DE69706157T2 - Diarylmethylidenefuran-derivate, verfahren zu deren herstellung und ihre verwendungen in therapie - Google Patents
Diarylmethylidenefuran-derivate, verfahren zu deren herstellung und ihre verwendungen in therapieInfo
- Publication number
- DE69706157T2 DE69706157T2 DE69706157T DE69706157T DE69706157T2 DE 69706157 T2 DE69706157 T2 DE 69706157T2 DE 69706157 T DE69706157 T DE 69706157T DE 69706157 T DE69706157 T DE 69706157T DE 69706157 T2 DE69706157 T2 DE 69706157T2
- Authority
- DE
- Germany
- Prior art keywords
- therapy
- production
- diarylmethylidenefuran derivatives
- diarylmethylidenefuran
- derivatives
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/06—Antiabortive agents; Labour repressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D307/56—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D307/58—One oxygen atom, e.g. butenolide
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pain & Pain Management (AREA)
- Endocrinology (AREA)
- Reproductive Health (AREA)
- Rheumatology (AREA)
- Gynecology & Obstetrics (AREA)
- Pregnancy & Childbirth (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Furan Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR9604236A FR2747123B1 (fr) | 1996-04-04 | 1996-04-04 | Nouveaux derives diarylmethylidene tetrahydrofurane, leurs procedes de preparation, et leurs utilisations en therapeutique |
FR9607922A FR2747124B1 (fr) | 1996-04-04 | 1996-06-26 | Nouveaux derives diarylmethylidene furaniques, leurs procedes de preparation et leurs utilisations en therapeutique |
PCT/FR1997/000602 WO1997037984A1 (fr) | 1996-04-04 | 1997-04-03 | Nouveaux derives diarylmethylidene furaniques, leurs procedes de preparation et leurs utilisations en therapeutique |
Publications (2)
Publication Number | Publication Date |
---|---|
DE69706157D1 DE69706157D1 (de) | 2001-09-20 |
DE69706157T2 true DE69706157T2 (de) | 2002-04-11 |
Family
ID=9490907
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69706157T Expired - Lifetime DE69706157T2 (de) | 1996-04-04 | 1997-04-03 | Diarylmethylidenefuran-derivate, verfahren zu deren herstellung und ihre verwendungen in therapie |
Country Status (28)
Country | Link |
---|---|
EP (1) | EP0891345B1 (de) |
JP (1) | JP2000508638A (de) |
KR (1) | KR20000005146A (de) |
CN (1) | CN1215396A (de) |
AR (1) | AR006539A1 (de) |
AT (1) | ATE204268T1 (de) |
AU (1) | AU717146B2 (de) |
BG (1) | BG62808B1 (de) |
BR (1) | BR9708510A (de) |
CA (1) | CA2248949A1 (de) |
CZ (1) | CZ318898A3 (de) |
DE (1) | DE69706157T2 (de) |
DK (1) | DK0891345T3 (de) |
EE (1) | EE03687B1 (de) |
ES (1) | ES2162678T3 (de) |
FR (2) | FR2747123B1 (de) |
GE (1) | GEP20032924B (de) |
IL (1) | IL126105A (de) |
NO (1) | NO984624L (de) |
NZ (1) | NZ331672A (de) |
PL (1) | PL329213A1 (de) |
PT (1) | PT891345E (de) |
RU (1) | RU2189979C2 (de) |
SI (1) | SI0891345T1 (de) |
SK (1) | SK283292B6 (de) |
TW (1) | TW353660B (de) |
WO (1) | WO1997037984A1 (de) |
ZA (1) | ZA972894B (de) |
Families Citing this family (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6180651B1 (en) * | 1996-04-04 | 2001-01-30 | Bristol-Myers Squibb | Diarylmethylidenefuran derivatives, processes for their preparation and their uses in therapeutics |
JP2001518087A (ja) * | 1997-04-02 | 2001-10-09 | メルク フロスト カナダ アンド カンパニー | 選択的シクロオキシゲナーゼ−2阻害薬としてのα−メチレン−γ−ラクトン類 |
FR2775477B1 (fr) * | 1998-02-27 | 2000-05-19 | Union Pharma Scient Appl | Nouveaux derives diarylmethylene heterocycliques, leurs procedes de preparation et leurs utilisations en therapeutique |
CN1106392C (zh) * | 2000-10-24 | 2003-04-23 | 中国科学院上海有机化学研究所 | 一种β位不含取代基的丁烯酸内酯及其合成的方法 |
CN102579427A (zh) * | 2002-11-05 | 2012-07-18 | 马格纳化学国际实验室公司 | 合成的内酯制剂及其使用方法 |
CA2524568C (en) * | 2003-03-31 | 2012-07-17 | Council Of Scientific & Industrial Research | Mercapto-phenyl-naphthyl-methane derivatives and preparation thereof |
EP2266585B1 (de) | 2003-05-07 | 2013-06-26 | Osteologix A/S | Wasserlösliche Strontiumsalze zur Behandlung von Knorpel- und Knochenerkrankungen |
US8779168B2 (en) * | 2010-12-16 | 2014-07-15 | Transitions Optical, Inc. | Lactone compounds and materials made therefrom |
IL305573A (en) | 2021-03-15 | 2023-10-01 | Saul Yedgar | Hyaluronic acid conjugated with dipalmitoyl phosphatidyl ethanolamine in combination with non-steroidal anti-inflammatory drugs (NSAIDs) for the treatment or suppression of inflammatory diseases |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DK0679157T3 (da) * | 1993-01-15 | 1998-07-27 | Searle & Co | Nye 3,4-diarylthiophener og analoge deraf til anvendelse som antiinflammatoriske midler |
US5474995A (en) * | 1993-06-24 | 1995-12-12 | Merck Frosst Canada, Inc. | Phenyl heterocycles as cox-2 inhibitors |
US5585504A (en) * | 1994-09-16 | 1996-12-17 | Merck & Co., Inc. | Process of making cox-2 inhibitors having a lactone bridge |
-
1996
- 1996-04-04 FR FR9604236A patent/FR2747123B1/fr not_active Expired - Fee Related
- 1996-06-26 FR FR9607922A patent/FR2747124B1/fr not_active Expired - Lifetime
-
1997
- 1997-03-24 TW TW086103701A patent/TW353660B/zh active
- 1997-04-03 CN CN97193543A patent/CN1215396A/zh active Pending
- 1997-04-03 EE EE9800333A patent/EE03687B1/xx unknown
- 1997-04-03 KR KR1019980707808A patent/KR20000005146A/ko not_active Application Discontinuation
- 1997-04-03 PL PL97329213A patent/PL329213A1/xx unknown
- 1997-04-03 AT AT97919476T patent/ATE204268T1/de active
- 1997-04-03 CA CA002248949A patent/CA2248949A1/fr not_active Abandoned
- 1997-04-03 CZ CZ983188A patent/CZ318898A3/cs unknown
- 1997-04-03 SK SK1375-98A patent/SK283292B6/sk not_active IP Right Cessation
- 1997-04-03 SI SI9730222T patent/SI0891345T1/xx unknown
- 1997-04-03 PT PT97919476T patent/PT891345E/pt unknown
- 1997-04-03 EP EP97919476A patent/EP0891345B1/de not_active Expired - Lifetime
- 1997-04-03 NZ NZ331672A patent/NZ331672A/en unknown
- 1997-04-03 AU AU23933/97A patent/AU717146B2/en not_active Ceased
- 1997-04-03 ES ES97919476T patent/ES2162678T3/es not_active Expired - Lifetime
- 1997-04-03 RU RU98119887/04A patent/RU2189979C2/ru not_active IP Right Cessation
- 1997-04-03 DK DK97919476T patent/DK0891345T3/da active
- 1997-04-03 BR BR9708510A patent/BR9708510A/pt not_active IP Right Cessation
- 1997-04-03 GE GEAP19974555A patent/GEP20032924B/en unknown
- 1997-04-03 IL IL12610597A patent/IL126105A/xx not_active IP Right Cessation
- 1997-04-03 JP JP9535910A patent/JP2000508638A/ja active Pending
- 1997-04-03 DE DE69706157T patent/DE69706157T2/de not_active Expired - Lifetime
- 1997-04-03 WO PCT/FR1997/000602 patent/WO1997037984A1/fr not_active Application Discontinuation
- 1997-04-04 AR ARP970101359A patent/AR006539A1/es not_active Application Discontinuation
- 1997-04-04 ZA ZA9702894A patent/ZA972894B/xx unknown
-
1998
- 1998-09-16 BG BG102771A patent/BG62808B1/bg unknown
- 1998-10-02 NO NO984624A patent/NO984624L/no not_active Application Discontinuation
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition |