DE69521465T2 - Benzisoselen-azoline und-azine-derivate, verfahren zu deren herstellung und ihre therapeutische verwendung - Google Patents

Benzisoselen-azoline und-azine-derivate, verfahren zu deren herstellung und ihre therapeutische verwendung

Info

Publication number
DE69521465T2
DE69521465T2 DE69521465T DE69521465T DE69521465T2 DE 69521465 T2 DE69521465 T2 DE 69521465T2 DE 69521465 T DE69521465 T DE 69521465T DE 69521465 T DE69521465 T DE 69521465T DE 69521465 T2 DE69521465 T2 DE 69521465T2
Authority
DE
Germany
Prior art keywords
benzisoselen
azoline
production
therapeutic use
azine derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69521465T
Other languages
English (en)
Other versions
DE69521465D1 (de
Inventor
Irene Erdelmeier
Jean Chaudiere
Marc Moutet
Jean-Claude Yadan
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Oxis Isle of Man Ltd
Original Assignee
Oxis Isle of Man Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Oxis Isle of Man Ltd filed Critical Oxis Isle of Man Ltd
Publication of DE69521465D1 publication Critical patent/DE69521465D1/de
Application granted granted Critical
Publication of DE69521465T2 publication Critical patent/DE69521465T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D293/00—Heterocyclic compounds containing rings having nitrogen and selenium or nitrogen and tellurium, with or without oxygen or sulfur atoms, as the ring hetero atoms
    • C07D293/10—Heterocyclic compounds containing rings having nitrogen and selenium or nitrogen and tellurium, with or without oxygen or sulfur atoms, as the ring hetero atoms condensed with carbocyclic rings or ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/16—Central respiratory analeptics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A61P39/02—Antidotes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A61P39/06—Free radical scavengers or antioxidants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D293/00—Heterocyclic compounds containing rings having nitrogen and selenium or nitrogen and tellurium, with or without oxygen or sulfur atoms, as the ring hetero atoms
    • C07D293/10—Heterocyclic compounds containing rings having nitrogen and selenium or nitrogen and tellurium, with or without oxygen or sulfur atoms, as the ring hetero atoms condensed with carbocyclic rings or ring systems
    • C07D293/12—Selenazoles; Hydrogenated selenazoles
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/10—Composition for standardization, calibration, simulation, stabilization, preparation or preservation; processes of use in preparation for chemical testing
    • Y10T436/108331—Preservative, buffer, anticoagulant or diluent

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Toxicology (AREA)
  • Cardiology (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Biochemistry (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
DE69521465T 1994-04-07 1995-04-07 Benzisoselen-azoline und-azine-derivate, verfahren zu deren herstellung und ihre therapeutische verwendung Expired - Fee Related DE69521465T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR9404107A FR2718441B1 (fr) 1994-04-07 1994-04-07 Nouveaux composés de structure benzisoséléna-zoline et -zine, leur procédé de préparation et leurs applications thérapeutiques.
PCT/FR1995/000447 WO1995027706A1 (fr) 1994-04-07 1995-04-07 Nouveaux composes de structure benzisoselen-azolin et -azine, leur procede de preparation et leurs applications therapeutiques

Publications (2)

Publication Number Publication Date
DE69521465D1 DE69521465D1 (de) 2001-08-02
DE69521465T2 true DE69521465T2 (de) 2002-05-29

Family

ID=9461850

Family Applications (2)

Application Number Title Priority Date Filing Date
DE69521465T Expired - Fee Related DE69521465T2 (de) 1994-04-07 1995-04-07 Benzisoselen-azoline und-azine-derivate, verfahren zu deren herstellung und ihre therapeutische verwendung
DE0701554T Pending DE701554T1 (de) 1994-04-07 1995-04-07 Benzisoselen-azoline und-azine-derivate, verfahren zu deren herstellung und ihre therapeutische verwendung

Family Applications After (1)

Application Number Title Priority Date Filing Date
DE0701554T Pending DE701554T1 (de) 1994-04-07 1995-04-07 Benzisoselen-azoline und-azine-derivate, verfahren zu deren herstellung und ihre therapeutische verwendung

Country Status (10)

Country Link
US (2) US5968920A (de)
EP (1) EP0701554B1 (de)
JP (1) JP4044133B2 (de)
AU (1) AU692542B2 (de)
CA (1) CA2164642C (de)
DE (2) DE69521465T2 (de)
DK (1) DK0701554T3 (de)
ES (1) ES2161879T3 (de)
FR (1) FR2718441B1 (de)
WO (1) WO1995027706A1 (de)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2751328B1 (fr) * 1996-07-17 1998-10-09 Oxis International Sa Utilisation de nouveaux composes organoselenies comme agents pro-oxydants ainsi que leurs procedes de preparation et des compositions pharmaceutiques en comportant application
AU727067B2 (en) * 1996-07-17 2000-11-30 Oxis Isle Of Man, Limited Use of novel organoselenium compounds as pro-oxidizing agents, their methods of preparation and pharmaceutical compositions and application thereof
US6407083B1 (en) 1996-07-17 2002-06-18 Oxis International, Inc. Uses of novel organoselenium compounds with pro-oxidant activity
FR2757860B1 (fr) * 1996-12-27 1999-04-23 Oxis International Sa Composes organoselenies cycliques, leur preparation et leurs utilisations, notamment therapeutiques
FR2757857B1 (fr) * 1996-12-27 1999-04-23 Oxis International Sa Diselenures et selenosulfures aromatiques, leur preparation et leurs utilisations, notamment therapeutiques
CN1509462A (zh) 2001-05-21 2004-06-30 NF-κB抑制剂在治疗干眼疾病中的用途
WO2008100629A2 (en) * 2007-02-16 2008-08-21 Synvista Therapeutics, Inc. Glutathione peroxidase mimetics for the treatment of dermatoses
US20080234283A1 (en) * 2007-02-16 2008-09-25 Noah Berkowitz Glutathione peroxidase mimetics for treatment of neurodegenerative, pulmonary and inflammatory diseases
EP2220208A4 (de) * 2007-11-23 2010-12-29 Rappaport Family Inst For Res Verwendung von haptoglobingenotypisierung zur diagnose und behandlung von herz-kreislauf-erkrankungen
JP5974093B2 (ja) * 2012-07-25 2016-08-23 国立大学法人大阪大学 組織保存液および組織保存方法
US10058542B1 (en) 2014-09-12 2018-08-28 Thioredoxin Systems Ab Composition comprising selenazol or thiazolone derivatives and silver and method of treatment therewith
CN111423395A (zh) * 2015-12-14 2020-07-17 杭州健昵福生物科技有限公司 一种具有药物活性的1，3，4-硒二唑类化合物

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3027074A1 (de) * 1980-07-17 1982-02-18 A. Nattermann & Cie GmbH, 5000 Köln Benzisoselenazolon enthaltende pharmazeutische praeparate und ihre verwendung
DE3407511A1 (de) * 1984-03-01 1985-09-05 A. Nattermann & Cie GmbH, 5000 Köln Benzisoselenazolthione, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische praeparate
DE3444135A1 (de) * 1984-12-04 1986-06-05 A. Nattermann & Cie GmbH, 5000 Köln Selenoxide, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische praeparate
FR2669633B1 (fr) * 1990-11-23 1993-01-22 Adir Nouveaux derives de la benzoselenazolinone, leur procede de preparation et les compositions pharmaceutiques qui les contiennent.

Also Published As

Publication number Publication date
DE69521465D1 (de) 2001-08-02
DE701554T1 (de) 1996-10-10
FR2718441B1 (fr) 1996-06-28
CA2164642A1 (en) 1995-10-19
AU692542B2 (en) 1998-06-11
US5968920A (en) 1999-10-19
US6093532A (en) 2000-07-25
JP4044133B2 (ja) 2008-02-06
FR2718441A1 (fr) 1995-10-13
ES2161879T3 (es) 2001-12-16
EP0701554B1 (de) 2001-06-27
DK0701554T3 (da) 2001-10-08
WO1995027706A1 (fr) 1995-10-19
AU2311195A (en) 1995-10-30
CA2164642C (en) 2008-03-25
EP0701554A1 (de) 1996-03-20
JPH11501005A (ja) 1999-01-26

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee