maria Batist
Arthur Friedrich Marx
Original Assignee
Gist Brocades Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gist Brocades Nv filed Critical Gist Brocades Nv
Publication of FI904877A0 publication Critical patent/FI904877A0/fi
Application granted granted Critical
Publication of FI108436B publication Critical patent/FI108436B/fi

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J13/00—Normal steroids containing carbon, hydrogen, halogen or oxygen having a carbon-to-carbon double bond from or to position 17
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J5/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond
    • C07J5/0007—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond not substituted in position 17 alfa
    • C07J5/0023—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond not substituted in position 17 alfa substituted in position 16
    • C07J5/003—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond not substituted in position 17 alfa substituted in position 16 by a saturated or unsaturated hydrocarbon group including 16-alkylidene substitutes
    • C07J5/0038—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond not substituted in position 17 alfa substituted in position 16 by a saturated or unsaturated hydrocarbon group including 16-alkylidene substitutes by an alkyl group
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J13/00—Normal steroids containing carbon, hydrogen, halogen or oxygen having a carbon-to-carbon double bond from or to position 17
    • C07J13/005—Normal steroids containing carbon, hydrogen, halogen or oxygen having a carbon-to-carbon double bond from or to position 17 with double bond in position 16 (17)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J13/00—Normal steroids containing carbon, hydrogen, halogen or oxygen having a carbon-to-carbon double bond from or to position 17
    • C07J13/007—Normal steroids containing carbon, hydrogen, halogen or oxygen having a carbon-to-carbon double bond from or to position 17 with double bond in position 17 (20)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J21/00—Normal steroids containing carbon, hydrogen, halogen or oxygen having an oxygen-containing hetero ring spiro-condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C07J21/005—Ketals
    • C07J21/006—Ketals at position 3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
    • C07J41/005—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 the 17-beta position being substituted by an uninterrupted chain of only two carbon atoms, e.g. pregnane derivatives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J5/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond
    • C07J5/0007—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond not substituted in position 17 alfa
    • C07J5/0015—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond not substituted in position 17 alfa not substituted in position 16
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J7/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms
    • C07J7/0005—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21
    • C07J7/001—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21 substituted in position 20 by a keto group
    • C07J7/0015—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21 substituted in position 20 by a keto group not substituted in position 17 alfa
    • C07J7/002—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21 substituted in position 20 by a keto group not substituted in position 17 alfa not substituted in position 16
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J7/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms
    • C07J7/0005—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21
    • C07J7/001—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21 substituted in position 20 by a keto group
    • C07J7/004—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21 substituted in position 20 by a keto group substituted in position 17 alfa
    • C07J7/0045—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21 substituted in position 20 by a keto group substituted in position 17 alfa not substituted in position 16
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J7/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms
    • C07J7/008—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms substituted in position 21
    • C07J7/009—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms substituted in position 21 by only one oxygen atom doubly bound

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Steroid Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
FI904877A 1988-04-08 1990-10-03 9a-hydroksi-17-metyleenisteroidit, menetelmõ niiden valmistamiseksi ja niiden kõytt÷ kortikosteroidien valmistamiseksi FI108436B (fi)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
EP88200675 1988-04-08
EP88200675 1988-04-08
PCT/NL1989/000020 WO1989009781A1 (en) 1988-04-08 1989-04-07 9-alpha-hydroxy-17-methylene steroids, their preparation and utilization
NL8900020 1989-04-07

Publications (2)

Publication Number Publication Date
FI904877A0 true FI904877A0 (fi) 1990-10-03
FI108436B FI108436B (fi) 2002-01-31

Family

ID=8199778

Family Applications (1)

Application Number Title Priority Date Filing Date
FI904877A FI108436B (fi) 1988-04-08 1990-10-03 9a-hydroksi-17-metyleenisteroidit, menetelmõ niiden valmistamiseksi ja niiden kõytt÷ kortikosteroidien valmistamiseksi

Country Status (18)

Country Link
US (1) US5194602A (fi)
EP (1) EP0336521B1 (fi)
JP (1) JP2812397B2 (fi)
KR (1) KR0138777B1 (fi)
CN (2) CN1032211C (fi)
AU (1) AU618350B2 (fi)
CA (1) CA1332409C (fi)
DE (1) DE68901104D1 (fi)
DK (1) DK175401B1 (fi)
ES (1) ES2033516T3 (fi)
FI (1) FI108436B (fi)
GR (1) GR3004539T3 (fi)
HU (1) HU208437B (fi)
IE (1) IE62277B1 (fi)
IL (1) IL89880A (fi)
NO (1) NO300894B1 (fi)
PT (1) PT90227B (fi)
WO (1) WO1989009781A1 (fi)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PT95988A (pt) * 1989-11-27 1991-09-13 Schering Corp Processo para a desidratacao de intermediarios corticoesteroides
FR2676740B1 (fr) * 1991-05-23 1993-11-05 Roussel Uclaf Nouveaux derives sterouides du pregna-4,9(11),17(20)-trie-3-one, leur preparation, leur application a la preparation de composes sterouides de type pregna-4,9(11),16-triene-3,20-dione et nouveaux intermediaires.
FR2677028B1 (fr) * 1991-05-23 1994-01-21 Roussel Uclaf Nouveaux derives sterouides du pregna-4,9(11),17(20)-trien-3-one.
FR2677029B1 (fr) * 1991-05-23 1994-01-21 Roussel Uclaf Nouveaux derives sterouides de l'andostra-4,9(11),16-trien-3-one.
FR2681069B1 (fr) * 1991-09-06 1995-04-28 Roussel Uclaf Nouveau procede de preparation de l'hydrocortisone et nouveaux intermediaires.
FR2683530B1 (fr) * 1991-11-08 1994-01-21 Roussel Uclaf Nouveau procede de preparation de derives 20-oxo 17 alpha, 21-dihydroxyles du pregnane et nouveaux intermediaires.
DE69321099D1 (de) * 1992-01-28 1998-10-22 Schering Corp Neue steroid-zwischenprodukte und verfahren zu ihrer herstellung
CN1061984C (zh) * 1996-04-18 2001-02-14 上海华联制药有限公司 甾体激素化合物中引入9-11双键的一种方法
EP1079859B1 (en) 1998-05-22 2010-07-14 The Board Of Trustees Of The Leland Stanford Junior University Bifunctional molecules and therapies based thereon
US6855836B2 (en) * 2000-10-26 2005-02-15 Jenapharm Gmbh & Co. Kg 17-Methylene steroids, process for their production and pharmaceutical compositions that contain these compounds
SI1889198T1 (sl) 2005-04-28 2015-02-27 Proteus Digital Health, Inc. Farma-informacijski sistem
JP2009508494A (ja) 2005-09-16 2009-03-05 ラプトール ファーマシューティカル インコーポレイテッド Ｃｒを含むタンパク質に対して特異的な受容体−結合タンパク質（ｒａｐ）変異体を含む組成物およびその使用
ES2550504T3 (es) * 2007-06-19 2015-11-10 Kythera Biopharmaceuticals, Inc. Preparación de ácido biliar sintético
US8242294B2 (en) 2007-06-19 2012-08-14 Kythera Biopharmaceuticals, Inc. Synthetic bile acid compositions and methods
US20080318870A1 (en) 2007-06-19 2008-12-25 Kythera Biopharmaceuticals, Inc. Synthetic bile acid compositions and methods
JOP20180077A1 (ar) 2007-06-19 2019-01-30 Kythera Biopharmaceuticals Inc تركيبات وطرق لحمض صفراوي تخليقي
DK2398500T3 (da) 2009-02-20 2019-05-13 2 Bbb Medicines B V Glutathion-baseret lægemiddelafgivelsessystem
ES2942923T3 (es) 2009-05-06 2023-06-07 Laboratory Skin Care Inc Composiciones de administración dérmica que comprenden complejos de agente activo-partículas de fosfato de calcio y métodos de uso de las mismas
GB2480632A (en) 2010-05-25 2011-11-30 Kythera Biopharmaceuticals Inc Preparation of 12-keto and 12-alpha-hydroxy steroids
CA2783017C (en) 2010-08-12 2018-05-15 Kythera Biopharmaceuticals, Inc. Synthetic bile acid compositions and methods
WO2013044119A1 (en) * 2011-09-22 2013-03-28 Kythera Biopharmaceuticals, Inc. Compositions and methods related to deoxycholic acid and its polymorphs

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL103170C (fi) * 1958-11-14
DE1568506A1 (de) * 1966-03-23 1970-07-16 Hoechst Ag Verfahren zur Herstellung von delta?-Pregnen-3,21-diol-20-on-21-acylaten
US3445907A (en) * 1967-02-16 1969-05-27 Ind Tectonics Inc Roller retaining method for roller bearing separators
US4255344A (en) * 1978-11-08 1981-03-10 Mitsubishi Chemical Industries, Limited 9-α-Hydroxy steroids
FR2462445A1 (fr) * 1979-07-31 1981-02-13 Roussel Uclaf Nouveaux derives 17-/(hydroxymethyl) (formamido) methylene/steroides, leur procede de preparation et leur application a l'introduction de la chaine laterale hydroxyacetyle
FR2486947A1 (fr) * 1980-07-15 1982-01-22 Roussel Uclaf Nouveaux derives steroides 20-isonitriles 17(20) insatures, leur procede de preparation et leur application a la preparation des steroides 17a-hydroxy 20-ceto
DE3136917A1 (de) * 1980-09-27 1982-05-19 Barmag Barmer Maschinenfabrik Ag, 5630 Remscheid "kraftstoffoerderpumpe"
FR2493324B1 (fi) * 1980-11-05 1983-01-21 Roussel Uclaf
FR2521567A1 (fr) * 1982-02-18 1983-08-19 Roussel Uclaf Nouveaux derives steroides 17(20)nitro, leur procede de preparation et leur application a la preparation de corticosteroides
EP0123734A1 (en) * 1983-04-29 1984-11-07 Gist-Brocades N.V. 17-(Isocyano-sulfonylmethylene)-steroids, 17-(formamido-sulfonylmethylene)-steroids and their preparation

Also Published As

Publication number Publication date
JP2812397B2 (ja) 1998-10-22
IE62277B1 (en) 1995-01-25
GR3004539T3 (fi) 1993-04-28
KR900700499A (ko) 1990-08-13
US5194602A (en) 1993-03-16
IL89880A (en) 1994-06-24
HU892602D0 (en) 1991-03-28
ES2033516T3 (es) 1993-03-16
NO300894B1 (no) 1997-08-11
AU618350B2 (en) 1991-12-19
CN1187365C (zh) 2005-02-02
CN1032211C (zh) 1996-07-03
NO904333D0 (no) 1990-10-05
DE68901104D1 (de) 1992-05-07
FI108436B (fi) 2002-01-31
DK175401B1 (da) 2004-09-27
CN1036774A (zh) 1989-11-01
EP0336521A1 (en) 1989-10-11
KR0138777B1 (ko) 1998-04-30
CN1141301A (zh) 1997-01-29
PT90227A (pt) 1989-11-10
DK240890D0 (da) 1990-10-05
IL89880A0 (en) 1989-12-15
WO1989009781A1 (en) 1989-10-19
JPH03503645A (ja) 1991-08-15
HUT55411A (en) 1991-05-28
CA1332409C (en) 1994-10-11
HU208437B (en) 1993-10-28
PT90227B (pt) 1994-06-30
NO904333L (no) 1990-12-03
AU3431389A (en) 1989-11-03
EP0336521B1 (en) 1992-04-01
DK240890A (da) 1990-10-05
IE891134L (en) 1989-10-08

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Legal Events

Date Code Title Description
GB Transfer or assigment of application

Owner name: HOECHST MARION ROUSSEL

GB Transfer or assigment of application

Owner name: HOECHST MARION ROUSSEL

FG Patent granted

Owner name: AVENTIS PHARMA S.A.

PC Transfer of assignment of patent

Owner name: AVENTIS PHARMA S.A.

MA Patent expired